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Open research questions in Allergic Rhinitis and Sensitization

31 unresolved questions extracted from the limitations and future-work sections of 293 Allergic Rhinitis and Sensitization papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • This should be validated through further experiments, which will be instructive for the develop‑ ment of QUE as a drug to prevent AR. The present study primarily evaluated the therapeutic effects of QUE on AR, but its toxicity and side effects were not explored in additional depth.

    Role and mechanism of quercetin via the TLR4/MyD88/IRAK4 signaling pathway in the treatment of allergic rhinitis · 2026 · DOI

  • Abstract Introduction Understanding how environmental allergens elicit bronchus-associated lymphoid tissue (BALT) is key to elucidating mechanisms of asthma pathophysiology; however, the extent to which different allergens elicit BALT and IgE responses is poorly understood.

    VEGF-C enhances BALT and skews IgE responses towards a pathogenic, anaphylactic profile in mouse models of allergic asthma 2259494 · 2026 · DOI

  • Abstract Purpose of Review Particulate matter (PM) exposure is increasingly associated with sinonasal disorders including allergic rhinitis (AR) and chronic rhinosinusitis (CRS), yet the mechanistic pathways linking PM to epithelial dysfunction remain incompletely defined.

    Systematic Review of Particulate Matter-Induced Upper Respiratory Disease with Mechanistic Signaling Pathway · 2026 · DOI

  • However, this is lacking in allergy and immunology (A&I) because no structured training is currently available on a national level specific to the APP role.

    Development of a Competency-Based Curriculum for Advanced Practice Providers in Allergy and Immunology. · 2026 · DOI

  • 1866527 transport, ciliary beat regulation, HA receptor signaling, mucus rheology, and ASL biophysical properties warrant further investigation.

    Protective effects of sodium hyaluronate nasal spray on murine nasal mucosa via preservation of airway surface liquid and mucociliary clearance · 2026 · DOI

  • Future studies should focus on these aspects to bridge the gap between mechanistic findings and clinical application. Additionally, while our preclinical models suggest that the dual regulatory capacity of kaempferol mirrors the core mechanism identified for the whole YPTQ formula, its in vivo therapeutic efficacy, pharmacokinetic profile, bioavailability, and long-term safety in relevant AR models remain to be rigorously validated before clinical translation.

    Multi-targeted protection of Yuping Tongqiao against allergic rhinitis: suppression of inflammatory response via TSLP signaling and reinforcement of epithelial barrier integrity via AhR signaling · 2026 · DOI

  • Research is needed to reduce misclassification bias by replacing administrative health records and self-reported diagnostic criteria with standardized, validated clinical assessments of both allergic rhinitis and migraine phenotypes in prospective cohorts.

    A systematic review and meta-analysis on the risk of migraine in patients with allergic rhinitis · 2026 · DOI

  • Future studies must separately investigate the age-dependent mechanisms—including early-onset neural priming of the trigeminal vascular system in children versus comorbidity-related diagnostic overlap in adults—to clarify the differential association between allergic rhinitis and migraine across life stages.

    A systematic review and meta-analysis on the risk of migraine in patients with allergic rhinitis · 2026 · DOI

  • The extreme heterogeneity (I² = 99%) among included studies reflects unresolved differences in diagnostic criteria, patient populations, and study designs for allergic rhinitis and migraine classification that require standardization to reduce residual variability in future meta-analyses.

    A systematic review and meta-analysis on the risk of migraine in patients with allergic rhinitis · 2026 · DOI

  • Genetic and epigenetic studies using large-scale genomic databases should be conducted to identify and characterize shared biological vulnerabilities between allergic rhinitis and migraine susceptibility.

    A systematic review and meta-analysis on the risk of migraine in patients with allergic rhinitis · 2026 · DOI

  • Mechanistic studies must explore the precise molecular interactions between neurogenic inflammation and allergic immune responses to elucidate the specific pathogenic pathways linking allergic rhinitis to migraine development.

    A systematic review and meta-analysis on the risk of migraine in patients with allergic rhinitis · 2026 · DOI

  • Prospective longitudinal studies and randomized controlled trials are needed to establish whether effective allergic rhinitis management can prospectively reduce migraine incidence, as all included studies were observational and cannot establish causality.

    A systematic review and meta-analysis on the risk of migraine in patients with allergic rhinitis · 2026 · DOI

  • The phased integrated treatment strategy combining TCM and Western medicine has been proposed theoretically but lacks comprehensive clinical trial evidence demonstrating efficacy and safety across different patient populations.

    Pathogenesis and Integrated Traditional Chinese and Western Medicine Treatment Strategies of Allergic Rhinitis Based on the “Spleen (Stomach)-Lung-Nose Axis” Theory · 2026 · DOI

  • The associations between TCM pathogenic factors (inherent deficiency, impaired Wei-defensive qi, insufficient qi and blood production, abnormal body fluid transformation) and modern medical factors (genetic susceptibility, epithelial immune barrier damage, endoplasmic reticulum stress-autophagy pathway effects, hypersecretion, vascular permeability) may constitute causal relationships but require further investigation.

    Pathogenesis and Integrated Traditional Chinese and Western Medicine Treatment Strategies of Allergic Rhinitis Based on the “Spleen (Stomach)-Lung-Nose Axis” Theory · 2026 · DOI

  • Thus, patients in whom the clinical history is doubtful regarding the relevance of allergen exposure, who remain insufficiently controlled, and/or who can be expected to obtain clinical benefit from specific interventions for AR and AA (both pharmacological or non-pharmacological) should be considered for allergen challenge testing.

    Abstracts of the 8th Congress of the Romanian Rhinologic Society · 2025 · DOI

  • The findings of this study regarding Bermuda grass pollen prevalence in rural versus urban areas disagreed with a Colombian/USA study by Sánchez et al., 2018, which found Bermuda grass pollen more prevalent in urban areas. The reason for this geographic discrepancy remains unexplored.

    Pollen sensitization among Egyptian patients with respiratory allergic diseases · 2022 · DOI

  • The discrepancy between sensitization frequency (30.45%) and actual allergy frequency (3.18%) warrants further investigation into the mechanisms linking allergen exposure and symptom occurrence.

    Frequency of ragweed sensitization and allergy among patients with respiratory allergy · 2022 · DOI

  • Studies show that adding bacterial lysates (BLs) to treatment can improve outcomes, but their effects on the immune system are still not fully understood.

    Intervention with Polyvalent Bacterial Lysate Modulates T Helper Cell Subsets in Polish Children with Grass Pollen-Induced Allergic Rhinitis · 2026 · DOI

  • Specific mechanisms by which intranasal acupuncture at points like Neiyingxiang and Biqiu reduces turbinate swelling and mucus secretion require further mechanistic investigation.

    Pathogenesis and Integrated Traditional Chinese and Western Medicine Treatment Strategies of Allergic Rhinitis Based on the “Spleen (Stomach)-Lung-Nose Axis” Theory · 2026 · DOI

  • The study lacks explanation for why most asthmatic patients had controlled or partially controlled disease and why disease duration was longer in patients with no ragweed allergy or sensitization.

    Frequency of ragweed sensitization and allergy among patients with respiratory allergy · 2022 · DOI

  • A review of sublingual immunotherapy confirmed both efficacy and safety, but evidence for appropriate dosing and for the effectiveness of sublingual immunotherapy employing multiple allergen mixes was still lacking.

    La norma linguistica · 1986 · DOI

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31 open questions have been extracted from the limitations and future-work passages of 293 Allergic Rhinitis and Sensitization papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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