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Open research questions in Intracerebral and Subarachnoid Hemorrhage Research

138 unresolved questions extracted from the limitations and future-work sections of 265 Intracerebral and Subarachnoid Hemorrhage Research papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The paper identifies a gap in the understanding of the relationship between CAA and lvPPA. The study highlights the importance of recognizing CAA in lvPPA patients due to its therapeutic implications. The dual burden of parenchymal and vascular amyloid pathology in atypical Alzheimer's disease syndromes is not well understood.

    Intersecting pathologies in atypical Alzheimer’s disease: a case of logopenic PPA with cerebral amyloid angiopathy · 2026 · DOI

  • Further studies are needed to understand the mechanisms underlying ICH, - Further studies are needed to explore the therapeutic potential of the RBM15/NXF1/E2F1 axis

    RBM15 affects mitophagy in intracerebral hemorrhage by promoting E2F1 nuclear translocation via NXF1 · 2026 · DOI

  • The mechanisms regulating the nuclear transport of E2F1 mRNA remain poorly understood. The role of RBM15 in mitophagy in intracerebral hemorrhage is unknown. The effect of NXF1 knockdown on ICH progression is not well understood.

    RBM15 affects mitophagy in intracerebral hemorrhage by promoting E2F1 nuclear translocation via NXF1 · 2026 · DOI

  • The study had a single-center design, - The sample size was limited to 171 participants, - The study was cross-sectional and did not include longitudinal follow-up

    Burden-dependent associations of serum sTREM2 with white matter injury and cognitive heterogeneity in cerebral small vessel disease · 2026 · DOI

  • Longitudinal studies are needed to determine the predictive value of serum sTREM2 for cognitive decline in CSVD, - Further research is needed to explore the mechanisms underlying the association between serum sTREM2 and CSVD, - Studies with larger sample sizes and diverse populations are needed to confirm the findings

    Burden-dependent associations of serum sTREM2 with white matter injury and cognitive heterogeneity in cerebral small vessel disease · 2026 · DOI

  • Further examination of the validation status of current prediction models, - Investigation of methodological and practical barriers to clinical implementation, - Emerging generative architectures, - Clinical trials evaluating strategies to limit HE

    Hematoma expansion in intracerebral hemorrhage: neuroimaging biomarkers, radiomics-based prediction models, and clinical translation · 2026 · DOI

  • The gap in accurate prediction of hematoma expansion using neuroimaging biomarkers. The need for effective prediction models that can guide interventions. The challenge of translating prediction models into clinical practice.

    Hematoma expansion in intracerebral hemorrhage: neuroimaging biomarkers, radiomics-based prediction models, and clinical translation · 2026 · DOI

  • The study is based on a non-clinical investigation using the FAERS database, - The analysis is limited to the data available in the FAERS database, - The study does not provide a comprehensive picture of the safety profile of lecanemab

    A real-world disproportionality analysis of FDA adverse event reporting system (FAERS) events for lecanemab · 2025 · DOI

  • Limited reports on adverse effects associated with lecanemab. The need for a comprehensive analysis of lecanemab-related adverse events. The importance of understanding the safety profile of lecanemab for its future clinical use.

    A real-world disproportionality analysis of FDA adverse event reporting system (FAERS) events for lecanemab · 2025 · DOI

  • small sample size (single case report), - lack of longitudinal data, - potential role of cognitive reserve in delayed recognition of deficits

    Intersecting pathologies in atypical Alzheimer’s disease: a case of logopenic PPA with cerebral amyloid angiopathy · 2026 · DOI

  • These findings contribute to the knowledge of the long-term effects of SAH and necessitate further research on the pathogenesis of AD in relation to cerebral ischemia.

    A Unique Case of Post-Subarachnoid Hemorrhage Cerebral Atrophy and Its Implications on Alzheimer’s Disease · 2026 · DOI

  • Due to the high mortality rate of SAH, there is limited research on its long-term effects and relation to neurodegenerative disorders.

    A Unique Case of Post-Subarachnoid Hemorrhage Cerebral Atrophy and Its Implications on Alzheimer’s Disease · 2026 · DOI

  • The molecular response of the neuron-rich cortex to blood within the first 24 hours of injury, and how this may precipitate secondary brain injury or neurodegeneration, remains poorly defined.

    Cross-omics profiling reveals cortical neuronal dysfunction following neonatal intraventricular haemorrhage that is attenuated by decorin treatment · 2026 · DOI

  • Given these uncertainties and the biological distinctions between deep and lobar ICH, future well-powered studies specifically designed to test whether intensive BP reduction has differential effects by hematoma location are warranted.

    Functional Outcomes After Intensive Blood Pressure Reduction in Deep and Lobar Intracerebral Hemorrhage · 2026 · DOI

  • Whether these potential benefits apply similarly to lobar and deep ICH, 2 biologically and clinically distinct subtypes, remains uncertain.

    Functional Outcomes After Intensive Blood Pressure Reduction in Deep and Lobar Intracerebral Hemorrhage · 2026 · DOI

  • While cortical cerebral microinfarcts (CMI) have been associated with cortical superficial siderosis (cSS), the mechanisms linking these lesions remain unknown.

    Spatiotemporal Associations Between Cortical Microinfarcts and Cortical Superficial Siderosis in Cerebral Amyloid Angiopathy · 2026 · DOI

  • BACKGROUND AND OBJECTIVES: Early intensive systolic blood pressure (SBP) reduction is a promising strategy for intracerebral hemorrhage (ICH), but the optimal magnitude of reduction in the first 2 hours remains uncertain.

    Optimal Magnitude of Blood Pressure Reduction and Hematoma Growth and Functional Outcomes in Intracerebral Hemorrhage · 2025 · DOI

  • Whether CAA is associated with isolated subdural hemorrhage (SDH), without an accompanying ICH, remains unclear.

    Association Between Cerebral Amyloid Angiopathy and Nontraumatic Subdural Hemorrhage · 2025 · DOI

  • Knowledge about the underlying pathophysiology is scarce, and it is hypothesized that they are related to either the ICH itself, adverse effects of treatment, or the activity of the underlying small vessel disease (SVD) causing the ICH.

    Incidence of Diffusion-Weighted Imaging Lesions in Patients With Intracerebral Hemorrhage in the Acute and Subacute Time Periods · 2025 · DOI

  • Cerebral microbleeds (CMBs) are associated with Aβ and CSVD, but their role on tau-related neurodegeneration remains unclear.

    Impact of Cerebral Microbleeds on Tau-Associated Cognitive and Structural Decline · 2025 · DOI

  • DISCUSSION: Our findings inform shared decision making about the tradeoffs of anti-amyloid mAbs but should be validated in populations with confirmed treatment eligibility.

    Risk of New Indications for Anticoagulants and Thrombolytics in People With Cognitive Impairment · 2025 · DOI

  • Given the inconsistent findings of previous trials and observational studies, this study aims to assess the effect of statins on ICH risk in Chinese population.

    Statin Use and Risk of Intracerebral Hemorrhage in Chinese Population · 2025 · DOI

  • Early implementation of a care bundle protocol (CBP) within 6 hours of symptom onset has been shown to improve functional outcomes, although its effect beyond this time frame remains unclear.

    Effect of Onset-to-Admission Time and Care Bundle Achievement on Functional Outcomes in Patients With ICH · 2025 · DOI

  • Moreover, the prevalence of these lesions before blood pressure lowering remains elusive.

    DWI-Positive Lesions in Acute Intracerebral Hemorrhage and Their Correlation With Small Vessel Disease · 2025 · DOI

  • BACKGROUND AND OBJECTIVES: Diffusion-weighted imaging (DWI)-positive lesions are identified in 11%-45% of patients with acute intracerebral hemorrhage (ICH); however, their underlying mechanisms and clinical implications remain unclear.

    DWI-Positive Lesions in Acute Intracerebral Hemorrhage and Their Correlation With Small Vessel Disease · 2025 · DOI

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138 open questions have been extracted from the limitations and future-work passages of 265 Intracerebral and Subarachnoid Hemorrhage Research papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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