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Open research questions in Childhood Cancer Survivors' Quality of Life

156 unresolved questions extracted from the limitations and future-work sections of 1,093 Childhood Cancer Survivors' Quality of Life papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Lack of practical, context-adapted protocols for nutritional assessment and intervention in limited resource settings. Limited access to nutrition support products and necessary adaptation of severe acute malnutrition guidelines. Need for scalable and accessible resources to optimize nutritional management and improve clinical outcomes.

    Consensus recommendations for the nutritional management of children with cancer in limited resource settings: a report from the International Initiative for Pediatrics and Nutrition · 2025 · DOI

  • To date, there is insufficient evidence on complex interventions and their application for families of hospitalised children with cancer in China.

    A complex family adaptation intervention for Chinese families of hospitalised children with newly diagnosed cancer: study protocol for a cluster randomized controlled trial design · 2026 · DOI

  • Although the National Comprehensive Cancer Network recommends that YAs be treated at centers with age‐specific expertise, standardized care pathways are lacking.

    Defining priorities for care among young adults diagnosed with breast cancer · 2026 · DOI

  • Future research should focus on the psychosocial functioning of preschool-aged siblings and target preschool-aged siblings of children with chronic disorders beyond autism.

    Psychosocial Functioning for Preschool‐Aged Siblings of Children With Chronic Disorders: A Scoping Review · 2025 · DOI

  • BACKGROUND: Children and young people (CYP) with different long-term physical health conditions report common needs at school, but little is known about the views of their parents.

    Parents of Children and Young People With Long‐Term Physical Health Conditions—Experiences of Navigating School · 2025 · DOI

  • Introduction: Malnutrition (under- and over-nutrition) is a critical challenge in pediatric oncology, particularly in low- and middle-income countries (LMIC), where supportive care resources are scarce.

    Consensus recommendations for the nutritional management of children with cancer in limited resource settings: a report from the International Initiative for Pediatrics and Nutrition · 2025 · DOI

  • Current challenges in rehabilitation nursing included a lack of studies on outcome measurement, insufficient knowledge and skills among nurses, and underdeveloped specialization in the field.

    Rehabilitation nursing for brain tumor patients: a scoping review · 2025 · DOI

  • Currently, few studies have explored the dyadic coping status of parents of children with leukemia and its influencing factors.

    Interactions among dyadic coping, self-efficacy, and negative emotions in Chinese parents of children with leukemia · 2025 · DOI

  • Limited information is available on parental distress and psychological well-being during the first treatment year, with most studies focusing on individuals rather than the family system.

    Parental Psychological Adjustment in Pediatric Acute Lymphoblastic Leukemia: The Mediating Role of Family Functioning and Resilience · 2025 · DOI

  • However, little is known about the interaction mechanism of social adaptive behaviors, social support and family function in children with acute leukaemia.

    Influence of social support on the social adaptive behaviors of children with acute leukemia in China: the mediating role of family functioning · 2025 · DOI

  • Although the mental health burden during treatment has been well documented, the long-term mental health trajectories of survivors of AYA cancer into later adulthood have not been explored.

    Mental Health Trajectories Among US Survivors of Adolescent and Young Adult Cancer as They Age · 2025 · DOI

  • Importance: There are conflicting data on the association of overweight or obesity with clinical outcomes in childhood acute lymphoblastic leukemia (ALL).

    Overweight or Obesity and Outcomes in Children With Acute Lymphoblastic Leukemia · 2025 · DOI

  • Future studies are needed to explore suicidality outcomes among CCSs to guide targeted support policies.

    Suicide and Suicidal Ideation Among Survivors of Childhood Cancer · 2025 · DOI

  • The willingness of patients, parents, and oncologists to engage in discussions about prognostic disclosure preferences and their perceptions of best practices in these discussions remain understudied.

    Preferences for Communication About Prognosis Among Children With Cancer, Parents, and Oncologists · 2025 · DOI

  • A fully powered efficacy trial is warranted to assess the validity of these findings.

    Pilot Randomized Controlled Trial of Lymfit: A Theory-Guided Exercise Intervention for Young Adults with Lymphoma · 2024 · DOI

  • However, empirical evidence is scarce for explaining individual differences in BFG.

    Testing a model of benefit-finding and growth in youths with chronic health conditions · 2024 · DOI

  • BACKGROUND: There are limited data available, particularly in low- and middle-income countries (LMICs), on the long-term quality of life (QoL) and family functioning of primary caregivers of children and young people (CYPs) affected by primary brain tumors (PBTs).

    Factors associated with changes in the quality of life and family functioning scores of primary caregivers of children and young people with primary brain tumors in Karachi, Pakistan: a prospective cohort study · 2024 · DOI

  • The use of commercial multichamber bags in HPN has not been extensively explored in oncologic patients and their association with complications is not well known.

    Ready-to-Use Multichamber Bags in Home Parenteral Nutrition for Patients with Advanced Cancer: A Single-Center Prospective Study · 2024 · DOI

  • Importance: There are limited studies assessing stage at diagnosis and risk of death among all 5 federally defined races in the US among adolescent and young adult (AYA) patients with cancer.

    Racial Disparities in Cancer Stage at Diagnosis and Survival for Adolescents and Young Adults · 2024 · DOI

  • However, little is known about the prevalence and risk factors of fear of cancer recurrence among adult survivors of childhood cancer who are also at high risk for subsequent malignant neoplasms.

    Fear of Cancer Recurrence in Adult Survivors of Childhood Cancer · 2024 · DOI

  • Longitudinal data on employment and associations with chronic health conditions for adult survivors of childhood cancer are lacking.

    Chronic Health Conditions and Longitudinal Employment in Survivors of Childhood Cancer · 2024 · DOI

  • Importance: Symptom burden and its characteristics among survivors of pediatric cancers aged 8 to 18 years remain understudied.

    Multilevel Characteristics of Cumulative Symptom Burden in Young Survivors of Childhood Cancer · 2024 · DOI

  • Future studies can explore the experiences of fathers and other family members. Future studies can examine the effectiveness of support services in improving the well-being of families. Future studies can investigate the cultural and societal factors that influence the experiences of Jordanian mothers.

    Lived experiences of Jordanian mothers of children with cancer: A descriptive qualitative study · 2026 · DOI

  • Little is known about the experiences of Jordanian mothers of children with cancer. There is a need to explore the coping mechanisms, support systems, and challenges of Jordanian mothers.

    Lived experiences of Jordanian mothers of children with cancer: A descriptive qualitative study · 2026 · DOI

  • The study identifies a gap in understanding the factors associated with HRQoL in cancer survivors. It highlights the need for more research on the specific needs of childhood and adult cancer survivors.

    Factors associated with health-related quality of life in survivors of childhood-onset and adult-onset cancer compared to controls · 2026 · DOI

Most-cited papers in Childhood Cancer Survivors' Quality of Life

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156 open questions have been extracted from the limitations and future-work passages of 1,093 Childhood Cancer Survivors' Quality of Life papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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