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Open research questions in Herpesvirus Infections and Treatments

584 gap statements mined from Herpesvirus Infections and Treatments papers in our 7.9M-paper local library, which holds 1,798 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • Limited real-world evidence of dose-to-dose comparison and impact of dose interval on reactogenicity. Prior studies have reported conflicting results regarding dose-related differences in adverse events. The need for evidence-based reassurance about potential adverse events after the second RZV dose.

    Short‐Term Adverse Events Following Recombinant Zoster Vaccination in Older Adults in Australia: A Survey Study Comparing Dose 1 and Dose 2 and Influence of Dose Interval · 2026 · DOI

  • The gap in the current vaccination strategy in Korea, where a single-dose schedule has been used since 2005. The need for a more effective vaccination strategy to reduce varicella incidence.

    A commentary on “Effect of varicella vaccine introduction on chickenpox incidence in Kingdom of Bahrain” · 2026 · DOI

  • However, HZ risk due to immunosuppressive medication remains underexplored across a broad spectrum of medication classes and conditions.

    Risk of herpes zoster among adults in the United States initiating immunosuppressive therapy: A retrospective cohort study · 2026 · DOI

  • In particular, the role of virus-encoded microRNAs (v-miRs) in shaping corneal immune responses during herpes simplex infection remains unclear.

    Viral microRNA inhibition enhances antiviral immunity by modulating corneal inflammatory and resolution pathways in HSV-1 induced keratitis · 2026 · DOI

  • Abnormalities in neural circuits, ion channels, inflammatory factors, and gene regulation are crucial factors contributing to the development of PNH; however, the underlying mechanism remains unclear.

    Post-Herpetic Neuralgia: Review of Pathophysiology, Mechanisms, and Drug Treatment · 2025 · DOI

  • The recombinant zoster vaccine (RZV) is recommended, but its efficacy in preventing recurrent HZ among patients with IBD is not well established.

    Recombinant herpes zoster vaccine lowers shingles complication risk in patients with inflammatory bowel disease · 2025 · DOI

  • The DPV UL42 gene product, pUL42, an accessory subunit of the viral DNA polymerase, whose nuclear import is critical for viral replication; however, the underlying mechanism remains unclear.

    Cooperative nuclear import of duck plague virus DNA polymerase subunits: pUL42 NLS Enhances pUL30 nuclear import and viral replication, with VP22 as a compensatory factor · 2025 · DOI

  • Our findings support that NMT inhibitors should be explored as therapeutics to treat viral infections associated with immunosuppression caused by treatments with JAK inhibitors.

    N-myristoyltransferase inhibitors as candidate broad-spectrum antivirals to treat viral infections promoted by immunosuppression associated with JAK inhibitors therapy · 2025 · DOI

  • However, there is lack of data regarding the long-term effectiveness in this population.

    Recombinant Zoster Vaccine [RZV] is Effective in Patients with Inflammatory Bowel Disease: A US Propensity Matched Cohort Study · 2024 · DOI

  • The lack of molecular diagnostics and advanced neuro-monitoring in resource-limited environments. The need for prompt antiviral intervention in pediatric patients with suspected herpes simplex encephalitis.

    Navigating Diagnostic Constraints in Pediatric Herpes Simplex Encephalitis: Successful Empirical Acyclovir Therapy without PCR Confirmation · 2026 · DOI

  • The need for evaluation of the impact of varicella immunization programs. The need for estimation of the relative vaccine effectiveness of two-dose versus single-dose regimens.

    The Impact and Effectiveness of a Two-Dose Varicella Immunization Program Among School Children: Evidence from Quasi-experimental Analyses · 2026 · DOI

  • The functional role of the UL50 gene in duck enteritis virus is not well understood. There is a need for effective vaccines against duck enteritis virus.

    Functional characterization of UL50 gene reveals its essential role in duck enteritis virus replication and pathogenesis · 2026 · DOI

  • Safety and challenge protection assays used limited sample sizes (n=10 for survival/temperature monitoring, n=5 for viral load), which may restrict statistical power and generalizability of protective efficacy findings.

    Functional characterization of UL50 gene reveals its essential role in duck enteritis virus replication and pathogenesis · 2026 · DOI

  • The need to develop therapeutic strategies to target viral R-loops.

    Herpes simplex virus type 1 R-loops are targets for APOBEC-mediated mutagenesis · 2026 · DOI

  • The efficiency and genomic distribution of APOBEC-mediated mutations remain poorly understood. The role of R-loops in APOBEC3-mediated mutagenesis is not well understood.

    Herpes simplex virus type 1 R-loops are targets for APOBEC-mediated mutagenesis · 2026 · DOI

  • There is a need for alternative strategies to treat economically significant viral diseases in cattle. The current treatment options for BVDV and BoHV-1 have limitations, including economic considerations.

    Pampa biome plant extracts and flavonoids show antiviral activity against Bovine Herpesvirus and Bovine Viral Diarrhea Virus · 2026 · DOI

  • Limited understanding of the disease burden of herpes zoster in immunocompromised populations. Insufficient targeted prevention and control measures.

    Analysis of Disease Burden of Herpes Zoster in Immunocompromised Populations Based on Healthcare Data · 2026 · DOI

  • The lack of disease burden evidence based on real-world medical data. Insufficient targeted prevention and control measures for high-risk populations with immunocompromised status.

    Analysis of Disease Burden of Herpes Zoster in Immunocompromised Populations Based on Healthcare Data · 2026 · DOI

  • Early computed tomography imaging is inherently unreliable; while typical images appear in 50 to 75 percent of cases, this typically image does not appear until after the first week of illness, limiting its utility in the acute phase.

    Navigating Diagnostic Constraints in Pediatric Herpes Simplex Encephalitis: Successful Empirical Acyclovir Therapy without PCR Confirmation · 2026 · DOI

  • The analysis is limited by excluding participants who did not complete surveys for RZV doses, - The study is limited by the limitations of the AusVaxSafety system, - The results may be biased if the AEFI experience of non-respondents…

    Short‐Term Adverse Events Following Recombinant Zoster Vaccination in Older Adults in Australia: A Survey Study Comparing Dose 1 and Dose 2 and Influence of Dose Interval · 2026 · DOI

  • Lack of systematic recording of clinical data, - Limited availability of immunological status in positive cases, - No comprehensive review of clinical data…

    Epidemiology of Herpes Simplex and Varicella Zoster Virus-Associated Central Nervous System Infections in Western Greece: A Five-Year Retrospective Analysis · 2025 · DOI

  • Further study of the epidemiology of herpesvirus CNS infections, - Investigation of the effectiveness of targeted vaccination programs, - Analysis of the impact of widespread immunization against bacterial…

    Epidemiology of Herpes Simplex and Varicella Zoster Virus-Associated Central Nervous System Infections in Western Greece: A Five-Year Retrospective Analysis · 2025 · DOI

  • The paper identifies a gap in the current knowledge of HZ, especially in immunocompromised patients. The study aims to fill this gap by analyzing the risk factors for HZ occurrence, complications, and recurrences.

    Herpes Zoster: Risk Factors for Occurrence, Complications, and Recurrence with a Focus on Immunocompromised Patients · 2025 · DOI

  • A review of the current knowledge of the zoster vaccines, - The results of vaccination rates in the Subcarpathian Province…

    Herpes Zoster: Risk Factors for Occurrence, Complications, and Recurrence with a Focus on Immunocompromised Patients · 2025 · DOI

  • The promising antiviral activity of 25R,26OHC and PFM067, along with their different mechanism of action compared to ACV, makes these molecules suitable candidates for further investigation of the molecular target of oxysterols.

    25R,26-hydroxycholesterol and an oxysterol synthetic analog inhibit Varicella zoster Virus replication · 2025 · DOI

Most-cited papers in Herpesvirus Infections and Treatments

Most recent work

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Open questions raised by papers listed on this page include: (1) HZ risk due to immunosuppressive medication remains underexplored across a broad spectrum of medication classes and conditions (“Risk of herpes zoster among adults in the United States initiating…”, 2026); (2) The role of virus-encoded microRNAs (v-miRs) in shaping corneal immune responses during herpes simplex infection remains unclear (“Viral microRNA inhibition enhances antiviral immunity by modulating corneal…”, 2026); (3) The lack of molecular diagnostics and advanced neuro-monitoring in resource-limited environments (“Navigating Diagnostic Constraints in Pediatric Herpes Simplex Encephalitis:…”, 2026); (4) The functional role of the UL50 gene in duck enteritis virus is not well understood (“Functional characterization of UL50 gene reveals its essential role in duck…”, 2026); (5) The efficiency and genomic distribution of APOBEC-mediated mutations remain poorly understood (“Herpes simplex virus type 1 R-loops are targets for APOBEC-mediated mutagenesis”, 2026). 584 gap statements have been mined from Herpesvirus Infections and Treatments papers in our 7.9M-paper local library, which holds 1,798 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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