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Open research questions in Acne and Rosacea Treatments and Effects

300 gap statements mined from Acne and Rosacea Treatments and Effects papers in our 7.9M-paper local library, which holds 1,286 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • The need for alternative probiotic strains that can positively influence the skin microbiome. Limited understanding of the relationship between the gut microbiome and skin health. Lack of effective cosmetic formulations with antimicrobial activity against Cutibacterium acnes.

    Weissella paramesenteroides M4: Optimization of bioprocesses, antioxidant property, and a potentially probiotic strain with in vitro activity against Cutibacterium acnes · 2026 · DOI

  • However, its effects on human sebocytes and dermal fibroblasts, which could be implicated in the management of acne and atrophic scarring, remain unexplored.

    Icariin Regulates Acne Pathophysiology and Extracellular Matrix Protein Synthesis: Implications for Acne Vulgaris and Atrophic Acne Scar Management · 2026 · DOI

  • Treatment variability was another concern, with reported durations ranging from 6 weeks to 6 months and doses varying from 20 mg twice daily to 200 mg once daily, reflecting a lack of standardized treatment protocols.

    Efficacy and safety of oral doxycycline for acne vulgaris treatment: A systematic review and meta-analysis · 2026 · DOI

  • Nowadays, a deep understanding of the intricate interplay of immune dysregulation, inflammatory mediators, and microbial factors and further study of the common pathogenetic mechanisms of these dermatoses, in particular the role of cathelicidin LL-37, is crucial for the diagnosis and monitoring of inflammatory activity in both conditions and the development of justified therapeutic strategies.

    COMPARATIVE CHARACTERISTICS OF PATHOGENIC FEATURES IN ROSACEA AND PSORIASIS (LITERATURE REVIEW) · 2026 · DOI

  • The current treatments for acne have limitations and can cause problems. There is a need for better options for treating acne without causing harm. Herbal drugs have the potential to fill this gap.

    A Comprehensive Review on Antibacterial Activity of Wet Wipes By Using Herbal Drugs For The Treatment of Acne Prone Skin and Acne Vulgaris. · 2026 · DOI

  • Beyond observational design, interventional trials targeting psychiatric distress and disordered eating, embedded within dermatologic care pathways, are warranted to determine whether modifying these domains yields measurable improvements in clinical severity and patient-reported outcomes.

    Multidimensional assessment of acne vulgaris: links between psychiatric symptoms, disordered eating, and dermatologic severity · 2026 · DOI

  • Limited generalizability of existing assessment methods. Need for objective and reproducible quantitative indices.

    Objective assessment of rosacea erythema severity: a multimodal artificial intelligence framework integrating VISIA® imaging and image-derived tabular features · 2026 · DOI

  • Further studies can explore the potential impact of other factors on erythema severity assessment. The framework can be applied to other populations or skin types to improve generalizability. Future research can investigate the use of other imaging modalities or features to improve accuracy.

    Objective assessment of rosacea erythema severity: a multimodal artificial intelligence framework integrating VISIA® imaging and image-derived tabular features · 2026 · DOI

  • Conventional therapies for acne vulgaris have limitations such as resistance and irritation. There is a need for safer, natural-based alternative therapies.

    Effectiveness Test of Epigallocatechin Gallate Cream Formula in Acne Vulgaris Therapy · 2026 · DOI

  • If results are insufficient: consider systemic metronidazole or tetracycline Refer to ophthalmologist when ocular rosacea is suspected Gambar 11.

    Rosacea: Gejala, Diagnosis, dan Tata Laksana · 2026 · DOI

  • Future research should focus on advanced formulation techniques, standardization protocols, and well-designed clinical studies to establish their efficacy and safety on a larger scale. However, despite their potential, challenges such as lack of standardization, variability in herbal composition, and limited clinical evidence need to be addressed.

    Polyherbal Face Packs in Acne Management and Skin Brightening: A Comprehensive Review on Formulation, Mechanism and Therapeutic Potential · 2026 · DOI

  • There is a need to evaluate the skin irritation potential of cosmetic products. The study aimed to fill this gap by assessing the safety of Venusia Glo face wash.

    Evaluation of the skin irritation potential of Venusia Glo face wash using human patch test · 2026 · DOI

  • Limited understanding of the relationship between psychological stress, sleep quality, and acne vulgaris in college students. Need for targeted prevention strategies to address the high prevalence of acne in this population.

    Mediating Effect of Sleep Quality on the Association Between Psychological Stress and Acne Vulgaris in Chinese College Students: A Cross-Sectional Study · 2026 · DOI

  • Future studies should focus on a longer treatment interval (≥90 days) and consider a control group using a cream base without MCTs to isolate the effects of the active compound. In conclusion, this study demonstrates that while topical betulinic acid is safe, a 30-day treatment interval is insufficient to determine its effectiveness for equine melanoma and sarcoid under real-world conditions.

    Topical betulinic acid for treatment of equine melanoma and sarcoid · 2026 · DOI

  • The exact mechanisms of rosacea pathogenesis are not fully understood. The role of the TLR2-KLK5-LL-37 axis in rosacea is not well studied. Neuroimmune regulation in rosacea is not well understood.

    Immunological aspects of rosacea pathogenesis: fundamental mechanisms and translational potential · 2026 · DOI

  • The current treatments for acne have limitations, such as antibiotic resistance and side effects. There is a need for new, effective, and safe treatments for acne.

    Lactobacillus gasseri extracellular proteins suppress acne inflammation and sebum secretion via the PI3K/AKT/mTOR pathway · 2026 · DOI

  • Another limitation of this study is the lack of clinical validation for acne and depression, as well as the potential influence of confounding factors such as stress related to the COVID-19 pandemic. The impact of acne on adolescents’ quality of life may vary over time, but this study does not account for those changes.

    Impact of Acne on Quality of Life in Adolescents of Honduras: A Cross-Sectional Analytical Study · 2026 · DOI

  • There is a lack of large-scale randomized controlled trials investigating the efficacy of treatments for rosacea. There is a need for more effective and personalized therapeutic strategies for rosacea. The optimal dosing regimens and treatment durations for these treatments are unclear.

    Therapeutic progress in rosacea: targeting the neuro-vascular-immune triad · 2026 · DOI

  • There is a need for new therapeutic strategies for acne vulgaris. Current treatments have limitations, including side effects and lack of clinical improvement. The study highlights the gap in current treatments and the potential of clascoterone to address this gap.

    BRIDGING THE GAP IN ACNE MANAGEMENT: A NARRATIVE REVIEW OF CURRENT THERAPIES AND THE EMERGENCE OF CLASCOTERONE · 2026 · DOI

  • Our study is one of the few studies on this topic that uses a split-face model to compare PRP with plasma gel injections for acne scars without combining it with other therapies.

    A prospective split-face comparative study of plasma gel versus platelet-rich plasma in the treatment of atrophic acne scars · 2026 · DOI

  • Investigating novel biologics, - Exploring the potential of bacteriophages, - Studying the effects of probiotics and peptides on acne, - Further research on the role of the gut microbiome…

    Exploring Acne Treatments: From Pathophysiological Mechanisms to Emerging Therapies · 2024 · DOI

  • Conventional treatments have adverse effects - Acne vulgaris is a multifactorial disorder - Herbal ingredients need to be formulated into effective…

    A Review of Herbal Gel for Acne Treatment · 2026 · DOI

  • Conventional treatments have limitations - Herbal ingredients offer a safer alternative - There is a need to review the potential of herbal ingredients in anti-acne gel…

    A Review of Herbal Gel for Acne Treatment · 2026 · DOI

  • Importantly, SA peels demonstrated a favorable safety profile in Fitzpatrick skin types III– V, with post-inflammatory hyperpigmentation rarely reported (only two cases in one splitface trial) (18).

    The Comprehensive Systematic Review of Effectiveness of Salicylic Acid in Chemical Peeling Procedures for Comedonal Acne · 2026 · DOI

  • Further studies on the anti-acne activity of Gomphrena globosa L. flower extract using in vivo models. The development of new topical medications using plant extracts.

    Characterization of Gomphrena globosa L. Flower Extract and Anti-Acne of Formulated Cream Against Cutibacterium acnes · 2026 · DOI

Most-cited papers in Acne and Rosacea Treatments and Effects

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Open questions raised by papers listed on this page include: (1) Lack of effective cosmetic formulations with antimicrobial activity against Cutibacterium acnes (“Weissella paramesenteroides M4: Optimization of bioprocesses, antioxidant…”, 2026); (2) Its effects on human sebocytes and dermal fibroblasts, which could be implicated in the management of acne and atrophic scarring, remain unexplored (“Icariin Regulates Acne Pathophysiology and Extracellular Matrix Protein…”, 2026); (3) Treatment variability was another concern, with reported durations ranging from 6 weeks to 6 months and doses varying from 20 mg twice daily to 200 mg once daily, reflecting a lack of standardized treatment protocols (“Efficacy and safety of oral doxycycline for acne vulgaris treatment: A…”, 2026); (4) There is a need for better options for treating acne without causing harm (“A Comprehensive Review on Antibacterial Activity of Wet Wipes By Using Herbal…”, 2026); (5) Future research can investigate the use of other imaging modalities or features to improve accuracy (“Objective assessment of rosacea erythema severity: a multimodal artificial…”, 2026). 300 gap statements have been mined from Acne and Rosacea Treatments and Effects papers in our 7.9M-paper local library, which holds 1,286 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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