Science AI Journal
Medicine · Research topic

Open research questions in Celiac Disease Research and Management

86 unresolved questions extracted from the limitations and future-work sections of 360 Celiac Disease Research and Management papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The associations between food-specific IgG and clinical symptoms remain limited. Regional epidemiological data on food-specific IgG are lacking. The complex association patterns between food-specific IgG and specific symptoms remain to be elucidated.

    Association rule analysis of food-specific IgG and clinical symptoms in pediatric patients · 2026 · DOI

  • Further investigation into the potential beneficial role of probiotics, - Evaluation of probiotics in primary prevention, - Assessment of combination probiotics

    Probiotics in Celiac Disease: Current Evidence and Future Directions · 2026 · DOI

  • The paper identifies a gap in the understanding of the effectiveness of probiotics in celiac disease. It notes that the current evidence is limited by variations in formulation, dietary regimen, and clinical outcome markers. It highlights the need for further investigation into the potential beneficial role of probiotics in celiac disease.

    Probiotics in Celiac Disease: Current Evidence and Future Directions · 2026 · DOI

  • Further prospective studies incorporating direct immunological and iron metabolism markers are warranted to clarify underlying mechanisms.

    The relationship between Helicobacter pylori severity and hematological parameters in pediatric patients with celiac disease · 2026 · DOI

  • AIM: The relationship between Helicobacter pylori infection and hematological parameters in pediatric celiac disease remains controversial.

    The relationship between Helicobacter pylori severity and hematological parameters in pediatric patients with celiac disease · 2026 · DOI

  • Further research on the implementation of growth based screening parameters in routine practice is warranted.

    Growth patterns in coeliac disease – a longitudinal study of children aged 0–6 years in Sweden · 2026 · DOI

  • However, there are limited data concerning adherence to GFD among adult CD patients in Saudi Arabia.

    Knowledge, Adherence, and Barriers to Gluten-Free Diet Among Adults with Celiac Disease in Saudi Arabia: A Pilot Study at a Tertiary Hospital in Madinah, Saudi Arabia · 2025 · DOI

  • In addition, we summarize the current knowledge and gaps in understanding related to screening programs for celiac disease in children and adolescents and discuss health benefits, psychosocial aspects and cost-effectiveness, and their potential implications for future public health strategies.

    Celiac disease screening in children: evaluating the evidence, benefits, and challenges · 2025 · DOI

  • Our study also indicates that novel treatments adjunctive to diet are warranted in children.

    Impact of ESPGHAN no-biopsy strategy on the outcome of celiac disease treatment in children · 2025 · DOI

  • Background and aim: The prevalence and clinical spectrum of symptoms due to inadvertent gluten exposure in children with celiac disease (CeD) on a gluten-free diet (GFD) are not well defined.

    Prevalence of acute reactions to gluten contamination of the diet in children with celiac disease · 2025 · DOI

  • However, there is a gap in the literature regarding the association between the severity of CD and the levels of these autoantibodies.

    Association of endocrine autoantibodies (anti-TPO, anti-GAD, anti-insulin) with histopathological severity in pediatric Celiac disease: a retrospective cohort study · 2025 · DOI

  • Celiac disease is a serious condition that remains under-recognized, resulting in an increased need for programs for better management.

    Celiac Disease: Beyond Diet and Food Awareness · 2025 · DOI

  • Few studies have looked at the role and perception of telehealth in relation to CD and selective nutrition both before and after the COVID-19 pandemic.

    Utilizing Telemedicine Applications in Celiac Disease and Other Gluten-Free-Diet-Dependent Conditions: Insights from the COVID-19 Pandemic · 2024 · DOI

  • The purpose of this review is to provide a more clear and up-to-date understanding of GRDs, and to help further research on this important topic.

    Gluten Unraveled: Latest Insights on Terminology, Diagnosis, Pathophysiology, Dietary Strategies, and Intestinal Microbiota Modulations—A Decade in Review · 2024 · DOI

  • While future technology-based strategies for proper vitamin D supplementation could be attractive in the context of personalized medicine, several issues remain to be defined, including standardized assays for vitamin D determination, timely recommendations on vitamin D intake for immune system functioning, and longitudinal studies and randomized controlled trials to definitely establish a causal relationship between serum vitamin D levels and the onset of AITD and CeD.

    Vitamin D: An Essential Nutrient in the Dual Relationship between Autoimmune Thyroid Diseases and Celiac Disease—A Comprehensive Review · 2024 · DOI

  • Importance: The extent and factors associated with risk of diagnostic delay in pediatric celiac disease (CD) are poorly understood.

    Diagnostic Delay of Celiac Disease in Childhood · 2024 · DOI

  • The literature on psychiatric symptoms in celiac disease is heterogeneous. There is a need for further research on the prevalence and treatment of psychiatric symptoms in celiac disease.

    Depression and Anxiety as Aspects of Mental Health in Celiac Disease: A Systematic Review and Meta-Analytical Synthesis · 2026 · DOI

  • The mechanisms by which strict dietary vigilance and perfectionism paradoxically increase anxiety in some celiac disease patients need empirical investigation through prospective studies measuring personality traits (conscientiousness, perfectionism) alongside anxiety trajectories during gluten-free diet initiation and adherence.

    Depression and Anxiety as Aspects of Mental Health in Celiac Disease: A Systematic Review and Meta-Analytical Synthesis · 2026 · DOI

  • There is a need for novel therapeutic strategies to improve disease management and quality of life for patients with celiac disease. The current treatment for celiac disease, a strict gluten-free diet, has important practical and biological limitations.

    Gut microbiome based therapeutic strategies and probiotic perspectives in celiac disease · 2026 · DOI

  • Oral glutenases (prolyl endopeptidases) Enzymatic cleavage of immunogenic proline-rich gliadin peptides In-vitro, animal models, Phase I–II human trials Clear biochemical detoxification; reduced mucosal immune activation ALV003…

    Gut microbiome based therapeutic strategies and probiotic perspectives in celiac disease · 2026 · DOI

  • The precise environmental factors and immunological mechanisms of coexistence of T1DM and CD are not well understood. The data available on the long-term cardiovascular, microvascular, and bone disease in patients with both diseases is still limited.

    Celiac Disease in Type1 Diabetes: Prevalence, Pathogenesis and Clinical Implications · 2026 · DOI

  • Investigating the role of zonulin and CHI3L1 in early disease pathogenesis. Examining the associations between zonulin, CHI3L1, and other biomarkers of intestinal permeability and inflammation.

    Serum Zonulin and Chitinase (CHI3L1) as Biomarkers of Intestinal Permeability and Disease Activity in Pediatric Celiac Disease · 2026 · DOI

  • Conventional follow-up parameters may not fully reflect ongoing disease activity. There is a need for biomarkers related to intestinal barrier dysfunction and mucosal inflammation.

    Serum Zonulin and Chitinase (CHI3L1) as Biomarkers of Intestinal Permeability and Disease Activity in Pediatric Celiac Disease · 2026 · DOI

  • The lack of gold-standard biomarkers for Self-Reported Wheat/Gluten Sensitivity. The complexity of the immunogenetic and serological patterns in individuals with self-reported wheat/gluten sensitivity.

    Immunogenetic HLA-DQ and IgG serological profiles in individuals with self-reported wheat/gluten sensitivity: a retrospective real-world evidence study · 2026 · DOI

  • The study has a small sample size of 100 participants. The study is based on a non-probabilistic convenience sampling. The study lacks a control group for comparison.

    Immunogenetic HLA-DQ and IgG serological profiles in individuals with self-reported wheat/gluten sensitivity: a retrospective real-world evidence study · 2026 · DOI

Most-cited papers in Celiac Disease Research and Management

Most recent work

Find a gap in your own Celiac Disease Research and Management sub-topic

This page shows what the Celiac Disease Research and Management literature already flags as unresolved. To narrow it to your specific question, run the guided finder — it searches the gap library on demand and checks candidates against 250M+ OpenAlex works.

Open the Research Gap Finder →

Related topics in Medicine

Artificial Intelligence in Healthcare and Education
2,044 open questions
Substance Abuse Treatment and Outcomes
1,964 open questions
Smoking Behavior and Cessation
990 open questions
Dementia and Cognitive Impairment Research
974 open questions
Innovations in Medical Education
960 open questions
Physical Activity and Health
923 open questions
Attention Deficit Hyperactivity Disorder
839 open questions
Schizophrenia research and treatment
709 open questions
86 open questions have been extracted from the limitations and future-work passages of 360 Celiac Disease Research and Management papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 120,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? A Tier 1–5 acceptance probability in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck prior-publication & salami-slicing risk across 8 sources.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.