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Open research questions in Colorectal Cancer Screening and Detection

161 unresolved questions extracted from the limitations and future-work sections of 707 Colorectal Cancer Screening and Detection papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Inadequate bowel preparation is a common issue in colonoscopy, affecting up to 20% of patients. The success rate of different salvage strategies varies, and effective approaches are needed to improve colon cleaning and patient outcomes. The paper identifies challenges in tailoring bowel preparation to individual patient needs, as colonoscopy is largely performed as open access in routine practice.

    Colon Cleaning after Inadequate Bowel Preparation: A Pooleddata Analysis · 2026 · DOI

  • Investigating factors predicting bowel preparation failure, - Developing more effective bowel preparation strategies, - Improving patient compliance with bowel preparation

    Colon Cleaning after Inadequate Bowel Preparation: A Pooleddata Analysis · 2026 · DOI

  • One of the challenges is the limited sensitivity of current screening methods for early cancers. Another challenge is the low participation rate in screening programs. The paper also highlights the need for further research to overcome the limitations of liquid biopsy, including its potential for false positives and false negatives.

    Liquid biopsy for colorectal cancer screening: chances and challenges · 2026 · DOI

  • limited sensitivity for detection of early cancers and AAs, - reduced repeat participation attenuates cumulative program sensitivity, - socioeconomic disadvantages and limited health literacy are associated with lower screening participation

    Liquid biopsy for colorectal cancer screening: chances and challenges · 2026 · DOI

  • The cross-institutional domain shift in narrow-band imaging classification of colorectal lesions. The class imbalance in the dataset, which is addressed using class weights. The need to prevent patches derived from the same lesion from being distributed across the training and validation partitions.

    Persistent Cross-Institutional Domain Shift in Narrow-Band Imaging Classification of Colorectal Lesions and the Utility of Site-Specific Fine-Tuning · 2026 · DOI

  • Investigating methods to improve cross-institutional generalizability, - Examining the effects of different patch selection and input linkage procedures, - Developing strategies to mitigate class imbalance

    Persistent Cross-Institutional Domain Shift in Narrow-Band Imaging Classification of Colorectal Lesions and the Utility of Site-Specific Fine-Tuning · 2026 · DOI

  • The study was a single-center retrospective cohort study, - The study had a limited sample size of 769 patients, - The study did not include a external validation set

    Machine Learning-Based Investigation of Factors Influencing Recurrence of Colorectal Adenomatous Polyps: A Retrospective Cohort Study · 2026 · DOI

  • Advanced endoscopic techniques have made many such lesions resectable, but the burden and temporal trends of surgery remain unclear.

    Burden and trends of endoscopically unresectable polyps requiring surgical intervention: A systematic review and meta-analysis · 2026 · DOI

  • AI systems designed to enhance polyp detection during colonoscopy have shown promise, but the extent to which they improve detection of different-sized polyps remains unclear.

    Comparative Efficacy of Different AI Systems for Polyp Detection by Size During Colonoscopy: Systematic Review and Network Meta-Analysis · 2026 · DOI

  • One underexplored factor is the heterogeneity in access to data sources used to exclude medically ineligible individuals, potentially affecting the accuracy of participation rate estimates.

    Impact of medical exclusion data sources on population-based colorectal cancer screening round participation in France: a counterfactual analysis · 2026 · DOI

  • Nonetheless, information regarding the clinico-pathological features of colorectal polyps in Bangladesh is still scarce.

    Clinico-Pathological Characteristics of Colorectal Polyps in Adults in A Tertiary Care Hospital · 2026 · DOI

  • Adequate bowel preparation is essential for colonoscopy quality, but predictors of suboptimal bowel preparation and individualized risk assessment tools remain insufficiently defined in this population.

    Development and internal validation of a prediction model for suboptimal bowel preparation in individuals aged ≤50 years undergoing colonoscopy · 2026 · DOI

  • In addition, expanding the list of stressful life events by including a validated scale of stressful life events for patients from historically marginalized groups is warranted.

    Using large language models for extracting stressful life events to assess their impact on preventive colon cancer screening adherence · 2025 · DOI

  • While CADe has standardized detection quality; its long-term impact on CRC incidence and mortality remains inconclusive.

    AI and Polyp Detection During Colonoscopy · 2025 · DOI

  • Future research should focus on refining CADe technology and assessing its effectiveness in reducing the global burden of CRC.

    AI and Polyp Detection During Colonoscopy · 2025 · DOI

  • Despite this growing public health concern, the molecular mechanisms driving EOCRC disparities remain poorly understood.

    Molecular Heterogeneity in Early-Onset Colorectal Cancer: Pathway-Specific Insights in High-Risk Populations · 2025 · DOI

  • Oncogenic pathways such as WNT, TGF-beta, and RTK/RAS are critical in colorectal cancer (CRC) progression, yet their specific roles in EOCRC across diverse populations have not been extensively studied.

    Molecular Heterogeneity in Early-Onset Colorectal Cancer: Pathway-Specific Insights in High-Risk Populations · 2025 · DOI

  • A major barrier impacting implementation is a lack of consensus on the best approach for risk stratified screening.

    A systems based qualitative analysis exploring the potential to implement risk stratified bowel cancer screening in England · 2025 · DOI

  • Patient navigation (PN) and tailored interventions increase CRC screening uptake, however there is limited information comparing their effectiveness or the effect of combining them.

    Patient Navigation Plus Tailored Digital Video Disc Increases Colorectal Cancer Screening Among Low-Income and Minority Patients Who Did Not Attend a Scheduled Screening Colonoscopy: A Randomized Trial · 2024 · DOI

  • BACKGROUND: Up to 50% of people scheduled for screening colonoscopy do not complete this test and no studies have focused on minority and low-income populations.

    Patient Navigation Plus Tailored Digital Video Disc Increases Colorectal Cancer Screening Among Low-Income and Minority Patients Who Did Not Attend a Scheduled Screening Colonoscopy: A Randomized Trial · 2024 · DOI

  • Despite ethical and historical arguments for removing race from clinical algorithms, the consequences of removal remain unclear.

    Race adjustments in clinical algorithms can help correct for racial disparities in data quality · 2024 · DOI

  • Background: Rising trends in early-onset colorectal cancer (CRC) burden have been observed, but the distribution and temporal patterns of early-onset CRC attributable to dietary risks remain unclear.

    The global burden and trends analysis of early-onset colorectal cancer attributable to dietary risk factors in 204 countries and territories, 1990–2019: a secondary analysis for the global burden of disease study 2019 · 2024 · DOI

  • However, there were still some factors, especially diet-related factors, that have not been fully elucidated in their association with the two lesions.

    Association between lifestyle and dietary preference factors and conventional adenomas and serrated polyps · 2024 · DOI

  • Two well-established drivers of early-onset CRC in the general population are alterations in the WNT and TGF-Beta signaling pathways; however, the specific roles of these pathways in Hispanics/Latinos are poorly understood.

    WNT and TGF-Beta Pathway Alterations in Early-Onset Colorectal Cancer Among Hispanic/Latino Populations · 2024 · DOI

  • The patterns of screening uptake and possible socioeconomic disparities in screening in this age group remain unknown.

    USPSTF Colorectal Cancer Screening Recommendation and Uptake for Individuals Aged 45 to 49 Years · 2024 · DOI

Most-cited papers in Colorectal Cancer Screening and Detection

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161 open questions have been extracted from the limitations and future-work passages of 707 Colorectal Cancer Screening and Detection papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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