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Open research questions in Food Allergy and Anaphylaxis Research

295 gap statements mined from Food Allergy and Anaphylaxis Research papers in our 7.9M-paper local library, which holds 2,509 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

Choosing where to publish on Food Allergy and Anaphylaxis Research? See the ranked Medicine journals.

What the literature leaves open

  • The potential interference of ICG's intrinsic fluorescence with the basophil activation test is unknown. There is a lack of systematic examination of the effect of fluorescent drugs on the reliability of the basophil activation test. The diagnosis of anaphylaxis caused by fluorescent drugs like ICG is challenging and requires accurate and reliable methods.

    Assessment of fluorescence interference in the basophil activation test: a case of indocyanine green-induced anaphylaxis · 2026 · DOI

  • The paper does not explicitly state the research gap, but it discusses the importance of physician awareness of Kounis syndrome. It highlights the need for further research on the causes and treatment of Kounis syndrome.

    Unusual, Uncommon, Intriguing, and Significant Causes of Kounis Syndrome: Important Medications and Chemicals Used to Treat Kounis Syndrome and Myocardial Infarction Can Cause Kounis Syndrome · 2025 · DOI

  • While regular ingestion of allergens within no-observed-adverse-effect-level (NOAEL) is known to promote immunological tolerance, its quantitative effect on EDs remains unclear.

    Impact of regular home allergen intake within no-observed-adverse-effect-level on eliciting dose: 10-year data from a Japanese center · 2026 · DOI

  • While allergic reactions to food additives occasionally pose clinical challenges, immediate-type hypersensitivity to xanthan gum has not been reported.

    Immediate-type allergy to xanthan gum with possible percutaneous sensitization · 2026 · DOI

  • Banana allergy varies geographically, but molecular sensitization patterns and fruit co-reactivity remain incompletely defined.

    A proposed thaumatin-like protein (TLP) syndrome: Sensitization patterns, reaction severity, and multiple-fruit reactivity in Thai and Austrian banana-allergic adult cohorts · 2026 · DOI

  • This case illustrates adult-onset atypical FPIES following chemotherapy, which has not been previously reported.

    Adult-Onset atypical food protein-induced enterocolitis syndrome after chemotherapy: A case report · 2026 · DOI

  • Despite growing research, including recent findings suggesting that asymptomatic α-gal sensitization may contribute to coronary artery disease, the precise immune mechanisms-particularly B cell-mediated IgE production following tick bites-remain poorly understood.

    Pre-clinical strategies and emerging technologies driving advances in the alpha-gal syndrome · 2025 · DOI

  • This review emphasizes the need for further research into the mechanisms of taste receptor involvement in FA and suggests that targeting these receptors could provide new avenues for therapeutic intervention in the future.

    The roles of bitter and sweet taste receptors in food allergy: Where are we now? · 2025 · DOI

  • Dosing intervals are important in determining oral food challenge (OFC) safety; however, the optimal interval remains unclear.

    Timing of symptom onset during 60-min interval oral food challenges in children · 2025 · DOI

  • Although the link between allergenicity and protein digestibility remains debated, integrating next-generation risk assessment (NGRA) tools into this process is increasingly recognized as essential.

    Integrating in vitro digestion and peptidomics into novel food allergenicity assessment: A study on Clostridium tyrobutyricum biomass · 2025 · DOI

  • It is approved for a number of atopic conditions; however, the effect of dupilumab on food allergy has not been fully evaluated.

    Food allergy clinical course in children and adolescents treated with dupilumab for atopic dermatitis · 2025 · DOI

  • Currently, effective treatment for patients with PFAS that allows safe consumption of raw foods is lacking, and avoiding the intake of causative foods is the basis of prevention.

    Comprehensive review of pollen-food allergy syndrome: Pathogenesis, epidemiology, and treatment approaches · 2024 · DOI

  • Furthermore, allergen immunotherapy for PFAS has not yet been established, but various attempts are underway to develop it into a novel treatment strategy.

    Comprehensive review of pollen-food allergy syndrome: Pathogenesis, epidemiology, and treatment approaches · 2024 · DOI

  • Currently, reports on sensitization profiles using peach-allergen components in a multicenter setting are lacking.

    Peach component-specific IgE measurement helps to differentiate between local and systemic reactions in peach-allergic Japanese patients · 2024 · DOI

  • A definitive trial including health economic analysis and FA-specific psychological measures with consideration of best routes to implementation, is warranted.

    Online, group, low-intensity psychological intervention for adults, children, and parents with food allergy · 2024 · DOI

  • Food allergy (FA) impairs psychological wellbeing because of constant vigilance, planning and preparation, dietary and social restrictions, and fear of accidental ingestion, though psychological interventions are sparse.

    Online, group, low-intensity psychological intervention for adults, children, and parents with food allergy · 2024 · DOI

  • Given the limited number of such cases, there is insufficient evidence regarding the infusion doses.

    Severe anaphylaxis requiring continuous adrenaline infusion during oral food challenge · 2024 · DOI

  • The understanding of the pathomechanism of FPIES remains limited. Many management aspects are still highly debated.

    Food protein-induced enterocolitis syndrome in children: An updated review on pathogenesis, diagnosis, and management · 2026 · DOI

  • Limited understanding of the condition among patients, caregivers, and healthcare professionals. Limited availability of new treatments, such as oral immunotherapy and biologics. Limited access to medications, such as epinephrine.

    Preventing Food Anaphylaxis · 2026 · DOI

  • Diagnosing the alpha-gal allergy can be challenging due to its non-habitual nature. Managing the allergy requires avoiding certain products, which can be challenging for some patients. There is a lack of understanding of the alpha-gal allergy and its diagnosis and management.

    Allergie à l’alpha-gal : A propos de trois observations · 2026 · DOI

  • Some infants with peanut-specific IgE tolerate peanut, but the cellular features that distinguish this sensitized tolerance from peanut allergy are poorly defined.

    Sensitized infants who tolerate peanut have more dendritic cells and HLA-DR+ memory CD4 T cells · 2026 · DOI

  • Myoglobin produced by fermentation using engineered Komagataella phaffii is an important color additive in meat analogue products, but its allergenicity is poorly understood.

    Allergenic risk assessment of porcine myoglobin expressed by engineered Komagataella Phaffii · 2024 · DOI

  • Although various clinical trials have revealed that most patients reaching maintenance dosing for peanut OIT will be desensitized, OIT can be limited by the frequency of adverse effects.

    The use of boiled peanut oral immunotherapy in children · 2024 · DOI

  • The study was conducted at a single tertiary referral center. The sample size was limited to 134 patients. Laboratory findings were excluded from the logistic regression analysis.

    Clinical predictors of persistence in IgE-mediated cow’s milk allergy in children with multiple food allergies · 2026 · DOI

  • AMCP Market Insights undertook a multiphase program to refine proposed actions from a previous program into a set of payer best practices in food allergy management and to gain insights on gaps in knowledge regarding food allergy mechanisms and management.

    AMCP Market Insights: Payer best practices in food allergy management · 2025 · DOI

Most-cited papers in Food Allergy and Anaphylaxis Research

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Open questions raised by papers listed on this page include: (1) The potential interference of ICG's intrinsic fluorescence with the basophil activation test is unknown (“Assessment of fluorescence interference in the basophil activation test: a case…”, 2026); (2) While regular ingestion of allergens within no-observed-adverse-effect-level (NOAEL) is known to promote immunological tolerance, its quantitative effect on EDs remains unclear (“Impact of regular home allergen intake within no-observed-adverse-effect-level…”, 2026); (3) The understanding of the pathomechanism of FPIES remains limited (“Food protein-induced enterocolitis syndrome in children: An updated review on…”, 2026); (4) There is a lack of understanding of the alpha-gal allergy and its diagnosis and management (“Allergie à l’alpha-gal : A propos de trois observations”, 2026); (5) Dosing intervals are important in determining oral food challenge (OFC) safety; however, the optimal interval remains unclear (“Timing of symptom onset during 60-min interval oral food challenges in children”, 2025). 295 gap statements have been mined from Food Allergy and Anaphylaxis Research papers in our 7.9M-paper local library, which holds 2,509 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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