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Open research questions in Cytomegalovirus and herpesvirus research

91 unresolved questions extracted from the limitations and future-work sections of 330 Cytomegalovirus and herpesvirus research papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The study did not collect gender identity data due to the age of the participants, - The study excluded participants with evidence of bacterial infection, - The study had a limited sample size for certain analyses

    Absent pleocytosis in infant viral central nervous system infections reflects lymphocyte depletion and cytokine activation · 2026 · DOI

  • Further studies are needed to distinguish viral CNS infection from other febrile illnesses based on clinical features in infants, - Investigation of the plasma proteome in relation to CSF white cell and peripheral lymphocyte counts is warranted, - Research on the distinct systemic immune response profile in infants without CSF pleocytosis

    Absent pleocytosis in infant viral central nervous system infections reflects lymphocyte depletion and cytokine activation · 2026 · DOI

  • Current HLArestricted αβ T-cell-based therapies have limitations, - Data on kidney transplant recipients with JC virus infection remain limited

    “Innovative diagnostics and treatments of infections in transplantation,” report from the 2025 spring highlights in transplantation sciences meeting · 2026 · DOI

  • Developing adoptive cellular therapies targeting CMV, - Exploring the use of metagenomic next-generation sequencing for diagnosing unexplained infections

    “Innovative diagnostics and treatments of infections in transplantation,” report from the 2025 spring highlights in transplantation sciences meeting · 2026 · DOI

  • The difficulty of studying programmed necrotic cell death in physiologically relevant cell types, - The need to develop methods to assess the intrinsic cell-death-inhibitory activity of UL45, - The challenge of differentiating monocytes into M1-like or M2-like macrophages

    UL45 of Human Cytomegalovirus Promotes Macrophage Survival and Modulates RIPK3-Associated Cell Death · 2026 · DOI

  • The study was found to be 'not human research' by the UMMC IRB, - No study procedures were performed on human subjects, - The study used a limited number of donors, - The study used a specific strain of HCMV (TB40E)

    UL45 of Human Cytomegalovirus Promotes Macrophage Survival and Modulates RIPK3-Associated Cell Death · 2026 · DOI

  • Despite expanding legislative screening requirements across the United States, there is no consensus guidance on the screening approach, resulting in wide variation in implementation.

    Implementing Congenital CMV Screening in a Large Hospital System · 2026 · DOI

  • As a result, it remains unclear whether common approaches for screening antibody combinations accurately capture biologically relevant interactions.

    Comparative evaluation of screening approaches for antiviral monoclonal antibody combinations · 2026 · DOI

  • Background/Objectives: Anti-T lymphocyte globulin (ATLG) is widely used as induction therapy in kidney transplantation; however, the clinical impact of the interval between individual ATLG doses remains poorly defined.

    Alternate-Day Versus Consecutive-Day Anti-T Lymphocyte Globulin Induction in First Living-Donor Kidney Transplant Recipients at Low Immunological Risk: A Retrospective Cohort Study · 2026 · DOI

  • Leveraging the absolute quantification capability of ddPCR without standard curves, we compared its performance, including dynamic range and limit of detection (LOD), against a homologous qPCR assay.

    Development and validation of a duplex droplet digital PCR assay for the simultaneous detection of cytomegalovirus and Epstein-Barr virus in plasma · 2026 · DOI

  • However, the regulatory roles of lactate during viral infections remain poorly understood.

    Infection-induced lysine lactylation enables herpesvirus immune evasion · 2025 · DOI

  • The role of gut microbiota dysbiosis in systemic lupus erythematosus (SLE) pathogenesis remains elusive.

    Microbiota‐Derived Inosine Suppresses Systemic Autoimmunity via Restriction of B Cell Differentiation and Migration · 2025 · DOI

  • A more comprehensive understanding of the tubular domain expansion remains to be established.

    Rab10-associated tubulation as an early marker for biogenesis of the assembly compartment in cytomegalovirus-infected cells · 2025 · DOI

  • However, emerging evidence suggests that HR-HPV infection alone is insufficient for cancer development, and other co-factors may contribute to cervical carcinogenesis.

    Molecular Insights into HR-HPV and HCMV Co-Presence in Cervical Cancer Development · 2025 · DOI

  • While knowledge of preventive measures among participants was insufficient to ensure comprehensive protection against CMV infection, it represents a significant improvement compared to previous studies.

    Awareness and knowledge of cytomegalovirus infection among pregnant women in French-speaking Switzerland · 2025 · DOI

  • Importantly, the mechanisms underlying establishment and maintenance of immune activation in ART-treated PWH remain incompletely defined.

    Inflammatory neutrophil responses and T cell activation in ART-treated SIVmac239-infected rhesus macaques · 2025 · DOI

  • However, further prospective multi-center studies are warranted to validate our conclusion in adolescent patients.

    Real-world efficacy and safety of letermovir versus ganciclovir prophylaxis in adolescent patients undergoing allogenic hematopoietic stem cell transplantation: a single center observational study · 2025 · DOI

  • However, its varied clinical presentations and outcomes are not fully understood.

    Gastrointestinal cytomegalovirus infection in persons with HIV: a retrospective case series study · 2025 · DOI

  • However, it remains to be determined whether HCMV-induced senescence contributes to organ-specific pathogenesis.

    Human cytomegalovirus infection triggers a paracrine senescence loop in renal epithelial cells · 2024 · DOI

  • Although the involvement of autophagy in porcine circovirus 2 (PCV2) infection has become apparent, it remains unclear whether selective autophagy plays a critical role in PCV2 restriction.

    Retinol binding protein 4 restricts PCV2 replication via selective autophagy degradation of viral ORF1 protein · 2024 · DOI

  • The mechanism by which these CD8+ T cells acquire a CCR9-dependent "brain-tropic" phenotype remains unclear.

    Cutting Edge: Retinoic Acid Promotes Brain-homing of CD8+ T Cells during Congenital Cytomegalovirus Infection · 2024 · DOI

  • Although CMV-specific Th17 cells are detectable in animal models and nontransplant clinical populations, evidence linking CMV and Th17 cells after renal transplantation remains unclear.

    Virus-specific Th17 Cells Are Induced by Human Cytomegalovirus after Renal Transplantation · 2024 · DOI

  • Nevertheless, the clinical characteristics for CMV reactivation are lacking among septic patients requiring mechanical ventilation.

    Active cytomegalovirus infection in mechanically ventilated patients with sepsis · 2024 · DOI

  • Further investigation of the underlying biology of these viral DNA infections in children with sepsis is warranted to determine whether they only reflect mortality risk or contribute to mortality.

    Viral DNAemia and DNA Virus Seropositivity and Mortality in Pediatric Sepsis · 2024 · DOI

  • CMVR can result in extensive retinal tissue damage and irreversible vision impairment if left untreated. The treatment of CMVR is challenging due to the lack of a clear standard for the length of treatment.

    Factors influencing the treatment duration and visual prognosis of cytomegalovirus retinitis after allogeneic hematopoietic stem cell transplantation · 2026 · DOI

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91 open questions have been extracted from the limitations and future-work passages of 330 Cytomegalovirus and herpesvirus research papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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