Science AI Journal
Medicine · Research topic

Open research questions in Aortic aneurysm repair treatments

299 gap statements mined from Aortic aneurysm repair treatments papers in our 7.9M-paper local library, which holds 1,925 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

Choosing where to publish on Aortic aneurysm repair treatments? See the ranked Medicine journals.

What the literature leaves open

  • Although succinate has been linked to vascular diseases, its regulation within the aorta and potential involvement in AAA remain unclear.

    Identification of a pathological feed‐forward loop linking succinate, HIF1α signalling and vascular remodelling in abdominal aortic aneurysm · 2026 · DOI

  • Coherent real-world data on stroke risk after EVAR, stratified by the proximal landing zone, and the impact of perioperative stroke on mid-term survival are scarce.

    Stroke risk and mid-term survival by proximal extent of endovascular aortic repair · 2026 · DOI

  • However, its prognostic value in patients undergoing endovascular aortic repair (EVAR) for abdominal aortic aneurysm (AAA) remains unclear.

    Prognostic Utility of Perivascular Adipose Tissue Attenuation in Patients Undergoing Endovascular Aneurysm Repair for Abdominal Aortic Aneurysms · 2026 · DOI

  • Intravenous thrombolysis is the standard treatment for acute ischemic stroke (AIS), but its safety in patients with a history of abdominal aortic aneurysm (AAA) repair remains unclear.

    Safety of thrombolysis in acute ischemic stroke patients with previous aortic abdominal aneurysm repair · 2025 · DOI

  • Information on the predictive determinants of abdominal aortic aneurysm rupture from CT angiography are scarce.

    Peak wall rupture index is associated with risk of rupture of abdominal aortic aneurysms, independent of size and sex · 2024 · DOI

  • Blood pressure variability (BPV) has emerged as an important cardiovascular risk factor, yet its relationship with AAA growth has not been investigated.

    624 A Retrospective Review of Blood Pressure Variability (BPV) and Abdominal Aortic Aneurysm (AAA) · 2024 · DOI

  • Blood pressure (BP) is considered a contributor to AAA formation, but the association with AAA growth remains unclear.

    624 A Retrospective Review of Blood Pressure Variability (BPV) and Abdominal Aortic Aneurysm (AAA) · 2024 · DOI

  • This study has several limitations. We acknowledge, however, that heatmaps show where the model “looked” without explaining biological significance—a direct pathophysiological link that remains elusive and requires future histopathological or biomechanical correlation.

    A multimodal deep learning model for predicting impending rupture in symptomatic abdominal aortic aneurysms using CTA and clinical data · 2026 · DOI

  • There is a lack of awareness about vascular causes of atypical lower gastrointestinal bleeding. Rupture of a superior rectal artery aneurysm is a rare condition that needs to be considered.

    Rupture of a Superior Rectal Artery Aneurysm · 2026 · DOI

  • The lack of effective medical therapy for AAA remains a major clinical challenge. The mechanisms underlying AAA progression are not fully understood. The role of macrophage-derived CCL20-CCR6 signaling in AAA is not well characterized.

    Macrophage-derived CCL20–CCR6 signaling as a driver of immune recruitment in abdominal aortic aneurysm · 2026 · DOI

  • Future research should incorporate process evaluations, explore optimal timing and intensity of information delivery, and consider the use of more sensitive, condition-specific outcome measures.

    Impact of nurse-led postoperative education on health outcomes following endovascular aortic repair: a randomized trial · 2026 · DOI

  • There is a need to evaluate the association of preoperative morphometric and morphovolumetric parameters with post-EVAR sac remodeling, endoleak development, and secondary interventions.

    Post-EVAR Endoleaks: A Morphovolumetric Approach to Prediction, Surveillance, and Management · 2026 · DOI

  • Data privacy is a significant challenge in the application of artificial intelligence in aortic aneurysm management. Algorithmic bias and model transparency are also challenges that need to be addressed. Clinician acceptance is another challenge that can impact the adoption of artificial intelligence in the field.

    Artificial Intelligence in Aorta Aneurysm Management: Translational Applications and Limits · 2026 · DOI

  • The current management approach for aortic aneurysms is based on the maximum aortic diameter, which fails to capture the biological and biomechanical complexity of the disease. There is a need for reliable methods to integrate diameter-based criteria into complication risk assessment and timing of elective repair. The application of artificial intelligence has the potential to address this gap.

    Artificial Intelligence in Aorta Aneurysm Management: Translational Applications and Limits · 2026 · DOI

  • Regarding the aortic endograft, there is still no consensus about the optimal management of the type II endoleak due to lumbar branches that allow retrograde flow into the aneurysm. The simultaneous approach contributed to an early postoperative recovery in the first case, where the evolution was uneventful with available follow-up, although longer-term follow-up data remain limited.

    Management of severe symptomatic aortic stenosis and concomitant large abdominal aortic aneurysm in high-risk patients: Review of literature and case series · 2026 · DOI

  • However, long-term outcomes remain uncertain. Still, randomized comparative trials and longer-term follow-up data are lacking.

    Delayed disaster: a case report on the limits of MFM® therapy in complex aortic aneurysms · 2026 · DOI

  • Further studies are needed to confirm the findings and explore the underlying mechanisms. Future research should investigate the long-term outcomes of patients undergoing EVAR or TEVAR for ruptured aortic aneurysms. The development of personalized anesthesia strategies based on patient characteristics is an area for future research.

    Anesthesia Strategy and Clinical Outcomes in Ruptured Aortic Aneurysm Repair: Insights from EVAR and TEVAR · 2026 · DOI

  • The impact of different anesthesia methods on clinical outcomes in patients treated with EVAR or TEVAR for ruptured abdominal or thoracic aortic aneurysms is not well understood. There is a need to investigate the association between anesthesia choice, patient characteristics, and clinical results.

    Anesthesia Strategy and Clinical Outcomes in Ruptured Aortic Aneurysm Repair: Insights from EVAR and TEVAR · 2026 · DOI

  • Yet, the relationship of adipose tissue to TLS and B-cell responses is poorly understood.

    Spatial multi-omics reveals novel vascular adipocyte and B cell biology in human abdominal aortic aneurysm · 2026 · DOI

  • Respiratory parameters from the anesthesia machine were unavailable and not incorporated into the study, and their potential impact on PIS cannot be ruled out.

    Developing a practical machine learning model to predict post implantation syndrome after endovascular aneurysm repair · 2026 · DOI

  • The specific mechanism of the difference in PIS incidence between cisatracurium (18%) and rocuronium (4.8%) needs further prospective research to verify.

    Developing a practical machine learning model to predict post implantation syndrome after endovascular aneurysm repair · 2026 · DOI

  • Mitochondrial dysfunction in the aortic wall is linked to AAA pathobiology. Current treatments do not address mitochondrial dysfunction.

    Delivery of Mitochondria Attenuates Elastase-Induced Abdominal Aortic Aneurysm in Mice · 2026 · DOI

  • However, the pooled mean IMA diameter does not account for baseline differences in study demographics nor other potential confounding factors.

    Predictive value of inferior mesenteric artery size in type 2 endoleak after endovascular abdominal aortic aneurysm repair—a systematic review and meta-analysis · 2026 · DOI

  • Expanding sample sizes through large-scale, multicenter clinical studies. Integrating multiomics approaches to better understand the immune mechanisms of the CCL20-CCR6 axis. Translating the results into clinical practice through extensive clinical trials.

    Macrophage-derived CCL20–CCR6 signaling as a driver of immune recruitment in abdominal aortic aneurysm · 2026 · DOI

  • The coexistence of a congenital pelvic kidney and an aortoiliac aneurysm is a rare medical condition with limited documented cases - Current treatment options have…

    Customized stent graft implantation for the management of an aortoiliac aneurysm in a patient with congenital pelvic kidney — case report · 2026 · DOI

Most-cited papers in Aortic aneurysm repair treatments

Most recent work

Find a gap in your own Aortic aneurysm repair treatments sub-topic

This page shows what the Aortic aneurysm repair treatments literature already flags as unresolved. To narrow it to your specific question, search the Research Gap Finder: the search is free with a free account and lists the papers closest to your topic first. Unlocking that topic (50 credits, charged once) fills the comparison table from our 7.9M-paper local library and writes the gaps from its rows.

Open the Research Gap Finder →

Related topics in Medicine

Artificial Intelligence in Healthcare and Education
4,200 open questions
Dementia and Cognitive Impairment Research
2,789 open questions
Substance Abuse Treatment and Outcomes
2,285 open questions
Cancer Immunotherapy and Biomarkers
2,273 open questions
Liver Disease Diagnosis and Treatment
2,102 open questions
Sports Performance and Training
1,952 open questions
Parkinson's Disease Mechanisms and Treatments
1,915 open questions
Mosquito-borne diseases and control
1,849 open questions
Open questions raised by papers listed on this page include: (1) Although succinate has been linked to vascular diseases, its regulation within the aorta and potential involvement in AAA remain unclear (“Identification of a pathological feed‐forward loop linking succinate, HIF1α…”, 2026); (2) Coherent real-world data on stroke risk after EVAR, stratified by the proximal landing zone, and the impact of perioperative stroke on mid-term survival are scarce (“Stroke risk and mid-term survival by proximal extent of endovascular aortic…”, 2026); (3) Its prognostic value in patients undergoing endovascular aortic repair (EVAR) for abdominal aortic aneurysm (AAA) remains unclear (“Prognostic Utility of Perivascular Adipose Tissue Attenuation in Patients…”, 2026); (4) There is a lack of awareness about vascular causes of atypical lower gastrointestinal bleeding (“Rupture of a Superior Rectal Artery Aneurysm”, 2026); (5) The lack of effective medical therapy for AAA remains a major clinical challenge (“Macrophage-derived CCL20–CCR6 signaling as a driver of immune recruitment in…”, 2026). 299 gap statements have been mined from Aortic aneurysm repair treatments papers in our 7.9M-paper local library, which holds 1,925 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 1,100,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? Acceptance odds for top, mid and open/emerging journals, in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck for prior publication across 7 sources and our local library.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

How Pre-Check worksHow AI Review works

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.