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Open research questions in Iron Metabolism and Disorders

212 unresolved questions extracted from the limitations and future-work sections of 864 Iron Metabolism and Disorders papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The study had to identify associations and hypothesis-generating patterns rather than causal or clinically predictive relationships. The explanatory performance of the models was limited, with an adjusted R2 of 0.16.

    Baseline Ferritin and Body Composition as Correlates of Longitudinal Metabolic Changes During an Energy-Restricted Mediterranean-Style Intervention Across Three Overweight Phlogistic-Related Clinical Conditions · 2026 · DOI

  • The explanatory performance of the models was limited (adjusted R 2 = 0.16 and 0.25). Most ferritin variability remained unexplained. No outcome-specific sample size calculation was performed for the present secondary analysis. The study did not estimate a causal treatment effect.

    Baseline Ferritin and Body Composition as Correlates of Longitudinal Metabolic Changes During an Energy-Restricted Mediterranean-Style Intervention Across Three Overweight Phlogistic-Related Clinical Conditions · 2026 · DOI

  • One challenge is the need for large-scale observational studies to examine the relationship between iron deficiency anemia and tuberculosis risk. Another challenge is the need for further research on the mechanisms by which iron deficiency anemia contributes to tuberculosis risk. A third challenge is the need for studies to examine the relationship between iron deficiency anemia and tuberculosis risk in diverse populations.

    Association between iron deficiency anemia and the risk of new-onset tuberculosis infection: a matched cohort analysis · 2026 · DOI

  • The association between iron deficiency anemia and tuberculosis risk remains inadequately characterized. Prior studies have not fully explored the relationship between iron deficiency anemia and tuberculosis. There is a need for further research on the relationship between iron deficiency anemia and tuberculosis risk.

    Association between iron deficiency anemia and the risk of new-onset tuberculosis infection: a matched cohort analysis · 2026 · DOI

  • Inadequate coverage of bread fortification in the Middle East, - Lack of political will, financial constraints, and coordination challenges between government and private sectors, - Difficulties in controlling wheat imports and small-scale flour production, - Limited data from some Middle Eastern countries

    Evaluating the effectiveness and risks of bread fortification programs in the middle eastern region: a comprehensive review · 2025 · DOI

  • Further studies across a wider range of countries to provide a comprehensive understanding of the regional impact and effectiveness of fortification policies, - Ongoing research to monitor potential risks of fortification, - Research on the effectiveness of fortification in addressing micronutrient deficiencies

    Evaluating the effectiveness and risks of bread fortification programs in the middle eastern region: a comprehensive review · 2025 · DOI

  • The molecular basis of the phenotypic heterogeneity in hereditary hemochromatosis is poorly defined. The existence of genetic or environmental modifiers that alter cellular responses to iron overload is implied, but not well understood. The role of copper in iron overload hepatocytes is not well understood.

    Cuproptosis in iron overload hepatocytes · 2026 · DOI

  • However, the role of hepcidin in different types of anemia among frail, acutely hospitalized older patients remains poorly understood.

    Hepcidin in hospitalized older medical patients: associations with inflammation, anemia, frailty, comorbidity, and renal function · 2026 · DOI

  • Background: The longitudinal fluctuations in maternal serum ferritin (SF) levels during gestation, acting as indirect indicators of iron supplementation, have not been thoroughly investigated in relation to the incidence of hypertensive disorders of pregnancy (HDP).

    The associations of maternal serum ferritin levels with hypertensive disorders of pregnancy: a longitudinal cohort study · 2025 · DOI

  • These findings highlight a potential sex-specific genetic risk factor for dementia and warrant further research into the underlying mechanisms linking p.

    Haemochromatosis Genotypes and Incident Dementia in a Prospective Study of Older Adults · 2025 · DOI

  • Due to limited research has been conducted on childhood anemia spatial disparities at the Ethiopian zonal level, and it is essential for developing zonal-level interventions for inform policy recommendations.

    Mapping the covariate-adjusted spatial effects of childhood anemia in Ethiopia using a semi-parametric additive model · 2025 · DOI

  • However, the research in this area is still emerging and the impact of moderators, such as birth weight, upon outcomes has not been fully explored.

    Combined effects of maternal supplementation of iron, calcium, folic acid, and multivitamin during pregnancy on obesity in Chinese preschoolers born macrosomia · 2025 · DOI

  • BACKGROUND: The relationship between serum ferritin levels and the risk of gestational diabetes mellitus (GDM) remains unclear.

    The association between serum ferritin levels and the risk of gestational diabetes mellitus: a prospective cohort study · 2025 · DOI

  • However, the prevalence of this devastating condition and its causes among pregnant teenagers in Ghana remain unclear.

    Determination of prevalence and cause of anaemia among adolescent pregnant girls in Ussher Hospital, James Town, Ghana · 2025 · DOI

  • However, the association between maternal anemia during pregnancy and newborn metabolic profiles remains unclear.

    Impact of maternal anemia during pregnancy on neonatal metabolic profiles: evidence from the Beijing Birth Cohort Study · 2025 · DOI

  • Despite its prevalence, the impact of nutritional iron deficiency on the establishment of memory T cell responses is poorly understood.

    Dietary iron deficiency impairs effector function of memory T cells following influenza infection · 2025 · DOI

  • Nevertheless, its specific prognostic relevance in elderly patients with CAP remains unclear.

    The independent predictive value of admission serum ferritin concentration for prognosis in elderly patients with community-acquired pneumonia in the emergency department · 2025 · DOI

  • Future research should focus on research of heme iron supplementation strategies to enhance absorption efficiency, gut microbiome health, and safety, ensuring optimal iron status across diverse populations.

    Dietary Heme Iron: A Review of Efficacy, Safety and Tolerability · 2025 · DOI

  • RESEARCH BACKGROUND: As the global population ages rapidly, anemia prevalence rises among older adults, yet its impact on quality of life and mortality in this group remains poorly understood.

    The prevalence and etiology of anemia and the association between anemia and all-cause mortality: a cohort study over a 9-year period · 2025 · DOI

  • However, very few studies have explored the association between IDA and cognitive function among Ghanaians.

    Iron deficiency anemia and its association with cognitive function among adolescents in the Ashanti Region - Ghana · 2024 · DOI

  • These findings challenge the assumption of low iron deficiency prevalence throughout Bangladesh and highlight iron deficiency in pregnancy as a potentially underrecognized public health problem, particularly in regions with low drinking water iron.

    High anaemia and iron deficiency prevalence among pregnant women living in low groundwater iron areas of Bangladesh · 2024 · DOI

  • Although the country has reduced its anemia rates, the progress is insufficient to achieve the WHO's 2030 targets for anemia reduction among women of reproductive age.

    Burden and causes of anemia in Vietnam: insights from the global burden of disease data · 2024 · DOI

  • How this iron-mediated, pathogenic anemia-inflammation crosstalk is regulated in the gut remains elusive.

    Butyrate Prevents the Pathogenic Anemia‐Inflammation Circuit by Facilitating Macrophage Iron Export · 2024 · DOI

  • Introduction: Few studies are about the relationship between anemia and obesity, and previous studies have only paid attention to BMI.

    Association between obesity and anemia in an nationally representative sample of United States adults: a cross-sectional study · 2024 · DOI

  • While existing studies have explored the correlation between serum iron levels and HT, limited research has specifically focused on this association in reproductive-age females.

    Inverse association between serum iron levels and Hashimoto’s thyroiditis in United States females of reproductive age: analysis of the NHANES 2007–2012 · 2024 · DOI

Most-cited papers in Iron Metabolism and Disorders

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212 open questions have been extracted from the limitations and future-work passages of 864 Iron Metabolism and Disorders papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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