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Open research questions in Alcoholism and Thiamine Deficiency

387 gap statements mined from Alcoholism and Thiamine Deficiency papers in our 7.9M-paper local library, which holds 1,811 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • Plasma NFL and GFAP are promising biomarkers of AW‐related brain pathology and should be investigated as biomarkers of therapeutic response to test innovative drug strategies for preventing this toxicity.

    Longitudinal Study of Plasma NFL and GFAP as Biomarkers of Alcohol Withdrawal–Associated Brain Injury · 2026 · DOI

  • There is a lack of research on the effectiveness of tPBM and taVNS for reducing alcohol craving. The study aims to address this gap by investigating the effects of tPBM, taVNS, and combined tPBM + taVNS on alcohol craving and related symptoms.

    The effectiveness of transcranial photobiomodulation therapy (tPBM) and transauricular vagus nerve stimulation (taVNS) on reducing alcohol craving · 2026 · DOI

  • The need for further research on the treatment and prevention of alcoholism.

    Alcoholism Research: A Narrative Review · 2026 · DOI

  • The review highlights the need for further research on the treatment and prevention of alcoholism. The review notes that only a few studies have addressed potential underlying biological mechanisms for alcoholism.

    Alcoholism Research: A Narrative Review · 2026 · DOI

  • Investigating the effects of alcohol on older adults is challenging due to the complexity of aging and alcohol interactions. Sex-dependent effects can be difficult to study due to the need for large sample sizes and careful experimental design.

    Aged rats have sex-dependent hypothermic effects but not spatial memory impairments following acute alcohol administration · 2026 · DOI

  • Construction disruptions in the building housing the animal colony limited the number of animals that could be included in the spatial memory test. Only a subset of the subjects underwent a spatial memory test.

    Aged rats have sex-dependent hypothermic effects but not spatial memory impairments following acute alcohol administration · 2026 · DOI

  • Zonisamide, an anticonvulsant with GABAergic and glutamatergic effects, has been investigated as a treatment for alcohol use disorder (AUD), but its efficacy and tolerability remain uncertain.

    Efficacy and Tolerability of Zonisamide for Alcohol Use Disorder · 2026 · DOI

  • The impact of alcohol on intracranial aneurysms remains underexplored. There is a lack of research on the relationship between alcohol consumption and the risk of rupture or severity of aneurysmal subarachnoid hemorrhage. The study aims to address this gap by investigating the influence of alcohol and THC use on the risk of intracranial aneurysm rupture and the clinical severity of aneurysmal subarachnoid hemorrhage.

    Recreational substance use and aneurysmal subarachnoid hemorrhage: differential effects of alcohol and THC · 2026 · DOI

  • Alcohol Use Disorder (AUD) is commonly associated with malnutrition, yet the relative contributions of inadequate intake versus alcohol-related metabolic disruption remain unclear.

    Dietary intake, quality, and assessment tools in individuals with problematic alcohol use: a scoping review and meta-analysis · 2026 · DOI

  • There is a need to investigate the effects of alcohol use disorder on the brain's incretin network.

    Impaired Brain Incretin and Gut Hormone Expression in Human Alcohol-Related Brain Damage: Opportunities for Therapeutic Targeting · 2026 · DOI

  • However, the extent to which lifetime AUD interacts with aging to accelerate subtle cognitive trajectories prior to overt clinical dementia remains unclear.

    Alcohol use disorder accelerates age-related cognitive decline · 2026 · DOI

  • BackgroundAlcohol use disorder (AUD) is associated with increased dementia risk, but its long-term relationship with dementia, variation by age and subtype, and how this risk compares with that associated with alcohol consumption remain poorly characterised.

    Clinically Recognised Alcohol Use Disorder and Risk of Dementia Subtypes in 1.3 Million Women: A Prospective Cohort Study · 2026 · DOI

  • The lack of understanding of the effect of Vitamin B1 on anxiety and depression-like behaviors in chronically stressed rats. The need to investigate the impact of Vitamin B1 on nicotine abstinence-induced anxiety and depression. The gap in current research on the behavioral improvements accompanied by restoration of oxidative balance and attenuation of neuroinflammatory markers.

    Vitamin B1 administration attenuates anxiety and depression-like behaviors induced by nicotine abstinence in chronically stressed rats · 2026 · DOI

  • There is a lack of knowledge regarding the prevalence of micronutrient deficiencies in hospitalized veterans without alcohol use disorder. Prior studies have focused on the prevalence of micronutrient deficiencies in patients with alcohol use disorder.

    Thiamine and Micronutrient Deficiencies in Hospitalized Veterans Without Alcohol Use Disorder · 2026 · DOI

  • There is a lack of awareness and validated biomarkers for thiamine deficiency. Prevalence data for thiamine deficiency are lacking. There is no consensus on reference intervals for thiamine biomarker results.

    Thiamine Deficiency in Hospitalized Veterans Without Alcohol Use Disorder: Prevalence, Biomarker Assessment, and Clinical Characteristics · 2026 · DOI

  • Four themes emerged: hospitalists are adaptable in responding to changing practices and drug shortages; a lack of consensus on AWS treatment practices leads to a "wild west approach" to therapy selection; hospitalists prioritize care-delivery outcomes when selecting medications; and patients are minimally involved in shared decision-making.

    Hospitalist perspectives and practices in treating hospitalized patients with alcohol withdrawal syndrome in the era of phenobarbital re‐emergence · 2026 · DOI

  • The need for a comprehensive analysis of the epidemic, including its epidemiological, clinical, neuropathological, therapeutic, and health aspects.

    Cuban epidemic neuropathy: lessons learned from scientific and political controversies · 2026 · DOI

  • However, whether the pronounced structural alterations in MD persist after remission from AUD, and their relation to cognitive impairments, remains unclear.

    Brain structural correlates of prior alcohol use disorder and their relation to cognitive impairment in individuals with mood disorders · 2025 · DOI

  • The potential and mechanisms of thiamine for alleviating obesity induced by a high-fat and high-fructose diet are unclear. There is a lack of understanding of the effects of high-dose thiamine supplementation on gut microbiota dysbiosis.

    High-dose thiamine supplementation ameliorates obesity induced by a high-fat and high-fructose diet in mice by reshaping gut microbiota · 2025 · DOI

  • Malnutrition is a complex issue in SUDs, affecting disease progression and recovery outcomes. The relationship between SUDs and nutrition is complex, with drug abuse affecting eating patterns and nutritional status. There is a need to develop effective nutritional therapies for SUD treatment and recovery.

    Malnutrition in Substance Use Disorders: A Critical Issue in Their Treatment and Recovery · 2025 · DOI

  • Because of its rarity and nonspecific clinical presentation, ASHS remains an underrecognized entity with limited collective experience in the literature, as most reports are restricted to individual case descriptions.

    A rare and underrecognized complication of sickle cell disease in a pediatric patient: acute soft head syndrome · 2026 · DOI

  • Investigate the potential impact of AUD-mediated circadian rhythm disruption in relation to the observed inhibitory effects on frontal lobe neuroendocrine, including incretin expression.

    Impaired Brain Incretin and Gut Hormone Expression in Human Alcohol-Related Brain Damage: Opportunities for Therapeutic Targeting · 2026 · DOI

  • Further studies on the prevalence of TD in different populations, - Development of validated biomarkers for TD, - Investigation of the utility of plasma and whole-blood thiamine biomarkers in identifying…

    Thiamine Deficiency in Hospitalized Veterans Without Alcohol Use Disorder: Prevalence, Biomarker Assessment, and Clinical Characteristics · 2026 · DOI

  • Intensive national and international collaboration can contribute to solving complex public health problems - The epidemic functioned as a natural laboratory in which the effects of interacting nutritional, metabolic, and environmental stressors on the nervous system could be observed at the population…

    Cuban epidemic neuropathy: lessons learned from scientific and political controversies · 2026 · DOI

  • Investigate the effects of high-dose thiamine supplementation on human obesity, - Examine the long-term effects of high-dose thiamine supplementation on gut microbiota dysbiosis, - Explore the potential of other B vitamins in regulating gut microbiota…

    High-dose thiamine supplementation ameliorates obesity induced by a high-fat and high-fructose diet in mice by reshaping gut microbiota · 2025 · DOI

Most-cited papers in Alcoholism and Thiamine Deficiency

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Open questions raised by papers listed on this page include: (1) There is a lack of research on the effectiveness of tPBM and taVNS for reducing alcohol craving (“The effectiveness of transcranial photobiomodulation therapy (tPBM) and…”, 2026); (2) The impact of alcohol on intracranial aneurysms remains underexplored (“Recreational substance use and aneurysmal subarachnoid hemorrhage: differential…”, 2026); (3) Alcohol Use Disorder (AUD) is commonly associated with malnutrition, yet the relative contributions of inadequate intake versus alcohol-related metabolic disruption remain unclear (“Dietary intake, quality, and assessment tools in individuals with problematic…”, 2026); (4) There is a need to investigate the effects of alcohol use disorder on the brain's incretin network (“Impaired Brain Incretin and Gut Hormone Expression in Human Alcohol-Related…”, 2026); (5) The extent to which lifetime AUD interacts with aging to accelerate subtle cognitive trajectories prior to overt clinical dementia remains unclear (“Alcohol use disorder accelerates age-related cognitive decline”, 2026). 387 gap statements have been mined from Alcoholism and Thiamine Deficiency papers in our 7.9M-paper local library, which holds 1,811 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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