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Open research questions in Electroconvulsive Therapy Studies

32 unresolved questions extracted from the limitations and future-work sections of 471 Electroconvulsive Therapy Studies papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Consequently, although melatonin and dexmedetomidine appear to be favorable options for sedated EEG, the potential anti- convulsant effect of melatonin and the limited data on other com- monly used sedatives necessitate a cautious, evidence-based ap- proach to agent selection.

    Neurophysiological Electroencephalography Signatures of Pediatric Sedation: A Comprehensive Comparative Review · 2026 · DOI

  • The existing literature on psychiatric disorders in PD has rarely examined the occurrence of BD. The occurrence of catatonia in comorbid BD and PD, and the efficacy 17 / 40 of ECT in this complex presentation, is based on only a few patient reports. Therefore, further research is essential to provide better insights regarding comorbid BD and PD with catatonia. Future research regarding BD and catatonia associated with PD should include larger, longitudinal studies, properly designed treatment trials, and investigations of underlying genetic, structural and functional mechanisms.

    Management of catatonia in Parkinson’s disease with comorbid bipolar disorder: A case report and review of literature · 2026 · DOI

  • Attempts to reconcile the differences have been made by suggesting that NMS and catatonia may represent different presentations of the same illness or that they lie within the same spectrum of a poorly understood clinical syndrome.

    Neuroleptic Malignant Syndrome or Catatonia? A Case Report · 2020 · DOI

  • The preliminary and limited evidence suggests the modest efficacy of continuation electroconvulsive therapy and maintenance electroconvulsive therapy with concomitant pharmacotherapy in preventing relapse and recurrence of depressive episodes for 1 year after the remission of index episode with the acute course of electroconvulsive therapy.

    Electroconvulsive therapy in the continuation and maintenance treatment of depression: Systematic review and meta-analyses · 2017 · DOI

  • CONCLUSIONS: This PRISMA systematic review illustrates that while there is available data on psychotropic medications and their proposed effect on EEG activity, further research is needed to confirm these findings to help allow clinical correlations to be made between the patient's response and the psychotropic agent.

    A systematic review on the impact of psychotropic drugs on electroencephalogram waveforms in psychiatry · 2016 · DOI

  • These results suggest that the benefits of modafinil are not clearly dose-related, and those from 100 mg are limited to the span of immediate verbal recall and short-term visual recognition memory, which is insufficient for it to be considered as a cognitive enhancer in non-sleep-deprived individuals.

    Does Modafinil Enhance Cognitive Performance in Young Volunteers Who Are Not Sleep-Deprived? · 2005 · DOI

  • Malignant hyperthermia due to the anaesthesia associated with ECT has not been reported in patients with NMS, and succinylcholine has been used safely with the exception of one report of fever and raised creatine kinase levels and another report of hyperkalemia.

    Electroconvulsive Treatment of Neuroleptic Malignant Syndrome: A Review and Report of Cases · 1999 · DOI

  • Further research is needed, however, to clarify the optimum use of MECT schedules and pharmacotherapy combinations to most effectively and safely prevent relapse of depression in different elderly populations and to help predict who will best respond to which treatment modalities.

    ECT in the elderly · 1997 · DOI

  • Although there are many proposed mechanisms for the emergence of a fever response, regardless of its cause, it is still not understood why some fever responses occur.

    Transient Fever Response After ECT in a Patient with Catatonic Schizophrenia: A Case Report · 2023 · DOI

  • Limitations in the evidence should be acknowledged and prompt cautious prescribing, particularly with respect to the duration of use of adjuvant medications, is warranted.

    The Assessment and Treatment of Antipsychotic-Induced Akathisia · 2018 · DOI

  • There was insufficient data to perform a meta-analysis of stand-alone continuation electroconvulsive therapy or maintenance electroconvulsive therapy beyond 1 year.

    Electroconvulsive therapy in the continuation and maintenance treatment of depression: Systematic review and meta-analyses · 2017 · DOI

  • Induction of seizures in order to improve the mental state has a long history, but electroconvulsive therapy (ECT) still remain controversial.

    Terapia elektrowstrząsowa — skuteczna i bezpieczna alternatywa dla nieskutecznej farmakoterapii · 2014

  • OBJECTIVE: The relationship between tinnitus and anxiety and depressive disorders has been frequently alluded to, but there are few studies on antidepressants in the treatment of tinnitus, and the efficacy of sertraline on severe refractory tinnitus has not been reported.

    The Effects of Sertraline on Severe Tinnitus Suffering-A Randomized, Double-blind, Placebo-Controlled Study · 2006 · DOI

  • There is a lack of consensus about the pharmacological agent of choice to treat trichotillomania and which rating scales are best suited to measure the clinical severity and improvement of this condition.

    An Overview of Trichotillomania and Its Response to Treatment with Quetiapine · 2002 · DOI

  • Because this association has not been confirmed in controlled studies, we conducted a retrospective cohort study in Tennessee Medicaid enrollees, which included many antipsychotic users; there were also computer files describing medication use and comorbidity.

    Antipsychotics and the Risk of Sudden Cardiac Death · 2001 · DOI

  • elapsed following admission before delirium spective study confirms in treating delirium associated with various conditions, view of our findings, we feel that a prospective is warranted.

    Electroconvulsive therapy in delirium tremens · 1972 · DOI

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32 open questions have been extracted from the limitations and future-work passages of 471 Electroconvulsive Therapy Studies papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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