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Open research questions in Childhood Cancer Survivors' Quality of Life

53 unresolved questions extracted from the limitations and future-work sections of 834 Childhood Cancer Survivors' Quality of Life papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Feasibility This study addressed a notable gap in the literature, as no previous intervention on FoP in paediatric oncology has been systematically evaluated, making the assessment of feasibility an essential first step. A more detailed examination of feasibility for children is warranted, given their very low participation (n = 6), albeit once enrolled, none of them discontinued partici- pation.

    An intervention for fear of progression in childhood cancer patients and their parents: feasibility and preliminary efficacy in a pilot randomised controlled trial · 2026 · DOI

  • A major limitation of this study is the small sample size, which is common in this area of care [54]. Additionally, further studies are warranted to assess the applicability and effectiveness of KIPA in other cohorts of children with chronic health conditions (e.

    An intervention for fear of progression in childhood cancer patients and their parents: feasibility and preliminary efficacy in a pilot randomised controlled trial · 2026 · DOI

  • Variations in ethics consultations (ECs) among different AYA age groups remain understudied, despite evolving developmental and psychosocial milestones.

    Ethical Consultation Utilization Patterns in Adolescent and Young Adult Oncology: A 10-Year Single-Center Study and Contemporary Ethics Framework · 2026 · DOI

  • The approach deserves further investigation of its full potential in a prospective clinical trial and in less advanced disease cohorts of patients, despite the recent announcement of discontinuation of development of NAV by the Company.

    Rescuing of the Chemotherapy Sensitivity in Relapsed/Refractory, Pediatric Acute Lymphoblastic Leukemia (r/r ALL) through the Combination of Navitoclax (NAV) and Venetoclax (VEN): Results of Compassionate Use across Four European Countries · 2024 · DOI

  • Study findings uncovered a concerning trend: patients with NAM experienced a notable decline in HRQoL, with reasons that warrant further investigation.

    Examining the impact of Native American myopathy on the quality of life and healthcare accessibility of patients and caregivers · 2024 · DOI

  • In the cases that the nodal status has not been assessed in endometrial adenocarcinoma, the presence of LVSI may be a reasonable surrogate in addition to other risk factors, in determining the need for adjuvant therapy.

    Evaluation of agreement levels between parents and children in reporting oral health-related quality of life in 11-14 year-old children of Isfahan city in 1389 · 2013 · DOI

  • In fact, although a recent review by Fuemmeler and colleagues (2002) of 31 studies focused on different areas of psychosocial adjustment of survivors of childhood brain tumors yielded mixed findings regarding the adjustment of these children, the authors did conclude that children treated for brain tumors are indeed at risk for significant deficits in social competence.

    Social skills training interventions: A promising approach for children treated for brain tumors. · 2007 · DOI

  • CONCLUSION: The PECI augments the current literature by providing a brief measure of parents' subjective distress and perceived Emotional Resources, domains that are critical but understudied in children with chronic illness and their caregivers.

    Development and Validation of the Parent Experience of Child Illness · 2005 · DOI

  • CONCLUSION: Clarification of the concept and measurement of PTG after childhood cancer is warranted, as are prospective studies of the association of PTG and PTSS and the role of demographic variables and illness-specific appraisals.

    Posttraumatic Growth in Adolescent Survivors of Cancer and Their Mothers and Fathers · 2005 · DOI

  • The major limitation of those studies is that the non-rituximab group included lymphomas, those subsets of that by natural history have been described to have a worse outcome (Evens et al, 2010).

    Modification of Children's Information Processing Behaviors Through Learning: A Review of the Literature. · 1973 · DOI

  • Professional grief, moral distress, and second victim experiences are increasingly recognized in pediatric oncology, yet they remain insufficiently characterized in pediatric neuro-oncological neurosurgery.

    Beyond burnout: professional grief and moral distress in pediatric neuro-oncological neurosurgery · 2026 · DOI

  • Greater attention should also be directed toward caregiver burden, patient-reported outcomes, and healthcare inequities, particularly in low- and middle-income settings where evidence remains limited.

    Emergency Readmission among Children with Chronic Conditions: A Scoping Review · 2026 · DOI

  • However, the factors independently associated with caregiver burden and the distribution of risk across caregiver subgroups remain incompletely characterized.

    Psychosocial and socioeconomic vulnerability among caregivers of children with retinoblastoma: a cross-sectional latent profile study · 2026 · DOI

  • CICI is a significant yet underrecognized late effect of pediatric cancer that broadly impacts cognitive, emotional, and academic development.

    Growing Up After Chemo: A Review of Cognitive, Behavioral, and Psychosocial Outcomes in Pediatric Cancer Survivors · 2026 · DOI

  • This methodological proposal seeks to address a gap in the literature by integrating physiological and motivational dimensions to optimize adherence and improve therapeutic outcomes in pediatric oncology.

    Design of an Integrated Physical Exercise Program and Motivational Strategies in Pediatric Oncologic Rehabilitation · 2026 · DOI

  • However, the early identification and assessment of this complex psychological burden remain insufficiently addressed owing to the lack of a valid and reliable assessment instrument.

    Developing the parenting concerns scale for cancer survivors and assessment of its validity and reliability in China · 2026 · DOI

  • Introduction Little is known about end-of-life care of young adult solid organ transplant-recipients and how it compares to care received by nontransplant-recipient young adults with chronic illness.

    End-of-Life Care of Young Adult Solid Organ Transplant Recipients Compared to Nontransplant Recipients · 2026 · DOI

  • Healthcare provider perspectives on the care experiences of Medicaid-insured childhood cancer survivors, an economically disadvantaged survivor population, remain understudied.

    Facilitators and barriers to Medicaid services for childhood cancer survivors: Perspectives from oncology providers and staff. · 2026 · DOI

  • Given the compelling evidence for the benefits of pediatric home-based hospice and/or palliative care, further research into disparities in care access, best models of care, and novel payment models are critical.

    Pediatric home-based hospice and palliative care: a scoping review · 2026 · DOI

  • Little is known about neurologic symptoms, signs, and morbidity in long‐term survivors of childhood Hodgkin lymphoma that were treated with radiation.

    Neurologic Morbidity in Survivors of Childhood Hodgkin Lymphoma Treated With Radiation · 2026 · DOI

  • CONCLUSIONS: appears to positively improve Hispanic mothers' distress and parenting competencies; efficacy testing is warranted within a larger randomized control trial.

    A pilot feasibility study of <i>Conexiones</i>, a telephone-delivered cancer parenting education program for Hispanic mothers · 2022 · DOI

  • This condition is reported to evoke a range of challenging emotions for parents, yet no studies have been conducted on the facilitating and hindering factors that affect Lebanese parents coping with a child with cancer.

    Facilitating and hindering factors for coping with the experience of having a child with cancer: A Lebanese perspective · 2017 · DOI

  • Five studies were identified that satisfied inclusion criteria and revealed common themes for preparatory interventions, but results were limited by a lack of empirical approaches and revealed little consensus on pre-operative support prior to amputation.

    Preparing youth with cancer for amputation: A systematic review · 2017 · DOI

  • BACKGROUND: The amount of information shared with children regarding their illness, as well as what knowledge children are entitled to know, varies widely among cultures.

    Children's knowledge of cancer diagnosis and treatment: Jordanian mothers' perceptions and satisfaction with the process · 2011 · DOI

  • Future research is needed to develop and test interventions that increase parents' potentials and strengthen relationships during the challenging trajectory of their children's cancer and treatment.

    Impact of Childhood Cancer on Parents’ Relationships: An Integrative Review · 2010 · DOI

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53 open questions have been extracted from the limitations and future-work passages of 834 Childhood Cancer Survivors' Quality of Life papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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