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Open research questions in Alcoholism and Thiamine Deficiency

371 unresolved questions extracted from the limitations and future-work sections of 1,535 Alcoholism and Thiamine Deficiency papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Investigate the effects of high-dose thiamine supplementation on human obesity, - Examine the long-term effects of high-dose thiamine supplementation on gut microbiota dysbiosis, - Explore the potential of other B vitamins in regulating gut microbiota dysbiosis

    High-dose thiamine supplementation ameliorates obesity induced by a high-fat and high-fructose diet in mice by reshaping gut microbiota · 2025 · DOI

  • The potential and mechanisms of thiamine for alleviating obesity induced by a high-fat and high-fructose diet are unclear. There is a lack of understanding of the effects of high-dose thiamine supplementation on gut microbiota dysbiosis.

    High-dose thiamine supplementation ameliorates obesity induced by a high-fat and high-fructose diet in mice by reshaping gut microbiota · 2025 · DOI

  • Indirect evidence and limited studies suggest either no link or a potentially complex interaction that requires further research to determine a definitive association.

    Is there a link between Lewy body dementia and alcohol abuse? · 2026 · DOI

  • The relationship between alcohol abuse and Lewy body dementia is not clearly established.

    Is there a link between Lewy body dementia and alcohol abuse? · 2026 · DOI

  • Objective Accumulating evidence highlights the important role of B vitamins in maintaining the balance of gut microbial ecology and metabolism, however, few studies have focused on changes in B vitamins homeostasis in the gut and their associations with disease.

    Multi-omics analyses reveal altered gut microbial thiamine production in obesity · 2025 · DOI

  • Dietary impact on pulmonary pressures is still poorly understood, but it seems that micronutrient deficiency could be a rare cause of pulmonary hypertension.

    Case Report: severe pulmonary hypertension in a child with micronutrient deficiency · 2025 · DOI

  • Conclusions: While certain supplements show potential in mitigating cognitive decline in AD, inconsistent findings and gaps in dosage and safety data highlight the need for rigorous, large-scale trials.

    Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer’s Disease · 2025 · DOI

  • However, many of these supplements are still under investigation, with mixed results highlighting the need for high-quality research.

    Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer’s Disease · 2025 · DOI

  • Importance: Phenobarbital monotherapy is increasingly used to treat alcohol withdrawal syndrome (AWS) in hospitalized patients, but its implementation outside academic emergency departments (EDs) and intensive care units (ICUs) remains understudied.

    Hospital-Wide Implementation, Clinical Outcomes, and Safety of Phenobarbital for Alcohol Withdrawal · 2025 · DOI

  • Further studies on the analgesic activity of D-phenylalanine (DPA) in mice and humans.

    Enkephalinase inhibition: Regulation of ethanol intake in genetically predisposed mice · 1987 · DOI

  • There is a lack of research on the effectiveness of tPBM and taVNS for reducing alcohol craving. The study aims to address this gap by investigating the effects of tPBM, taVNS, and combined tPBM + taVNS on alcohol craving and related symptoms.

    The effectiveness of transcranial photobiomodulation therapy (tPBM) and transauricular vagus nerve stimulation (taVNS) on reducing alcohol craving · 2026 · DOI

  • The heterogeneity of the definitions of alcoholism. Variability in sampling methods, measures, and results. The need for further research on the treatment and prevention of alcoholism.

    Alcoholism Research: A Narrative Review · 2026 · DOI

  • The review highlights the need for further research on the treatment and prevention of alcoholism. The review notes that only a few studies have addressed potential underlying biological mechanisms for alcoholism.

    Alcoholism Research: A Narrative Review · 2026 · DOI

  • Investigating the effects of alcohol on older adults is challenging due to the complexity of aging and alcohol interactions. Sex-dependent effects can be difficult to study due to the need for large sample sizes and careful experimental design.

    Aged rats have sex-dependent hypothermic effects but not spatial memory impairments following acute alcohol administration · 2026 · DOI

  • Construction disruptions in the building housing the animal colony limited the number of animals that could be included in the spatial memory test. Only a subset of the subjects underwent a spatial memory test.

    Aged rats have sex-dependent hypothermic effects but not spatial memory impairments following acute alcohol administration · 2026 · DOI

  • Limited gender-specific data from tertiary care settings in India. Lack of knowledge about the demographic and clinical profile of women with alcohol dependence syndrome. Need for gender-responsive and integrated approaches in the treatment of substance use disorders.

    Demographic and clinical profile of alcohol dependence syndrome in women availing de-addiction services in a tertiary care hospital: A Retrospective crosssectional study · 2026 · DOI

  • Purpose: Zonisamide, an anticonvulsant with GABAergic and glutamatergic effects, has been investigated as a treatment for alcohol use disorder (AUD), but its efficacy and tolerability remain uncertain.

    Efficacy and Tolerability of Zonisamide for Alcohol Use Disorder · 2026 · DOI

  • However, whether the pronounced structural alterations in MD persist after remission from AUD, and their relation to cognitive impairments, remains unclear.

    Brain structural correlates of prior alcohol use disorder and their relation to cognitive impairment in individuals with mood disorders · 2025 · DOI

  • As delirium itself is an under-recognised clinical syndrome, this scoping review aimed to determine the epidemiology and clinical phenotype of delirium-onset DLB.

    2351 Clinical phenotype and epidemiology of delirium-onset dementia with Lewy bodies – a scoping review · 2024 · DOI

  • AIMS: While clinical consequences of thiamine deficiency in alcohol use disorder (AUD) are severe, evidence-based recommendations on dosage, type of administration and duration of thiamine substitution (TS), and its' target levels remain sparse.

    Can thiamine substitution restore cognitive function in alcohol use disorder? · 2023 · DOI

  • Although autonomic nervous system (ANS) activity has been attributed to the ventromedial prefrontal cortex (VmPFC)-limbic-striatal regions, the specific role of ANS disruption in AUD and its association with these regions remain unclear.

    Irregular Autonomic Modulation Predicts Risky Drinking and Altered Ventromedial Prefrontal Cortex Response to Stress in Alcohol Use Disorder · 2021 · DOI

  • AIM: Impulsivity has been identified as a key relapse risk factor in patients with alcohol use disorder (AUD); however, the inherent characteristics of this relationship have been largely understudied.

    The Association Between Impulsivity and Relapse in Patients With Alcohol Use Disorder: A Literature Review · 2020 · DOI

  • METHOD: A sample 810 (364 females) young adults aged 18-30 recruited from the community, who varied widely in lifetime alcohol problems, were administered diagnostic interviews and measures of a trait anxiety, depression, and BPD symptoms.

    Sex differences in trait anxiety’s association with alcohol problems in emerging adults: The influence of symptoms of depression and borderline personality · 2019 · DOI

  • Future research is needed to improve understanding of how cannabis adds to the ARB risk and to find genes that contribute to risks for ARBs among drinkers.

    Predictors of Patterns of Alcohol-Related Blackouts Over Time in Youth From the Collaborative Study of the Genetics of Alcoholism: The Roles of Genetics and Cannabis · 2016 · DOI

  • CONCLUSIONS: Pharmacogenetic studies of AUD treatment that use greater methodological rigor and better statistical controls, such as corrections for multiple testing, may help to resolve inconsistent findings.

    The Pharmacogenetics of Alcohol Use Disorder · 2015 · DOI

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371 open questions have been extracted from the limitations and future-work passages of 1,535 Alcoholism and Thiamine Deficiency papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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