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Open research questions in Gastric Cancer Management and Outcomes

665 gap statements mined from Gastric Cancer Management and Outcomes papers in our 7.9M-paper local library, which holds 2,865 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • The current evidence on the impact of previous abdominal surgery on perioperative outcomes after minimally invasive gastrectomy for gastric cancer is inconsistent. There is a need for a quantitative analysis of comparative studies to evaluate the effect of previous abdominal surgery on perioperative outcomes.

    Impact of previous abdominal surgery on perioperative outcomes after minimally invasive gastrectomy for gastric cancer: an evidence synthesis and quantitative analysis · 2026 · DOI

  • The next phase of metastasis research should combine paired primary and metastatic lesions, serial liquid biopsies, singlecell and spatial multi-omics, and phylogenetic reconstruction. Research on lymph-node-specific prediction and intervention is needed.

    Metastasis Pattern‐Specific Biomarkers and Therapeutic Targets in Gastric Cancer: From Surgical Specimens to Clinical Translation · 2026 · DOI

  • The study highlights the need for larger independent cohorts to validate the findings.

    Exploring Molecular Determinants of Long-Term Survival in Metastatic Gastric Cancer: An mRNA Expression Pilot Study · 2026 · DOI

  • Data on the epidemiology and trends of gastric cancer in Bangladesh remain limited. There is a need to analyze the demographic characteristics, endoscopic findings, and histopathological reports of gastric cancer patients in Bangladesh.

    Assessing the Epidemiological Trend of Gastric Cancer: A Retrospective Analysis From a Tertiary Care Hospital in Bangladesh · 2026 · DOI

  • The lack of a comprehensive review of the clinical and biological continuum of gastric cancer, from epidemiology to management, with a focus on macrophages poses a challenge for understanding the disease.

    Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management · 2026 · DOI

  • Need for a model that incorporates multiple variables, including oncologic characteristics and treatment strategy. Limited generalizability of prior studies due to lack of external validation.

    Treatment Effects of Different Therapeutic Strategies and Development of a Prognostic Prediction Model for Early Gastric Cancer: A Population-Based and Multicenter Study · 2026 · DOI

  • The reliability and consistency of EUS in the locoregional staging of gastric cancer have been increasingly called into question. There is a need for emerging techniques to improve the accuracy of EUS. The paper identifies a gap in the current literature regarding the applications of EUS in gastric cancer.

    Endoscopic Ultrasound (EUS) in Gastric Cancer: Current Applications and Future Perspectives · 2025 · DOI

  • Because comparative data of both methods are lacking, we aimed to compare the clinical outcomes between EFTR and LECS for gastric SMT.

    Clinical Outcomes of Endoscopic Full‐Thickness Resection Versus Laparoscopic and Endoscopic Cooperative Surgery: A Propensity Score‐Matched Comparative Study · 2026 · DOI

  • Although Endoscopic Grading of Gastric Intestinal Metaplasia (EGGIM) is used for risk stratification, it remains poorly defined whether gastric intestinal metaplasia (IM) follows reproducible anatomic patterns or has structured evolution.

    Reproducible Topographic Phenotypes and Three‐Phase Anatomical Evolution of Gastric Intestinal Metaplasia · 2026 · DOI

  • Randomized evidence is insufficient to establish a consistent DFS or OS benefit from routine postoperative CRT over effective CT after R0 D2 gastrectomy.

    Adjuvant chemoradiotherapy vs chemotherapy after R0 D2 gastrectomy for gastric cancer: Meta-analysis of randomized trials · 2026 · DOI

  • Severe toxicity and treatment completion were not pooled because reporting was insufficiently comparable.

    Adjuvant chemoradiotherapy vs chemotherapy after R0 D2 gastrectomy for gastric cancer: Meta-analysis of randomized trials · 2026 · DOI

  • Gastric cancer is a major global health burden, but histologic subtype-specific epidemiologic and survival trends remain unclear.

    Trends in Gastric Cancer Incidence, Mortality, and Survival by Histologic Subtype in the United States (2000–2022) and a Contemporary Chinese Cohort · 2026 · DOI

  • Since results of the Trastuzumab for Gastric Cancer (ToGA) trial were published in 2010, the addition of trastuzumab to chemotherapy is the standard of care for first-line treatment of human epidermal growth factor receptor 2 (HER2)-positive metastatic gastroesophageal adenocarcinoma, yet data from European real-world cohorts are scarce.

    Trastuzumab in Addition to Chemotherapy in Patients With Metastatic Human Epidermal Growth Factor Receptor 2–Positive Gastroesophageal Cancer—A Real-World Experience · 2026 · DOI

  • The learning process for probe-based confocal laser endomicroscopy (pCLE) is challenging, and standardized training protocols are currently lacking.

    Establishment and Evaluation of a Probe-Based Confocal Laser Endomicroscopy Training System for Gastric Cancerous Lesions Diagnosis: Evidence From a National Training Program · 2026 · DOI

  • To date, clinicians' views on this technology for precision oncology have not been reported despite these insights being invaluable to understanding how organoids may be effectively integrated into clinical practice.

    The role of gastric cancer patient-derived organoids in precision medicine: Clinicians’ perspective · 2026 · DOI

  • The optimal management strategy in patients undergoing curative-intent treatment remains unclear.

    Curative-intent treatment for distal gastric cancer with gastric outlet obstruction: Management pathways and clinical outcomes from a Swedish multicenter cohort · 2026 · DOI

  • Gastric cancer exhibits diverse patterns of lymph node (LN) metastasis, yet the relationship between LN stations and tumor location, histological subtype and pT-stage remains unclear.

    Nodal metastatic pattern in gastric cancer: A descriptive study of a single institution cohort · 2026 · DOI

  • ObjectiveRobotic-assisted distal gastrectomy (RADG) and laparoscopic distal gastrectomy (LDG) serve as minimally invasive alternatives to open distal gastrectomy (ODG); however, the magnitude of their perioperative benefits remains controversial.

    Single-center, retrospective cohort study of perioperative outcomes in robotic-assisted, laparoscopic, and open distal gastrectomy: A propensity score matching analysis · 2026 · DOI

  • Although precursor gastric lesions are commonly identified, adherence to current recommendations for their surveillance and to established quality indicators in EGDs is scarce.

    Tackling Post‐Endoscopy Gastric Cancer in a Low‐Risk Area: Prevalence, Features, and Prevention Opportunities Through Better Clinical Practice · 2025 · DOI

  • Limited number of studies - Insufficient subgroup-specific data - Observational studies with low certainty of evidence - Limited generalizability due to heterogeneity across…

    Impact of previous abdominal surgery on perioperative outcomes after minimally invasive gastrectomy for gastric cancer: an evidence synthesis and quantitative analysis · 2026 · DOI

  • The study was conducted in an exploratory, hypothesis-generating framework, - The sample size was limited, - The analyses were regarded as exploratory and were interpreted conservatively, - No prognostic or causal interpretation was assigned to cluster…

    Exploring Molecular Determinants of Long-Term Survival in Metastatic Gastric Cancer: An mRNA Expression Pilot Study · 2026 · DOI

  • Investigating the role of macrophages in GC, - Exploring therapeutic strategies targeting macrophages, - Studying the relationship between GC…

    Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management · 2026 · DOI

  • Limited availability of molecular techniques in many institutions - High cost of molecular techniques - Absence of optimal markers for diagnosing each molecular type - Complexity of molecular…

    Molecular Classifications in Gastric Cancer: A Call for Interdisciplinary Collaboration · 2024 · DOI

  • Development of consensus molecular categories - Design of innovative molecular studies - Validation of molecular classifications - Search for alternative molecular…

    Molecular Classifications in Gastric Cancer: A Call for Interdisciplinary Collaboration · 2024 · DOI

  • Notably, two patients in our cohort exhibited congenital tooth agenesis, a phenotypical feature rarely reported in patients with HDGC and previously undocumented in East Asian cohorts.

    Dental agenesis as a novel phenotypical feature associated with hereditary diffuse gastric cancer in China · 2025 · DOI

Most-cited papers in Gastric Cancer Management and Outcomes

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Open questions raised by papers listed on this page include: (1) There is a need for a quantitative analysis of comparative studies to evaluate the effect of previous abdominal surgery on perioperative outcomes (“Impact of previous abdominal surgery on perioperative outcomes after minimally…”, 2026); (2) Research on lymph-node-specific prediction and intervention is needed (“Metastasis Pattern‐Specific Biomarkers and Therapeutic Targets in Gastric…”, 2026); (3) Data on the epidemiology and trends of gastric cancer in Bangladesh remain limited (“Assessing the Epidemiological Trend of Gastric Cancer: A Retrospective Analysis…”, 2026); (4) The lack of a comprehensive review of the clinical and biological continuum of gastric cancer, from epidemiology to management, with a focus on macrophages poses a challenge for understanding the disease (“Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features,…”, 2026); (5) Limited generalizability of prior studies due to lack of external validation (“Treatment Effects of Different Therapeutic Strategies and Development of a…”, 2026). 665 gap statements have been mined from Gastric Cancer Management and Outcomes papers in our 7.9M-paper local library, which holds 2,865 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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