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Open research questions in Gestational Diabetes Research and Management

301 unresolved questions extracted from the limitations and future-work sections of 1,213 Gestational Diabetes Research and Management papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Investigate the associations of TTP and use of ART with gestational weight gain in multiple pregnancies, - Examine the impact of gestational weight gain trajectories on pregnancy outcomes

    Subfertility in relation to gestational weight gain and gestational diabetes: the Norwegian Mother, Father and Child Cohort Study · 2026 · DOI

  • Further evaluation of the GLM7 index as a candidate composite metabolic marker for early GDM risk stratification - Validation of the GLM7 index as a clinical prediction tool - Investigation of the GLM7 index in other populations

    Association of the GLM7 composite metabolic index with gestational diabetes mellitus in early pregnancy: a secondary analysis of a Korean prospective pregnancy cohort · 2026 · DOI

  • The ability of surrogate indices to discriminate incident GDM in early gestation remains suboptimal. There is a need for a more accurate and reliable marker for early GDM risk stratification. The study aims to address this gap by evaluating the association of the GLM7 composite metabolic index with GDM.

    Association of the GLM7 composite metabolic index with gestational diabetes mellitus in early pregnancy: a secondary analysis of a Korean prospective pregnancy cohort · 2026 · DOI

  • The study included a limited number of studies, - The studies had different GDM diagnostic criteria, - The studies reported different sample sizes and follow-up periods, - The analysis was limited by the availability of data

    Long-term metabolic consequences of in-utero gestational diabetes exposure and maternal treatment interventions: a systematic review and meta-analysis · 2026 · DOI

  • Further studies are needed to explore the effects of GDM on offspring health, - Research should investigate the optimal GDM diagnostic criteria, - Studies should examine the long-term effects of maternal hyperglycaemia on offspring health

    Long-term metabolic consequences of in-utero gestational diabetes exposure and maternal treatment interventions: a systematic review and meta-analysis · 2026 · DOI

  • The findings should be interpreted as exploratory because several interaction signals were attenuated after covariate adjustment. The study did not account for other potential factors that may influence GDM susceptibility. The study was limited to a specific population of Chinese women.

    Associations of ASIC2, IKZF3, and GSDMB Variants with Gestational Diabetes Mellitus and Their Interactions with Environmental Exposures Among Chinese Women · 2026 · DOI

  • Further validation in independent populations is needed to confirm the findings. Investigation of the mechanisms by which genetic and environmental factors contribute to GDM susceptibility is necessary. Examination of the potential interactions between genetic variants, environmental exposures, and other factors that may influence GDM susceptibility is required.

    Associations of ASIC2, IKZF3, and GSDMB Variants with Gestational Diabetes Mellitus and Their Interactions with Environmental Exposures Among Chinese Women · 2026 · DOI

  • Further studies are needed to explore the mechanisms underlying the relationship between previous GDM and LGA/macrosomia, - Research should investigate the effectiveness of weight management and other interventions in reducing the risk of LGA and macrosomia in women with prior GDM

    Gestational diabetes mellitus in previous pregnancy associated with the risk of large for gestational age and macrosomia in the second pregnancy · 2025 · DOI

  • The relationship between previous GDM and the occurrence of LGA and macrosomia is not well understood. The impact of previous GDM on LGA and macrosomia in the second pregnancy across different groups is not clear.

    Gestational diabetes mellitus in previous pregnancy associated with the risk of large for gestational age and macrosomia in the second pregnancy · 2025 · DOI

  • further research is needed to determine the optimal pre-pregnancy BMI thresholds for macrosomia prevention in GDM and non-GDM populations

    Pre-pregnancy body mass index and risk of macrosomia: glycemic status-specific thresholds and subgroup interactions in a prospective cohort · 2025 · DOI

  • Longitudinal studies or intervention studies can be used to verify the results of this study in the future. Future studies can develop an e-health literacy scale that considers the specificity of GDM in pregnant women.

    The mediating effect of e-health literacy on social support and behavioral decision-making on glycemic management in pregnant women with gestational diabetes: a cross-sectional study · 2024 · DOI

  • INTRODUCTION: The timing of gestational diabetes mellitus (GDM) diagnosis may influence maternal and neonatal outcomes, yet the differential impact of early-onset versus late-onset GDM remains incompletely characterized, particularly in Chinese populations.

    Early‐ vs. late‐onset gestational diabetes: Differential impact on maternal and neonatal outcomes · 2026 · DOI

  • How co-exposure affects placental morphology and nutrient transport across gestation remains unclear.

    Combined Metabolic and Viral Insults in Pregnancy Disrupt Specific Placental Nutrient Transporter Systems in Mice · 2026 · DOI

  • Larger prospective and ancestry-specific pregnancy studies integrating pregnancy-relevant molecular data are warranted to clarify temporality and tissue-specific mechanisms.

    Triglycerides and gestational diabetes mellitus: integrated clinical and genetic evidence linking LPL-related lipid metabolism · 2026 · DOI

  • Elevated triglyceride (TG) levels have been consistently associated with GDM; however, it remains unclear whether this association is independent of correlated lipid traits and which genetic pathways may link TG metabolism to GDM.

    Triglycerides and gestational diabetes mellitus: integrated clinical and genetic evidence linking LPL-related lipid metabolism · 2026 · DOI

  • The impact of adverse pregnancy outcomes (APOs) and their interaction with modifiable lifestyle factors on the overall occurrence and long-term progression of Cardio-Renal-Metabolic Diseases (CRMDs) in women remains unclear.

    Association of adverse pregnancy outcomes history and lifestyle factors with cardio-renal-metabolic multimorbidity: a prospective cohort study · 2026 · DOI

  • Although small-town rural participants reported fewer environmental supports for PA, this was not associated with LTPA, warranting further investigation in larger samples to determine whether improving environmental supports would translate into increased LTPA during pregnancy.

    Environmental Supports, Expectations, and Barriers to Leisure‐Time Physical Activity During Pregnancy: A Rural–Urban Comparison · 2026 · DOI

  • This study emphasizes three major contributions: (i) highlighting regression-based birth weight prediction as a novel and underexplored approach, (ii) achieving superior predictive accuracy over existing methods, and (iii) integrating explainable AI to bridge predictive power with clinical interpretability.

    A regression-based multi-task machine and deep learning framework for explainable AI driven birth weight prediction in maternal and neonatal care · 2026 · DOI

  • Subsequent studies are warranted to validate these findings across diverse populations and to assess the effectiveness of tailored first-trimester interventions based on this risk stratification.

    Distinct modifiable risk factors and preventable burdens of preterm birth: a risk-stratified analysis of pregnancies with and without gestational diabetes mellitus · 2026 · DOI

  • Although various early-pregnancy exposures are associated with PTB, their differential contributions in GDM-affected and unaffected pregnancies remain inadequately explored.

    Distinct modifiable risk factors and preventable burdens of preterm birth: a risk-stratified analysis of pregnancies with and without gestational diabetes mellitus · 2026 · DOI

  • The specific etiology of many EPL cases is not well understood, and first trimester maternal diet may play a role in EPL occurrence.

    The relationship between first trimester maternal diet and early pregnancy loss: a retrospective case–control study · 2026 · DOI

  • Continued monitoring of maternal characteristics and pregnancy outcomes is warranted.

    Prevalence of Gestational Diabetes Mellitus and associations with adverse pregnancy outcomes in the Faroe Islands: a population-based study · 2026 · DOI

  • In Sri Lanka, limited evidence exists on physical activity patterns among pregnant women, particularly primigravida mothers.

    Level of physical activity during pregnancy among Sri Lankan primigravida mothers: a cross-sectional study · 2026 · DOI

  • BACKGROUND: Whether diagnostic oral glucose tolerance test (OGTT) values are associated with neonatal hypoglycemia (NH) in women with diet-controlled gestational diabetes mellitus (GDM) remains uncertain.

    Association of diagnostic oral glucose tolerance test values with neonatal hypoglycemia in diet-controlled gestational diabetes mellitus: a retrospective cohort study · 2026 · DOI

  • However, robust diagnostic models integrating exo-miRNAs profiles for early prediction of GDM remain lacking.

    Identification of exosomal miRNA-based predictive signatures for gestational diabetes mellitus via multi-algorithm machine learning · 2026 · DOI

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301 open questions have been extracted from the limitations and future-work passages of 1,213 Gestational Diabetes Research and Management papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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