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Open research questions in Acute Myocardial Infarction Research

497 gap statements mined from Acute Myocardial Infarction Research papers in our 7.9M-paper local library, which holds 2,537 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • The incidence of right ventricular involvement among patients with RCA-related STEMI is not well established. The relationship between right ventricular involvement and bleeding and mortality outcomes is not fully understood. The study aims to address this gap by analyzing data from a nationwide registry.

    Impact of Right Ventricular Involvement on Bleeding and Mortality in Patients With Right Coronary Artery-Related Myocardial Infarction ― Insights From Nationwide Registry ― · 2026 · DOI

  • The gap is the lack of understanding of the long-term prognosis in STEMI patients with HFpEF. The gap is the limited knowledge on the prognostic impact of HFpEF on STEMI patients.

    Long-Term Prognosis in Patients with ST-Elevation Myocardial Infarction Complicated by Heart Failure with Preserved Left Ventricular Ejection Fraction · 2025 · DOI

  • The current study aims to address the gap in identifying laboratory, clinical, and imaging indicators of distal coronary embolism. Prior studies have identified distal coronary embolism as a predictor of poor outcomes, but the current study seeks to identify specific biomarkers and indicators.

    Markers in Acute Coronary Syndrome: Distal Coronary Embolism at Percutaneous Coronary Intervention · 2025 · DOI

  • The NIS also lacks information on the quality of care. The study focused on in-hospital outcomes due to the limitations of the NIS database, which does not provide post-discharge follow-up data. The CKM classification depends on ICD codes, which may not fully reflect the syndrome's complexity.

    Impact of Cardiovascular–Kidney–Metabolic Syndrome Staging on Myocardial Infarction Outcomes: A Retrospective Analysis of 2.7 Million Patients · 2025 · DOI

  • Additional studies are needed to evaluate the optimal diagnosis and management of AMI in patients without traditional cardiovascular risk factors. Future research should focus on identifying specific mechanisms underlying AMI in this population, - Developing targeted strategies to improve their outcomes, - Better understanding the interplay between CKM severity, treatment strategies, and long-term prognosis.

    Impact of Cardiovascular–Kidney–Metabolic Syndrome Staging on Myocardial Infarction Outcomes: A Retrospective Analysis of 2.7 Million Patients · 2025 · DOI

  • However, up-to-date information on the incidence and prognostic impact of arrhythmias following this event is lacking.

    Clinical Impact of Arrhythmias Detected by an Implantable Cardiac Monitoring Device With Real-Time Transmission Among Patients With Early Reduced Left Ventricular Ejection Fraction After ST-Segment Elevation Acute Myocardial Infarction · 2026 · DOI

  • Although infusion of supersaturated oxygen (SSO 2) after primary percutaneous coronary intervention (PPCI) has been shown to reduce IS among patients with acute anterior ST-segment elevation myocardial infarction (STEMI), the cost-effectiveness of this approach remains unknown.

    Cost-Effectiveness of Supersaturated Oxygen Delivery for Infarct Size Reduction in Patients With Anterior ST-Segment Elevation Myocardial Infarction · 2026 · DOI

  • The PI population remains vastly understudied in contemporary interventional cardiology practice.

    An Evaluation of the Use of Fibrinolytic Therapy for Treatment of STEMI in Northern New England Over Two Decades · 2026 · DOI

  • Adding Gal-3 to established risk scores yielded higher apparent discrimination and secondary exploratory reclassification metrics; however, the magnitude of these differences remains uncertain and may still be optimistic despite bootstrap correction.

    Galectin-3–enhanced prognostic models for major adverse cardiovascular events in Vietnamese patients with acute coronary syndrome: A prospective cohort study · 2026 · DOI

  • Although guidelines recommend invasive management for non–ST-segment–elevation myocardial infarction (NSTEMI), there is considerable variability in the application of these recommendations across different hospitals, reflecting a lack of standardized clinical pathways and highlighting ongoing uncertainty in real-world practice.

    Hospital-Level Variability in NSTEMI Management: Findings From the NCDR Chest Pain-MI Registry · 2026 · DOI

  • Oxidative stress and ferroptosis are increasingly recognized as key contributors to the pathogenesis of ST-segment elevation myocardial infarction (STEMI), although the clinical relevance of circulating molecules linked to these processes remains insufficiently defined.

    Circulating 4-Hydroxynonenal Is Associated with Clinical Severity in ST-Segment Elevation Myocardial Infarction · 2026 · DOI

  • Cardiogenic shock (CS) elevates mortality rates among patients with acute myocardial infarction (AMI), yet there are insufficient data on trends in mortality.

    Trends in Mortality Among Adults With Acute Myocardial Infarction With Cardiogenic Shock in the United States, 1999-2023 · 2025 · DOI

  • Periodontal disease is linked to increased cardiovascular morbidity, but its impact on outcomes in ST elevation myocardial infarction (STEMI) remains understudied.

    A-2 | Associations between Periodontal Disease and Hospitalization Outcomes in ST Elevation Myocardial Infarction: Insights from the United States National Inpatient Sample · 2025 · DOI

  • Telemedicine has been conversely hypothesized to carry an excess of false-positive diagnoses; however, comparisons with a traditional diagnostic process at non-percutaneous coronary intervention capable (“Spoke”) hospitals are lacking.

    Comparative performance of spoke centers versus telemedicine service in the emergency activation of ST elevation myocardial infarction network: Insights from the “detective” registry · 2025 · DOI

  • While high sensitivity cardiac troponin (hs‐cTn) research has focused on HBEDs, its application in FSEDs remains unexplored.

    Comparing Outcomes of a Rapid High‐Sensitivity Troponin Protocol Between Hospital‐Based and Freestanding Emergency Departments · 2025 · DOI

  • Renal transplantation (RT) significantly improves quality of life & improves survival; however, reduction in CV mortality is understudied.

    A-5 | Outcomes of ST Elevations Myocardial Infarction in Renal Transplant Recipients Compared to Patients without Kidney Disease · 2024 · DOI

  • Outcomes of STEMI in the presence of Chronic total occlusion (CTO) of a secondary vessel are not well known.

    A-8 | Propensity Matched In-Hospital Outcomes of Acute ST Elevation Myocardial Infarction in Patients with Simultaneous Chronic Total Occlusion · 2024 · DOI

  • Recent studies show that patients without standard modifiable risk factors (SMuRF-less) have poorer outcomes in acute myocardial infarction (AMI).

    OR6-6 | In-Hospital Outcomes of Post-Myocardial Infarction Complications In Patients Without Standard Modifiable Risk Factors: A Nationwide Analysis · 2024 · DOI

  • Outdated derivation cohorts - Overfitting - Lack of generalizability - High inter-observer variability - Limited predictive ability for long-term…

    Personalized Treatment of Patients with Coronary Artery Disease: The Value and Limitations of Predictive Models · 2025 · DOI

  • Development of more accurate and generalizable predictive models - Integration of artificial intelligence and machine learning models into clinical practice - Investigation of ethical issues, such as equity in model application…

    Personalized Treatment of Patients with Coronary Artery Disease: The Value and Limitations of Predictive Models · 2025 · DOI

  • Emerging technologies, particularly artificial intelligence for ECG interpretation, offer promise for further time reduction, - Evaluation of the effectiveness of public awareness campaigns and regionalized STEMI…

    The Irreversible March of Time: Ischemic Delay and Impact on Outcomes in ST-Segment Elevation Myocardial Infarction · 2025 · DOI

  • Persistent disparities based on geography, presentation timing, sex, race, and age remain problematic, - The need for targeted interventions to reduce total ischemic…

    The Irreversible March of Time: Ischemic Delay and Impact on Outcomes in ST-Segment Elevation Myocardial Infarction · 2025 · DOI

  • Retrospective study design, - Limited to patients with isolated LAD artery disease, - No comparison to conventional sternotomy-based CABG, - Potential for selection bias in patient…

    Sex-Based Comparative Analysis of Outcomes Following Minimally Invasive Direct Coronary Artery Bypass: A 20-Year Study · 2025 · DOI

  • Investigation of sex-specific differences in MIDCAB outcomes in larger, more diverse populations, - Comparison of MIDCAB to conventional CABG in terms of long-term outcomes and sex-specific differences, - Examination of the impact of clinical risk factors on prognosis in MIDCAB…

    Sex-Based Comparative Analysis of Outcomes Following Minimally Invasive Direct Coronary Artery Bypass: A 20-Year Study · 2025 · DOI

  • Further studies are needed to confirm the findings and explore the relationship between DHEA-S and distal coronary embolism, - Research should investigate the potential therapeutic applications of DHEA-S in the management of ACS, - Studies should examine the relationship between other biomarkers and distal coronary…

    Markers in Acute Coronary Syndrome: Distal Coronary Embolism at Percutaneous Coronary Intervention · 2025 · DOI

Most-cited papers in Acute Myocardial Infarction Research

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Open questions raised by papers listed on this page include: (1) The incidence of right ventricular involvement among patients with RCA-related STEMI is not well established (“Impact of Right Ventricular Involvement on Bleeding and Mortality in Patients…”, 2026); (2) Up-to-date information on the incidence and prognostic impact of arrhythmias following this event is lacking (“Clinical Impact of Arrhythmias Detected by an Implantable Cardiac Monitoring…”, 2026); (3) The gap is the lack of understanding of the long-term prognosis in STEMI patients with HFpEF (“Long-Term Prognosis in Patients with ST-Elevation Myocardial Infarction…”, 2025); (4) Additional studies are needed to evaluate the optimal diagnosis and management of AMI in patients without traditional cardiovascular risk factors (“Impact of Cardiovascular–Kidney–Metabolic Syndrome Staging on Myocardial…”, 2025); (5) Periodontal disease is linked to increased cardiovascular morbidity, but its impact on outcomes in ST elevation myocardial infarction (STEMI) remains understudied (“A-2 | Associations between Periodontal Disease and Hospitalization Outcomes in…”, 2025). 497 gap statements have been mined from Acute Myocardial Infarction Research papers in our 7.9M-paper local library, which holds 2,537 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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