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Open research questions in Chronic Disease Management Strategies

492 gap statements mined from Chronic Disease Management Strategies papers in our 7.9M-paper local library, which holds 1,997 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • However, further investigation is needed to ensure that integrated care in South Africa leads to good health outcomes. Guidelines and protocols for treating patients with multimorbidity are not yet available in SA, and further research is needed to develop and implement these to ensure efficient, quality, and cost-effective multimorbidity management.

    The economic cost of outpatient primary care of adults with multimorbidity (HIV, diabetes, and hypertension) in rural South Africa · 2026 · DOI

  • Future research should focus on interoperable multimorbidity-aware infrastructures that integrate heterogeneous patient data, support coordinated care pathways, and investigate how disease interactions can be represented computationally and translated into transparent, clinically actionable decision support.

    eHealth Approaches to Multimorbidity Management: Scoping Review of Interventions and Multidisease Strategies · 2026 · DOI

  • May 5, 2026 11 / 16 evidence is limited, this interpretation aligns with previous research on cognitive disorders that demonstrates high levels of unmet healthcare needs in such populations.

    Multimorbidity, health service use, and health insurance by socioeconomic groups in 31 countries: A multi-cohort study · 2026 · DOI

  • This study examined how commonly used operational definitions of multimorbidity, including count-based definitions and a cluster-based approach, compare when applied within the same population, addressing the limited evidence on how these methodological choices influence prevalence estimates and associations with health outcomes and mortality.

    Comparison of count-based and clustering definitions of multimorbidity and their association with prevalence of multimorbidity, health profiles, and mortality: A cohort study of UK Biobank participants · 2026 · DOI

  • Methodological advances mean that multimorbidity research has progressed beyond simple counts of conditions to account for complexity and clustering, but temporality is still under-studied.

    Genetic and sociodemographic factors associated with trajectories of physical and mental health multimorbidity in a South Asian cohort in the UK: A multistate modelling analysis · 2026 · DOI

  • The prevalence of cardiometabolic multimorbidity is increasing worldwide, but there is a lack of studies on the association between dietary patterns and cardiometabolic multimorbidity among Chinese rural older adults.

    Association between Dietary Patterns and Cardiometabolic Multimorbidity among Chinese Rural Older Adults · 2024 · DOI

  • The association between socioeconomic position (SEP) and non-communicable diseases (NCDs) is well established, but its role in driving multimorbidity remains unclear.

    A longitudinal Analysis of the Association between Socioeconomic Position and Multimorbidity in the European Prospective Investigation into Cancer and Nutrition Study · 2024 · DOI

  • The low prevalence of intestinal parasitic infections reflects improvements in sanitation and health behaviors over time, though vigilance remains warranted.

    ANNUAL REPORT 2026: SURVEY OF DEMOGRAPHIC DATA AND PREVALENCE OF HEALTH RISK FACTORS IN NAYAO, CHACHOENSAO PROVINCE, THAILAND · 2026 · DOI

  • Health outcomes of patients accessing the clinics in Agincourt were not investigated and so quality of care has not been assessed.

    The economic cost of outpatient primary care of adults with multimorbidity (HIV, diabetes, and hypertension) in rural South Africa · 2026 · DOI

  • Prevalence and incidence for Romania rest on thin national input and are fitted with a Bayesian meta-regression that borrows strength across the region when country data are sparse, so a Romanian estimate can sit closer to the Central European fit than a national survey would place it.

    Nonfatal Burden of Disease and Risk-Attributable Burden in Romania, 1990 to 2023: A Secondary Analysis of Global Burden of Disease 2023 Estimates · 2026 · DOI

  • While this stratification is an intentional design feature, the extent of this dependence has not been previously quantified and is a central finding of this paper.

    Demographic determinants of REMS-derived BMD and fragility score · 2026 · DOI

  • Future translational studies are warranted to determine how multimorbidity definitions can be optimized to ultimately improve clinical management and health outcomes in practice.

    Comparison of count-based and clustering definitions of multimorbidity and their association with prevalence of multimorbidity, health profiles, and mortality: A cohort study of UK Biobank participants · 2026 · DOI

  • Absence of mental health data is a major limitation, likely underestimating multimorbidity complexity.

    Beyond disease counts: multimorbidity patterns and self-rated health in South African adults–a network analysis of the 2016 demographic and health survey · 2026 · DOI

  • Social isolation, neighbourhood environments, and socio-economic inequalities warrant further investigation as potential targets for prevention policies, and their effects, together with the life stages at which they operate, should be evaluated in longitudinal and intervention studies.

    Social and Environmental Determinants Show Greater Predictive Attribution than Health Behaviours for Multimorbidity: A Population-Based Machine Learning Study · 2026 · DOI

  • While psychological distress (including anxiety and depression) and systemic inflammation have each been linked to individual cardiometabolic conditions, their combined associations with multimorbidity remain insufficiently understood.

    Association of anxiety, depressive symptoms, and inflammatory indices with cardiometabolic multimorbidity · 2026 · DOI

  • Although care coordination programs have been shown to result in shorter-term cost benefits, little is known about patients who remain in such programs beyond 2 years.

    Care Coordination Engagement Patterns in Long-Term Patients · 2025 · DOI

  • Further research on prioritization and potential pathways for reaching an agreement could help healthcare professionals to accurately identify their patients’ priorities and provide effective care.

    Living with Multimorbidity through Time: A Meta-Synthesis of Qualitative Longitudinal Evidence · 2024 · DOI

  • Before the intervention, most participants (over 80%) had limited knowledge about kidney functions, CKD risks, and renal function tests.

    Patients’ Perspectives on the Acceptability and Effectiveness of a Community Health Worker-Led Intervention to Increase Chronic Kidney Disease Knowledge and Screening among Underserved Latine Adults: The CARE 2.0 Study · 2024 · DOI

  • Multimorbidity may increase the risk of depression in older adults, but the global average effect of multimorbidity on depression remains unknown.

    Association Between Multimorbidity and Depression in Older Adults: Evidence From Six Large Longitudinal Cohorts · 2024 · DOI

  • Cardiovascular diseases often occur together, but little is known about what increases the risk of developing cardiovascular multimorbidity (CVM), particularly in women.

    Risk factors for multimorbidity of cardiovascular diseases in the prospective Million Women Study · 2026 · DOI

  • Reducing polypharmacy by introducing single-pill combinations for common age-related diseases is another intervention that should be explored.

    Multimorbidity Management: A Scoping Review of Interventions and Health Outcomes · 2025 · DOI

  • However, no studies have assessed whether grip strength is associated with the risk of metabolic multimorbidity.

    Association between grip strength and risk of metabolic multimorbidity in Chinese adults: A prospective cohort study · 2025 · DOI

  • Sensitivity analyses further demonstrated that cardiometabolic and respiratory disease burden contributed independently to expenditure variation beyond cluster membership, whereas cancer burden could not be evaluated separately because cluster assignment fully captured cancer status.

    Economic and Humanistic Burden of Multimorbidity in the United States: A Longitudinal Study of Expenditure and Quality of Life Trajectories, 2019–2022 · 2025 · DOI

  • INTRODUCTION Multimorbidity – the coexistence of multiple chronic conditions – is common among older adults with cognitive impairment but is rarely addressed in an integrated manner.

    Management of multimorbidity in the midst of cognitive decline through clinical decision‐support software · 2026 · DOI

  • Cancer’s link to parental stress—a previously underexplored outcome—exposes the familial burden often overlooked in cancer care.

    Chronic Illnesses: Varied Health Patterns and Mental Health Challenges · 2025 · DOI

Most-cited papers in Chronic Disease Management Strategies

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Open questions raised by papers listed on this page include: (1) Further investigation is needed to ensure that integrated care in South Africa leads to good health outcomes (“The economic cost of outpatient primary care of adults with multimorbidity…”, 2026); (2) Future translational studies are warranted to determine how multimorbidity definitions can be optimized to ultimately improve clinical management and health outcomes in practice (“Comparison of count-based and clustering definitions of multimorbidity and…”, 2026); (3) While psychological distress (including anxiety and depression) and systemic inflammation have each been linked to individual cardiometabolic conditions, their combined associations with multimorbidity remain insufficiently understood (“Association of anxiety, depressive symptoms, and inflammatory indices with…”, 2026); (4) Cardiovascular diseases often occur together, but little is known about what increases the risk of developing cardiovascular multimorbidity (CVM), particularly in women (“Risk factors for multimorbidity of cardiovascular diseases in the prospective…”, 2026); (5) Although care coordination programs have been shown to result in shorter-term cost benefits, little is known about patients who remain in such programs beyond 2 years (“Care Coordination Engagement Patterns in Long-Term Patients”, 2025). 492 gap statements have been mined from Chronic Disease Management Strategies papers in our 7.9M-paper local library, which holds 1,997 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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