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Open research questions in Cardiac Health and Mental Health

186 unresolved questions extracted from the limitations and future-work sections of 1,058 Cardiac Health and Mental Health papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Further research is needed to investigate the effectiveness of different strategies to improve adherence to exercise-based phase II cardiac rehabilitation, - Research on intervention strategies for special populations is needed

    Strategies to improve adherence to exercise-based phase II cardiac rehabilitation after percutaneous coronary intervention: a best evidence summary · 2026 · DOI

  • There is a lack of evidence-based guidance for improving adherence to exercise-based phase II cardiac rehabilitation. Existing studies have identified various challenges and barriers to adherence, but there is a need for a comprehensive synthesis of the evidence.

    Strategies to improve adherence to exercise-based phase II cardiac rehabilitation after percutaneous coronary intervention: a best evidence summary · 2026 · DOI

  • The study faces challenges in establishing a causal link between depression and gastrointestinal diseases. The study needs to address potential reverse causality and attrition bias. The study needs to investigate the extent to which any attrition bias from the missing data affects the results.

    Association of depression and gastrointestinal diseases: a three-stage study · 2026 · DOI

  • Investigate the extent to which any attrition bias from the missing data affected the results, - Analyze the degree of heterogeneity present among the various forms of inheritance, - Examine the overall risk of digestive diseases associated with depression

    Association of depression and gastrointestinal diseases: a three-stage study · 2026 · DOI

  • Investigating the effects of reducing baseline inflammatory burden on MSIMI. Examining the relationship between IL-6 and MSIMI in other populations, such as men or individuals with obstructive coronary artery disease.

    Dose-dependent association between elevated resting IL-6 levels and severity of mental stress-induced myocardial perfusion defects · 2026 · DOI

  • The study faces challenges in identifying distinct latent classes while maintaining model stability and interpretability. The study needs to ensure sufficient statistical power to identify the factors influencing adherence. The study requires the establishment of a comprehensive patient education platform to facilitate self-learning and real-time communication with medical staff.

    Adherence to phase I cardiac rehabilitation in post-PCI patients: a latent class analysis · 2025 · DOI

  • Investigate the long-term effects of cardiac rehabilitation, - Examine the impact of different factors on adherence to cardiac rehabilitation, - Develop and test interventions to improve adherence to cardiac rehabilitation

    Adherence to phase I cardiac rehabilitation in post-PCI patients: a latent class analysis · 2025 · DOI

  • No participants aged 18-34 were enrolled due to the low prevalence of CHD in this age group, - The study was conducted in a single tertiary hospital in Shanghai, China, - The sample size was limited to 27 participants

    Exploring challenges to medication adherence aacmong young and middle-aged adults with coronary heart disease in China: a qualitative study · 2025 · DOI

  • There is a lack of understanding about the challenges faced by young and middle-aged adults with CHD in maintaining medication adherence. The study identifies a gap in the literature regarding the use of psychological approaches and nurse-led initiatives to support medication adherence in this population.

    Exploring challenges to medication adherence aacmong young and middle-aged adults with coronary heart disease in China: a qualitative study · 2025 · DOI

  • The underlying mechanisms of mental stress-induced myocardial ischemia remain incompletely understood. The relationship between interleukin-6 and mental stress-induced myocardial ischemia remains unclear. The deeper biological pathways of mental stress-induced myocardial ischemia remain insufficiently characterized.

    Dose-dependent association between elevated resting IL-6 levels and severity of mental stress-induced myocardial perfusion defects · 2026 · DOI

  • However, patients’ interest in virtual CR, especially among those in the inpatient setting, has not been fully explored.

    Digital Health Use and Interest in Virtual Cardiac Rehabilitation Among Cardiac Inpatients: Cross-Sectional Study · 2026 · DOI

  • However, no studies have yet investigated the correlation between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol(NHHR), residual cholesterol (RC), and LLD in China, nor the mediating function of CMD.

    Nonlinear association between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR), residual cholesterol (RC), and late-life depression: the potential mediating role of cardiovascular metabolic diseases in the elderly population of China · 2026 · DOI

  • However, its application in phase I cardiac rehabilitation (CR) after coronary artery bypass grafting (CABG) remains under explored.

    Physical performance on the early 6-minute walk test in coronary artery bypass grafting patients during inpatient cardiac rehabilitation · 2025 · DOI

  • The quantitative instrument for measuring cardiac rehabilitation adherence is scarce.

    Psychometric evaluation of the cardiac rehabilitation adherence scale in patients with coronary heart disease: an observational study · 2025 · DOI

  • Background Although cardiovascular disease (CVD) and depressive symptoms frequently co-occur, their temporal directional relationship remains poorly understood.

    The longitudinal bidirectional association between cardiovascular disease and depressive symptoms among middle-aged and elderly adults: evidence from a nationwide cohort study in China · 2025 · DOI

  • Background: While the triglyceride-glucose (TyG) index and related indices have been recognized as markers of insulin resistance and cardiometabolic disorders, few studies have examined their association with all-cause mortality in individuals with depression.

    Association between triglyceride-glucose and triglyceride-glucose related indices with all-cause mortality in depression participants: a cohort study from NHANES · 2025 · DOI

  • Objective: The complex interplay between visceral adiposity and mental health outcomes, particularly suicidal ideation, remains a critical yet understudied area.

    Threshold effect of visceral adiposity index on suicidal ideation: a mediation analysis through fasting blood glucose · 2025 · DOI

  • BACKGROUND: Chronic diseases and depression pose significant health challenges among older adults, but their dynamic relationship is not fully understood.

    Depressive trajectories and their associations with chronic diseases among older adults: a national longitudinal cohort study from China · 2025 · DOI

  • The relationships and potential mechanisms linking physical activity with its influencing factors remain incompletely understood, limiting the development of effective interventions.

    The mediating role of physical activity self-efficacy between knowledge, psychological factors, and early physical activity in elderly post-PCI patients: a cross-sectional study · 2025 · DOI

  • While mobile health CR (mHealth-CR) provides a novel opportunity to deliver care, age-specific impairments to technology use may limit uptake, and efficacy data are currently lacking.

    Rehabilitation at Home Using Mobile Health for Older Adults Hospitalized for Ischemic Heart Disease · 2025 · DOI

  • BACKGROUND: Despite the high burden of anxiety and hypertension in Hispanic/Latino adults, little is known about their association in this population.

    Associations of Anxiety Symptoms With 6-Year Blood Pressure Changes and Incident Hypertension: Results From the Hispanic Community Health Study/Study of Latinos · 2024 · DOI

  • However, the relationship between psychological factors and atherosclerosis is complex and poorly understood.

    Associations of psychological factors with atherosclerosis and cardiovascular health in middle-age: the population-based Swedish CArdioPulmonary bioImage study (SCAPIS) · 2024 · DOI

  • However, the long-term prospective association between trimethylamine N-oxide (TMAO) level and major adverse clinical events (MACEs) in patients with coronary artery disease (CAD) with or without diabetes mellitus (DM) habitus remains to be investigated.

    Trimethylamine N-oxide predicts cardiovascular events in coronary artery disease patients with diabetes mellitus: a prospective cohort study · 2024 · DOI

  • Despite this growing awareness, the specific mechanisms through which depression contributes to the development of CHD remain unclear.

    Depression and coronary heart disease: mechanisms, interventions, and treatments · 2024 · DOI

  • However, the precise role of sleep disturbance in the connection between depression and CVD is poorly understood.

    The mediating role of sleep disturbance in the relationship between depression and cardiovascular disease · 2024 · DOI

Most-cited papers in Cardiac Health and Mental Health

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186 open questions have been extracted from the limitations and future-work passages of 1,058 Cardiac Health and Mental Health papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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