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Open research questions in Dialysis and Renal Disease Management

253 unresolved questions extracted from the limitations and future-work sections of 1,051 Dialysis and Renal Disease Management papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • further studies are needed to confirm the findings, - research on the long-term effects of IPD on nutritional status is needed, - studies on the clinical outcomes of IPD, such as RKF, patient survival, technique survival, and quality of life, are needed

    Impact of incremental peritoneal dialysis on long-term nutritional trajectories in end-stage kidney disease: a longitudinal cohort study · 2026 · DOI

  • Further studies are needed to confirm the association between ECW/BCM and CAC in larger and more diverse populations, - Research is needed to explore the mechanisms underlying the relationship between ECW/BCM and CAC, - Studies should investigate the potential of ECW/BCM as a predictor for cardiovascular events in PD patients

    Ratio of extracellular water and body cell mass is associated with coronary artery calcification in peritoneal dialysis patients · 2026 · DOI

  • The relationship between ECW/BCM and CAC at peritoneal dialysis initiation is unclear. Prior studies have not explored the association between ECW/BCM and CAC in incident PD patients. There is a need to identify risk factors for CAC in PD patients.

    Ratio of extracellular water and body cell mass is associated with coronary artery calcification in peritoneal dialysis patients · 2026 · DOI

  • Inappropriate financial incentives and limited oversight. Longstanding misinformation about peritoneal dialysis. Increased workload for nurses providing hemodialysis and decreased capacity for peritoneal dialysis.

    The path to safe, equitable and sustainable dialysis provision for people with chronic kidney disease · 2026 · DOI

  • The lack of clear policy goals and inclusive participation in dialysis policy reform. The insufficient consideration of system-level implications of dialysis policies. The need for robust data systems for monitoring, evaluation, and adaptive implementation.

    The path to safe, equitable and sustainable dialysis provision for people with chronic kidney disease · 2026 · DOI

  • convenience sampling was used, - the study was cross-sectional, - the sample size was limited to 230 couples

    Relationships between dyadic coping, marital adjustment, and post-traumatic growth in patients with maintenance hemodialysis patients and their spouses · 2024 · DOI

  • further studies could investigate the longitudinal effects of dyadic coping on posttraumatic growth, - research could explore the impact of interventions on dyadic coping and marital adjustment, - studies could examine the generalizability of the findings to other patient populations

    Relationships between dyadic coping, marital adjustment, and post-traumatic growth in patients with maintenance hemodialysis patients and their spouses · 2024 · DOI

  • 1. Regular monitoring of electrolytes should be mandatory in ESRD patients undergoing maintenance haemodialysis.

    A Comparative Study of Serum Electrolytes, Calcium, Phosphorus and Uric Acid Levels in End Stage Renal Disease Patients Undergoing Haemodialysis · 2026 · DOI

  • Conclusions: Direct clinical evidence that incretin-based therapies prevent or treat peritoneal fibrosis in humans undergoing PD is currently lacking.

    Beyond Weight Loss and Glycemic Control: Molecular Mechanisms and Hypothesis-Generating Therapeutic Potential of Incretin-Based Therapies Against Peritoneal Fibrosis in Peritoneal Dialysis · 2026 · DOI

  • Chronotype may influence vulnerability to stress and emotional dysregulation, yet its psychosocial pathways to depression remain unclear.

    Depressive symptoms among kidney transplant recipients: Modeling stress-related pathways involving chronotype, perceived stress, rumination, and sleep quality · 2025 · DOI

  • BACKGROUND AND OBJECTIVES: Impaired kidney function has been linked to altered concentrations of blood biomarkers of Alzheimer disease (AD), but the underlying mechanisms and its potential role in dementia development remain poorly understood.

    Kidney Function, Alzheimer Disease Blood Biomarkers, and Dementia Risk in Community-Dwelling Older Adults · 2025 · DOI

  • Background Benefit finding (BF) improves quality of life in maintenance hemodialysis (MHD) patients, yet population heterogeneity remains understudied.

    Heterogeneity of benefit finding in maintenance hemodialysis patients: a decision tree-based subgroup analysis of self-efficacy and social support · 2025 · DOI

  • We address a gap in the literature with our results by noting specific demographic characteristics that are associated with poor mental health in chronic kidney disease populations and discuss practical and policy recommendations aimed at enhancing the mental well-being of chronic kidney disease patients.

    Investigating the Interplay Between Sleep, Anxiety, and Depression in Chronic Kidney Disease Patients: Implications for Mental Health · 2025 · DOI

  • Further investigation into the underlying mechanisms revealed that the combination of PS-NPs and HFD disrupts mouse lipid metabolism through pathways involving tryptophan metabolism and glycerophospholipid metabolism, exacerbating the disorder of gut microbiota.

    Exploring the Mechanism of Kidney Injury in Mice Induced by High-Fat Diet and Polystyrene Nanoplastics Co-Exposure Through the Kidney-Gut Axis · 2025 · DOI

  • Randomized clinical trials have yielded conflicting results on efficacy, resulting in conflicting guidelines.

    Dos and Don’ts in Kidney Nutrition: Practical Considerations of a Panel of Experts on Protein Restriction and Plant-Based Diets for Patients Living with Chronic Kidney Disease · 2025 · DOI

  • Despite the increasing recognition of DAO, its association with CI in MHD patients remains uncertain.

    Associations of dynapenic abdominal obesity and its components with cognitive impairment among hemodialysis patients · 2025 · DOI

  • However, there is limited research on these patients' overall dietary knowledge, attitude, and practice (KAP) status.

    Dietary knowledge-attitude-practice status in hemodialysis patients: a latent profile analysis · 2024 · DOI

  • Introduction: Oxidative stress status is associated with CKD; however, few studies have investigated this association.

    Association between oxidative balance score in adults with and without chronic kidney disease: 2011–2028 NHANES · 2024 · DOI

  • However, research dealing with the relationship between PNI and albuminuria remains scarce.

    Prognostic nutritional index and albuminuria in adults aged 20 years and above: a cross-sectional analysis in the United States · 2024 · DOI

  • Background The risk factors of cardiovascular disease (CVD) in end-stage renal disease (ESRD) with hemodialysis remain not fully understood.

    Causal factors of cardiovascular disease in end-stage renal disease with maintenance hemodialysis: a longitudinal and Mendelian randomization study · 2024 · DOI

  • Exercise plays a beneficial role in depressive patients, but its quantitative effects remain elusive.

    The effects of exercise training interventions on depression in hemodialysis patients · 2024 · DOI

  • Many factors, including the patient's level of social support, influence treatment adherence, but few studies have addressed these relationships.

    Social Support and Adherence to Treatment Regimens among Patients Undergoing Hemodialysis · 2024 · DOI

  • Approximately half of the patients perceive transport costs as a burden or limitation, yet only about 30% receive financial support, for which there is no standard process.

    The Socioeconomic Impact of Transport Costs for Adult Patients Requiring Haemodialysis: A Mixed Methods Study · 2024 · DOI

  • Implementation of a standardised process for financial support should be explored.

    The Socioeconomic Impact of Transport Costs for Adult Patients Requiring Haemodialysis: A Mixed Methods Study · 2024 · DOI

  • Large-scale multi-centre trials are warranted to fully examine the acceptability of the model.

    The feasibility of integrating a home telehealth model for older persons living with hemodialysis · 2024 · DOI

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253 open questions have been extracted from the limitations and future-work passages of 1,051 Dialysis and Renal Disease Management papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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