Science AI Journal
Medicine · Research topic

Open research questions in Herpesvirus Infections and Treatments

120 unresolved questions extracted from the limitations and future-work sections of 540 Herpesvirus Infections and Treatments papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Further studies are needed to establish the clinical effectiveness and safety of corticosteroids in HSVE, - More research is needed to understand the role of corticosteroids in alleviating edema and inflammatory injury, - Future studies should aim to address the limitations of the current evidence base

    Adjunctive corticosteroids in herpes simplex virus encephalitis: a meta-analysis of randomized and observational studies · 2026 · DOI

  • The clinical effectiveness and safety of adjunctive corticosteroids in herpes simplex virus encephalitis are unknown. Prior studies have limitations and inconsistencies. There is a need for a comprehensive review of the current evidence.

    Adjunctive corticosteroids in herpes simplex virus encephalitis: a meta-analysis of randomized and observational studies · 2026 · DOI

  • Confirmation in external data sets with laboratory viral typing, antiviral treatment records, and mortality linkage is warranted.

    Association of Herpes Simplex Virus Type-1 With Dementia Outcomes: Longitudinal Retrospective Cohort Study Using Real-World Electronic Health Record Data · 2026 · DOI

  • Epidemiologic findings remain inconsistent, partly because many studies lack standardized designs for real-world data.

    Association of Herpes Simplex Virus Type-1 With Dementia Outcomes: Longitudinal Retrospective Cohort Study Using Real-World Electronic Health Record Data · 2026 · DOI

  • OBJECTIVE: Herpes zoster has been associated with immune and metabolic disturbances; however, its relationship with newly diagnosed Type 2 diabetes mellitus (T2DM) remains unclear.

    Herpes zoster as a potential clinical marker of undiagnosed Type 2 diabetes in older adults: a retrospective cohort study · 2026 · DOI

  • Abstract Background Herpetic keratitis (HK) is associated with frequent recurrences and vision-threatening sequelae, yet predictors of relapse remain poorly defined in children.

    Pediatric Herpetic Keratitis: Recurrence Predictors and Antiviral Prophylaxis Outcomes · 2026 · DOI

  • While the role of type 1 IFN in HSV-1 infection has been studied extensively, how IFN type 1 responses crosstalk with latency-associated transcript (LAT) in sensory neurons remains to be elucidated.

    HSV-1 LAT promotes ocular diseases in the absence of type I IFN responses in sensory neurons · 2026 · DOI

  • Although HZ vaccination is expected to reduce both HZ and its complications, comprehensive epidemiological data to guide vaccination strategies are scarce.

    Epidemiology of herpes zoster and postherpetic neuralgia in Japan: analysis of a large-scale claims database · 2026 · DOI

  • However, there are insufficient data on the transfer of amenamevir into breast milk among breastfeeding patients with RHS.

    Transfer of amenamevir into breast milk in breastfeeding patients with recurrent herpes simplex: study protocol for a single-arm, open-label study · 2025 · DOI

  • However, the heterogeneity and functionality of VZV-specific memory T cells in older individuals remain poorly understood.

    Heterogeneity and functional diversity of VZV-specific memory CD4 T cells across age 9198 · 2025 · DOI

  • The necessity or the timing of booster vaccination warrants further investigation.

    Real-world effectiveness of recombinant herpes Zoster vaccine: a retrospective, cohort study in Japan · 2025 · DOI

  • Although aging is the most well-known risk factor for herpes zoster, little is known about the strength of the association between patient-related characteristics, including comorbidities, and their contribution to an increased risk of mortality, among patients hospitalized for HZ.

    Comorbidities in hospitalized patients with herpes zoster: an Italian retrospective observational study in the years 2011–2023 · 2025 · DOI

  • Factors such as sex, age at treatment initiation, coinfections, and pre-ART CD4 + T-cell count may influence this insufficient recovery.

    The influence of extrinsic apoptosis gene expression on immunological reconstitution of male ART-treated PLHIV · 2025 · DOI

  • There is limited information about the role of co-infections in pathogenesis and the current prevalence of pathogens in North America.

    Feline respiratory disease complex: insights into the role of viral and bacterial co-infections · 2024 · DOI

  • These results enriched the genome sequence data of ALV-K in Chinese geoducks, and laid the foundation for further research on the pathogenesis and prevention of ALV-K.

    Detection and genetic diversity of subgroup K avian leukosis virus in local chicken breeds in Jiangxi from 2021 to 2023 · 2024 · DOI

  • Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain relief and inflammation, though their potential role as KVE triggers remains uncertain.

    Kaposi varicelliform eruption: an unusual presentation caused by varicella zoster virus in a healthy adult patient - a case report · 2024 · DOI

  • Although SRLV infection and its impact on animal production are well established in the country, little is known about the circulating SRLV strains and their prevalence.

    A Combined Approach for the Characterization of Small Ruminant Lentivirus Strains Circulating in the Islands and Mainland of Greece · 2024 · DOI

  • The lack of molecular diagnostics and advanced neuro-monitoring in resource-limited environments. The need for prompt antiviral intervention in pediatric patients with suspected herpes simplex encephalitis.

    Navigating Diagnostic Constraints in Pediatric Herpes Simplex Encephalitis: Successful Empirical Acyclovir Therapy without PCR Confirmation · 2026 · DOI

  • Early computed tomography imaging is inherently unreliable; while typical images appear in 50 to 75 percent of cases, this typically image does not appear until after the first week of illness, limiting its utility in the acute phase.

    Navigating Diagnostic Constraints in Pediatric Herpes Simplex Encephalitis: Successful Empirical Acyclovir Therapy without PCR Confirmation · 2026 · DOI

  • The need for evaluation of the impact of varicella immunization programs. The need for estimation of the relative vaccine effectiveness of two-dose versus single-dose regimens.

    The Impact and Effectiveness of a Two-Dose Varicella Immunization Program Among School Children: Evidence from Quasi-experimental Analyses · 2026 · DOI

  • The functional role of the UL50 gene in duck enteritis virus is not well understood. There is a need for effective vaccines against duck enteritis virus.

    Functional characterization of UL50 gene reveals its essential role in duck enteritis virus replication and pathogenesis · 2026 · DOI

  • Safety and challenge protection assays used limited sample sizes (n=10 for survival/temperature monitoring, n=5 for viral load), which may restrict statistical power and generalizability of protective efficacy findings.

    Functional characterization of UL50 gene reveals its essential role in duck enteritis virus replication and pathogenesis · 2026 · DOI

  • The complexity of the HSV-1 genome. The difficulty of detecting R-loops and APOBEC enzyme binding. The need to develop therapeutic strategies to target viral R-loops.

    Herpes simplex virus type 1 R-loops are targets for APOBEC-mediated mutagenesis · 2026 · DOI

  • The efficiency and genomic distribution of APOBEC-mediated mutations remain poorly understood. The role of R-loops in APOBEC3-mediated mutagenesis is not well understood.

    Herpes simplex virus type 1 R-loops are targets for APOBEC-mediated mutagenesis · 2026 · DOI

  • There is a need for alternative strategies to treat economically significant viral diseases in cattle. The current treatment options for BVDV and BoHV-1 have limitations, including economic considerations.

    Pampa biome plant extracts and flavonoids show antiviral activity against Bovine Herpesvirus and Bovine Viral Diarrhea Virus · 2026 · DOI

Most-cited papers in Herpesvirus Infections and Treatments

Most recent work

Find a gap in your own Herpesvirus Infections and Treatments sub-topic

This page shows what the Herpesvirus Infections and Treatments literature already flags as unresolved. To narrow it to your specific question, run the guided finder — it searches the gap library on demand and checks candidates against 250M+ OpenAlex works.

Open the Research Gap Finder →

Related topics in Medicine

Artificial Intelligence in Healthcare and Education
2,044 open questions
Substance Abuse Treatment and Outcomes
1,964 open questions
Smoking Behavior and Cessation
990 open questions
Dementia and Cognitive Impairment Research
974 open questions
Innovations in Medical Education
960 open questions
Physical Activity and Health
923 open questions
Attention Deficit Hyperactivity Disorder
839 open questions
Schizophrenia research and treatment
709 open questions
120 open questions have been extracted from the limitations and future-work passages of 540 Herpesvirus Infections and Treatments papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 120,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? A Tier 1–5 acceptance probability in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck prior-publication & salami-slicing risk across 8 sources.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.