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Open research questions in Cervical Cancer and HPV Research

337 unresolved questions extracted from the limitations and future-work sections of 1,773 Cervical Cancer and HPV Research papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • the study had a small sample size (53 patients), - the study was retrospective, - further studies with control tissues and validated FFPE-specific protocols are needed

    DNA methylation as a complementary biomarker for HPV diagnostics in cervical lesions analyzed from FFPE material: new possibilities for stratification from pilot study · 2026 · DOI

  • further studies with control tissues, - validation of FFPE-specific protocols, - investigation of DNA methylation in larger cohorts

    DNA methylation as a complementary biomarker for HPV diagnostics in cervical lesions analyzed from FFPE material: new possibilities for stratification from pilot study · 2026 · DOI

  • The study identifies technical challenges, such as avoiding thermal injury to surrounding tissues during the procedure. The study also identifies domain challenges, such as the need for early detection and intervention for AIN. Another challenge is the lack of a universally standardized therapeutic protocol for AIN.

    Short-term efficacy and safety of CO2 laser vaporization for anal intraepithelial neoplasia · 2026 · DOI

  • There is a lack of a universally standardized therapeutic protocol for AIN. The study aims to evaluate the short-term efficacy and safety of CO2 laser vaporization for AIN and identify independent predictors of persistent postoperative HPV infection.

    Short-term efficacy and safety of CO2 laser vaporization for anal intraepithelial neoplasia · 2026 · DOI

  • Further studies are needed to quantify the difference in Hr-HPV prevalence associated with HIV status, - Research on the specific characteristics of WLHIV that contribute to the high prevalence of Hr-HPV infection

    Prevalence, high-risk HPV type profile, and factors associated with high-risk HPV infection among women living with HIV in Kinshasa, Democratic Republic of the Congo · 2026 · DOI

  • Cultural and social barriers to cervical cancer screening, including myths and misconceptions about the disease. Limited access to preventive services. Poor utilization of existing screening services.

    “Even with one Man, but with many women, you can get cervical cancer”: Qualitative exploration of women’s perceptions and experiences of cervical cancer screening in Uganda: A community-based study · 2026 · DOI

  • Scale up targeted education, community outreach, and health system support to dispel myths, reduce stigma, and ensure sustainable access to quality screening services

    “Even with one Man, but with many women, you can get cervical cancer”: Qualitative exploration of women’s perceptions and experiences of cervical cancer screening in Uganda: A community-based study · 2026 · DOI

  • Small retrospective cohorts and cross-site extrapolation constrain vaginal, vulvar and penile cancers, - Heterogeneity in assays and histological composition remains substantial, - Manufacturing, lymphodepletion and tissue availability remain major limitations for rare cancers, - HPV DNA alone is insufficient for candidate selection

    Divergent immune ecosystems in HPV-associated and HPV-independent lower anogenital tract malignancies · 2026 · DOI

  • Investigating the role of HPV-reactive tumor-infiltrating lymphocyte therapy in other lower anogenital tract malignancies, - Developing therapeutic vaccines, T-cell receptor-engineered therapies, myeloid or stromal sensitization and artificial-intelligence-guided selection, - Elucidating the mechanisms of immune suppression in HPV-associated and HPV-independent tumors

    Divergent immune ecosystems in HPV-associated and HPV-independent lower anogenital tract malignancies · 2026 · DOI

  • Small sample size of 15 participants, - Limited to female Chinese university students, - Data collection limited to January and April 2024

    Understanding cultural perceptions of sexuality in China and their influence on human papillomavirus vaccine hesitancy · 2025 · DOI

  • Further research on the impact of cultural perceptions on HPV vaccine hesitancy, - Studies on the effectiveness of interventions to address vaccine hesitancy, - Research on the role of socio-cultural factors in shaping health behaviors

    Understanding cultural perceptions of sexuality in China and their influence on human papillomavirus vaccine hesitancy · 2025 · DOI

  • Vaccine unavailability is a major challenge faced by providers in recommending HPV vaccination. Lack of effective communication tools and informational materials is another challenge. Need for adequate training is also a challenge faced by providers.

    HPV vaccination in Africa in the COVID-19 era: a cross-sectional survey of healthcare providers’ knowledge, training, and recommendation practices · 2024 · DOI

  • Further studies are needed to assess the impact of the COVID-19 pandemic on HPV vaccination uptake in Africa, - Research on effective strategies to improve HPV vaccine availability and provider training is needed

    HPV vaccination in Africa in the COVID-19 era: a cross-sectional survey of healthcare providers’ knowledge, training, and recommendation practices · 2024 · DOI

  • Exploring the potential of virtual reality technology to increase vaccine acceptance, - Investigating the effectiveness of different strategies for facilitating HPV vaccination among college students

    Exploring human papillomavirus vaccine hesitancy among college students and the potential of virtual reality technology to increase vaccine acceptance: a mixed-methods study · 2024 · DOI

  • Prior interventions have shown limitations in reducing HPV vaccine hesitancy in college students. There is a need to explore new approaches to increase vaccine acceptance among college students.

    Exploring human papillomavirus vaccine hesitancy among college students and the potential of virtual reality technology to increase vaccine acceptance: a mixed-methods study · 2024 · DOI

  • Variability in individual microbiota poses challenges in establishing clear causative links. The dynamic interplay between genetics, lifestyle factors, and microbial influences requires further exploration. The absence of specific symptoms and signs that allow an early diagnosis of ovarian cancer results in approximately 70% of cases being diagnosed in an advanced stage of the disease.

    Gynecological Cancers and Microbiota Dynamics: Insights into Pathogenesis and Therapy · 2024 · DOI

  • To explore personalized therapeutic approaches based on an individual's unique microbiota profile - To unravel the complexity of the relationships between genetics, lifestyle factors, and microbial influences

    Gynecological Cancers and Microbiota Dynamics: Insights into Pathogenesis and Therapy · 2024 · DOI

  • Some clinicians have advised women with high-grade CIN to undergo HPV vaccination to reduce their subsequent risk, despite a lack of evidence for this practice.

    HPV vaccination following cervical intraepithelial neoplasia grade 2 diagnosis and risk of progression · 2026 · DOI

  • However, limited data are available regarding the timing and determinants of HPV clearance in this population.

    Human papillomavirus persistence and clearance in women living with HIV : A five‐year retrospective analysis from an Italian university center · 2026 · DOI

  • Health and Human Services and International Anal Neoplasia Society guidelines in 2024, implementation remains constrained by high-resolution anoscopy capacity, workforce shortages, stigma, and limited evidence on optimal screening algorithms.

    Elimination of HPV-associated cancers: universal HPV vaccination and the role of anal screening – a meeting report · 2026 · DOI

  • However, gaps in knowledge and practice among PHC workers may hinder effective cervical cancer control programs.

    Gaps in Knowledge and Practice of Cervical Cancer Screening among Primary Health Care Workers in Lagos State, Nigeria: A Cross-Sectional Study · 2026 · DOI

  • At-home testing may be a viable option to expand access to anal dysplasia screening, but its feasibility and reliability have not yet been tested.

    The THOMAS Study: A Pilot Study for Patient-Administered Anal Cancer Screening · 2026 · DOI

  • However, little is known on treatment efficacy and post-treatment surveillance for older women.

    High rate of persistent HPV detection after diagnostic cervical excision in older screen‐positive women · 2025 · DOI

  • Furthermore, given the absence of specific guidelines, the optimal surveillance frequency remains unknown.

    High rate of persistent HPV detection after diagnostic cervical excision in older screen‐positive women · 2025 · DOI

  • BACKGROUND: Hispanic/Latina women in the United States have high rates of cervical cancer and little is known regarding how sociocultural factors might be related to their cervical cancer prevention behaviors.

    Sociocultural correlates of cervical cancer prevention behaviors among Hispanic/Latina women in the United States · 2025 · DOI

Most-cited papers in Cervical Cancer and HPV Research

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337 open questions have been extracted from the limitations and future-work passages of 1,773 Cervical Cancer and HPV Research papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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