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Open research questions in Dialysis and Renal Disease Management

854 gap statements mined from Dialysis and Renal Disease Management papers in our 7.9M-paper local library, which holds 3,843 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • There is a lack of understanding of the factors influencing the allostatic load of maintenance hemodialysis patients. There is a need to develop a novel allostatic load index for maintenance hemodialysis patients. There is a need to investigate the relationship between social support, self-management ability, and allostatic load.

    Status of and Factors Influencing the Allostatic Load of Maintenance Hemodialysis Patients: A Cross-Sectional Study · 2026 · DOI

  • The lack of recognition of the importance of physician oversight in maintenance hemodialysis. The need for a more nuanced understanding of the role of physicians in this process.

    Beyond procedure counts: reconsidering physician involvement in maintenance hemodialysis · 2026 · DOI

  • There is a gap in understanding health-related quality of life differences between public and private sector hemodialysis patients in Morocco. Prior studies have not evaluated the impact of employment status and weekly dialysis frequency on health-related quality of life among hemodialysis patients.

    Assessing health related quality of life of patients on maintenance hemodialysis in north-western Morocco · 2026 · DOI

  • The gap in the current literature is the lack of studies investigating the association of the systemic coagulation inflammation index with mortality in peritoneal dialysis patients. Prior studies have investigated the SCI index in other diseases, but its role in peritoneal dialysis patients is not well understood.

    Systemic coagulation inflammation index and risk of mortality in peritoneal dialysis patients: a multicenter cohort study · 2026 · DOI

  • Patients experience dietary limitations due to the need for strict fluid control and the fear of excessive dietary intake of salt, phosphorus, and potassium.

    Illness coping experiences among patients receiving peritoneal dialysis: a descriptive phenomenological study · 2026 · DOI

  • One challenge is the lack of independent external validation of the prediction models. Another challenge is the incomplete calibration reporting and unclear missing-data handling in the models. The paper also identifies the challenge of effect modification that separation within a single network may not capture.

    Risk of bias and applicability of prediction models for outcomes of peritoneal dialysis-related peritonitis: a PROBAST systematic review · 2026 · DOI

  • The gap in the current literature is the lack of systematic reviews on prediction models for post-peritonitis outcomes. There is a need to assess the risk of bias and applicability of these models. The current literature has focused on peritonitis incidence rather than post-diagnosis outcomes.

    Risk of bias and applicability of prediction models for outcomes of peritoneal dialysis-related peritonitis: a PROBAST systematic review · 2026 · DOI

  • Lack of consensus on optimal approaches for preserving residual kidney function. Absence of clinical guidelines for preserving residual kidney function. Difficulty in accurate assessment of residual kidney function. Limited patient awareness of the importance of preserving residual kidney function.

    Preserving Residual Kidney Function in Haemodialysis: Current Practices, Challenges, and Perspectives From Renal Clinicians · 2026 · DOI

  • The need to balance the burden of participant engagement with the need for robust and meaningful data. The challenge of implementing patient-reported outcome measures in a way that is feasible and sustainable in clinical practice.

    Developing a Set of Core Patient‐Reported Outcomes for Kidney Replacement Therapy: A Modified Delphi Study · 2026 · DOI

  • The lack of standardized patient-reported outcome measures in Australian and New Zealand kidney care. The limited and heterogeneous implementation of patient-reported outcome measures in kidney replacement therapy. The need for a consensus among stakeholders on the selection and implementation of patient-reported outcome measures.

    Developing a Set of Core Patient‐Reported Outcomes for Kidney Replacement Therapy: A Modified Delphi Study · 2026 · DOI

  • Pruritus is a fluctuating burden affecting sleep, daily comfort, and social roles. Participants described trial-and-error self-management strategies and expressed a need for proactive assessment, practical guidance, and individualised nursing care.

    Chronic Kidney Disease‐Associated Pruritus in Haemodialysis: A Mixed‐Methods Study of Symptom Burden and Patient Experience · 2026 · DOI

  • There is a need to examine pruritus not only in terms of prevalence and severity but also through patients' lived experiences of the symptom in everyday life.

    Chronic Kidney Disease‐Associated Pruritus in Haemodialysis: A Mixed‐Methods Study of Symptom Burden and Patient Experience · 2026 · DOI

  • Less is known about the barriers and facilitators experienced by patients with advanced chronic kidney disease not yet receiving kidney replacement therapy. Few studies have been consumer-led or have integrated clinician and patient perspectives in a shared discussion environment.

    “Understanding Chronic Kidney Disease Self‐Management Barriers and Facilitators: A Consumer‐Led Qualitative Study” · 2026 · DOI

  • The symptom of 'feeling cold' in patients with kidney failure is underexplored in the literature. Existing literature addressing the symptom of feeling cold among patients with kidney failure is sparse. The study aims to address this gap by exploring the phenomenon of 'feeling cold' in patients undergoing haemodialysis.

    The Experience of “Feeling Cold” in Patients Undergoing In‐Centre Haemodialysis · 2026 · DOI

  • The lack of a validated instrument to assess perceived benefits and barriers of exercise among Japanese patients receiving haemodialysis. The need for a culturally adapted version of the Dialysis Patient-Perceived Exercise Benefits and Barriers Scale for use in Japan.

    Translation and Validation of the Japanese Version of the Dialysis Patient‐Perceived Exercise Benefits and Barriers Scale · 2026 · DOI

  • The need for point-of-care (POC) detection of chronic kidney disease (CKD) at home. The lack of a suitable device for CKD monitoring at home using lateral flow immunoassays (LFIAs) for serum Cystatin C (CysC) detection.

    Performance of Colorimetric Lateral Flow Immunoassays for Renal Function Evaluation with Human Serum Cystatin C · 2025 · DOI

  • The study highlights the need for detailed characterization of hematological and biochemical status in end-stage CKD patients.

    Leukocyte Dysregulation and Biochemical Alterations in End-Stage Kidney Disease Patients Under Hemodialysis · 2025 · DOI

  • There is a lack of evidence about statistical and biological correlation among hematological and biochemical biomarkers in end-stage CKD patients. The etiology of end-stage CKD adds a layer of complexity to any evaluation.

    Leukocyte Dysregulation and Biochemical Alterations in End-Stage Kidney Disease Patients Under Hemodialysis · 2025 · DOI

  • It also highlights the challenge of understanding the molecular mechanisms underlying cardiorenal syndrome due to the lack of pre-clinical and human studies.

    Novel Perspectives in Chronic Kidney Disease-Specific Cardiovascular Disease · 2024 · DOI

  • It highlights the need to develop effective interventions for diabetic nephropathy. The paper also discusses the challenge of translating the findings of experimental studies to clinical practice.

    Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism · 2024 · DOI

  • Patient passivity and limited awareness of chronic kidney disease. Fragmented care and impersonal clinical approaches. Physical and emotional distress experienced by patients with chronic kidney disease.

    “Understanding Chronic Kidney Disease Self‐Management Barriers and Facilitators: A Consumer‐Led Qualitative Study” · 2026 · DOI

  • Well-designed, prospective intervention studies that thoroughly evaluate the efficacy of renal replacement therapies in enhancing health outcomes for HD…

    Assessing health related quality of life of patients on maintenance hemodialysis in north-western Morocco · 2026 · DOI

  • The survey was limited to renal clinicians in Western Australia, - The response rate was approximately 52%, - The survey was based on self-reported data, - The study did not investigate the effectiveness of specific strategies for preserving residual kidney…

    Preserving Residual Kidney Function in Haemodialysis: Current Practices, Challenges, and Perspectives From Renal Clinicians · 2026 · DOI

  • Explore how culturally embedded values shape exercise perceptions among people receiving HD in Japan - Assess predictive validity by evaluating associations between JDPEBBS scores and subsequent exercise adherence, functional outcomes or hospitalisation risk - Examine temporal stability - Examine…

    Translation and Validation of the Japanese Version of the Dialysis Patient‐Perceived Exercise Benefits and Barriers Scale · 2026 · DOI

  • Further studies on the molecular mechanisms underlying CRS, - Investigation of the potential for disease-specific therapies and biomarker disease detection, - Exploration of the role of innate immune signalling in the development of CRS, - Examination of the effects of established antiinflammatory agents…

    Novel Perspectives in Chronic Kidney Disease-Specific Cardiovascular Disease · 2024 · DOI

Most-cited papers in Dialysis and Renal Disease Management

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Open questions raised by papers listed on this page include: (1) There is a lack of understanding of the factors influencing the allostatic load of maintenance hemodialysis patients (“Status of and Factors Influencing the Allostatic Load of Maintenance…”, 2026); (2) The lack of recognition of the importance of physician oversight in maintenance hemodialysis (“Beyond procedure counts: reconsidering physician involvement in maintenance…”, 2026); (3) The gap in the current literature is the lack of studies investigating the association of the systemic coagulation inflammation index with mortality in peritoneal dialysis patients (“Systemic coagulation inflammation index and risk of mortality in peritoneal…”, 2026); (4) One challenge is the lack of independent external validation of the prediction models (“Risk of bias and applicability of prediction models for outcomes of peritoneal…”, 2026); (5) Lack of consensus on optimal approaches for preserving residual kidney function (“Preserving Residual Kidney Function in Haemodialysis: Current Practices,…”, 2026). 854 gap statements have been mined from Dialysis and Renal Disease Management papers in our 7.9M-paper local library, which holds 3,843 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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