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Open research questions in Acute Kidney Injury Research

152 unresolved questions extracted from the limitations and future-work sections of 481 Acute Kidney Injury Research papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The complexity of current severity scores. The need for simpler and faster biomarkers for early risk stratification. The challenge of developing a reliable and reproducible prediction model.

    Association between lactate dehydrogenase-to-albumin ratio and short-term mortality in critically ill patients with urosepsis: evidence from dual retrospective cohorts · 2026 · DOI

  • The current severity scores are complex and challenging to apply in emergency settings. There is a lack of simpler and faster biomarkers for early risk stratification in urosepsis patients.

    Association between lactate dehydrogenase-to-albumin ratio and short-term mortality in critically ill patients with urosepsis: evidence from dual retrospective cohorts · 2026 · DOI

  • Further studies are needed to investigate the effects of RIPC on CIN prevention - Research on the optimal number of RIPC cycles and cuff pressure strategy is required - Investigation of the long-term outcomes of RIPC in patients undergoing coronary angiography or percutaneous coronary intervention is necessary

    Remote ischemic preconditioning reduces contrast-induced nephropathy in patients undergoing coronary angiography or percutaneous coronary intervention: an updated meta-analysis of randomized controlled trials · 2026 · DOI

  • The evidence from randomized controlled trials on the efficacy of RIPC for preventing CIN remains inconsistent. There is a need for an updated meta-analysis to evaluate the efficacy of RIPC for preventing CIN.

    Remote ischemic preconditioning reduces contrast-induced nephropathy in patients undergoing coronary angiography or percutaneous coronary intervention: an updated meta-analysis of randomized controlled trials · 2026 · DOI

  • Substantial external overprediction - Low positive predictive values - The composite is neither independently adjudicated nor a universal definition of clinical RRT need - Actual RRT initiation is both a clinical event and a treatment decision

    Development and external validation of prediction models for a trial-informed operational composite after stage 3 acute kidney injury · 2026 · DOI

  • The lack of established timing rules for renal replacement therapy in critically ill patients with severe AKI. The need for prediction models to identify patients who will develop severe complications after stage 3 AKI.

    Development and external validation of prediction models for a trial-informed operational composite after stage 3 acute kidney injury · 2026 · DOI

  • The paper identifies a gap in understanding the molecular mechanisms of lipocalin-2 in atherosclerosis. It highlights the need for novel therapeutic strategies targeting lipocalin-2. The paper notes that the diagnostic and prognostic value of lipocalin-2 is not fully understood.

    Targeting lipocalin-2 in atherosclerosis: biological functions, pathogenic mechanisms, and therapeutic potential · 2026 · DOI

  • Experimental investigations have remarkably illuminated promising strategies for enhancing AKI prognosis through the modulation of mitochondrial function - Targeting mitochondrial dynamics is a valuable avenue for therapeutic interventions to prevent or ameliorate AKI in various clinical scenarios

    Mitochondrial Signaling, the Mechanisms of AKI-to-CKD Transition and Potential Treatment Targets · 2024 · DOI

  • The mechanism of mitochondrial signaling in PTCs for AKI-to-CKD transition is not well understood. The role of mitochondrial dysfunction in the development of CKD is not fully elucidated.

    Mitochondrial Signaling, the Mechanisms of AKI-to-CKD Transition and Potential Treatment Targets · 2024 · DOI

  • Abstract Whether proactive early renal replacement therapy (RRT) improves outcomes in higher-risk patients with KDIGO stage 2 sepsis-associated acute kidney injury (SA-AKI) and sustained oliguria remains uncertain.

    Early renal replacement therapy and short-term mortality in higher-risk KDIGO stage 2 sepsis-associated acute kidney injury with sustained oliguria: a target trial emulation · 2026 · DOI

  • In patients undergoing endovascular thrombectomy (EVT) for acute ischemic stroke (AIS), the incidence and clinical impact are poorly characterized, and no validated prediction tool is currently available.

    Contrast-Associated Acute Kidney Injury After Thrombectomy for Ischemic Stroke · 2026 · DOI

  • We aimed to investigate how the time between acute kidney injury (AKI) and CRRT initiation impacts outcomes in children, as this relationship remains uncertain.

    Time from acute kidney injury to continuous renal replacement therapy and outcomes in critically ill children · 2026 · DOI

  • However, existing literature provides limited data regarding the risk factors associated with AKI in pediatric sepsis patients and the impact of AKI on hospital outcomes for these patients.

    Pediatric severe sepsis: epidemiology and risk factors associated with acute kidney injury · 2026 · DOI

  • Conclusion Pediatric AKI remains underrecognized in Rwandan district hospitals, with major gaps in knowledge, staging, and monitoring.

    Pediatric acute kidney injury in Rwanda: awareness, early detection, and timely management to improve outcomes, a multi-center mixed method study · 2026 · DOI

  • Although extensively studied in coronary angiography, its incidence, associated factors, and outcomes following interventional radiology and other non-coronary endovascular procedures remain incompletely characterized.

    Incidence, risk factors, and outcomes of contrast-associated acute kidney injury following interventional radiology procedures: a systematic review and meta-analysis · 2026 · DOI

  • Nevertheless, the implications of varying BCR levels for outcomes among heart failure patients remain to be fully understood.

    Predicting mortality in heart failure: BUN/creatinine ratio in MIMIC-III · 2025 · DOI

  • Short-term outcomes included kidney recovery, mortality, and hospitalization metrics; long-term data were scarce, primarily focusing on kidney function preservation.

    The relevance of acute kidney injury in dehydrated children · 2025 · DOI

  • The majority of existing research on pediatric acute kidney injury primarily focuses on cases occurring after cardiac surgery or in critically ill children, leaving dehydration-associated AKI understudied.

    The relevance of acute kidney injury in dehydrated children · 2025 · DOI

  • Serum neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a potential early biomarker for AKI, but its utility in neonates remains unclear.

    The role of serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) in detecting acute kidney injury in preterm neonates exposed to nephrotoxic drugs · 2025 · DOI

  • While the synergism between dysregulated host response and renal vulnerability is increasingly recognized, the multifactorial drivers of poor prognosis remain poorly defined.

    Characteristics and prognosis of patients with pathogenic microorganism-positive sepsis AKI from ICU: a retrospective cohort study · 2025 · DOI

  • BACKGROUND: Sepsis-Associated Acute Kidney Injury (SA-AKI) has high fatality rates, but clear outcome markers are lacking.

    Association between lactate to albumin ratio and mortality among sepsis associated acute kidney injury patients · 2025 · DOI

  • Despite some advancements, the specific mechanisms underlying the AKI to CKD transition remain incompletely understood.

    Histone modification–mediated epigenetic regulation in AKI-to-CKD transition: a cell-type-specific perspective · 2025 · DOI

  • However, its precise role in NSCLC and the underlying molecular mechanisms remain incompletely understood.

    Lipocalin-2 promotes NSCLC progression by activating the JAK2/STAT3 signaling pathway · 2025 · DOI

  • However, cell membrane biomimetic‐modified nanozymes as anti‐inflammatory drug delivery systems for the treatment of kidney injury is rarely reported.

    ROS Responsive Cerium Oxide Biomimetic Nanoparticles Alleviates Calcium Oxalate Crystals Induced Kidney Injury via Suppressing Oxidative Stress and M1 Macrophage Polarization · 2024 · DOI

  • The specific mechanisms through which lipotoxicity contributes to acute kidney injury (AKI) remain poorly understood.

    Lipotoxicity and immunometabolism in ischemic acute kidney injury: current perspectives and future directions · 2024 · DOI

Most-cited papers in Acute Kidney Injury Research

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152 open questions have been extracted from the limitations and future-work passages of 481 Acute Kidney Injury Research papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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