Science AI Journal
Medicine · Research topic

Open research questions in Heart Failure Treatment and Management

227 unresolved questions extracted from the limitations and future-work sections of 964 Heart Failure Treatment and Management papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Proportional hazards assumptions were violated in the final Cox models. Missing values in the variables required by ADHERE, GWTG-HF, and the 8-variable model. Limited availability of certain variables, such as BUN, in the external validation cohort.

    An eight-variable risk model for short- and long-term mortality in hospitalized heart failure · 2026 · DOI

  • Most prognostic models for heart failure target long-term outcomes and are not optimized for acute-phase risk stratification. Limited ability to identify patients at high risk of death within the first 28 days after admission.

    An eight-variable risk model for short- and long-term mortality in hospitalized heart failure · 2026 · DOI

  • direct myocardial toxicity remains primarily observed in vitro and lacks clinical confirmation - evidence for genetic susceptibility and direct cardiotoxicity remains limited - clinical data are scarce for the mechanism of myocardial contractile dysfunction in pioglitazone-induced heart failure

    Research progress on the pathophysiological mechanisms of pioglitazone-induced heart failure: a review · 2026 · DOI

  • Identifying and addressing the complex and multifaceted needs of Chinese patients with chronic heart failure. Developing a comprehensive framework that incorporates psychosocial and lifestyle-related dimensions. Ensuring the validity and reliability of the framework through expert consultation and Delphi rounds.

    Construction of a home-based social support service content framework for Chinese patients with chronic heart failure based on Maslow's hierarchy of needs · 2026 · DOI

  • The existing literature on CHF focuses primarily on clinical parameters, neglecting psychosocial and lifestyle-related dimensions that affect long-term quality of life. There is a need for a comprehensive framework that addresses the home-based social support needs of Chinese patients with CHF.

    Construction of a home-based social support service content framework for Chinese patients with chronic heart failure based on Maslow's hierarchy of needs · 2026 · DOI

  • the study had a limited sample size, - the study only looked at NYHA class III HF patients, - the study did not provide a direct comparison with other treatment options, - the study relied on data from clinical trials and observational studies, - the study did not account for potential biases in the data

    An Era of Digital Healthcare—A Comprehensive Review of Sensor Technologies and Telehealth Advancements in Chronic Heart Failure Management · 2024 · DOI

  • further studies are needed to evaluate the long-term effectiveness of the CardioMEMS HF system, - research is needed to develop new technologies for remote HF monitoring, - studies should investigate the cost-effectiveness of remote PAP monitoring, - future research should focus on improving the accuracy of hemodynamic biomarkers, - the development of novel weight scales to track multiple hemodynamic parameters should be explored

    An Era of Digital Healthcare—A Comprehensive Review of Sensor Technologies and Telehealth Advancements in Chronic Heart Failure Management · 2024 · DOI

  • Rural populations experience higher mortality and fragmented care, yet limited research has explored how demographic, clinical, structural, and socioeconomic factors influence 30-day readmission risk across geographic locations.

    Heart failure readmissions in urban and rural hospital settings: An analysis of 30‐day readmissions using the 2021 Nationwide Readmissions Database · 2026 · DOI

  • Earlier studies have suggested that low-dose digoxin might be beneficial, but evidence from rigorous randomized clinical trials is lacking.

    Low-dose digoxin in patients with heart failure with reduced or mildly reduced ejection fraction: a randomized controlled trial · 2026 · DOI

  • However, there is limited knowledge on what matters to these patients and if current care pathways address their needs.

    Healthcare needs and priorities of older people living with heart failure and frailty: a multi-perspective study of patients, carers and clinicians · 2026 · DOI

  • Functional capacity is a key prognostic marker in heart failure (HF), yet it is frequently under-assessed at hospital discharge, and its clinical and demographic determinants during this critical period remain insufficiently characterized.

    Clinical Determinants of Functional Capacity at Hospital Discharge in Patients with Heart Failure: A Secondary Observational Analysis · 2026 · DOI

  • However, whether CCM can bridge the hemodynamic vulnerability phase to facilitate GDMT optimization and improve patient prognosis remains unclear.

    Cardiac contractility modulation to enhance optimized medical therapy and improve cardiac remodeling in advanced heart failure: a case report · 2025 · DOI

  • However, most of the existing literature focuses on short-term readmission rates and causes, with limited data on long-term readmissions.

    One-year unplanned readmission after percutaneous coronary intervention in ST-elevation myocardial infarction: rates, causes, and predictors—a retrospective cohort study · 2025 · DOI

  • To date, no studies have evaluated the unplanned readmission post-PCI in STEMI patients within the Arab Gulf region.

    One-year unplanned readmission after percutaneous coronary intervention in ST-elevation myocardial infarction: rates, causes, and predictors—a retrospective cohort study · 2025 · DOI

  • Bendopnea, defined as dyspnea occurring within 30 s of forward trunk flexion, has emerged as a potential marker of hemodynamic compromise, yet its clinical significance in large multicenter cohorts remains underexplored.

    Bendopnea as an independent prognostic marker for adverse events in hospitalized heart failure patients: insights from a multicenter prospective cohort study · 2025 · DOI

  • Objective: Mild cognitive impairment (MCI) has increasingly been recognized as a significant comorbidity in patients with chronic heart failure (CHF), adversely affecting prognosis and quality of life, despite limited research examining the role of sleep quality in this relationship.

    Association between mild cognitive impairment and sleep quality in patients with chronic heart failure: a cross-sectional study · 2025 · DOI

  • However, there is lack of data regarding how the implementation of a discharge planning system influences the length of stay (LOS) in hospital and readmission rates among patients with neurological diseases.

    The Role of the Discharge Planning Team on the Length of Hospital Stay and Readmission in Patients with Neurological Conditions: A Single-Center Retrospective Study · 2025 · DOI

  • HFpEF has a significant impact on individuals' life expectancy and quality of life, but the exact pathogenesis remains unclear.

    The gut microbiota-inflammation-HFpEF axis: deciphering the role of gut microbiota dysregulation in the pathogenesis and management of HFpEF · 2025 · DOI

  • Although natriuretic peptides like B-type natriuretic peptide (BNP) are valuable biomarkers for diagnosing and managing HF, the utility of combining BNP with other blood-based biomarkers to predict subtypes of new-onset HF remains underexplored.

    Proteomic-based biomarker discovery reveals panels of diagnostic biomarkers for early identification of heart failure subtypes · 2025 · DOI

  • Future research should examine additional components of EHR interventions to understand and account for remaining gaps in effectiveness.

    Electronic Health Record Interventions to Reduce Risk of Hospital Readmissions · 2025 · DOI

  • Few studies have explored modifiable risk factors such as health beliefs from patients' perspective to explore the complexity of risk factors for readmission.

    ‘I didn’t want to go home’ patient-identified modifiable risk factors associated with hospital readmission: a qualitative study · 2024 · DOI

  • 28)), and had higher prevalence of many chronic conditions than non-responders, and thus may not be representative of all HF patients.

    A large, multi-center survey assessing health, social support, literacy, and self-management resources in patients with heart failure · 2024 · DOI

  • Future research employing a more extended follow-up period, larger sample size, or randomized design is warranted to investigate the treatment effects in this subpopulation.

    Real-world experience of angiotensin receptor-neprilysin inhibitors in patients with heart failure and dialysis · 2024 · DOI

  • However, the effects of sacubitril/valsartan on these outcomes, as well as on ventricular tachyarrhythmias, have not been well studied in women with HFrEF.

    Sex differences and clinical outcomes, including ventricular tachyarrhythmias, of patients with heart failure with reduced ejection fraction treated with sacubitril/valsartan · 2024 · DOI

  • The epidemiology of cardiorenal syndrome among the general population is incompletely characterized and despite shared risk factors with HF, differences in mortality risk across key demographics have not been well described.

    Demographic trends of cardiorenal and heart failure deaths in the United States, 2011–2020 · 2024 · DOI

Most-cited papers in Heart Failure Treatment and Management

Most recent work

Find a gap in your own Heart Failure Treatment and Management sub-topic

This page shows what the Heart Failure Treatment and Management literature already flags as unresolved. To narrow it to your specific question, run the guided finder — it searches the gap library on demand and checks candidates against 250M+ OpenAlex works.

Open the Research Gap Finder →

Related topics in Medicine

Artificial Intelligence in Healthcare and Education
2,044 open questions
Substance Abuse Treatment and Outcomes
1,964 open questions
Smoking Behavior and Cessation
990 open questions
Dementia and Cognitive Impairment Research
974 open questions
Innovations in Medical Education
960 open questions
Physical Activity and Health
923 open questions
Attention Deficit Hyperactivity Disorder
839 open questions
Schizophrenia research and treatment
709 open questions
227 open questions have been extracted from the limitations and future-work passages of 964 Heart Failure Treatment and Management papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 120,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? A Tier 1–5 acceptance probability in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck prior-publication & salami-slicing risk across 8 sources.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.