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Open research questions in Diabetes and associated disorders

373 gap statements mined from Diabetes and associated disorders papers in our 7.9M-paper local library, which holds 1,721 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • It remains unclear if human beta cells show a similar deficiency during T1D or exhibit a higher degree of intrinsic resistance to oxidative stress.

    Distribution of glutathione peroxidase-1 immunoreactive cells in pancreatic islets from type 1 diabetic donors and non-diabetic donors with and without islet cell autoantibodies is variable and independent of disease · 2025 · DOI

  • In summary, our observations suggest that Vemurafenib and its analogue warrant further exploration as potential antiviral agents for the treatment of enterovirus-induced diseases, including T1D.

    Vemurafenib inhibits the replication of diabetogenic enteroviruses in intestinal epithelial and pancreatic beta cells · 2024 · DOI

  • There is a need to determine the time to resolution of diabetic ketoacidosis and its predictors among adult diabetic patients in public hospitals of Northeast Ethiopia. There is a need to identify predictors of time to resolution of diabetic ketoacidosis.

    Time to Resolution of Diabetic Ketoacidosis and Its Predictors among Adult Diabetic Patients in Public Hospitals of Northeast, Ethiopia · 2026 · DOI

  • This study has several limitations. Using secondary data, we were unable to assess certain predictors of time to DKA resolution, including admission pH, potassium levels, and adherence to treatment protocols.

    Time to Resolution of Diabetic Ketoacidosis and Its Predictors among Adult Diabetic Patients in Public Hospitals of Northeast, Ethiopia · 2026 · DOI

  • Limited evidence from randomised trials in transplant recipients. Variability in trial duration and enrolment criteria. Incompletely and variably reported outcomes.

    Comparison of incidence patterns and risk profiles of ST-elevation and non-ST-elevation myocardial infarction in type 1 diabetes in Finland: a nationwide cohort study · 2026 · DOI

  • There is limited evidence from randomised trials in transplant recipients. The assumption that treatments proven in the general population apply to patients who have been treated with dialysis or kidney transplantation continues to require confirmation.

    Comparison of incidence patterns and risk profiles of ST-elevation and non-ST-elevation myocardial infarction in type 1 diabetes in Finland: a nationwide cohort study · 2026 · DOI

  • These findings provide mechanistic insights into T1D immunopathogenesis and support further investigation of the IL-21/STAT3 axis as a candidate immunomodulatory strategy.

    Aberrant IL-21/STAT3 signaling disrupts regulatory T cell function and CD4+ T cell homeostasis in children with type 1 diabetes · 2026 · DOI

  • There is a need for a nationwide screening program for Type 1 Diabetes in Austria. Current screening programs may not detect all cases of Type 1 Diabetes.

    Diabetes-Typ-1-Screening – welche Screeningprogramme gibt es und wo stehen wir in Österreich? · 2026 · DOI

  • The lack of studies on the prognostic significance of dynamic evaluation of C-peptide levels in predicting T1DM in healthy siblings. The need for a screening tool to predict the risk of T1DM development in healthy siblings.

    Prognostic significance of dynamic evaluation of C-peptide level in prediction type 1 diabetes mellitus in children · 2026 · DOI

  • Evidence supporting the use of NLR in patients with T1DM remains limited and inconclusive.

    Neutrophil-to-Lymphocyte Ratio as a Marker of Diabetic Ketoacidosis Severity in Type 1 Diabetes Mellitus: A Retrospective Study · 2026 · DOI

  • Our study specifically addresses the relationship between semaglutide and TED-related outcomes, which has not been previously reported in the literature.

    Association between semaglutide use and thyroid eye disease-related outcomes in autoimmune thyroiditis with type II diabetes · 2026 · DOI

  • There is a need to understand the role of inflammation in T1DM and its complications. The current study aims to address this gap by characterizing circulating cytokine profiles across different stages of T1DM.

    Dynamic cytokine profiles across the progression of Type 1 diabetes mellitus are associated with diabetic retinopathy development · 2026 · DOI

  • However, due to the observational design, the absence of matching for key confounders, and the lack of data on important covariates such as BMI, dietary intake and sun exposure, the findings support only associations and cannot establish causality. Finally, the effects of vitamin D supplementation on patients with T1DM were not investigated.

    A study of 25‑(OH)D 3 levels in children with type 1 diabetes mellitus and its influencing factors · 2026 · DOI

  • The relationship between T1DM duration and linear growth in children is not well understood. The effects of T1DM on the GH-IGF-1 axis and growth in children are not fully elucidated.

    Association between disease duration, GH-IGF-1 axis markers, and linear growth in children with type 1 diabetes mellitus: a cross-sectional study · 2026 · DOI

  • Many studies on the incidence of newly diagnosed T1D during the pandemic period yield conflicting results: some suggest an increase in incidence, while others report a decrease or no change compared to pre-pandemic levels.

    Ketoacidosis in new-onset type 1 diabetes: return to pre-COVID-19 pandemic reality? · 2026 · DOI

  • The lack of detailed longitudinal documentation of successful sulfonylurea therapy in a young adult with the ABCC8 C418R variant. The need for precision treatment in patients with atypical diabetes.

    When Type 1, Type 2, and Monogenic Diabetes Collide — a Case of ABCC8-Related Diabetes with the C418R Variant · 2026 · DOI

  • While observational studies have highlighted a potential link between diabetes and oral lichen planus (OLP), the causal relationship remains unclear, and it is uncertain which specific form of diabetes might promote OLP development.

    Effect of type 1 diabetes on oral lichen planus mediated by IL-10 · 2026 · DOI

  • The analysis was limited to patients with complete data for the corresponding period. The study had to exclude values exceeding three standard deviations above the mean to avoid influencing mean cost estimates.

    Increasing incidence and clinical burden of paediatric type 1 diabetes in Italy: insights from a large administrative database · 2026 · DOI

  • However, the handling of suspected monogenic diabetes in diabetes clinics in Greenland has not been described.

    High Prevalence and Common Forms of Maturity-onset Diabetes of the Young in Greenland · 2025 · DOI

  • The authors suggest adaptive trials that dynamically adjust fluid type and rate based on real-time biochemical parameters. They recommend assessing long-term neurocognitive effects using age-appropriate neuropsychological tests at 3, 6, and 12 months post-discharge.

    Normal Saline Versus Ringer’s Lactate for Intravenous Fluid Therapy in Children with Diabetic Ketoacidosis: A Randomized Controlled Trial – Correspondence · 2026 · DOI

  • The current study does not assess long-term neurocognitive effects of severe DKA or cerebral edema. The fixed ISPAD-guided regimen may not suit all patients.

    Normal Saline Versus Ringer’s Lactate for Intravenous Fluid Therapy in Children with Diabetic Ketoacidosis: A Randomized Controlled Trial – Correspondence · 2026 · DOI

  • The paper identifies a gap in the consideration of left truncation in survival analysis of islet autoantibodies. The authors acknowledge the potential for overestimation of autoantibody survival.

    Pattern and Persistence of Islet Autoantibodies and their Immunogenetic Association among Type 1 Diabetes Patients from North India: Authors’ Reply · 2026 · DOI

  • The model is not uncontested, - Three objections carry weight, - Sample sizes that Finland approaches and Sardinia does not possess, - The detection…

    The Enigma of Finnish and Sardinian Type 1 Diabetes Incidence: Where Population History Meets Genetics · 2026 · DOI

  • Data are fragmented and mostly derived from regional registries or limited cohorts, - Only tests recorded in the OSS database were captured, - Tests performed during hospitalisations were untraceable, - Medical devices were not captured due to unavailability…

    Increasing incidence and clinical burden of paediatric type 1 diabetes in Italy: insights from a large administrative database · 2026 · DOI

  • Increasing the sample size of group 3 to obtain more accurate results, - Conducting further studies to validate the findings, - Investigating the relationship between C-peptide concentration and the development of T1DM in other…

    Prognostic significance of dynamic evaluation of C-peptide level in prediction type 1 diabetes mellitus in children · 2026 · DOI

Most-cited papers in Diabetes and associated disorders

Most recent work

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Open questions raised by papers listed on this page include: (1) There is a need to determine the time to resolution of diabetic ketoacidosis and its predictors among adult diabetic patients in public hospitals of Northeast Ethiopia (“Time to Resolution of Diabetic Ketoacidosis and Its Predictors among Adult…”, 2026); (2) There is limited evidence from randomised trials in transplant recipients (“Comparison of incidence patterns and risk profiles of ST-elevation and…”, 2026); (3) There is a need for a nationwide screening program for Type 1 Diabetes in Austria (“Diabetes-Typ-1-Screening – welche Screeningprogramme gibt es und wo stehen wir…”, 2026); (4) The lack of studies on the prognostic significance of dynamic evaluation of C-peptide levels in predicting T1DM in healthy siblings (“Prognostic significance of dynamic evaluation of C-peptide level in prediction…”, 2026); (5) Evidence supporting the use of NLR in patients with T1DM remains limited and inconclusive (“Neutrophil-to-Lymphocyte Ratio as a Marker of Diabetic Ketoacidosis Severity in…”, 2026). 373 gap statements have been mined from Diabetes and associated disorders papers in our 7.9M-paper local library, which holds 1,721 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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