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Open research questions in Glaucoma and retinal disorders

572 gap statements mined from Glaucoma and retinal disorders papers in our 7.9M-paper local library, which holds 2,871 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

Choosing where to publish on Glaucoma and retinal disorders? See the ranked Medicine journals.

What the literature leaves open

  • There is a need to evaluate the effects of switching from fixed dorzolamide/timolol to netarsudil on ocular surface symptoms and intraocular pressure. The study aims to address this gap by assessing the impact of this switch on patient-reported symptoms and objective measures of ocular health.

    Ocular Surface Symptoms, Objective Redness, and Intraocular Pressure After a Switch from Fixed Dorzolamide/Timolol to Netarsudil in Latanoprost-Treated Glaucoma and Ocular Hypertension: A Prospective Real-World Cohort Study · 2026 · DOI

  • Previous studies have compared IOP profiles between independent individuals, which may be influenced by inter-patient variability. There is a need to investigate the differences in IOP profiles between medically and surgically controlled eyes in the same patient. This study aims to address this gap by comparing two different eyes of the same patient.

    Intraocular pressure profiles between ipsilateral surgically and contralateral medically-controlled in primary open angle glaucoma patients · 2026 · DOI

  • Limited effective and safe treatments for glaucoma, particularly for advanced cases. Need for alternative therapeutic approaches to reduce intraocular pressure and slow disease progression.

    Safety and efficacy of micropulse transscleral laser therapy for glaucoma: a two-year follow-up · 2026 · DOI

  • The disease has a significant impact on patients' mental health and quality of life. The paper highlights the need for a more comprehensive approach that addresses the biopsychosocial aspects of the disease.

    Research progress on glaucoma complicated with anxiety and depression · 2026 · DOI

  • Limited evidence comparing mydriasis-induced IOP changes across cataract, pseudophakic, and young adult eyes. The need to investigate the effect of pharmacological mydriasis on intraocular pressure across different phakic statuses and age groups.

    Pharmacological Impact of Mydriatic Drops on Intraocular Pressure: Variations across Different Phakic Status and Demographic Groups · 2026 · DOI

  • The need to develop a standardized examination protocol to assess periocular findings.

    Periocular morphology during long-term topical ophthalmic treatment: associations with prostaglandin analogs, preservatives, and eyelid manipulation · 2026 · DOI

  • The study is a cross-sectional study, which may not capture the full range of treatment-related periocular findings. The study's sample size is limited to 165 participants. The study did not measure the magnitude, duration, direction, and frequency of eyelid contact during each instillation.

    Periocular morphology during long-term topical ophthalmic treatment: associations with prostaglandin analogs, preservatives, and eyelid manipulation · 2026 · DOI

  • The cross-correlation method has limitations, such as requiring a large dataset. The need for a rapid and accurate method for assessing glaucoma. The challenge of developing a method that can compensate for confounding variables.

    Rapid, Non-Contact, Objective Multifocal Assessment of Visual Function in Glaucoma · 2026 · DOI

  • Current methods for assessing glaucoma are time-consuming. There is a need for a rapid and accurate method for assessing glaucoma. The diagnostic power of rapid objectiveFIELD Analyser tests has not been fully evaluated.

    Rapid, Non-Contact, Objective Multifocal Assessment of Visual Function in Glaucoma · 2026 · DOI

  • The extraction of irregular pupil boundaries can result in poor fitting of the ellipse using the conventional method. The presence of Pulchin spots, eyelashes, and gaze direction can affect the extraction of the pupil boundary. The need for accurate and consistent data collection in natural activities, rather than controlled settings.

    High-Accuracy Intermittent Strabismus Screening via Wearable Eye-Tracking and AI-Enhanced Ocular Feature Analysis · 2025 · DOI

  • The need for animal models that mimic the complex pathology of glaucoma beyond elevated IOP, - The lack of understanding of the exact mechanisms that lead to glaucoma, - The need for models that can investigate aspects of glaucoma not solely dependent on high IOP.

    Glaucoma Animal Models beyond Chronic IOP Increase · 2024 · DOI

  • Current treatments for glaucoma have limitations, and there is a need for novel therapeutic options. Rho kinase inhibitors have emerged as a potential treatment option, but their efficacy and safety need to be further evaluated.

    The Application of Rho Kinase Inhibitors in the Management of Glaucoma · 2024 · DOI

  • Further longitudinal studies with larger and more diverse populations are warranted to investigate additional behavioral, environmental, and clinical factors influencing IOP trajectories.

    Longitudinal Modeling of Intraocular Pressure and Its Associated Factors Among Glaucoma Patients: Evidence from Jimma University Medical Center · 2026 · DOI

  • Novel associations with CCBs, CGRP monoclonal antibodies, and PCSK9 inhibitors warrant further investigation.

    Epidemiology, Safety of Dilation, and Medication-Associated Risk of Acute Angle-Closure Crisis in the United States · 2026 · DOI

  • Early-onset angle-closure glaucoma (EOACG), defined as onset of angle-closure glaucoma (ACG) manifesting at or before 40 years of age, represents a distinct and understudied subset of angle-closure disease, with limited literature describing its clinical and demographic diversity.

    Phenotypic Spectrum of Early Onset Angle Closure Glaucoma in Young Indian Patients · 2026 · DOI

  • Elevated intraocular pressure (IOP) is the only established modifiable risk factor of primary open-angle glaucoma (POAG), but the contribution of body mass index (BMI) to disease severity remains inconsistent across populations, and data from Sub-Saharan Africa are scarce.

    Body Mass Index and Severity of Primary Open-Angle Glaucoma: A Multicenter Cross-Sectional Study in a Cameroonian Setting · 2026 · DOI

  • Systemic hypertension is a risk factor for glaucoma, a leading cause of irreversible blindness, yet the mechanistic basis connecting the 2 conditions remains elusive.

    Endothelin 2-Mediated Neuroinflammation Drives Hypertensive Retinal Dysfunction · 2026 · DOI

  • However, the mechanism underlying MYOC mutation-associated POAG is poorly understood.

    Disease modeling of myocilin mutation-dependent normal tension glaucoma: human retinal ganglion cell susceptibility to unfolded protein response and mTOR signaling · 2026 · DOI

  • Further studies are needed to investigate the effects of mydriatic agents on IOP in different populations, - Research should be conducted to develop guidelines for the use of mydriatic agents, - Studies should be done to examine the long-term effects of mydriatic agents on IOP, - Investigations into the mechanisms underlying mydriatic agent-induced IOP changes…

    Pharmacological Impact of Mydriatic Drops on Intraocular Pressure: Variations across Different Phakic Status and Demographic Groups · 2026 · DOI

  • Large-scale implementation of the wearable eye-tracking device - Further analysis of the data pertaining to eye movement - Development of more advanced pupil extraction…

    High-Accuracy Intermittent Strabismus Screening via Wearable Eye-Tracking and AI-Enhanced Ocular Feature Analysis · 2025 · DOI

  • Limited availability of results for new ROCK inhibitor ophthalmic solutions, - Some ROCK inhibitors have not yet produced available results, - Antimetabolites may result in severe side effects…

    The Application of Rho Kinase Inhibitors in the Management of Glaucoma · 2024 · DOI

  • The study did not detect any influence of eye drop composition on the OSM, - Research specifically focusing on the OSM in animal models has been…

    Exploring the Ocular Surface Microbiome and Tear Proteome in Glaucoma · 2024 · DOI

  • Examining changes in the microbiome pre-and post-glaucoma induction using animal models, - Determining whether changes in the microbiome are a direct result of glaucoma or secondary to treatments involving preservative-laden eye…

    Exploring the Ocular Surface Microbiome and Tear Proteome in Glaucoma · 2024 · DOI

  • These findings support further investigation of gaze-related optic nerve traction as a potential non-IOP-related biomechanical factor in myopic NTG.

    Association of Adduction-Induced Optic Nerve Head Strain with Visual Field Loss Progression in Myopic Normal-Tension Glaucoma: The Wenzhou Glaucoma Progression Study · 2026 · DOI

  • Cilastatin attenuated the OHT-associated reduction in Brn3a+ RGC counts and glial activation without producing a sustained IOP-lowering effect, supporting further investigation of its potential relevance in glaucoma.

    Retinal neuroinflammation and neurodegeneration in a mouse model of glaucoma: cilastatin as a protective agent in male and female mice · 2026 · DOI

Most-cited papers in Glaucoma and retinal disorders

Most recent work

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Open questions raised by papers listed on this page include: (1) There is a need to evaluate the effects of switching from fixed dorzolamide/timolol to netarsudil on ocular surface symptoms and intraocular pressure (“Ocular Surface Symptoms, Objective Redness, and Intraocular Pressure After a…”, 2026); (2) There is a need to investigate the differences in IOP profiles between medically and surgically controlled eyes in the same patient (“Intraocular pressure profiles between ipsilateral surgically and contralateral…”, 2026); (3) There is a need for a rapid and accurate method for assessing glaucoma (“Rapid, Non-Contact, Objective Multifocal Assessment of Visual Function in…”, 2026); (4) Further longitudinal studies with larger and more diverse populations are warranted to investigate additional behavioral, environmental, and clinical factors influencing IOP trajectories (“Longitudinal Modeling of Intraocular Pressure and Its Associated Factors Among…”, 2026); (5) Systemic hypertension is a risk factor for glaucoma, a leading cause of irreversible blindness, yet the mechanistic basis connecting the 2 conditions remains elusive (“Endothelin 2-Mediated Neuroinflammation Drives Hypertensive Retinal Dysfunction”, 2026). 572 gap statements have been mined from Glaucoma and retinal disorders papers in our 7.9M-paper local library, which holds 2,871 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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