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Open research questions in Celiac Disease Research and Management

250 gap statements mined from Celiac Disease Research and Management papers in our 7.9M-paper local library, which holds 1,081 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • There is a lack of research on the relationship between personality traits and dietary behaviors in adolescents with celiac disease. Prior studies have not used the Big Five Inventory to assess personality traits in this population.

    Personality Traits Are Associated with Dietary Behaviors and Psychosocial Outcomes in Adolescents with Celiac Disease: A Cross-Sectional Study · 2026 · DOI

  • One challenge is the high frequency of asymptomatic, atypical, or oligosymptomatic forms of celiac disease, leading to diagnostic delay. Another challenge is the lack of disease-specific genetic markers. The study also faces the challenge of false-negative serological results due to selective IgA deficiency.

    Beyond Anti-Ttg Antibodies: Diagnostic Value Of Antibodies Against Deamidated Gliadin Peptides In Celiac Disease · 2026 · DOI

  • One challenge is the need to reduce gliadin content in wheat flour while maintaining the viscoelastic properties essential for dough functionality. Another challenge is the potential for variability in the proteolytic activity of lactic acid bacteria. The study does not explicitly state other technical or domain challenges.

    Effects of Co-Fermentation with Lactic Acid Bacteria and Yeast on Gliadin Degradation in Whole-Wheat Sourdough · 2025 · DOI

  • There is a need to reduce gliadin content in wheat flour to produce gluten-free or low-gluten fermented products. Current methods may not be effective in reducing gliadin content. The study identifies a gap in the use of lactic acid bacteria and yeast fermentation to degrade gliadin in whole-wheat sourdough.

    Effects of Co-Fermentation with Lactic Acid Bacteria and Yeast on Gliadin Degradation in Whole-Wheat Sourdough · 2025 · DOI

  • The epidemiology of Olmesartan-induced enteropathy is not well known. There is a need for rapid diagnosis to limit organ damage such as chronic kidney disease.

    Atypical Rapid Onset of Olmesartan-Induced Enteropathy with Recurrence After Rechallenging · 2025 · DOI

  • Nevertheless, it appears logical to monitor these patients and provide appropriate counselling, although the optimal methods and intensity of follow-up remain unclear.

    From Recommendation to Reality: The Follow‐Up Gap in Coeliac Disease · 2026 · DOI

  • While this threshold likely reflects a pragmatic compromise, there is limited evidence supporting this age cut-off or the proposed use of FRAX in this age group.

    Metabolic Bone Disease in Coeliac Disease: Protecting Bone, Resources, or Both? · 2026 · DOI

  • Improved strategies for diagnosis and long-term monitoring of patients with both conditions are warranted.

    Immunoglobulin a Deficiency in Coeliac Disease: A Scoping Review · 2026 · DOI

  • IgG-based serology remains essential for diagnosis and monitoring, but its reliability during follow-up is limited by the slow decline of antibodies.

    Immunoglobulin a Deficiency in Coeliac Disease: A Scoping Review · 2026 · DOI

  • Future research should explore whether population-based CD screening aligns with UK National Screening Committee criteria and requires a long-term randomized controlled trial of screening strategies.

    OP13 Improving Case Finding For Celiac Disease In Children And Adults: Evidence Synthesis And Economic Modeling · 2024 · DOI

  • The precise environmental factors and immunological mechanisms of coexistence of T1DM and CD are not well understood. The data available on the long-term cardiovascular, microvascular, and bone disease in patients with both diseases is still limited.

    Celiac Disease in Type1 Diabetes: Prevalence, Pathogenesis and Clinical Implications · 2026 · DOI

  • Conventional follow-up parameters may not fully reflect ongoing disease activity. There is a need for biomarkers related to intestinal barrier dysfunction and mucosal inflammation.

    Serum Zonulin and Chitinase (CHI3L1) as Biomarkers of Intestinal Permeability and Disease Activity in Pediatric Celiac Disease · 2026 · DOI

  • The lack of gold-standard biomarkers for Self-Reported Wheat/Gluten Sensitivity. The complexity of the immunogenetic and serological patterns in individuals with self-reported wheat/gluten sensitivity.

    Immunogenetic HLA-DQ and IgG serological profiles in individuals with self-reported wheat/gluten sensitivity: a retrospective real-world evidence study · 2026 · DOI

  • The study has a small sample size of 100 participants. The study is based on a non-probabilistic convenience sampling. The study lacks a control group for comparison.

    Immunogenetic HLA-DQ and IgG serological profiles in individuals with self-reported wheat/gluten sensitivity: a retrospective real-world evidence study · 2026 · DOI

  • Future studies should validate these findings in larger multi-center cohorts with longer follow-up to better assess the long-term efficacy, safety, and durability of IV FCM therapy in patients with gastrointestinal iron malabsorption. Randomized controlled trials comparing FCM with oral iron and other intravenous formulations are needed to establish optimal therapeutic strategies for AIG, CD, and post-GS patients.

    Efficacy, Safety, and Hematologic Recovery Following Intravenous Ferric Carboxymaltose in Patients with Iron Malabsorption-Related Iron Deficiency Anemia: A Prospective Clinical Study · 2026 · DOI

  • This may be explained by nocebo effects, warranting research into novel mechanisms and re-evaluating the NCGS definition.

    Impact of Acute and Sub‐Acute Gluten Exposure on Gastrointestinal Symptoms and Psychological Responses in Non‐Coeliac Gluten Sensitivity: A Randomised Crossover Study · 2025 · DOI

  • Currently, there are only very few studies on the protein composition of ancient wheat species.

    Protein composition in ancient wheats is determined by ploidy level · 2025 · DOI

  • With minor exceptions, comparisons among all food categories regarding nutrient profile and nutritional claims showed mixed results, though supporting an overly comparable nutritional profile of the GFPs.

    Nutritional value of cereal-based gluten-free products and comparison to that of gluten containing counterparts in the Greek market · 2024 · DOI

  • Quantitative antibody measurements, - Systematic correlations with histopathological findings, - Investigation of the coexistence of IgA anti-tTG and IgA anti-DGP…

    Beyond Anti-Ttg Antibodies: Diagnostic Value Of Antibodies Against Deamidated Gliadin Peptides In Celiac Disease · 2026 · DOI

  • Investigating the long-term stability of the modified electrode. Comparing the performance of the modified electrode with existing methods. Exploring the application of the modified electrode in clinical settings.

    Anti-Tissue-Transglutaminase IgA Antibodies Presence Determination Using Electrochemical Square Wave Voltammetry and Modified Electrodes Based on Polypyrrole and Quantum Dots · 2025 · DOI

  • Investigating the use of different gluten-detecting ELISA kits - Studying the variability in results when testing gluten using different…

    Development of a Gluten Standard from Relevant Sources of Wheat and Investigation into Gluten Content of Supplemental Enzymes Generated During Fermentation · 2025 · DOI

  • Oral glutenases (prolyl endopeptidases) Enzymatic cleavage of immunogenic proline-rich gliadin peptides In-vitro, animal models, Phase I–II human trials Clear biochemical detoxification; reduced mucosal immune activation ALV003…

    Gut microbiome based therapeutic strategies and probiotic perspectives in celiac disease · 2026 · DOI

  • Investigating the role of zonulin and CHI3L1 in early disease pathogenesis. Examining the associations between zonulin, CHI3L1, and other biomarkers of intestinal permeability and inflammation.

    Serum Zonulin and Chitinase (CHI3L1) as Biomarkers of Intestinal Permeability and Disease Activity in Pediatric Celiac Disease · 2026 · DOI

  • Atypical presentations or apparent lack of symptoms make diagnosis challenging - The trigger for disease development in genetically susceptible individuals is still…

    Pitfalls in the Diagnosis and Treatment of Celiac Disease–Why “Gluten Free” Is Not Free · 2026 · DOI

  • The study is a single case report, - There is limited literature on the association between CD and UIP, - The patient had multiple comorbidities that may have affected…

    Usual Interstitial Pneumonia in a Patient With Celiac Disease: Expanding the Spectrum of Pulmonary Manifestations · 2026 · DOI

Most-cited papers in Celiac Disease Research and Management

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Open questions raised by papers listed on this page include: (1) There is a lack of research on the relationship between personality traits and dietary behaviors in adolescents with celiac disease (“Personality Traits Are Associated with Dietary Behaviors and Psychosocial…”, 2026); (2) Another challenge is the lack of disease-specific genetic markers (“Beyond Anti-Ttg Antibodies: Diagnostic Value Of Antibodies Against Deamidated…”, 2026); (3) It appears logical to monitor these patients and provide appropriate counselling, although the optimal methods and intensity of follow-up remain unclear (“From Recommendation to Reality: The Follow‐Up Gap in Coeliac Disease”, 2026); (4) While this threshold likely reflects a pragmatic compromise, there is limited evidence supporting this age cut-off or the proposed use of FRAX in this age group (“Metabolic Bone Disease in Coeliac Disease: Protecting Bone, Resources, or Both?”, 2026); (5) Improved strategies for diagnosis and long-term monitoring of patients with both conditions are warranted (“Immunoglobulin a Deficiency in Coeliac Disease: A Scoping Review”, 2026). 250 gap statements have been mined from Celiac Disease Research and Management papers in our 7.9M-paper local library, which holds 1,081 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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