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Open research questions in Allergic Rhinitis and Sensitization

93 unresolved questions extracted from the limitations and future-work sections of 363 Allergic Rhinitis and Sensitization papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The complexity of the immune mechanisms involved in AR. The need for further research to confirm the therapeutic potential of CGRP in AR. The challenge of developing effective treatments that target the underlying mechanisms of the disease.

    Calcitonin gene-related peptide as a neuroimmune amplifier in allergic rhinitis: from disease worsening to targeted drug intervention · 2026 · DOI

  • Further studies are needed to establish the role of CGRP in AR, - Dedicated randomized controlled trials are needed to test the efficacy of anti-CGRP agents or CGRP receptor antagonists in AR

    Calcitonin gene-related peptide as a neuroimmune amplifier in allergic rhinitis: from disease worsening to targeted drug intervention · 2026 · DOI

  • evaluating AIT selection, response, or longitudinal therapeutic outcomes, - monitoring the impact of environmental change on allergic sensitization over time, - conducting similar studies in other geographic areas

    Molecular sensitization clusters in adult atopy: an ALEX2-based analysis from Eastern Europe · 2026 · DOI

  • There is a lack of data on allergen sensitization profiles in Eastern Europe. The study addresses the gap in understanding the molecular sensitization patterns in a Romanian adult atopic cohort. The study provides insights into the molecular sensitization clusters in a specific geographic region.

    Molecular sensitization clusters in adult atopy: an ALEX2-based analysis from Eastern Europe · 2026 · DOI

  • A proposed framework integrating clinical phenotype, allergen sensitization and exposure, nasal cytology, local biomarkers, and multi-omic information toward validated mucosal endotypes and longitudinal reassessment should be tested prospectively, - The future value of nasal cytology may lie in its role as the first accessible layer of a multidimensional mucosal assessment

    From nasal cytology to cellular endotyping: mast cell–eosinophil interactions and overlapping inflammation in allergic rhinitis · 2026 · DOI

  • The traditional framework of allergen sensitization and type 2 inflammation does not fully capture the biological heterogeneity of allergic rhinitis. There is a need to understand the local inflammatory landscape in allergic rhinitis. The concept of overlapping rhinitis is not well understood and requires further study.

    From nasal cytology to cellular endotyping: mast cell–eosinophil interactions and overlapping inflammation in allergic rhinitis · 2026 · DOI

  • Athlete-specific sources were preferred, with selected clinical studies included when sports-related evidence was limited.

    Nasal Decongestants in Competitive Athletes: A Narrative Review · 2026 · DOI

  • Rhinitis is the best documented sinonasal disorder in this group, while chronic rhinosinusitis and septal deviation remain insufficiently studied.

    Nasal Decongestants in Competitive Athletes: A Narrative Review · 2026 · DOI

  • Due to their photostability as well as their backgroundless and continuous luminescence, SPT trajectories obtained with UCNP labels are no longer limited by the photophysics of the label but only by the dynamics of the system and, in particular, the movement of the label out of the field of view and/or focal plane.

    Targeted Single Particle Tracking with Upconverting Nanoparticles · 2024 · DOI

  • However, detailed epidemiological data on AR in children from Bayannur City are lacking.

    Epidemiological investigation of allergic rhinitis in children aged 6–12 years in Bayannur City, China · 2024 · DOI

  • The pathogenic mechanism of lung-spleen deficiency is complex and not fully elucidated. The integration of traditional Chinese and Western medicine poses challenges. The treatment of allergic rhinitis is often symptomatic and does not address the underlying causes.

    Pathogenesis and Integrated Traditional Chinese and Western Medicine Treatment Strategies of Allergic Rhinitis Based on the “Spleen (Stomach)-Lung-Nose Axis” Theory · 2026 · DOI

  • The pathogenic mechanism of lung-spleen deficiency has not been fully elucidated. There is a lack of integrated therapeutic strategies for allergic rhinitis.

    Pathogenesis and Integrated Traditional Chinese and Western Medicine Treatment Strategies of Allergic Rhinitis Based on the “Spleen (Stomach)-Lung-Nose Axis” Theory · 2026 · DOI

  • The evidence on the association between allergic rhinitis and migraine risk remains inconsistent. There is a need for a comprehensive meta-analysis to systematically evaluate the association between allergic rhinitis and migraine risk.

    A systematic review and meta-analysis on the risk of migraine in patients with allergic rhinitis · 2026 · DOI

  • Research is needed to reduce misclassification bias by replacing administrative health records and self-reported diagnostic criteria with standardized, validated clinical assessments of both allergic rhinitis and migraine phenotypes in prospective cohorts.

    A systematic review and meta-analysis on the risk of migraine in patients with allergic rhinitis · 2026 · DOI

  • There is a need for more convenient and patient-friendly treatment options for allergic rhinitis. The current standard treatment regimen can be time-consuming and inconvenient, which may affect patient adherence.

    A multicenter randomized study: safety of an optimized accelerated house dust mite immunotherapy for patients with allergic rhinitis in China (PERFECT study) · 2026 · DOI

  • Future studies should focus on these aspects to bridge the gap between mechanistic findings and clinical application. Additionally, while our preclinical models suggest that the dual regulatory capacity of kaempferol mirrors the core mechanism identified for the whole YPTQ formula, its in vivo therapeutic efficacy, pharmacokinetic profile, bioavailability, and long-term safety in relevant AR models remain to be rigorously validated before clinical translation.

    Multi-targeted protection of Yuping Tongqiao against allergic rhinitis: suppression of inflammatory response via TSLP signaling and reinforcement of epithelial barrier integrity via AhR signaling · 2026 · DOI

  • Long-term follow-up studies to evaluate the durability of PNN's effects. Comparative studies to evaluate PNN against other surgical options. Investigation of the potential applications of PNN in other conditions.

    Endoscopic posterior nasal nerve neurectomy efficacy and outcome in cases of allergic rhinitis · 2026 · DOI

  • The lack of precise and accessible methods of allergen identification. The limitations of established laboratory techniques for routine or point-of-need testing.

    Ratiometric fluorescent sensor based on biomass-derived carbon dots for on-site detection of pollen allergen · 2026 · DOI

  • The underlying factors contributing to the heterogeneity in treatment efficacy remain unclear. Robust biomarkers capable of predicting SCIT outcomes are still lacking.

    Serum metabolomic profiling identifies taurolithocholic acid as a predictor of HDM-SCIT response in allergic rhinitis: clinical discovery and experimental validation · 2026 · DOI

  • The pathogenic mechanisms of NAR remain incompletely understood. Conventional phenotyping inadequately captures disease complexity. There is a need for endotype analysis in chronic rhinitis.

    Local immune and inflammatory endotypes of the nasal mucosa in allergic and non-allergic chronic rhinitis · 2026 · DOI

  • There is a lack of studies examining the relationship between SAR and sleep disturbances in children.

    Prevalence and clinical predictors of sleep disturbances in childrenwith seasonal allergic rhinitis · 2026 · DOI

  • There is a lack of understanding about the perceived value and intended use of real-time pollen data among seasonal allergic rhinitis patients. There is a need to identify factors associated with perceived informational needs and to investigate the potential of real-time pollen data to contribute to managing seasonal allergic rhinitis symptoms.

    Potential of real-time pollen data: perceived needs and symptom management among seasonal allergic rhinitis patients · 2026 · DOI

  • The disease has a significant impact on the quality of life of affected children. There is a need to develop effective treatment plans that consider environmental factors and medication adherence.

    Health-related quality of life and its determinants in children with allergic rhinitis · 2026 · DOI

  • The modifiable determinants of HRQoL in children with allergic rhinitis are not well understood. There is a need to investigate the relationship between AR and HRQoL in children.

    Health-related quality of life and its determinants in children with allergic rhinitis · 2026 · DOI

  • Conventional saline irrigation may not replicate the physicochemical properties of airway surface liquid - Limited understanding of the protective effects of sodium hyaluronate nasal spray on murine nasal mucosa

    Protective effects of sodium hyaluronate nasal spray on murine nasal mucosa via preservation of airway surface liquid and mucociliary clearance · 2026 · DOI

Most-cited papers in Allergic Rhinitis and Sensitization

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93 open questions have been extracted from the limitations and future-work passages of 363 Allergic Rhinitis and Sensitization papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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