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Open research questions in Menopause: Health Impacts and Treatments

256 unresolved questions extracted from the limitations and future-work sections of 1,189 Menopause: Health Impacts and Treatments papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The gap between how illness is experienced and how it is studied produces findings that generalise poorly to care. Research rarely operates around hormonally defined reproductive transitions and stages.

    Hormone blindness in precision psychiatry · 2026 · DOI

  • The study identifies the challenge of supporting women who struggle with spiritual engagement during menopause. The study highlights the need for targeted interventions in healthcare to address the spiritual and psychological needs of women during menopause. The study notes the importance of considering cultural and religious contexts in supporting women during menopause.

    Spiritual Experiences and Psychological Reflections during Menopause in Turkey · 2026 · DOI

  • Targeted interventions in health care to support women struggling with spiritual engagement, - Further studies on the relationship between spiritual practices and menopausal symptoms, - Investigations into the effects of cultural and religious norms on women's perceptions of menopause

    Spiritual Experiences and Psychological Reflections during Menopause in Turkey · 2026 · DOI

  • The methodological heterogeneity of the included studies limited the ability to pool the results. The lack of longitudinal evidence on this topic makes it difficult to establish causal relationships. The variable methodological quality of the included studies may have introduced bias into the review.

    Reproductive life stages and cognitive outcomes: a systematic review in Latin American and Caribbean women · 2026 · DOI

  • The association between reproductive life stages and cognitive outcomes in Latin American and Caribbean women remains largely understudied. There is a lack of longitudinal evidence on this topic, with most studies being cross-sectional. The methodological quality of the included studies is variable, with some studies having significant limitations.

    Reproductive life stages and cognitive outcomes: a systematic review in Latin American and Caribbean women · 2026 · DOI

  • The study identifies the challenge of translating preclinical findings to clinical practice due to species differences in pharmacokinetics. The study identifies the challenge of limited systematic information on toxicity and safety. The study identifies the challenge of poor aqueous solubility and limited oral bioavailability of quercetin.

    Screening traditional Chinese medicine monomers for premature ovarian insufficiency: from network meta-analysis to the effects of a promising candidate on oxidative stress biomarkers · 2026 · DOI

  • restricting the literature search to mainstream English and Chinese databases may have introduced language bias, - small sample sizes and unclear risk of bias may have compromised the robustness of the pooled estimates, - substantial heterogeneity across animal models may have reduced confidence in the findings, - the very low certainty of evidence for most comparisons and potential publication bias for several outcomes reduce confidence in the findings

    Screening traditional Chinese medicine monomers for premature ovarian insufficiency: from network meta-analysis to the effects of a promising candidate on oxidative stress biomarkers · 2026 · DOI

  • The study faces challenges in terms of the complexity of the data and the need for sophisticated analytical techniques. The study must also consider the potential biases and confounding variables in the dataset. Additionally, the study faces challenges in interpreting the results and drawing meaningful conclusions about the impact of menopause and HRT on mental health, cognitive function, and brain structure.

    Emotional and cognitive effects of menopause and hormone replacement therapy · 2026 · DOI

  • The role of estradiol in associations between adiposity and menopausal symptoms is unclear. The relationship between body composition and menopausal symptoms is not fully understood.

    Estradiol mediates the association of waist-to-hip ratio, but not body fat percentage, with menopause-related symptoms in Chinese women aged 40–60 years · 2026 · DOI

  • One challenge is the lack of understanding of the discussion of menopausal symptoms at work and their associations with taboo, symptom severity, and need for recovery. Another challenge is the need to promote an open workplace culture and accessible support to promote work participation during menopause. The study also highlights the challenge of measuring the need for recovery after work and the severity of menopausal symptoms.

    Discussing menopausal symptoms at work and associations with taboo, symptom severity, and need for recovery after work · 2026 · DOI

  • There is a lack of understanding of the discussion of menopausal symptoms at work and their associations with taboo, symptom severity, and need for recovery. Prior work has not examined the extent to which menopausal symptoms are discussed with colleagues, supervisors, and occupational professionals.

    Discussing menopausal symptoms at work and associations with taboo, symptom severity, and need for recovery after work · 2026 · DOI

  • Studies in postmenopausal women using hormone therapy are scarce - The effects of E4 use in menopausal HT on hemostasis are lacking

    Chapter 3. Impact of estrogens on hemostasis · 2025 · DOI

  • The exact molecular mechanism of estrogen-induced thrombosis is unclear. The effects of different types and doses of estrogens on hemostatic parameters are not well understood. There is a lack of studies on the effects of estetrol on hemostasis in menopausal hormone therapy users.

    Chapter 3. Impact of estrogens on hemostasis · 2025 · DOI

  • INTRODUCTION: Women with polycystic ovary syndrome (PCOS) have been suggested to experience later menopause, yet population-based studies are lacking.

    Women with PCOS have a later menopausal transition and a lower prevalence of menopausal symptoms at age 46: A population‐based birth cohort study · 2026 · DOI

  • Furthermore, recent research has highlighted the impact of the menopause on the development and severity of metabolic dysfunction-associated steatotic liver disease (MASLD) that has been poorly studied in the context of HRT.

    Hormone Replacement Therapy for Menopausal Symptoms and the Risk of Cardiometabolic Disease: Current Evidence and Future Directions · 2026 · DOI

  • Common treatments for VMS and genitourinary symptoms, MHT and vaginal oestrogen, have not been evaluated for all core outcomes, with treatment satisfaction and dysuria reported in only 9% of studies.

    Modern Management of the Menopause: Are We Measuring What Matters? · 2026 · DOI

  • Implications of menopause hormone therapy (MHT) for cognitive aging remain unclear despite decades of research.

    Associations of menopause hormone therapy with late-life cognition and brain health vary by formulation and APOEε4 presence · 2026 · DOI

  • Although there have been surveys of affected women on perception, impairment and personal management of gynaecological ailments, the use of medication using real-world data based on everyday practice is poorly understood.

    A German online cross-sectional survey on herbal medicinal products for the treatment and management of gynaecological ailments · 2026 · DOI

  • As a result, we received limited information about menopausal symptoms and therefore excluded these cases from the quantitative analyses.

    A German online cross-sectional survey on herbal medicinal products for the treatment and management of gynaecological ailments · 2026 · DOI

  • While pharmacological treatments carry well-documented risks, evidence-based non-pharmacological interventions such as Mindfulness-Based Stress Reduction (MBSR) remain understudied in this population, particularly with respect to multiple psychosocial outcomes.

    The Effect of a Mindfulness‐Based Stress Reduction ( MBSR ) Program on Quality of Life, Life Satisfaction, Sleep Quality, and Mental Well‐Being in Menopausal Women: A Randomized Controlled Trial · 2026 · DOI

  • Mobile health (mHealth) applications increasingly deliver education, symptom tracking, and self-management support to menopausal women, yet the evidence base is fragmented, and how well this research captures MSK symptoms, rather than leaving them embedded within broader symptom measures, remains unclear.

    mHealth Applications in the Assessment of Musculoskeletal Pain in Menopausal Women: Protocol for a Scoping Review · 2026 · DOI

  • Exercise has emerged as a promising non-pharmacological strategy for alleviating depression, yet the extent to which different intervention characteristics influence outcomes remains unclear.

    Exercise as a therapeutic strategy for depression in menopausal women: a metaanalysis of randomized trials · 2025 · DOI

  • Diet influences both menopausal symptoms and cardiovascular health, but the impact of chrononutrition, namely food timing, is not well understood.

    Timing matters: lipid intake and its influence on menopausal-related symptoms · 2025 · DOI

  • Importance: Medical gaslighting, in which a patient's concerns are dismissed without proper evaluation, has been described anecdotally in vulvovaginal patient care, but has not been quantified.

    Experiences of Care and Gaslighting in Patients With Vulvovaginal Disorders · 2025 · DOI

  • Importance: There is limited evidence regarding the association between age at menopause and incident type 2 diabetes (T2D).

    Age at Menopause and Development of Type 2 Diabetes in Korea · 2025 · DOI

Most-cited papers in Menopause: Health Impacts and Treatments

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256 open questions have been extracted from the limitations and future-work passages of 1,189 Menopause: Health Impacts and Treatments papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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