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Open research questions in Cerebral Palsy and Movement Disorders

478 gap statements mined from Cerebral Palsy and Movement Disorders papers in our 7.9M-paper local library, which holds 2,893 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • Future research should investigate potential joint moderating effects of youth age and sex. Related to the small sample size was the inability to test for youth age as a possible moderator in the context of sex differences on account of sparse data.

    Mediating effect of perceived physical appearance in the association of disability and psychopathology in youth with chronic physical illness: a sex-stratified analysis · 2026 · DOI

  • Due to limited data on the long-term advantages of THA in this demographic, there has been hesitation in conducting THA procedures for patients with CP, primarily out of concerns regarding potential dislocations, premature prosthetic loosening, and heightened perioperative complications.

    Total hip arthroplasty as reconstructive treatment in patients with cerebral palsy: a comparative study of postoperative outcomes between patients with developmental hip dysplasia and cerebral palsy hip dysplasia · 2026 · DOI

  • The International Classification of Functioning, Disability, and Health (ICF) framework could be considered for this purpose; however, the ICF is a conceptual and technical description of daily life and participation. As such, the use of ICF terminology may not correctly label the everyday language of nonprofessional respondents, whose opinions are crucial in this context.

    “Do It by Myself” or Autonomy, Participation, and Assistive Devices and Technology Needs of Children and Youth With Disabilities: Text Mining Analysis of a National Survey in France · 2026 · DOI

  • We show how the pathway to fatigue differs between a group of young and older adults, highlighting a need for appropriate approaches to physical therapy dependent on age and level of mobility.

    Exercise-induced fatigability is exacerbated amongst older adults with cerebral palsy compared to younger counterparts · 2026 · DOI

  • Although proprioceptive impairments, affecting 46-90% of children with CP, are commonly observed, their role in postural control remains insufficiently understood.

    The relationship between lower limb proprioception and balance performance in children with cerebral palsy: a multisystem and multi-joint approach · 2026 · DOI

  • There is a lack of performance-based evaluations of sensory integration and praxis in children with idiopathic toe walking. Prior studies have not fully investigated the sensory-motor contributions to idiopathic toe walking.

    Sensory Integration and Praxis Characteristics in Children with Idiopathic Toe Walking: A Case–Control Study · 2026 · DOI

  • Differences in other commonly assessed impairments, such as femoral anteversion, were also not included in the current analyses and should be explored in future research. The current findings might be limited by the underrepresentation of certain gait patterns or patient-specific characteristics in the sample.

    The Gait Pattern Classification System for Children with Spastic Cerebral Palsy (GaP-CP)—A Validity Study · 2025 · DOI

  • Given the increasing utilization of growth-friendly implants in children with CP and EOS, it is important to understand whether the initiation of this “surgical journey”—whereby multiple operations either for device lengthenings and/or revisions will be invariably required—for these patients who are often medically fragile is warranted, in view of the potential risks involved.

    Traditional Growth-Friendly Implants Result in Improved Health-Related Quality of Life in Cerebral Palsy Patients with Early-Onset Scoliosis · 2025 · DOI

  • Descriptions of how centers implement standardized screening for pain and how pain affects activities among adults with cerebral palsy (CP) are lacking.

    Multi-center improvement in screening for pain that affects activities in adults with cerebral palsy · 2025 · DOI

  • As this study was carried out in Al Baha area, which is located in the southwest of the country, it may only demonstrate the social attributes of a particular region; however, given the lack of data on the KAB toward children with CP, the results provide a background to the perception of the general population toward CP in KSA.

    Caregiver Knowledge, Attitude, and Behavior toward Care of Children with Cerebral Palsy: A Saudi Arabian Perspective · 2024 · DOI

  • While interventions to support positive self-perceptions exist, the methodological quality of these studies is mixed, and evidence is lacking for male youth and youth with chronic physical illness.

    Mediating effect of perceived physical appearance in the association of disability and psychopathology in youth with chronic physical illness: a sex-stratified analysis · 2026 · DOI

  • Although both yielded satisfactory immediate results, long-term stability remains uncertain. While conservative treatment remains the first-line approach, including physical therapy and orthotic use, surgical correction is warranted when symptoms persist, or deformity progresses.

    Dynamic radiographic angle changes in planovalgus foot correction among children with cerebral palsy · 2026 · DOI

  • More than 1000 answers were obtained; however, some respondents did not complete the optional open questions.

    “Do It by Myself” or Autonomy, Participation, and Assistive Devices and Technology Needs of Children and Youth With Disabilities: Text Mining Analysis of a National Survey in France · 2026 · DOI

  • These differing findings highlight the need for further investigation of lesion type as a potential factor contributing to variability in observed changes during early development.

    Therapy onset and characteristics associated with improvement following HABIT-ILE in infants with unilateral cerebral palsy: secondary analysis of a randomized controlled trial · 2026 · DOI

  • Future research is recommended to explore the long-term sustainability of these benefits and determine the effectiveness of home-based core stability programs in accelerating improvements in balance and gait.

    Effects of Core Stability Training on Balance, Standing, and Gait in Children with Mild Cerebral Palsy: A Randomized Controlled Trial · 2025 · DOI

  • However, the specific examination of speech areas in individuals with CP has not yet been explored.

    Correlation of Neuroanatomical Structures Related to Speech in Cerebral Palsy Patients Aged 0–17: A Retrospective MRI Study · 2025 · DOI

  • Future research should focus on refining protocols, exploring long-term effects, and expanding application to other populations, ultimately clearing the path for more effective, personalized rehabilitation strategies that empower children to achieve their full motor potential.

    Movement-Based Priming: A Clinical Trial on the Effect of Cross-Training on Locomotor Abilities of Children with Unilateral Cerebral Palsy · 2025 · DOI

  • Based on the findings from this research and as part of a Doctor of Philosophy, the first author will be conducting further research on oral health care for people with disability in Australia and the experience, confidence, and current practice of dental professionals.

    A Survey of Oral Health-Related Quality of Life for Adults with Cerebral Palsy in Australia · 2025 · DOI

  • Results support the feasibility and tolerability of SAR-based intervention in this population and provide preliminary evidence warranting further investigation through controlled longitudinal designs.

    USE of SARs in the Rehabilitation of Children with Cerebral Palsy · 2026 · DOI

  • Socially assistive robots (SARs) have shown promise in supporting these domains, yet empirical evidence in Central Asian rehabilitation contexts remains scarce.

    USE of SARs in the Rehabilitation of Children with Cerebral Palsy · 2026 · DOI

  • Few studies have explored the participation of children with CP in different settings as assessment tools rarely include data collection across multiple environments.

    Participation of Children and Youth with and Without Cerebral Palsy Across Settings: An Exploratory Study · 2025 · DOI

  • The associations between physical activity and various social determinants with quality of life (QoL) among teenagers with cerebral palsy (CP) are inconclusive.

    Quality of life, physical activity, and social determinants in teenagers with cerebral palsy: A cross-sectional study in Sweden · 2025 · DOI

  • Following the promising outcomes of our study, further research is needed to standardize protocols for piano therapy and deepen our understanding…

    Motor-Sensory Learning in Children with Disabilities: Does Piano Practice Help? · 2025 · DOI

  • Future studies are needed to identify the most responsive parameter…

    Dynamic Stability, Symmetry, and Smoothness of Gait in People with Neurological Health Conditions · 2024 · DOI

  • Studies evaluating the quality and reliability of information produced by AI-based systems for various disease groups yield inconsistent findings.

    Evaluation of the quality, reliability, and readability of ChatGPT-4 responses related to the treatment and rehabilitation of children with cerebral palsy · 2026 · DOI

Most-cited papers in Cerebral Palsy and Movement Disorders

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Open questions raised by papers listed on this page include: (1) Future research should investigate potential joint moderating effects of youth age and sex (“Mediating effect of perceived physical appearance in the association of…”, 2026); (2) Although proprioceptive impairments, affecting 46-90% of children with CP, are commonly observed, their role in postural control remains insufficiently understood (“The relationship between lower limb proprioception and balance performance in…”, 2026); (3) There is a lack of performance-based evaluations of sensory integration and praxis in children with idiopathic toe walking (“Sensory Integration and Praxis Characteristics in Children with Idiopathic Toe…”, 2026); (4) While conservative treatment remains the first-line approach, including physical therapy and orthotic use, surgical correction is warranted when symptoms persist, or deformity progresses (“Dynamic radiographic angle changes in planovalgus foot correction among…”, 2026); (5) More than 1000 answers were obtained; however, some respondents did not complete the optional open questions (““Do It by Myself” or Autonomy, Participation, and Assistive Devices and…”, 2026). 478 gap statements have been mined from Cerebral Palsy and Movement Disorders papers in our 7.9M-paper local library, which holds 2,893 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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