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Open research questions in Antifungal resistance and susceptibility

216 unresolved questions extracted from the limitations and future-work sections of 1,027 Antifungal resistance and susceptibility papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • the study only included urban households with access to an intradomiciliary water distribution system, - the study was conducted in a single city in Colombia, - the sample size was limited to 104 households

    First Isolation of Candida parapsilosis from Water-Related Domestic Environments in Colombia: A Public Health Concern? · 2026 · DOI

  • The occurrence of antifungal-resistant Candida species in domestic water systems in Colombia remains largely unexplored. There is a need to investigate the environmental reservoirs of C. parapsilosis.

    First Isolation of Candida parapsilosis from Water-Related Domestic Environments in Colombia: A Public Health Concern? · 2026 · DOI

  • Investigate the association between Qat use and gastrointestinal mucormycosis, - Study the effects of Qat leaves chewing on the gastrointestinal mucosa, - Examine the role of transient immune dysfunction in gastrointestinal mucormycosis

    Gastrointestinal mucormycosis with no classical immunosuppression and the potential for Qat leaves chewing as an unidentified risk factor: a case report · 2026 · DOI

  • One challenge is the formation of biofilms on medical devices, which can lead to high mortality rates. Another challenge is the limited understanding of the effect of HI FBS on C. glabrata biofilm formation. A technical challenge is the quantification of biofilm formation and cell attachment.

    Effects of Fetal Bovine Serum on Biofilm Formation and Cell Attachment of Candida glabrata · 2026 · DOI

  • further investigation of the effect of HI FBS on biofilm formation, - exploration of the mechanisms by which HI FBS influences cell attachment, - investigation of the effect of HI FBS on other types of cells or biofilms

    Effects of Fetal Bovine Serum on Biofilm Formation and Cell Attachment of Candida glabrata · 2026 · DOI

  • auris in Türkiye remain scarce, largely limited to isolated case reports, a recent national addressing and epidemiology, treatment recommendations,²² and limited case-control data on candidemia risk factors.

    Clinical Characteristics, Antifungal Susceptibility, and Prognosis of Candidozyma auris Infections: A Single-Center Retrospective Study · 2026 · DOI

  • Single case report, - No control group, - Limited generalizability, - No long-term follow-up

    Gastrointestinal mucormycosis with no classical immunosuppression and the potential for Qat leaves chewing as an unidentified risk factor: a case report · 2026 · DOI

  • Candida species of the CTG (CUG-Ser1) clade vary widely in ecology and clinical importance, raising the question of whether stationary-phase survival is linked to pathogenicity across species or among strains.

    Chronological lifespan correlates with virulence within Candida albicans but long lifespan is not restricted to pathogenic Candida species · 2026 · DOI

  • Although CLS is well characterized in Saccharomyces cerevisiae as a model of postmitotic aging, its relevance to human-associated fungi remains poorly understood.

    Chronological lifespan correlates with virulence within Candida albicans but long lifespan is not restricted to pathogenic Candida species · 2026 · DOI

  • Sub-analyses could not demonstrate the superiority of one PCR target over another due to limited data.

    Diagnostic performance of panfungal PCR on tissue specimens for the diagnosis of invasive fungal diseases: a systematic review and meta-analysis of the Fungal PCR Initiative (FPCRI) · 2026 · DOI

  • Whether its frequency and prognostic significance differ across viral etiologies in hospitalized adults remains unknown.

    Detection of Aspergillus in the lower respiratory tract and its association with mortality in patients with different viral pneumonias: a retrospective multicenter cohort study from China · 2026 · DOI

  • The value of metagenomic next-generation sequencing (mNGS) in kidney transplant patients with fungal infections remains insufficiently explored, especially regarding diagnosis and antimicrobial stewardship.

    Metagenomic next-generation sequencing enhances diagnosis of fungal infections in kidney transplant recipients: a retrospective study · 2026 · DOI

  • Targeted next-generation sequencing (tNGS) of bronchoalveolar lavage fluid (BALF) enables rapid pathogen detection; however, its capacity for quantitative assessment of fungal load remains unclear.

    Integrative diagnosis of invasive pulmonary aspergillosis in non-neutropenic patients using BALF-tNGS–derived Aspergillus load and host risk factors: a multicenter study · 2026 · DOI

  • • Real-world use of isavuconazole in pediatric hematology-oncology has not been systematically described.

    A survey on the institutional practices of the use of isavuconazole in onco-hematological children, on behalf of the Infectious Working Group of AIEOP · 2026 · DOI

  • Concurrent mucormycosis infection may worsen patient outcomes, and further clinical exploration of the pathogenesis and treatment recommendations for mucormycosis associated with mycoplasma pneumoniae is warranted.

    Case Report: Co-infection of mucormycosis with mycoplasma pneumoniae in children with diabetes mellitus: report of two rare cases · 2025 · DOI

  • However, the mechanisms through which IFN-λ modulates neutrophil effector function beyond ROS remain unexplored.

    Pathogen-tailored role of interferon-λs in neutrophil function during fungal immunity 2235 · 2025 · DOI

  • Complement protein C3 plays critical roles in systemic antifungal host defense, but its functions and regulation for protection during IPA remains elusive.

    Complement C3 promotes protective pulmonary antifungal response 9295 · 2025 · DOI

  • albicans biofilm and its interaction with the host under immunosuppressive conditions remains largely understudied.

    A mouse model of immunosuppression facilitates oral Candida albicans biofilms, bacterial dysbiosis and dissemination of infection · 2025 · DOI

  • aureus co-existence on virulence factor secretion and pro-inflammatory effects remain elusive.

    Candida albicans and Staphylococcus aureus reciprocally promote their virulence factor secretion and pro-inflammatory effects · 2025 · DOI

  • However, investigations assessing the value of metagenomic next-generation sequencing (mNGS) for distinguishing Mucorales infection from colonization are currently insufficient.

    Clinical performance of metagenomic next-generation sequencing for distinction and diagnosis of Mucorales infection and colonization · 2025 · DOI

  • While aneuploidy formation is a well-documented adaptive mechanism under various stress conditions, the response to brefeldin A—a compound that induces endoplasmic reticulum stress—remains poorly understood.

    Aneuploidy enables adaptation to brefeldin A in Candida albicans · 2025 · DOI

  • This evolutionary divergence emphasizes the need for additional studies on fluconazole tolerance in other pathogenic fungi.

    Understanding adaptation to fluconazole: comparative insights into tolerance and resistance in Saccharomyces cerevisiae and Candida albicans · 2025 · DOI

  • These factors were shown to regulate alveolar permeability, surfactant secretion, cell contractility and apoptosis, but their role in fungal infections remains unknown.

    Biological boundary conditions regulate the internalization of Aspergillus fumigatus conidia by alveolar cells · 2025 · DOI

  • Despite its clinical significance, the genetic basis of PG remains poorly understood.

    Caspofungin paradoxical growth in Candida albicans requires stress pathway activation and promotes unstable echinocandin resistance mediated by aneuploidy · 2025 · DOI

  • albicans) growth, its role in macrophage-mediated clearance remains poorly understood.

    Cinnamaldehyde triggers cell wall remodeling and enhances macrophage-mediated phagocytic clearance of Candida albicans · 2025 · DOI

Most-cited papers in Antifungal resistance and susceptibility

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216 open questions have been extracted from the limitations and future-work passages of 1,027 Antifungal resistance and susceptibility papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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