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Open research questions in Meningioma and schwannoma management

101 unresolved questions extracted from the limitations and future-work sections of 234 Meningioma and schwannoma management papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • There are no prior reports of meningiomas originating in the temporal muscle. The diagnosis and treatment of meningiomas in extracranial locations are not well established.

    Meningioma extracraneal en músculo temporal: Reporte de un caso · 2026 · DOI

  • Estudio de más casos de meningioma del músculo temporal - Análisis de la efectividad de la radioterapia adyuvante en casos de resección incompleta

    Meningioma extracraneal en músculo temporal: Reporte de un caso · 2026 · DOI

  • Additional research that evaluates the clinical risk–benefit ratio associated with DMPA use is warranted.

    Depot medroxyprogesterone acetate and the risk for developing an intracranial meningioma · 2026 · DOI

  • Abemaciclib warrants further investigation for patients with progressive grade 2 or 3 meningiomas harboring NF2 or CDK pathway alterations.

    Abemaciclib in meningiomas with somatic NF2 or CDK pathway alterations: the phase 2 Alliance A071401 trial · 2026 · DOI

  • Nevertheless, clinically applicable non-invasive candidate imaging markers capable of reflecting pathological alterations within the inner ear have not yet been well established.

    Multi-sequence MRI signal intensity ratios as candidate imaging correlates for audiovestibular dysfunction in vestibular schwannoma · 2026 · DOI

  • The potential for these metrics to guide personalized management strategies remains to be evaluated in future studies.

    Multi-sequence MRI signal intensity ratios as candidate imaging correlates for audiovestibular dysfunction in vestibular schwannoma · 2026 · DOI

  • Women should be cautioned about the prolonged use of MPA, and future research should examine whether the extended use of MPA is associated with the meningioma grade.

    The Association between Medroxyprogesterone Acetate Exposure and Meningioma · 2024 · DOI

  • Therefore, careful consideration of an appropriate management strategy is warranted.

    Bevacizumab Treatment for Patients with NF2-Related Schwannomatosis: A Single Center Experience · 2024 · DOI

  • Furthermore, the role of adjuvant radiotherapy for grade 1 and 2 meningioma remains controversial.

    The Evolving Classification of Meningiomas: Integration of Molecular Discoveries to Inform Patient Care · 2024 · DOI

  • The clinical presentation of pediatric meningiomas varies widely depending on their location within the central nervous system.

    Case Report: Unmasked: Deceptive pediatric spinal meningioma · 2024 · DOI

  • The study has a limited sample size of 350 patients. The study only evaluates the application of VLSM to intracranial meningiomas, and not to other types of tumors. The study uses a retrospective design, which may be subject to biases.

    Extending voxel-based lesion mapping to neurosurgical oncology: applications in intracranial meningiomas · 2026 · DOI

  • To evaluate the effectiveness of VLSM in other types of tumors. To develop new methods to improve the interpretability of VLSM. To apply VLSM to larger cohorts of patients with intracranial meningiomas.

    Extending voxel-based lesion mapping to neurosurgical oncology: applications in intracranial meningiomas · 2026 · DOI

  • Future work should prioritize multicenter, prospective cohorts with standardized reporting of clinical, dosimetric, and surgical variables. Harmonized definitions of local con- trol, prospectively collected late toxicity graded with con- temporary systems (e.g., CTCAE), and routine reporting of grade ≥ 3 events would substantially reduce measurement bias and strengthen future meta-analytic inferences. Larger, more granular datasets would also enable adequately pow- ered meta-regression to test candidate moderators such as total dose, WHO grade, treatment year (technology era), and fractionation type. In parallel, collaborative registries and, where feasible, randomized or pragmatic comparative trials against modern photon IMRT and stereotactic radio- surgery could validate the survival and toxicity advantages suggested by this review and inform cost-effectiveness across different healthcare settings.

    Effectiveness and safety of proton therapy in intracranial meningioma treatment: a systematic review and meta-analysis · 2026 · DOI

  • The proximity of critical neurovascular structures to the surgical site. The complexity of the anatomy of the skull base. The need for minimally invasive techniques to reduce morbidity.

    Safety profile and surgical outcomes of the endoscopic transorbital approach as a skull base surgical corridor: a systematic review and meta-analysis · 2026 · DOI

  • The lack of systematic evaluation of complication rates associated with the endoscopic transorbital approach. The need for a comprehensive review of the current literature on this approach.

    Safety profile and surgical outcomes of the endoscopic transorbital approach as a skull base surgical corridor: a systematic review and meta-analysis · 2026 · DOI

  • The study has a limited sample size. The dataset is retrospective. The performance estimates should be interpreted cautiously due to the limited size of the held-out test set.

    Feasibility of Deep Learning-Based Segmentation of the Facial and Vestibulocochlear Nerves on High-Resolution Magnetic Resonance Imaging · 2026 · DOI

  • Manual segmentation of the facial and vestibulocochlear nerves is labor-intensive and subject to interobserver variability. There is a need for automated segmentation methods that can accurately delineate these nerves.

    Feasibility of Deep Learning-Based Segmentation of the Facial and Vestibulocochlear Nerves on High-Resolution Magnetic Resonance Imaging · 2026 · DOI

  • There is a lack of literature on pediatric PIOMs, with few cases reported. There is a need for more research on the surgical management and outcomes of PIOMs in children.

    Primary intraosseous meningioma in a child: an unusual case report and literature review · 2026 · DOI

  • The main strength of this report relies on detailed, stepwise description of surgical strategy. The integration of preoperative 3D CT planning, intraoperative neuronavigation, and custom implant technology represents a reproducible approach for the management of similar lesions. These techniques reflect advancements in neurosurgical technology and highlight the importance of tailored surgical planning. The main limitation is represented by the single case report like almost all the literature concerning pediatric patients. Secondly, while the 1-year follow-up is reassuring with respect to early recurrence, it is insufficient to draw definitive conclusions regarding long-term tumor behavior, given the characteristically indolent growth of meningiomas and the possibility of late recurrence. Moreover, no molecular or genetic profiling, including NF2 mutation analysis or DNA methylation profiling, was performed in the present case, limiting mechanistic insight into tumor pathogenesis in this age group. Lastly, the long-term impact of a titanium cranioplasty on cranial growth and remodelling in a 9-year-old patient remains unknown and warrants longitudinal monitoring. The potential need for implant revision in the context of progressive skull growth should be anticipated and discussed with the family during follow-up.

    Primary intraosseous meningioma in a child: an unusual case report and literature review · 2026 · DOI

  • future studies of ILS systematically evaluate IAC morphology, - consider including the hyperventilation test as an adjunctive bedside assessment of retrocochlear involvement

    Comment on Chen et al. Vestibulo-Ocular Reflex Results in Patients with Intralabyrinthine Schwannomas: Case Series with a Literature Review. Diagnostics 2025, 15, 2093 · 2026 · DOI

  • The lack of systematic evaluation of IAC morphology in patients with intralabyrinthine schwannomas, - the potential for diagnostic ambiguity and overattribution of vestibular manifestations, - the need for adjunctive bedside assessments such as the hyperventilation test

    Comment on Chen et al. Vestibulo-Ocular Reflex Results in Patients with Intralabyrinthine Schwannomas: Case Series with a Literature Review. Diagnostics 2025, 15, 2093 · 2026 · DOI

  • The study excluded participants who had multiple meningiomas. The study had a limited number of participants (37).

    Multimodal brain MRI and clinical data in olfactory groove meningioma: a prospective data report · 2026 · DOI

  • The complexity of the vestibular system. The need to develop new diagnostic and treatment strategies for patients with unilateral vestibular schwannoma.

    Oculomotor and Caloric Test Findings in 122 Patients With Unilateral Vestibular Schwannoma · 2026 · DOI

  • To examine the long-term effects of unilateral vestibular schwannoma on oculomotor and caloric test findings. To compare the test metrics between different types of vestibular disorders.

    Oculomotor and Caloric Test Findings in 122 Patients With Unilateral Vestibular Schwannoma · 2026 · DOI

  • The need for surgical solutions that maintain safety and control while maintaining minimal invasion. The limitations of traditional open approaches to the anterior skull base.

    Transorbital microsurgery (TOMS): Step-by-Step technique, tips and tricks · 2026 · DOI

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101 open questions have been extracted from the limitations and future-work passages of 234 Meningioma and schwannoma management papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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