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Open research questions in Food Allergy and Anaphylaxis Research

98 unresolved questions extracted from the limitations and future-work sections of 494 Food Allergy and Anaphylaxis Research papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Investigation of the interplay between nutritional, microbial, genetic, and environmental factors in food allergy development and prevention. Examination of the effects of early-life medical and feeding practices on the developmental trajectory of FA. Study of the role of microbial metabolites in the development of oral tolerance.

    Early-Life Nutrition: The Interplay of Nutritional, Microbial, Genetic, and Environmental Factors in Food Allergy Development and Prevention · 2026 · DOI

  • There is a need to better understand the interplay between nutritional, microbial, genetic, and environmental factors in the development of food allergy. Current evidence on preventive approaches such as maternal allergen avoidance and probiotics is insufficient or inconsistent. Further research is needed to establish effective strategies for the prevention of food allergy.

    Early-Life Nutrition: The Interplay of Nutritional, Microbial, Genetic, and Environmental Factors in Food Allergy Development and Prevention · 2026 · DOI

  • Peripheral immune processes can shape animal behavior, yet how noninfectious inflammatory reactions affect neural activity and behavioral outputs remains poorly understood.

    Repeated shrimp allergen exposure drives 5-lipoxygenase-dependent avoidance and selective gut-brain activation · 2026 · DOI

  • Abstract Local data on food allergen sensitization in the West Bank of Palestine are scarce, and clinicians rely on allergen panels derived from dissimilar Western populations.

    Food allergen sensitization on a standardized specific-IgE core panel in the West Bank, Palestine: a retrospective analysis of 1,339 Patients, 2016–2026 · 2026 · DOI

  • Hymenoptera stings, especially wasps and bees, are relatively common but under-reported in tropical countries.

    Acute Kidney Injury Following Bee and Wasp Stings: A Case Series from Bangladesh · 2026 · DOI

  • Abstract BACKGROUND Shrimp allergy is a global health concern, yet how common domestic thermal processing methods affect the allergenicity of shrimp myofibrillar protein (MP) remains poorly understood.

    Thermal processing methods differentially modulate shrimp myofibrillar protein allergenicity through alterations in protein structure and digestive stability · 2026 · DOI

  • Future research should focus on optimizing these methods to ensure that they effectively reduce allergenic risks while maintaining the nutritional quality and safety of alternative protein products.

    Allergenicity of Alternative Proteins: Reduction Mechanisms and Processing Strategies · 2025 · DOI

  • It emphasizes the necessity of further research on prevention measures and guidelines for managing such a case.

    A critical case of anaphylaxis triggered by exercise in a pediatric asthma patient · 2025 · DOI

  • It remains unclear why some sensitized individuals with food allergen-specific IgE develop anaphylaxis upon oral exposure while others do not.

    Uncovering mechanisms of anaphylaxis heterogeneity using a murine food allergy model 2261 · 2025 · DOI

  • While sickness behaviors induced by pathogens are well-characterized, how immune sensing affects behavior in allergies remains unknown.

    Allergic inflammation drives avoidance and anxiety behaviors 2974 · 2025 · DOI

  • Nevertheless, the structure-activity relationship of seafood allergens remains insufficiently elucidated, despite its critical role in guiding processing technologies for allergenicity elimination and elucidating the fundamental mechanisms involved.

    An Overview of Seafood Allergens: Structure–Allergenicity Relationship and Allergenicity Elimination Processing Techniques · 2025 · DOI

  • Moreover, shared extraction buffers remain elusive, which limits the effectiveness of multiplex (multi-target) technology.

    Optimising Extraction of Specific Food Allergens from Challenging Food Matrices for Immunoassay Quantification · 2025 · DOI

  • Kounis Syndrome (KS), a seldom-seen adverse reaction to iodine contrast agents, has an incidence that remains unclear.

    Case Report: A case of Kounis syndrome induced by iodine contrast agent during coronary angiography · 2024 · DOI

  • Furthermore, a systematic summary of the underlying mechanisms of WFDC protein activity is lacking.

    Versatile whey acidic protein four-disulfide core domain proteins: biology and role in diseases · 2024 · DOI

  • The comparison of ultrasound before, under, and after other technologies to decrease food allergenicity should be further investigated in the future.

    Effect of the Combined Ultrasound with Other Technologies on Food Allergenicity: Ultrasound before, under, and after Other Technologies · 2024 · DOI

  • However, there remains limited knowledge regarding the effect of structural modifications on CN allergenicity.

    Allergenicity Modulation of Casein with the Modifications of Linearization, Cross-Linking, and Glycation via the Regulation of Th1/Th2 Homeostasis · 2024 · DOI

  • However, little is known about how an unhealthy diet in early life affects FA reactions in offspring.

    Maternal High-Fat Diet Exacerbates Epicutaneous Sensitization and Oral Challenge-Induced Food Allergy to Ovalbumin in Offspring Mice · 2024 · DOI

  • Research on probiotics and prebiotics during pregnancy as preventive measures is promising, though evidence remains limited.

    Food Allergy Risk: A Comprehensive Review of Maternal Interventions for Food Allergy Prevention · 2024 · DOI

  • Although gut dysbiosis is associated with cow’s milk allergy (CMA), causality remains uncertain.

    Specific Gut Microbiome Signatures in Children with Cow’s Milk Allergy · 2024 · DOI

  • Altogether, these results suggest that in dogs, as in humans, anti-CCD IgE are likely to have little pathogenic potential and blocking them in allergen-specific IgE serological tests is warranted to avoid false-positive results to plant extracts.

    Evaluating the Pathogenic Potential of IgE Targeting Cross-Reactive Carbohydrate Determinants in Dogs · 2024 · DOI

  • Lastly, it was concluded that there are still many unknown variables and open questions regarding potential hazards possibly present in meat analogues, including processing-related compounds such as n-nitrosamines, acrylamide, and heterocyclic aromatic amino acids.

    Plant-Based Meat Analogues in the Human Diet: What Are the Hazards? · 2024 · DOI

  • Unlike IgE-mediated allergies, the mechanisms of disease pathogenesis in non-IgE-mediated food allergy and an association with microbiome has not been well established.

    Immunoglobulin-coating patterns reveal altered humoral responses to gut bacteria in pediatric cow milk allergies · 2024 · DOI

  • The heterogeneity of the immune response in children with multiple food allergies. The limited availability of laboratory tests in every clinical setting. The need for early identification of the risk phenotype for effective clinical management.

    Clinical predictors of persistence in IgE-mediated cow’s milk allergy in children with multiple food allergies · 2026 · DOI

  • The study was conducted at a single tertiary referral center. The sample size was limited to 134 patients. Laboratory findings were excluded from the logistic regression analysis.

    Clinical predictors of persistence in IgE-mediated cow’s milk allergy in children with multiple food allergies · 2026 · DOI

  • The understanding of the pathomechanism of FPIES remains limited. Many management aspects are still highly debated.

    Food protein-induced enterocolitis syndrome in children: An updated review on pathogenesis, diagnosis, and management · 2026 · DOI

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98 open questions have been extracted from the limitations and future-work passages of 494 Food Allergy and Anaphylaxis Research papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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