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Open research questions in Cutaneous Melanoma Detection and Management

586 gap statements mined from Cutaneous Melanoma Detection and Management papers in our 7.9M-paper local library, which holds 2,746 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • They highlight the need for further validation of the proposed thresholds.

    Authors’ reply to “Plaque vulnerability or lesion geometry? Interpreting CT-derived translesional gradients” · 2026 · DOI

  • Delays in the healthcare system can negatively impact patient care. The paper identifies the need for uniform and protocol-driven care to address these challenges.

    Optimizing time and care coordination for melanoma patients in the Onkonetwork system · 2026 · DOI

  • The increase in melanoma incidence is not matched by an equivalent increase in publications on the topic. There is a need for innovative frameworks and practical examples of integrative oncology care.

    Optimizing time and care coordination for melanoma patients in the Onkonetwork system · 2026 · DOI

  • Poor image quality can decrease diagnostic accuracy. Case difficulty can decrease diagnostic accuracy, particularly for cases rated 'hard' or 'very hard'. The need to balance sensitivity and specificity when using multiple teledermatologists, as increasing the number of assessors can increase sensitivity but decrease specificity.

    Teledermoscopic triage of melanoma-suspicious skin lesions is safe: A retrospective comparative diagnostic accuracy study with multiple assessors · 2024 · DOI

  • Cutaneous melanoma (CM) is highly invasive with limited prognostic tools, and the prognostic relevance of lactylation, a novel post-translational modification, remains unexplored.

    A relative methylation ordering biomarker of lactylation-related genes predicts prognosis and therapeutic response in cutaneous melanoma · 2026 · DOI

  • Accurate segmentation of skin lesions is of critical clinical importance for early melanoma diagnosis; however, the direct application of large foundation models like the Segment Anything Model (SAM) to medical images characterized by low contrast and fuzzy boundaries remains insufficient due to substantial domain gaps.

    Comparative Analysis and Adaptation Strategies of Vision Foundation Models in Dermoscopic Image Segmentation · 2026 · DOI

  • However, the impact of CPP implementation on melanoma stage distribution and outcomes has not been assessed.

    Fast-track Cancer Patient Pathways and their impact on melanoma stage distribution and prognosis: A nationwide Danish cohort study · 2026 · DOI

  • Because of its unique molecular alterations, the applicability of findings from Western-based clinical trials to AM remains uncertain, leading to a lack of high-level evidence for this subtype.

    Current Surgical Management for Acral Melanoma · 2025 · DOI

  • Interleukin (IL)-4 is considered essential for Th2-polarisation in the TME; however, its source remains unknown.

    Basophil‐Derived IL ‐4 Production and Its Potential Pro‐Tumoural Role in Th2‐Polarisation Within Sentinel Lymph Nodes of Primary Cutaneous Melanoma · 2025 · DOI

  • Further studies with larger sample sizes are warranted to validate these findings and explore the broader applicability of EVCM in clinical practice.

    Precision at the Cutting Edge: Ex Vivo Confocal Microscopy for Perioperative Tumour Thickness Assessment in Melanoma · 2025 · DOI

  • The study addresses a range of skin disorders, including acne, vitiligo, hyperpigmentation, nail psoriasis, and SJS-TEN, focusing on aspects that remain underexplored in previous research.

    Explainable AI for skin disease classification using gradient-weighted class activation mapping and transfer learning in digital health to identify contours · 2025 · DOI

  • Little is known about the characteristics of PRAME expression in pediatric melanoma.

    Characterization of PRAME immunohistochemistry reveals lower expression in pediatric melanoma compared to adult melanoma · 2024 · DOI

  • However, the relationship between MetS, its individual components and melanoma metastasis remains unexplored.

    Association Between Melanoma Metastasis and Metabolic Syndrome: A Cross‐Sectional Study in a Chinese Population · 2024 · DOI

  • Despite this, we believe a reconsideration of the role of radical surgery is warranted given the increase in survival seen when combined with neoadjuvant immunotherapy.

    Neoadjuvant immunotherapy versus adjuvant chemotherapy in anorectal melanoma · 2024 · DOI

  • However, exactly which nodal basins to examine has not been established, should it be focused on the positive sentinel node site or all basins indicated by the lymphoscintigraphy? This study aims to describe the patterns of recurrences in patients with trunk melanoma.

    72235 - Pattern of regional recurrences in patients with trunk melanoma and implications for ultrasound follow-up · 2024 · DOI

  • Optimal management remains unclear but surgical resection is considered the mainstay of treatment for this condition.

    426 Nasopharyngeal Malignant Melanoma Masquerading in the Gallbladder: The Importance of Histological Assessment · 2024 · DOI

  • As effective melanoma treatments have become available, utilizing isolated limb perfusion (ILP) to treat unresectable melanoma limited to the limb has decreased.

    Association of Pretreatment Tumour Microenvironment and Treatment Outcome in Patients With Locally Advanced Melanoma Treated With Isolated Limb Perfusion · 2025 · DOI

  • Many factors concerning melanoma mortality are poorly understood, posing an obstacle to optimal care.

    Causes of death and patterns of metastatic disease at the end of life for patients with advanced melanoma in the immunotherapy era · 2024 · DOI

  • The study used data from a large-scale survey, but the analysis was limited to participants with complete data. The study did not account for all potential confounding variables.

    Machine learning-based association analysis of triglyceride-glucose index with melanoma prevalence and all-cause mortality: insights from cross-sectional NHANES 1999–2018 data and an external hospital-based dataset · 2026 · DOI

  • The study utilized a relatively small sample size of 72 patients, - The patient enrollment period was limited to February 2024 to May 2026, - Internal validation was critical due to the large number of candidate variables relative to sample…

    Melanoma Intelligence: Explainable AI Reveals Histopathologic Aggressiveness as the Dominant Axis of Lymph-Node Metastasis · 2026 · DOI

  • Investigating emerging non-invasive techniques in melanoma diagnosis, staging, and monitoring, - Incorporating sensing technologies and spectroscopy methods not commonly considered…

    Review of Non-Invasive Imaging Technologies for Cutaneous Melanoma · 2025 · DOI

  • Further investigation of non-CDKN2A germline variants - Exploration of the genetic alterations associated with melanoma - Study of the clinical phenotype observed in families with CDK4…

    Germline Non-CDKN2A Variants in Melanoma and Associated Hereditary Cancer Syndromes · 2025 · DOI

  • Future teledermoscopy guidelines should encompass safety procedures and protocols for disagreement between assessors, - Further research on the application of TDT in different populations…

    Teledermoscopic triage of melanoma-suspicious skin lesions is safe: A retrospective comparative diagnostic accuracy study with multiple assessors · 2024 · DOI

  • Even though matching reduced the bias and enhanced the validity of these findings, the major limitations lie in the retrospective nature and sample size.

    Neoadjuvant immunotherapy versus adjuvant chemotherapy in anorectal melanoma · 2024 · DOI

  • Further investigation of HSI as a complementary imaging modality for early melanoma detection. Development of computer-aided diagnostic systems for melanoma detection using HSI.

    Minimizing the False Negative Rate in Convolutional Neural Network-Based Melanoma Classification Using Hyperspectral Data to Reduce Misdiagnosis · 2026 · DOI

Most-cited papers in Cutaneous Melanoma Detection and Management

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Open questions raised by papers listed on this page include: (1) There is a need for innovative frameworks and practical examples of integrative oncology care (“Optimizing time and care coordination for melanoma patients in the Onkonetwork…”, 2026); (2) Cutaneous melanoma (CM) is highly invasive with limited prognostic tools, and the prognostic relevance of lactylation, a novel post-translational modification, remains unexplored (“A relative methylation ordering biomarker of lactylation-related genes predicts…”, 2026); (3) Because of its unique molecular alterations, the applicability of findings from Western-based clinical trials to AM remains uncertain, leading to a lack of high-level evidence for this subtype (“Current Surgical Management for Acral Melanoma”, 2025); (4) Interleukin (IL)-4 is considered essential for Th2-polarisation in the TME; however, its source remains unknown (“Basophil‐Derived IL ‐4 Production and Its Potential Pro‐Tumoural Role in…”, 2025); (5) Further studies with larger sample sizes are warranted to validate these findings and explore the broader applicability of EVCM in clinical practice (“Precision at the Cutting Edge: Ex Vivo Confocal Microscopy for Perioperative…”, 2025). 586 gap statements have been mined from Cutaneous Melanoma Detection and Management papers in our 7.9M-paper local library, which holds 2,746 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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