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Open research questions in Folate and B Vitamins Research

140 unresolved questions extracted from the limitations and future-work sections of 580 Folate and B Vitamins Research papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • the study was a secondary analysis of existing data, - the survey was distributed to PAS members, which may not be representative of the general population, - 63 participants were excluded due to lack of diagnostic information

    Patient-reported symptom profiles in vitamin B12 deficiency and pernicious anemia: a cross-sectional study using latent class analysis · 2026 · DOI

  • The current treatments for obesity are difficult to accomplish. There is a need to identify more therapy targets for safer and more efficient obesity treatments. The details of the effects of betaine on adipose tissue remain to be elucidated.

    Betaine alleviates obesity-related metabolic disorders in rats: insights from microbiomes, lipidomics, and transcriptomics · 2025 · DOI

  • individuals' reluctance to share dietary information - lack of public education on nutrition's benefits for mental health - inadequate funding for research - challenges in translating animal model studies to human applications - individual dietary response variations - environmental factors complicate this field

    Epigenetics, Nutrition, and the Brain: Improving Mental Health through Diet · 2024 · DOI

  • understanding how methyl-donor micronutrients influence genes related to metabolic and stress-related pathways - aiming to improve health outcomes and prevent diseases - focusing on the role of specific micronutrients during critical stages of brain development

    Epigenetics, Nutrition, and the Brain: Improving Mental Health through Diet · 2024 · DOI

  • There are still gaps in understanding the metabolic pathways of vitamin B12. The manifestation of clinical outcomes of vitamin B12 deficiency is relatively late, making early diagnosis difficult.

    Vitamin B12 Metabolism: A Network of Multi-Protein Mediated Processes · 2024 · DOI

  • Instead, we found that physiological folate levels are insufficient to support deoxynucleotide triphosphate (dNTP) synthesis for genome replication, leading to DNA replication stress and impaired proliferation when nucleotide salvage is disrupted.

    Physiological folate levels constrain nucleotide synthesis and increase dependence on nucleotide salvage · 2026 · DOI

  • Proliferating cells must acquire nucleotides to support DNA replication, yet how cells meet these nucleotide demands for proliferation under physiological conditions remains understudied.

    Physiological folate levels constrain nucleotide synthesis and increase dependence on nucleotide salvage · 2026 · DOI

  • Adipocyte signaling adaptively responds to macronutrients, but how essential micronutrients impact lipid homeostasis remains poorly understood.

    Folic acid polyglutamylation triggers MAP2K5 signaling to induce adipocyte lipid catabolism · 2026 · DOI

  • While evidence suggests an inverse relationship between dietary folate intake and adult obesity, whether this association persists in the younger population remains unclear.

    Association between dietary folate intake and obesity in children and adolescents: a cross-sectional NHANES study · 2026 · DOI

  • Background: Betaine is a natural food component that plays an important role in improving body composition, but the details of its effects on adipose tissue remains to be elucidated.

    Betaine alleviates obesity-related metabolic disorders in rats: insights from microbiomes, lipidomics, and transcriptomics · 2025 · DOI

  • These results support the potential role of homocysteine as a biomarker for HFpEF severity and progression, warranting further investigation into its utility for risk stratification and targeted therapy.

    Echocardiographic assessment of the relationship between cardiac function and plasma homocysteine levels in patients with heart failure and preserved ejection fraction · 2025 · DOI

  • The role of plasma homocysteine (Hcy) levels in HFpEF has been understudied, though elevated levels are known to affect cardiovascular health.

    Echocardiographic assessment of the relationship between cardiac function and plasma homocysteine levels in patients with heart failure and preserved ejection fraction · 2025 · DOI

  • BACKGROUND AND OBJECTIVES: has been implicated in cerebrovascular disease risk, although research in diverse populations is lacking.

    MTHFR Polymorphisms, Homocysteine Elevation, and Ischemic Stroke Susceptibility in East Asian and European Populations · 2025 · DOI

  • Introduction: Previous studies have found that depressive patients tend to have low levels of creatinine; however, the extent to which creatinine levels are associated with depression has been poorly investigated.

    Lower creatinine levels are associated with an increased risk of depression: evidence from the China Health and Retirement Longitudinal Study · 2025 · DOI

  • However, the impact of Vitamin B metabolism alterations on pregnancy outcomes remains unclear.

    Maternal red blood cell folate and vitamin B metabolism with pregnancy outcomes: a retrospective study · 2025 · DOI

  • Clinical studies investigating associations between folic acid supplementation and pre-eclampsia produced inconsistent results.

    The relationship between folic acid deficiency and preeclampsia-like phenotypes in rats · 2025 · DOI

  • However, the underlying mechanisms remain unclear, necessitating further research and clinical trials to elucidate these relationships.

    Adverse events during pregnancy, circulating metabolites, and congenital malformations: a Mendelian randomization study · 2025 · DOI

  • Studies addressing the societal perspectives were scarce, therefore this study aimed to explore beliefs and perceptions in the community about congenital anomalies.

    Beliefs and perceptions towards congenital anomalies in Dilla town, Gedeo Zone, Southern Ethiopia; a qualitative study · 2025 · DOI

  • While its deficiency is well recognized, the clinical significance of elevated serum Cbl levels remains unclear, particularly in children.

    Elevated serum cobalamin levels in childhood: a retrospective analysis · 2025 · DOI

  • INTRODUCTION: Dietary choline has been implicated in bone health, but its association with bone mineral density (BMD) in adolescents remains unclear.

    Association between dietary choline intake and bone mineral density in adolescents: a NHANES-based study · 2025 · DOI

  • Therefore, we could not establish a correlation between vitamin B6 deficiency and anemia in children on HD.

    Contribution of vitamin B 6 deficiency to anemia in children on regular hemodialysis · 2025 · DOI

  • However, the rates of diagnosis and association with morbidity, mortality, and congenital anomalies in preterm infants are poorly characterized.

    Genetic disorders and associated morbidity, mortality, and congenital anomalies in preterm infants born at less than 34 weeks of gestation · 2025 · DOI

  • However, whether supplementation of B vitamins is associated with risk reduction in thromboembolic events and confers clinical benefits remains inconclusive.

    Effects of B Vitamins on Homocysteine Lowering and Thrombotic Risk Reduction—A Review of Randomized Controlled Trials Published Since January 1996 · 2025 · DOI

  • The findings from these studies are inconsistent, and the impact of B vitamins on thrombosis prevention remains uncertain.

    Effects of B Vitamins on Homocysteine Lowering and Thrombotic Risk Reduction—A Review of Randomized Controlled Trials Published Since January 1996 · 2025 · DOI

  • Although many studies have confirmed the link between micronutrient status and thyroid health, the effects of nutrient imbalances and environmental stressors on thyroid DNA remain underexplored.

    The Influence of Micronutrients and Environmental Factors on Thyroid DNA Integrity · 2025 · DOI

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140 open questions have been extracted from the limitations and future-work passages of 580 Folate and B Vitamins Research papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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