Science AI Journal
Medicine · Research topic

Open research questions in Childhood Cancer Survivors' Quality of Life

452 gap statements mined from Childhood Cancer Survivors' Quality of Life papers in our 7.9M-paper local library, which holds 2,353 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

Choosing where to publish on Childhood Cancer Survivors' Quality of Life? See the ranked Medicine journals.

What the literature leaves open

  • Further research is needed to determine the specific effects of aerobic components in exercise interventions. More studies with larger sample sizes and more homogeneous methodologies are needed. Research on the long-term effects of exercise interventions in children and adolescents with ALL is necessary.

    Exercise Interventions Incorporating Aerobic Components in Children and Adolescents with Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis · 2026 · DOI

  • There is a need to evaluate the effects of exercise interventions with aerobic components on quality of life and functional outcomes in children and adolescents with acute lymphoblastic leukemia. The current evidence is uncertain and heterogeneous, requiring a systematic review and meta-analysis.

    Exercise Interventions Incorporating Aerobic Components in Children and Adolescents with Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis · 2026 · DOI

  • In the general population, accelerated aging is associated with increased malignancy risk; however, this has not been evaluated in survivors.

    Accelerated Aging and Risk of Subsequent Neoplasms in Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study · 2026 · DOI

  • Although global research highlights the psychological, informational, and financial strains faced by parents of children with cancer, studies from Saudi Arabia remain scarce.

    Perceived Needs of Parents Caring for Children With Cancer in Saudi Arabia: A Cross‐Sectional Study · 2025 · DOI

  • Rurality has been understudied; thus, we examined whether rural CCS are at increased risk for non-engagement in survivor care compared with their urban counterparts.

    Rurality of Residence and Distance to Clinic Are Risk Factors for Non-engagement in Childhood Cancer Survivor Care · 2025 · DOI

  • In low-income and middle-income countries, QoL has not been studied in depth in CYP.

    Sociodemographic and clinical predictors of quality-of-life outcome in children and young people with primary brain tumour in Karachi, Pakistan: a prospective cohort study · 2024 · DOI

  • It highlights the need for more research on the specific needs of childhood and adult cancer survivors.

    Factors associated with health-related quality of life in survivors of childhood-onset and adult-onset cancer compared to controls · 2026 · DOI

  • The lack of standardized outcomes for the management of ALL. The variability in the measurement and reporting of outcomes in the existing literature. The need to prioritize outcomes for 32 research questions relevant to the guideline development.

    Prioritized health outcomes for adolescents and young adults with acute lymphoblastic leukemia · 2026 · DOI

  • Future research should focus on the development of clinical practice guidelines that incorporate the prioritized outcomes. Future studies should aim to standardize the measurement and reporting of outcomes in the field of ALL.

    Prioritized health outcomes for adolescents and young adults with acute lymphoblastic leukemia · 2026 · DOI

  • There is a need for continued efforts to ensure equitable access to quality palliative care. There is a lack of access to medicines, trained teams, and sustainable funding in some settings.

    Milestones and Horizons: Highlights from the 4th International Children’s Palliative Care Network Conference in Manila, Philippines · 2026 · DOI

  • Uncertainty remains regarding the acceptability of health promotion interventions to families during the cancer journey. Uncertainty remains regarding the effectiveness of these interventions in improving children's functional outcomes.

    Acceptability and functional benefits of a health promotion program in pediatric oncology: a mixed-methods study · 2026 · DOI

  • Further studies should explore the long-term effects of cancer on physical and emotional wellbeing. Interventions to improve physical activity and emotional wellbeing among adolescent cancer survivors should be developed.

    School-Related Challenges Among Adolescent Cancer Survivors: Associations Between Physical Activity, Emotional Wellbeing, Post-Traumatic Growth, and Quality of Life · 2026 · DOI

  • Substantial methodological variability and limited standardization in existing interventions. Persistent challenges in sustaining patients' active participation. Interrelated side effects in pediatric oncology treatments.

    Design of an Integrated Physical Exercise Program and Motivational Strategies in Pediatric Oncologic Rehabilitation · 2026 · DOI

  • Existing interventions exhibit substantial methodological variability and limited standardization. There is a lack of integration of physiological and motivational dimensions in exercise protocols for pediatric oncology patients.

    Design of an Integrated Physical Exercise Program and Motivational Strategies in Pediatric Oncologic Rehabilitation · 2026 · DOI

  • There is a lack of data concerning the professional, emotional, and relational experiences of psychologists working with adolescent cancer patients. The study aims to address this gap by exploring the experiences of psychologists working in pediatric oncology.

    The Professional, Emotional, and Relational Experience of Psychologists Working With Adolescent Cancer Patients · 2026 · DOI

  • Longitudinal studies are needed to examine the causal relationships between family environment and symptom distress in AYAs with cancer. Interventions targeting family strength and support should be developed and tested. Studies should investigate the mechanisms by which family environment influences symptom distress in AYAs with cancer.

    Family Environment Factors Associated with Symptom Distress Among Korean Adolescents and Young Adults with Cancer: A Cross-Sectional Study · 2026 · DOI

  • There is a lack of understanding of the family environment factors associated with symptom distress among Korean AYAs with cancer. Prior studies have not fully explored the relationship between family environment factors and symptom distress among AYAs with cancer.

    Family Environment Factors Associated with Symptom Distress Among Korean Adolescents and Young Adults with Cancer: A Cross-Sectional Study · 2026 · DOI

  • The current comparison of HRQoL scores to general population norms may not provide appropriate clinical context. There is a need for an oncology-specific reference curve to support patient-centered care.

    Designing oncology-specific patient-reported outcome dashboards: end-user preferences for reference curve inclusion and visualization in pediatric cancer care · 2026 · DOI

  • There is a need to understand the growth and symptom changes in children and adolescents receiving chemotherapy for ALL. The study addresses the gap in knowledge on trajectory patterns and associated factors.

    Assessment of growth and pain trajectories for children and adolescents receiving chemotherapy for acute lymphoblastic leukemia in Northern Thailand using group-based trajectory modeling · 2026 · DOI

  • Variations in ethics consultations (ECs) among different AYA age groups remain understudied, despite evolving developmental and psychosocial milestones.

    Ethical Consultation Utilization Patterns in Adolescent and Young Adult Oncology: A 10-Year Single-Center Study and Contemporary Ethics Framework · 2026 · DOI

  • There is a lack of up-to-date information on the epidemiological characteristics and trends of childhood cancer in eastern Libya. The absence of a national cancer registry in eastern Libya limits the understanding of the true incidence of childhood cancer in the region.

    Epidemiological Characteristics and Trends of Childhood Cancer in Eastern Libya: A Five-Year Retrospective Study · 2026 · DOI

  • Feasibility This study addressed a notable gap in the literature, as no previous intervention on FoP in paediatric oncology has been systematically evaluated, making the assessment of feasibility an essential first step. A more detailed examination of feasibility for children is warranted, given their very low participation (n = 6), albeit once enrolled, none of them discontinued participation.

    An intervention for fear of progression in childhood cancer patients and their parents: feasibility and preliminary efficacy in a pilot randomised controlled trial · 2026 · DOI

  • A major limitation of this study is the small sample size, which is common in this area of care.

    An intervention for fear of progression in childhood cancer patients and their parents: feasibility and preliminary efficacy in a pilot randomised controlled trial · 2026 · DOI

  • The study may not be generalizable beyond the Swedish population, - The study had a limited sample size, - The study only included siblings whose grades were set after…

    Academic achievements among siblings of children with cancer in Sweden: a nationwide register-based cohort study · 2026 · DOI

  • Further studies with larger sample sizes are needed to examine the impact of childhood cancer on academic performance, - Studies should examine the association between childhood cancer and academic performance in different…

    Academic achievements among siblings of children with cancer in Sweden: a nationwide register-based cohort study · 2026 · DOI

Most-cited papers in Childhood Cancer Survivors' Quality of Life

Most recent work

Find a gap in your own Childhood Cancer Survivors' Quality of Life sub-topic

This page shows what the Childhood Cancer Survivors' Quality of Life literature already flags as unresolved. To narrow it to your specific question, search the Research Gap Finder: the search is free with a free account and lists the papers closest to your topic first. Unlocking that topic (50 credits, charged once) fills the comparison table from our 7.9M-paper local library and writes the gaps from its rows.

Open the Research Gap Finder →

Related topics in Medicine

Artificial Intelligence in Healthcare and Education
4,200 open questions
Dementia and Cognitive Impairment Research
2,789 open questions
Substance Abuse Treatment and Outcomes
2,285 open questions
Cancer Immunotherapy and Biomarkers
2,273 open questions
Liver Disease Diagnosis and Treatment
2,102 open questions
Sports Performance and Training
1,952 open questions
Parkinson's Disease Mechanisms and Treatments
1,915 open questions
Mosquito-borne diseases and control
1,849 open questions
Open questions raised by papers listed on this page include: (1) Further research is needed to determine the specific effects of aerobic components in exercise interventions (“Exercise Interventions Incorporating Aerobic Components in Children and…”, 2026); (2) In the general population, accelerated aging is associated with increased malignancy risk; however, this has not been evaluated in survivors (“Accelerated Aging and Risk of Subsequent Neoplasms in Survivors of Childhood…”, 2026); (3) The lack of standardized outcomes for the management of ALL (“Prioritized health outcomes for adolescents and young adults with acute…”, 2026); (4) There is a need for continued efforts to ensure equitable access to quality palliative care (“Milestones and Horizons: Highlights from the 4th International Children’s…”, 2026); (5) Further studies should explore the long-term effects of cancer on physical and emotional wellbeing (“School-Related Challenges Among Adolescent Cancer Survivors: Associations…”, 2026). 452 gap statements have been mined from Childhood Cancer Survivors' Quality of Life papers in our 7.9M-paper local library, which holds 2,353 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 1,100,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? Acceptance odds for top, mid and open/emerging journals, in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck for prior publication across 7 sources and our local library.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

How Pre-Check worksHow AI Review works

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.