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Open research questions in Acne and Rosacea Treatments and Effects

121 unresolved questions extracted from the limitations and future-work sections of 390 Acne and Rosacea Treatments and Effects papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The development of effective microbiome-based treatments for acne, considering the complexity of the skin microbiome. The need to address antimicrobial resistance, which is a major concern in acne treatment. The challenge of maintaining a balanced skin microbiome, while targeting pathogenic strains, to prevent infections and promote healthy skin.

    The Role of the Skin Microbiome in Acne: Challenges and Future Therapeutic Opportunities · 2024 · DOI

  • Biomarker and microbiological studies suggest additional effects on inflammatory, extracellular-matrix, and antimicrobial pathways, but their clinical significance remains uncertain.

    SYSTEMIC ISOTRETINOIN AND ORAL HEALTH: SALIVARY, MUCOSAL, AND PERIODONTAL CHANGES AND IMPLICATIONS FOR DENTAL PRACTICE · 2026 · DOI

  • Oral manifestations may include xerostomia, reduced salivary flow, cheilitis, mucosal discomfort, and changes in periodontal parameters, but their clinical significance for dental practice remains incompletely defined.

    SYSTEMIC ISOTRETINOIN AND ORAL HEALTH: SALIVARY, MUCOSAL, AND PERIODONTAL CHANGES AND IMPLICATIONS FOR DENTAL PRACTICE · 2026 · DOI

  • BACKGROUND: Despite its widespread use in acne vulgaris treatment, the potential cytological and genotoxic effects of systemic isotretinoin on oral mucosal cells remain poorly understood.

    Cytological and Genotoxic Effects of Systemic Isotretinoin on Oral Mucosa Cells · 2025 · DOI

  • Despite the efficacy of conventional therapies, including antibiotics and retinoids, their use is frequently limited by adverse effects and the emergence of drug resistance.

    Multi-target mechanisms and potential applications of quercetin in the treatment of acne vulgaris · 2025 · DOI

  • Differentiating sebocytes delaminate from the basal membrane and dislodge towards the gland's middle, where they eventually undergo a poorly understood death mode in which the whole cell becomes a secretion product (holocrine secretion).

    The metabolic underpinnings of sebaceous lipogenesis · 2025 · DOI

  • Although research has begun to explore this relationship, the role of the skin microbiome in adolescents experiencing emotional disturbances and acne remains poorly understood.

    Amplicon-based analysis reveals link between adolescent acne and altered facial skin microbiome induced by negative emotional states · 2025 · DOI

  • However, the lack of standardized methodologies, limited longitudinal studies, and the narrow focus on bacterial communities are major limitations in current research.

    The Role of the Skin Microbiome in Acne: Challenges and Future Therapeutic Opportunities · 2024 · DOI

  • So far, the search for the molecular background of such diverse behavior has led to inconsistent results.

    Whole genome sequencing distinguishes skin colonizing from infection-associated Cutibacterium acnes isolates · 2024 · DOI

  • The role of diet in acne remains inconclusive, but the very low-calorie ketogenic diet (VLCKD), known for weight loss and generating anti-inflammatory ketone bodies, presents promising potential.

    Very low-calorie ketogenic diet (VLCKD): a therapeutic nutritional tool for acne? · 2024 · DOI

  • The current understanding of the pathogenetic features of rosacea and psoriasis is limited. There is a need to identify the common elements of pathogenesis between the two diseases. The study aims to address this gap by reviewing the literature and highlighting the similarities between rosacea and psoriasis.

    COMPARATIVE CHARACTERISTICS OF PATHOGENIC FEATURES IN ROSACEA AND PSORIASIS (LITERATURE REVIEW) · 2026 · DOI

  • Conventional treatments have adverse effects - Acne vulgaris is a multifactorial disorder - Herbal ingredients need to be formulated into effective gels

    A Review of Herbal Gel for Acne Treatment · 2026 · DOI

  • Conventional treatments have limitations - Herbal ingredients offer a safer alternative - There is a need to review the potential of herbal ingredients in anti-acne gel formulation

    A Review of Herbal Gel for Acne Treatment · 2026 · DOI

  • The current treatments for acne have limitations and can cause problems. There is a need for better options for treating acne without causing harm. Herbal drugs have the potential to fill this gap.

    A Comprehensive Review on Antibacterial Activity of Wet Wipes By Using Herbal Drugs For The Treatment of Acne Prone Skin and Acne Vulgaris. · 2026 · DOI

  • The interplay between psychiatric symptoms, eating behaviors, and quality of life in acne patients is underexplored. There is a need to evaluate the associations between these variables in patients with acne vulgaris compared to healthy controls.

    Multidimensional assessment of acne vulgaris: links between psychiatric symptoms, disordered eating, and dermatologic severity · 2026 · DOI

  • Inter-observer variability in clinical assessment. Limited generalizability of existing assessment methods. Need for objective and reproducible quantitative indices.

    Objective assessment of rosacea erythema severity: a multimodal artificial intelligence framework integrating VISIA® imaging and image-derived tabular features · 2026 · DOI

  • Further studies can explore the potential impact of other factors on erythema severity assessment. The framework can be applied to other populations or skin types to improve generalizability. Future research can investigate the use of other imaging modalities or features to improve accuracy.

    Objective assessment of rosacea erythema severity: a multimodal artificial intelligence framework integrating VISIA® imaging and image-derived tabular features · 2026 · DOI

  • Conventional therapies for acne vulgaris have limitations such as resistance and irritation. There is a need for safer, natural-based alternative therapies.

    Effectiveness Test of Epigallocatechin Gallate Cream Formula in Acne Vulgaris Therapy · 2026 · DOI

  • if results are insufficient: consider combination with systemic azithromycin Consider for ocular rosacea artificial tears and eyelid hygiene, and if results are not sufficient consider topical fusidic acid gel or (only by ophthalmologist) ciclosporin ophthalmic emulsion Children consider for papules/pustules topical metronidazole cream/gel bid. If results are insufficient: consider systemic metronidazole or tetracycline Refer to ophthalmologist when ocular rosacea is suspected Gambar 11.

    Rosacea: Gejala, Diagnosis, dan Tata Laksana · 2026 · DOI

  • There is a need to evaluate the skin irritation potential of cosmetic products. The study aimed to fill this gap by assessing the safety of Venusia Glo face wash.

    Evaluation of the skin irritation potential of Venusia Glo face wash using human patch test · 2026 · DOI

  • The development of antimicrobial resistance to conventional acne treatments. The need for safer and more effective therapeutic approaches. The challenge of stabilizing and delivering herbal constituents.

    POLYHERBAL EMULGEL AS A TOPICAL STRATEGY FOR ACNE MANAGEMENT: A COMPREHENSIVE REVIEW · 2026 · DOI

  • The need for safer alternatives to conventional acne treatments. The potential of polyherbal formulations for acne management. The advantages of emulgel systems for topical delivery.

    POLYHERBAL EMULGEL AS A TOPICAL STRATEGY FOR ACNE MANAGEMENT: A COMPREHENSIVE REVIEW · 2026 · DOI

  • Limited understanding of the relationship between psychological stress, sleep quality, and acne vulgaris in college students. Need for targeted prevention strategies to address the high prevalence of acne in this population.

    Mediating Effect of Sleep Quality on the Association Between Psychological Stress and Acne Vulgaris in Chinese College Students: A Cross-Sectional Study · 2026 · DOI

  • The study had a limited sample size. The treatment period was only 30 days. The study did not evaluate the long-term efficacy of the treatment.

    Topical betulinic acid for treatment of equine melanoma and sarcoid · 2026 · DOI

  • There is limited in vivo evidence evaluating the clinical efficacy of betulinic acid for equine melanoma and sarcoid. Current topical treatments can produce significant local inflammation. There is a need for new, safe, and effective treatments for equine melanoma and sarcoid.

    Topical betulinic acid for treatment of equine melanoma and sarcoid · 2026 · DOI

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121 open questions have been extracted from the limitations and future-work passages of 390 Acne and Rosacea Treatments and Effects papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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