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Open research questions in Nasal Surgery and Airway Studies

88 unresolved questions extracted from the limitations and future-work sections of 870 Nasal Surgery and Airway Studies papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • There is a need for further research to improve the understanding of the causes and methods of prevention of beak-like deformity of the nose after rhinoplasty. The current literature on beak-like deformity of the nose after rhinoplasty is limited, and there is a need for more studies to address this gap.

    ORGAN-SAVING APPROACHES IN THE SURGICAL CORRECTION OF AESTHETIC DEFORMATIONS OF THE NOSE · 2026 · DOI

  • The long-term physiological effects of alarplasty on pulmonary function remain unclear. There is a need for studies that investigate the effects of alarplasty on respiratory function.

    Alarplasty and its effects on respiratory function: a cross-sectional study · 2026 · DOI

  • The study did not directly measure chronic changes in airflow patterns and their potential contribution to long-term functional adaptations affecting lung volumes and airway patency. Future research must employ time-series analysis of airflow dynamics over extended post-operative periods to characterize how nasal structural modifications influence sustained respiratory efficiency.

    Alarplasty and its effects on respiratory function: a cross-sectional study · 2026 · DOI

  • Objective evaluation metrics for Empty Nose Syndrome treatment outcomes require development and validation to be consistently applied across different studies; solutions such as using natural disease progression as a control and independent assessor blinding need implementation but lack specific operational definitions.

    Evidence-based approaches for Empty Nose Syndrome management: a systematic review highlighting current treatments and future directions · 2026 · DOI

  • Only one randomized controlled trial exists for Empty Nose Syndrome management despite multiple surgical, regenerative, and neurostimulation modalities being explored, with concerns noted regarding sample size justification and outcome assessment blinding; rigorous RCT designs are needed to establish evidence-based treatment standardization.

    Evidence-based approaches for Empty Nose Syndrome management: a systematic review highlighting current treatments and future directions · 2026 · DOI

  • Anatomical variations in the nasal cavity and paranasal sinuses can impact postoperative satisfaction, - Limited data on the frequency of sinonasal anatomical variations in Iranian populations

    Computed tomography-detected sinonasal anatomical variations in rhinoplasty candidates: a cross-sectional study · 2026 · DOI

  • Limited data on the frequency of sinonasal anatomical variations in Iranian populations, - Need for a comprehensive analysis of preoperative CT findings in rhinoplasty candidates

    Computed tomography-detected sinonasal anatomical variations in rhinoplasty candidates: a cross-sectional study · 2026 · DOI

  • The technique does not address internal septal deviation or improve nasal airflow. The technique is not suitable for patients with significant sagittal septal deviation.

    The Semi-columellar Strut Technique: Correction of Slight Sagittal Deviation of the Septum · 2026 · DOI

  • This study has several limitations. First, it is a retrospec- tive case series with a rather small sample size (n = 15) that restricts the generalisability of the results. Second, there is no control group, which does not allow for comparison of the results with other standard approaches to septal perfora- tion repair. Third, there might be a risk of selection bias due to the exclusion of patients with autoimmune disease, active cocaine use, or perforations larger than 3.5 cm. Fourth, the functional outcomes were measured on a clinical basis and not with a validated patient-reported outcome measure like the NOSE or SNOT-22 scales. Lastly, the mean follow-up was over 22 months, yet the longer-term results are still unknown. Multicentre prospective trials involving larger groups of patients are necessary in future to ascertain the reproducibility and long-term efficacy of this method.

    Dynamic septal reconstruction using the Tsubasa flap: integration of depressor septi nasi muscle and temporoparietal fascia · 2026 · DOI

  • Future research should focus on establishing evidence-based guidelines for technique selection and patient candidacy. Studies should investigate the psychological impact of preservation rhinoplasty on patients.

    Shaping the Future of Nasal Surgery: A Systematic Review of Preservation Rhinoplasty · 2026 · DOI

  • There is a lack of standardized protocols for preservation techniques. The long-term psychological impact of preservation rhinoplasty remains underexplored.

    Shaping the Future of Nasal Surgery: A Systematic Review of Preservation Rhinoplasty · 2026 · DOI

  • The limited number of included studies, - Low-to-moderate certainty of evidence, - The cumulative sample size in the meta-analysis was 334, which is less than the Required Information Size (RIS) of 1672 participants, - Most trials were open-label in design

    Septoplasty Versus Non-Surgical Treatment for Deviated Nasal Septum: A Systematic Review and Meta-Analysis · 2026 · DOI

  • The methodological robustness of the included evidence was limited. The body of literature was dominated by preclinical, non-comparative studies using surrogate laboratory outcomes. Human studies were lacking, particularly for EMR.

    From Conventional Septoplasty to Patient-Specific Cartilage Reshaping: A Systematic Review of Laser-Mediated and Electromechanical Approaches · 2026 · DOI

  • The translation of LCR and EMR to human clinical practice has progressed slowly. There is a need for further research on the safety and efficacy of LCR and EMR in humans.

    From Conventional Septoplasty to Patient-Specific Cartilage Reshaping: A Systematic Review of Laser-Mediated and Electromechanical Approaches · 2026 · DOI

  • The study only included 60 consecutive patients. The age range of the patients was limited to 20-30 years.

    Determining the relationship between the evaluation time of rhinoplasty outcome and patient satisfaction: a comparative study · 2026 · DOI

  • There is a lack of research on the relationship between the evaluation time of rhinoplasty outcome and patient satisfaction. The study aims to address this gap by examining the relationship between the evaluation time of rhinoplasty outcome and patient satisfaction.

    Determining the relationship between the evaluation time of rhinoplasty outcome and patient satisfaction: a comparative study · 2026 · DOI

  • The complex interplay of modifications to both the osseocartilaginous framework and the behavior of the overlying skin-soft tissue envelope - The need for a comprehensive framework for optimizing rhinoplasty outcomes

    Skin and Soft Tissue Management in Primary Rhinoplasty · 2026 · DOI

  • The review identifies a need for a comprehensive framework for optimizing rhinoplasty outcomes through thoughtful SSTE management

    Skin and Soft Tissue Management in Primary Rhinoplasty · 2026 · DOI

  • The management of caudal septal deformities is a challenging component of rhinoplasty and nasal septal reconstruction. There is a need for a comprehensive review of septal anatomy, patient evaluation, and an updated algorithm for management of caudal septal deformities.

    Contemporary Management of Caudal Septal Deformities: An Algorithmic Approach · 2026 · DOI

  • Traditional training methods have limitations. There is a need for a cost-effective and reusable model for training in nasal endoscopic examination and artificial lacrimal duct intubation.

    Application of 3D-Printed nasal models in lacrimal surgery training · 2026 · DOI

  • There is a need for alternative methods to traditional nasal packing. The effectiveness of continuous through-suture of the nasal septum in improving postoperative quality of life is not well established.

    Clinical application and curative effects of continuous through-suture of the nasal septum for endoscopic septoplasty in randomised trials · 2026 · DOI

  • There is a need for effective treatment approaches for oronasal fistulae in dogs with challenging local conditions. The standard single-flap technique may not be sufficient in cases with complex local conditions, such as marked loss of buccal gingiva and insufficient alveolar bone support.

    Adjunctive use of a collagen membrane for surgical closure of oronasal fistulae in dogs with challenging local conditions: a case series · 2026 · DOI

  • Furthermore, the exact in vivo persistence and behavior of the collagen membrane used in this study remain unknown, and early resorption or displacement after placement cannot be excluded. Further studies involving larger case numbers and comparative designs are warranted to better define the indications and potential utility of this approach.

    Adjunctive use of a collagen membrane for surgical closure of oronasal fistulae in dogs with challenging local conditions: a case series · 2026 · DOI

  • Traditional alar batten grafts have a limited impact on alar margin contour and tip-alar harmony. There is a need for a technique that addresses both functional and aesthetic components of zone II lateral nasal wall insufficiency.

    The Modified Alar Batten Graft as a Tip-Alar Superstructure: A Technique to Restore Soft Triangle Stability and External Valve Support · 2026 · DOI

  • The study had a relatively small sample size of 50 patients. The follow-up period was limited to a mean of 2 years. The study did not compare the results with other surgical techniques.

    Asymmetric Puzzle Spreader Graft: A Systematic Approach for Correction of Crooked Nose Deformity · 2026 · DOI

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88 open questions have been extracted from the limitations and future-work passages of 870 Nasal Surgery and Airway Studies papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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