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Open research questions in Alcoholism and Thiamine Deficiency

97 unresolved questions extracted from the limitations and future-work sections of 1,474 Alcoholism and Thiamine Deficiency papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • AIMS: While clinical consequences of thiamine deficiency in alcohol use disorder (AUD) are severe, evidence-based recommendations on dosage, type of administration and duration of thiamine substitution (TS), and its' target levels remain sparse.

    Can thiamine substitution restore cognitive function in alcohol use disorder? · 2023 · DOI

  • Although autonomic nervous system (ANS) activity has been attributed to the ventromedial prefrontal cortex (VmPFC)-limbic-striatal regions, the specific role of ANS disruption in AUD and its association with these regions remain unclear.

    Irregular Autonomic Modulation Predicts Risky Drinking and Altered Ventromedial Prefrontal Cortex Response to Stress in Alcohol Use Disorder · 2021 · DOI

  • AIM: Impulsivity has been identified as a key relapse risk factor in patients with alcohol use disorder (AUD); however, the inherent characteristics of this relationship have been largely understudied.

    The Association Between Impulsivity and Relapse in Patients With Alcohol Use Disorder: A Literature Review · 2020 · DOI

  • METHOD: A sample 810 (364 females) young adults aged 18-30 recruited from the community, who varied widely in lifetime alcohol problems, were administered diagnostic interviews and measures of a trait anxiety, depression, and BPD symptoms.

    Sex differences in trait anxiety’s association with alcohol problems in emerging adults: The influence of symptoms of depression and borderline personality · 2019 · DOI

  • BACKGROUND: Despite growing evidence for neurobehavioral deficits in social cognition in alcohol use disorder (AUD), the clinical relevance remains unclear, and little is known about its impact on treatment outcome.

    Impact of Social Cognition on Alcohol Dependence Treatment Outcome: Poorer Facial Emotion Recognition Predicts Relapse/Dropout · 2017 · DOI

  • Future research is needed to improve understanding of how cannabis adds to the ARB risk and to find genes that contribute to risks for ARBs among drinkers.

    Predictors of Patterns of Alcohol-Related Blackouts Over Time in Youth From the Collaborative Study of the Genetics of Alcoholism: The Roles of Genetics and Cannabis · 2016 · DOI

  • CONCLUSIONS: Pharmacogenetic studies of AUD treatment that use greater methodological rigor and better statistical controls, such as corrections for multiple testing, may help to resolve inconsistent findings.

    The Pharmacogenetics of Alcohol Use Disorder · 2015 · DOI

  • However, as there is no consensus regarding how to predict the development of severe alcohol withdrawal syndrome (SAWS), we sought to determine independent predictors of SAWS.

    Predictors of Severe Alcohol Withdrawal Syndrome: A Systematic Review and Meta‐Analysis · 2014 · DOI

  • The precise mechanisms of alcohol-related brain damage (ARBD) remain to be fully understood and several papers in this series describe the limits of knowledge.

    Alcohol-Related Brain Damage: Report from a Medical Council on Alcohol Symposium, June 2010 · 2012 · DOI

  • AIMS: Alcohol acutely reduces agitation and is widely used in social situations, but the neural substrates of emotion processing during its intoxication are not well understood.

    Alcohol Attenuates Activation in the Bilateral Anterior Insula during an Emotional Processing Task: A Pilot Study† · 2011 · DOI

  • However, little is known about the specific and common cognitive processes associated with NS and sensation-seeking personality traits in detoxified sober alcoholic abusers.

    Neurocognitive Determinants of Novelty and Sensation-Seeking in Individuals with Alcoholism · 2011 · DOI

  • The relative roles of alcohol and TD in causing brain damage remain controversial and it is important to try to determine the role played by each factor.

    Biomarkers in Alcohol Misuse: Their Role in the Prevention and Detection of Thiamine Deficiency · 2009 · DOI

  • Little is known concerning the ERP profiles or alcohol cue reactivity of social drinkers at risk for alcoholism due to low sensitivity to alcohol's effects.

    Effects of alcohol sensitivity on P3 event-related potential reactivity to alcohol cues. · 2007 · DOI

  • The material presented also contributes to ongoing discussions about treatment strategies for comorbid alcoholism and cigarette smoking and will hopefully stimulate further research into the neurobiological and neurocognitive consequences of chronic smoking in alcoholism and other substance use disorders.

    The neurobiological and neurocognitive consequences of chronic cigarette smoking in alcohol use disorders · 2007 · DOI

  • Further investigation of differential responders may lead to improvements in the pharmacological treatment of co-occurring alcohol dependence and PTSD.

    Sertraline in the Treatment of Co‐occurring Alcohol Dependence and Posttraumatic Stress Disorder · 2005 · DOI

  • Psychomotor performance measures used in human studies of alcohol tolerance provide reliable assessments of tolerance but do not identify specific mechanisms involved in the re-establishment of control, and little is known about how acute tolerance is expressed in terms of changes in fundamental mechanisms that regulate and control behavior.

    Acute tolerance to alcohol effects on inhibitory and activational mechanisms of behavioral control. · 2005 · DOI

  • Both linkage and association to the region on chromosome 15q that contains a cluster of GABAA receptor genes have previously been reported, but the role of these genes in alcoholism remains inconclusive.

    Association of <i>GABRG3</i> With Alcohol Dependence · 2004 · DOI

  • Future research is needed to explore the performance of a re-worded HSS in laboratory settings, which may help bridge the gap between laboratory and survey investigations of hangover.

    Development and Initial Validation of the Hangover Symptoms Scale: Prevalence and Correlates of Hangover Symptoms in College Students · 2003 · DOI

  • BACKGROUND: Accumulating evidence shows the efficacy of the gamma-aminobutyric acid (GABA(B)) receptor agonist baclofen in reducing alcohol intake in rats, but no studies have been performed in alcoholics.

    Ability of Baclofen in Reducing Alcohol Craving and Intake: II—Preliminary Clinical Evidence · 2000 · DOI

  • Moreover, there are no guidelines available to assist the clinician or the researcher in distinguishing Alcohol Related Dementia from other causes of dementia such as Alzheimer's Disease (AD).

    Alcohol related dementia: proposed clinical criteria · 1998 · DOI

  • Ethanol exposure during development is particularly deleterious to cerebellar Purkinje cells and granule cells, but the mechanism(s) underlying this sensitivity and the variables which affect it remain unknown.

    The Effects of the Timing of Ethanol Exposure during the Brain Growth Spurt on the Number of Cerebellar Purkinje and Granule Cell Nuclear Profiles · 1993 · DOI

  • In view of conflicting results concerning differences between sons of alcoholics and sons of nonalcoholics in response to a single alcohol challenge (with a given dose), we exposed these high and low risk groups to several sessions in which they drank alcohol at the same dose in order to measure the development of chronic tolerance or sensitization with repeated doses.

    Chronic Tolerance and Sensitization to Alcohol in Sons of Alcoholics · 1991 · DOI

  • The finding of circadian variations in ethanol metabolism in alcoholics may also help explain the inconsistent findings between alcoholics and non-aicohohcs in rate of ethanol metabolism (Wallgren and Barry, 1970).

    Circadian Variation of Ethanol Metabolism in Alcoholics* · 1974 · DOI

  • Measurements of Change During Alcohol Wtthdrawal in Chronic Alcoholics 270 While there is a need for an objecti\'e description of "withdrawal'', few studies have generated results to pinpoint psychological and physiological changes during the time eourse of withdrawal.

    Measurements of Change during Alcohol Withdrawal in Chronic Alcoholics* · 1970 · DOI

  • The ever-increasing medical and social services are bound to obey the law of diminishing retums, and in the context of an overstrained economy, with many worthwhile services completing for the available money and skill, there is an urgent need for further investigation into the proper indications for various types of support.

    After‐care for Alcoholics—a Follow‐up Study · 1969 · DOI

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97 open questions have been extracted from the limitations and future-work passages of 1,474 Alcoholism and Thiamine Deficiency papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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