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Open research questions in Cerebrovascular and Carotid Artery Diseases

377 gap statements mined from Cerebrovascular and Carotid Artery Diseases papers in our 7.9M-paper local library, which holds 1,885 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • The gap in current research is the lack of effective methods to identify patients with asymptomatic carotid artery stenosis who are at high risk of developing symptomatic disease. The paper aims to address this gap by using machine learning models and electronic medical records.

    Clinical Decision Support for Patient Cases with Asymptomatic Carotid Artery Stenosis Using AI Models and Electronic Medical Records · 2025 · DOI

  • The study highlights the need to consider sex-related differences in carotid artery stenting outcomes. There is a gap in understanding the impact of sex on technical success and complications in carotid artery stenting. The study aims to address this gap by evaluating sex-related differences in a large patient population.

    Sex-Related Differences in Early In-Hospital Outcome (Technical Success and Complications) of Carotid Artery Stenting and Risk Factors of Carotid Artery Stenosis · 2025 · DOI

  • The choice of optimal surgical tactics remains debatable due to contradictory data on the immediate and long-term outcomes of surgery. The risk of stroke and myocardial infarction is a significant challenge in the postoperative course and prognosis.

    Early and Long-Term Results of Simultaneous and Staged Revascularization of Coronary and Carotid Arteries · 2024 · DOI

  • Severe carotid artery stenosis or occlusion (CASO) is associated with white matter injury and cognitive impairment, but markers of accompanying microvascular dysfunction remain incompletely characterized.

    Retinal Microvascular Abnormalities, White Matter Injury, and Cognitive Impairment in Carotid Stenosis or Occlusion · 2026 · DOI

  • Proposed mechanisms include endothelial dysfunction, platelet activation, and metabolic disturbances that may accelerate atherosclerotic processes; however, histopathological evidence of nilotinib-associated plaque formation has not been reported.

    A case report with histopathological evaluation of nilotinib-associated carotid artery plaque following carotid endarterectomy · 2026 · DOI

  • Data are scarce regarding the frequency, characteristics, and associated recurrent event risks of cerebrovascular fibromuscular dysplasia (cFMD) in patients presenting with ischemic stroke and transient ischemic attack (TIA).

    Clinical and radiological characteristics and recurrent event risk of cerebrovascular fibromuscular dysplasia in patients with Ischemic stroke or transient ischemic attack – a population-level study · 2026 · DOI

  • In-stent restenosis (ISR) is a clinically important complication of carotid artery stenting (CAS); however, practical risk markers remain understudied.

    Higher fibrosis-4 index is associated with 1-year in-stent restenosis after carotid artery stenting · 2026 · DOI

  • The burden of subclinical atherosclerosis in patients with retinal vein occlusion (RVO) remains incompletely understood.

    Subclinical carotid atherosclerosis in patients with retinal vein occlusion: Differential cardiovascular risk profiles · 2026 · DOI

  • Background and purpose Intracranial atherosclerotic stenosis (ICAS) is common in patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA), but its relationship with long-term cognitive impairment remains unclear.

    Association of intracranial atherosclerotic stenosis with 1-year cognitive impairment after acute ischemic stroke or transient ischemic attack: a nationwide prospective cohort study · 2026 · DOI

  • Carotid plaque instability is associated with ischemic stroke; however, its relationship with systemic pathways remains incompletely understood.

    Integrative analysis of systemic biomarkers and carotid plaque instability in patients with atherosclerosis: A retrospective cross-sectional study · 2026 · DOI

  • Indirect revascularization after bypass surgery for intracranial atherosclerotic steno-occlusive disease (ICAD) remains controversial.

    Indirect revascularization after bypass surgery for intracranial atherosclerotic steno-occlusive disease · 2025 · DOI

  • Limited research has explored the effect of Circle of Willis (CoW) anatomy among blunt cerebrovascular injuries (BCVI) on outcomes.

    The effect of circle of willis anatomy and scanning practices on outcomes for blunt cerebrovascular injuries · 2024 · DOI

  • It remains unclear if current BCVI screening and scanning practices are sufficient in identification of concomitant COW anomalies and how they affect outcomes.

    The effect of circle of willis anatomy and scanning practices on outcomes for blunt cerebrovascular injuries · 2024 · DOI

  • Any neck swelling should be investigated vigorously regardless of any previous trauma or surgery.

    1157 A Giant Pseudoaneurysm of Carotid Artery · 2024 · DOI

  • The study suggests that future breakthroughs will rely heavily on multidisciplinary convergence. The study highlights the importance of artificial intelligence and radiomics in present-day research. The study suggests that the development of physics-informed carotid digital twins is a future direction for precise, patient-specific stroke risk management.

    Bibliometric Analysis and Visualization of Vulnerable Carotid Plaque Research (2010-2025): From Morphological Imaging to Artificial Intelligence and Digital Twins · 2026 · DOI

  • Identifying asymptomatic patients with carotid stenosis who are at high stroke risk remains clinically challenging. A circulating biomarker capable of identifying high-risk plaque in combination with imaging could aid clinical risk stratification.

    Detection of serum amyloid A in Saliva of patients with internal carotid artery stenosis: a pilot study · 2026 · DOI

  • Carotid artery web is a rare and underrecognized cause of ischemic stroke.

    Carotid revascularization is associated with reduced recurrence in symptomatic carotid web · 2026 · DOI

  • Basilar artery web is a rare and under-recognized vascular anomaly that may contribute to posterior circulation ischemic stroke.

    A rare case of bilateral basilar artery webs · 2025 · DOI

  • Use of the dual-layer microporous CASPER RX stent has had mixed results in prior reports.

    Seven years of CRAFT: Clinical results of a multicenter cohort of carotid artery relining with the CASPER RX stent · 2025 · DOI

  • The study notes that plaque rupture is a biophysical event that is still subjective to measure.

    Bibliometric Analysis and Visualization of Vulnerable Carotid Plaque Research (2010-2025): From Morphological Imaging to Artificial Intelligence and Digital Twins · 2026 · DOI

  • Limited clinical application of MRI due to high costs and practical implementation barriers.

    Deep learning-based early prediction of carotid plaque response to lipid-lowering therapy using longitudinal multimodal ultrasound imaging · 2026 · DOI

  • Estudiar la relación entre la densidad vascular y la presión de perfusión ocular en pacientes hipertensos - Investigar los efectos de la dosis del antihipertensivo en la densidad vascular - Analizar la relación entre la densidad vascular y el tiempo de diagnóstico de la hipertensión…

    Asociación de los parámetros vasculares y nerviosos de la angio-OCT con la cuantificación objetiva del color del nervio óptico por foto color en pacientes con y sin antecedente de hipertensión arterial · 2026 · DOI

  • La falta de estudios que investiguen la asociación entre los parámetros vasculares y nerviosos de la angio-OCT y la cuantificación objetiva del color del nervio óptico en pacientes con y sin antecedente de hipertensión arterial. La necesidad de evaluar las características cuantitativas de la densidad vascular utilizando angio-OCT en pacientes HTARAII y en sujetos sanos.

    Asociación de los parámetros vasculares y nerviosos de la angio-OCT con la cuantificación objetiva del color del nervio óptico por foto color en pacientes con y sin antecedente de hipertensión arterial · 2026 · DOI

  • Incorporating natural language processing techniques to extract valuable clinical features from unstructured EMR data - Exploring clinical imaging data to offer predictive insights through plaque characteristics - Further validation to assess the generalizability of the approach to larger…

    Clinical Decision Support for Patient Cases with Asymptomatic Carotid Artery Stenosis Using AI Models and Electronic Medical Records · 2025 · DOI

  • Retrospective, observational design, - Study population was exclusively composed of individuals from Eastern Europe, and all participants were Caucasian, - Lack of longitudinal…

    Sex-Related Differences in Early In-Hospital Outcome (Technical Success and Complications) of Carotid Artery Stenting and Risk Factors of Carotid Artery Stenosis · 2025 · DOI

Most-cited papers in Cerebrovascular and Carotid Artery Diseases

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Open questions raised by papers listed on this page include: (1) Severe carotid artery stenosis or occlusion (CASO) is associated with white matter injury and cognitive impairment, but markers of accompanying microvascular dysfunction remain incompletely characterized (“Retinal Microvascular Abnormalities, White Matter Injury, and Cognitive…”, 2026); (2) Data are scarce regarding the frequency, characteristics, and associated recurrent event risks of cerebrovascular fibromuscular dysplasia (cFMD) in patients presenting with ischemic stroke and transient ischemic attack (TIA) (“Clinical and radiological characteristics and recurrent event risk of…”, 2026); (3) In-stent restenosis (ISR) is a clinically important complication of carotid artery stenting (CAS); however, practical risk markers remain understudied (“Higher fibrosis-4 index is associated with 1-year in-stent restenosis after…”, 2026); (4) The burden of subclinical atherosclerosis in patients with retinal vein occlusion (RVO) remains incompletely understood (“Subclinical carotid atherosclerosis in patients with retinal vein occlusion:…”, 2026); (5) Background and purpose Intracranial atherosclerotic stenosis (ICAS) is common in patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA), but its relationship with long-term cognitive impairment remains unclear (“Association of intracranial atherosclerotic stenosis with 1-year cognitive…”, 2026). 377 gap statements have been mined from Cerebrovascular and Carotid Artery Diseases papers in our 7.9M-paper local library, which holds 1,885 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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