Science AI Journal
Biochemistry, Genetics and Molecular Biology · Research topic

Open research questions in Cleft Lip and Palate Research

218 unresolved questions extracted from the limitations and future-work sections of 2,654 Cleft Lip and Palate Research papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Se requieren ensayos clínicos bien diseñados y con tamaños muestrales adecuados, - Es necesario considerar otros factores que podrían influir en los resultados, - Deben realizarse más estudios para determinar el verdadero efecto de los métodos de alimentación postoperatoria

    Effect of postoperative feeding methods in patients with cleft lip and palate: A systematic review and meta-analysis · 2026 · DOI

  • The current evidence on the effect of postoperative feeding methods in infants with cleft lip and palate is uncertain. There is a need for well-designed clinical trials to determine the true effect of these methods.

    Effect of postoperative feeding methods in patients with cleft lip and palate: A systematic review and meta-analysis · 2026 · DOI

  • Investigate cultural constructions of CL/P in other cultures, - Examine the role of spirituality and religion in coping with CL/P, - Compare the experiences of parents with children with CL/P across different cultures

    ‘This is the Test of Our Faith’: An Exploratory Study of the Religio–spiritual and Cultural Construction of Cleft Lip and Palate Among Muslim Parents in Punjab, Pakistan · 2026 · DOI

  • The lack of understanding of the religio-spiritual and cultural construction of cleft lip and palate among Muslim parents in Punjab, Pakistan. The need to explore the lived experiences of parents regarding the religio-spiritual and cultural construction of cleft lip and palate. The gap in the literature on the cultural and religio-spiritual aspects of cleft lip and palate.

    ‘This is the Test of Our Faith’: An Exploratory Study of the Religio–spiritual and Cultural Construction of Cleft Lip and Palate Among Muslim Parents in Punjab, Pakistan · 2026 · DOI

  • One challenge is the under-recognition of mouth breathing by patients and caregivers, which can delay appropriate interventions. Another challenge is the complexity of the relationships among adenoid hypertrophy, mouth breathing, and craniofacial development. The paper also identifies the need for further research on the pathogenic factors contributing to adenoid hypertrophy.

    Adenoid facies: a long-term vicious cycle of mouth breathing, adenoid hypertrophy, and atypical craniofacial development · 2024 · DOI

  • BACKGROUND/OBJECTIVES: In individuals with cleft lip and palate, nasolabial asymmetry and dysmorphology are associated with lower aesthetic ratings, though this relationship remains unclear.

    Nasolabial shape and aesthetics in patients with cleft lip and palate: analysis of 3D facial images · 2025 · DOI

  • Previously, we found that SLC23A2 is closely related to the occurrence of cleft palate through gene–environment interaction studies, but whether SLC23A2 is related to the occurrence of cleft lip has not been reported.

    Oxidative stress-mediated apoptosis via the SLC23A2-ascorbic acid interaction contributes to cleft lip development · 2025 · DOI

  • BACKGROUND: Several methods have been proposed to assess outcome of bone-grafted alveolar clefts on cone beam computed tomography (CBCT), but so far these methods have not been compared and clinically validated.

    Validation and comparison of 2D grading scales and 3D volumetric measurements for outcome assessment of bone-grafted alveolar clefts in children · 2024 · DOI

  • The case demonstrates BFP flap success in very advanced age with geriatric constraints such as frailty and limited anesthetic tolerance, but broader clinical evidence from comparative studies across elderly populations is needed.

    Reconstruction of a partial maxillectomy defect using a pedicled buccal fat pad flap in an elderly oral squamous cell carcinoma patient · 2026 · DOI

  • The complex interactions between various cellular and molecular events in palatogenesis are not fully understood. The mechanisms underlying cleft palate development are not fully elucidated.

    Multiscale Convergence of Signaling, Epigenetic, and Environmental Networks in Mammalian Palatogenesis and Cleft Palate Pathogenesis · 2026 · DOI

  • Prolonged treatment trajectory and repeated hospital visits impose significant psychological, emotional, and financial strain. Caregivers experience significant emotional distress and psychosocial burden. Gaps in standardized mental health assessment and limited integration of psychological services remain evident.

    Mental Health Challenges in Cleft Lip and/or Palate Care: A Narrative Review with an Indian Perspective · 2026 · DOI

  • Gaps in standardized mental health assessment and limited integration of psychological services remain evident. The need for clinical vigilance and early identification of at-risk individuals is highlighted.

    Mental Health Challenges in Cleft Lip and/or Palate Care: A Narrative Review with an Indian Perspective · 2026 · DOI

  • Purpose: American Indian and Alaska Native (AI/AN) children are disproportionately affected by orofacial clefts, yet access to comprehensive cleft and craniofacial care has not been systematically quantified.

    Mapping Disparities In Access To Cleft And Craniofacial Care For American Indian And Alaska Native Populations · 2026 · DOI

  • Further investigation of the 309 high-order interactor genes not previously associated with OFC. Exploration of the potential therapeutic applications of the identified genetic drivers.

    Comprehensive analysis of de novo variants across 2,497 orofacial cleft trios reveals novel genetic drivers of disease · 2026 · DOI

  • The genetic etiology of OFC subtypes is not well understood. The biological mechanisms differentiating each subtype and syndromic forms are still poorly understood.

    Comprehensive analysis of de novo variants across 2,497 orofacial cleft trios reveals novel genetic drivers of disease · 2026 · DOI

  • The communication between oral and nasal cavities results in inadequate generation of negative pressure required for suckling. The impression making process can be challenging due to lack of cooperation from the parent, small oral cavity, and undercuts of the defects.

    SINGLE-VISIT FEEDING PLATE REHABILITATION IN AN 8-DAY-OLD INFANT WITH UNILATERAL CLEFT LIP AND PALATE: A CASE REPORT · 2026 · DOI

  • The communication between oral and nasal cavities in neonates with cleft palate often results in difficulty in feeding. There is a need for an effective treatment modality to improve feeding efficiency in these infants.

    SINGLE-VISIT FEEDING PLATE REHABILITATION IN AN 8-DAY-OLD INFANT WITH UNILATERAL CLEFT LIP AND PALATE: A CASE REPORT · 2026 · DOI

  • There is a need to understand the frequency of risk factors associated with orofacial malformations and neural tube defects. There is a lack of studies on the prevalence of these malformations in specific populations.

    Factores de riesgo ambientales asociados a malformaciones orofaciales y defectos del tubo neural en recién nacidos · 2026 · DOI

  • Data on children with cleft palate in Nigeria remain scarce. There is a need for further studies on middle ear dysfunction in children with cleft palate in Nigeria.

    PREVALENCE OF MIDDLE EAR DYSFUNCTION IN CHILDREN WITH CLEFT PALATE IN LAGOS, NIGERIA · 2026 · DOI

  • To investigate the genetic and environmental risk factors. To develop more effective treatment approaches. To improve outcomes for children with cleft lip and/or palate.

    Cleft Lip and/or Palate: A Comprehensive Review and our Treatment Approach · 2026 · DOI

  • Unilateral cleft lip and palate is a complex condition that affects multiple aspects of development. The condition requires a multidisciplinary approach to treatment. There is a need for early intervention and rehabilitation to improve motor masticatory function.

    Motor masticatory function in children with cleft lip and palate · 2026 · DOI

  • There is a lack of understanding of the effects of unilateral cleft lip and palate on motor masticatory function. There is a need for studies that examine the impact of surgical treatment on motor masticatory function. There is a need for studies that assess the long-term effects of unilateral cleft lip and palate on motor masticatory function.

    Motor masticatory function in children with cleft lip and palate · 2026 · DOI

  • The current staging systems for MPS maturation are subjective and qualitative. There is a need for a quantitative, reproducible measure of MPS maturation.

    Fractal Dimension as a Tool for Mid-palatal Suture Maturation Assessment- A Cone Beam Computed Tomography Study · 2026 · DOI

  • Future studies should investigate the effects of chewing habits on TMJ morphology. Future studies should examine the relationship between AE inclination and TMJ function. Future studies should develop new treatments for UCLP patients based on the morphological differences in TMJ structures.

    Temporomandibular joint morphology in patients with unilateral cleft lip and palate · 2026 · DOI

  • The relationship between the shape of the articular eminence and the function of the TMJ has not been clearly revealed yet. The subject of AE and TMJ still has attracted the attention of researchers today. There is a need to investigate the differences in TMJ morphology between UCLP patients and healthy individuals.

    Temporomandibular joint morphology in patients with unilateral cleft lip and palate · 2026 · DOI

Most-cited papers in Cleft Lip and Palate Research

Most recent work

Find a gap in your own Cleft Lip and Palate Research sub-topic

This page shows what the Cleft Lip and Palate Research literature already flags as unresolved. To narrow it to your specific question, run the guided finder — it searches the gap library on demand and checks candidates against 250M+ OpenAlex works.

Open the Research Gap Finder →

Related topics in Biochemistry, Genetics and Molecular Biology

Gut microbiota and health
1,024 open questions
Single-cell and spatial transcriptomics
602 open questions
Genetic Associations and Epidemiology
393 open questions
Antibiotic Resistance in Bacteria
360 open questions
Inflammatory Bowel Disease
353 open questions
Extracellular vesicles in disease
305 open questions
Mitochondrial Function and Pathology
296 open questions
Human-Animal Interaction Studies
294 open questions
218 open questions have been extracted from the limitations and future-work passages of 2,654 Cleft Lip and Palate Research papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 120,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? A Tier 1–5 acceptance probability in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck prior-publication & salami-slicing risk across 8 sources.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.