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Open research questions in Nasal Surgery and Airway Studies

243 gap statements mined from Nasal Surgery and Airway Studies papers in our 7.9M-paper local library, which holds 1,572 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • It remains uncertain whether SAT performed at the time of AT confers additional improvement in nasal symptoms compared to AT alone.

    Turbinate Surgery in Children With Sleep‐Disordered Breathing: A Randomized Prospective Study · 2026 · DOI

  • However, no data have shown that aggressive turbinate reductions consistently lead to ENS.

    Does Total Inferior and Middle Turbinectomy Always Lead to Empty Nose Syndrome? · 2026 · DOI

  • Patient‑specific factors, surgical techniques, and differences in subjective and psychophysical outcome measures likely contribute to variability in olfactory performance after surgery and are not yet fully understood.

    Association of Nasal Anatomy, Airflow, and Surgery With Olfactory Outcomes: A State‐of‐the‐Art Review · 2026 · DOI

  • Future studies are needed to clarify the impact of treating psychiatric disorders on postoperative outcomes following otolaryngology procedures.

    Association of Depression and Anxiety With Postoperative Complications After Septoplasty With Turbinoplasty · 2026 · DOI

  • Previous studies synthesizing published data on nasal septal perforation (NSP) repair outcomes have cited the lack of standardization in evaluation and data reporting.

    Nasal Septal Perforation Surgical Repair Study Methodology: A State of the Art Review · 2025 · DOI

  • Limited data (n = 24) for follow-up beyond 1 year showed sustained improvement in all measures-NOSE 32, SN-5 Likert 2.

    Durability of Quality‐of‐Life Improvements Following Pediatric Septorhinoplasty · 2025 · DOI

  • A consensus on the content of an informed consent in rhino(septo)plasty is currently lacking despite the high unmet need.

    Rhino(septo)plasty Informed Consent Consensus by the European Rhinoplasty Course Faculty – EUFOREA · 2025 · DOI

  • There is a need for further research to improve the understanding of the causes and methods of prevention of beak-like deformity of the nose after rhinoplasty. The current literature on beak-like deformity of the nose after rhinoplasty is limited, and there is a need for more studies to address this gap.

    ORGAN-SAVING APPROACHES IN THE SURGICAL CORRECTION OF AESTHETIC DEFORMATIONS OF THE NOSE · 2026 · DOI

  • Objective evaluation metrics for Empty Nose Syndrome treatment outcomes require development and validation to be consistently applied across different studies; solutions such as using natural disease progression as a control and independent assessor blinding need implementation but lack specific operational definitions.

    Evidence-based approaches for Empty Nose Syndrome management: a systematic review highlighting current treatments and future directions · 2026 · DOI

  • Only one randomized controlled trial exists for Empty Nose Syndrome management despite multiple surgical, regenerative, and neurostimulation modalities being explored, with concerns noted regarding sample size justification and outcome assessment blinding; rigorous RCT designs are needed to establish evidence-based treatment standardization.

    Evidence-based approaches for Empty Nose Syndrome management: a systematic review highlighting current treatments and future directions · 2026 · DOI

  • Human evidence is limited to a small number of uncontrolled LCR studies, while EMR has not yet been evaluated clinically for septoplasty. Significant challenges remain, including narrow safety margins, lack of standardized dosimetry, limited understanding of long-term biological responses, and the absence of clinically suitable intranasal devices.

    From Conventional Septoplasty to Patient-Specific Cartilage Reshaping: A Systematic Review of Laser-Mediated and Electromechanical Approaches · 2026 · DOI

  • The management of caudal septal deformities is a challenging component of rhinoplasty and nasal septal reconstruction. There is a need for a comprehensive review of septal anatomy, patient evaluation, and an updated algorithm for management of caudal septal deformities.

    Contemporary Management of Caudal Septal Deformities: An Algorithmic Approach · 2026 · DOI

  • Traditional training methods have limitations. There is a need for a cost-effective and reusable model for training in nasal endoscopic examination and artificial lacrimal duct intubation.

    Application of 3D-Printed nasal models in lacrimal surgery training · 2026 · DOI

  • There is a need for alternative methods to traditional nasal packing. The effectiveness of continuous through-suture of the nasal septum in improving postoperative quality of life is not well established.

    Clinical application and curative effects of continuous through-suture of the nasal septum for endoscopic septoplasty in randomised trials · 2026 · DOI

  • Furthermore, the exact in vivo persistence and behavior of the collagen membrane used in this study remain unknown, and early resorption or displacement after placement cannot be excluded. Further studies involving larger case numbers and comparative designs are warranted to better define the indications and potential utility of this approach.

    Adjunctive use of a collagen membrane for surgical closure of oronasal fistulae in dogs with challenging local conditions: a case series · 2026 · DOI

  • Observational studies in rhinology are vulnerable to confounding and bias. Prior work has not provided a comprehensive overview of propensity score methods for rhinologic research. There is a need for careful consideration of study design and variable selection in propensity score methods.

    Propensity Score Methods in Rhinologic Observational Research: Principles, Applications, Extensions, and Practical Considerations · 2026 · DOI

  • The factors influencing the outcomes of endoscopic dacryocystorhinostomy are unclear. Previous studies have identified several prognostic factors, but the current study aims to evaluate clinical factors associated with surgical success.

    Clinical Factors Affecting the Surgical Outcomes of Endoscopic Dacryocystorhinostomy · 2026 · DOI

  • Introduction Although nasal structural and functional changes after total laryngectomy (TL) have been documented, the influence of clinical variables and symptoms remains underexplored.

    Alterations in Nasal Function Following Total Laryngectomy and Their Clinical Correlates · 2026 · DOI

  • Only a few studies have analyzed nasal soft tissue morphology, actively involved in air-conditioning physiology.

    Beyond skeletal studies: A computational analysis of nasal airway function in climate adaptation · 2024 · DOI

  • The technique does not address internal septal deviation or improve nasal airflow. The technique is not suitable for patients with significant sagittal septal deviation.

    The Semi-columellar Strut Technique: Correction of Slight Sagittal Deviation of the Septum · 2026 · DOI

  • Anatomical variations in the nasal cavity and paranasal sinuses can impact postoperative satisfaction, - Limited data on the frequency of sinonasal anatomical variations in Iranian…

    Computed tomography-detected sinonasal anatomical variations in rhinoplasty candidates: a cross-sectional study · 2026 · DOI

  • Limited data on the frequency of sinonasal anatomical variations in Iranian populations, - Need for a comprehensive analysis of preoperative CT findings in rhinoplasty…

    Computed tomography-detected sinonasal anatomical variations in rhinoplasty candidates: a cross-sectional study · 2026 · DOI

  • The complex interplay of modifications to both the osseocartilaginous framework and the behavior of the overlying skin-soft tissue envelope - The need for a comprehensive framework for optimizing rhinoplasty…

    Skin and Soft Tissue Management in Primary Rhinoplasty · 2026 · DOI

  • The review identifies a need for a comprehensive framework for optimizing rhinoplasty outcomes through thoughtful SSTE…

    Skin and Soft Tissue Management in Primary Rhinoplasty · 2026 · DOI

  • Investigate the impact of CIS insertion on surgical outcomes in a prospective study - Examine the effect of allergic rhinitis on epiphora improvement in a larger cohort - Explore the role of adjunctive procedures in improving surgical…

    Clinical Factors Affecting the Surgical Outcomes of Endoscopic Dacryocystorhinostomy · 2026 · DOI

Most-cited papers in Nasal Surgery and Airway Studies

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Open questions raised by papers listed on this page include: (1) Patient‑specific factors, surgical techniques, and differences in subjective and psychophysical outcome measures likely contribute to variability in olfactory performance after surgery and are not yet fully understood (“Association of Nasal Anatomy, Airflow, and Surgery With Olfactory Outcomes: A…”, 2026); (2) Future studies are needed to clarify the impact of treating psychiatric disorders on postoperative outcomes following otolaryngology procedures (“Association of Depression and Anxiety With Postoperative Complications After…”, 2026); (3) There is a need for further research to improve the understanding of the causes and methods of prevention of beak-like deformity of the nose after rhinoplasty (“ORGAN-SAVING APPROACHES IN THE SURGICAL CORRECTION OF AESTHETIC DEFORMATIONS OF…”, 2026); (4) Human evidence is limited to a small number of uncontrolled LCR studies, while EMR has not yet been evaluated clinically for septoplasty (“From Conventional Septoplasty to Patient-Specific Cartilage Reshaping: A…”, 2026); (5) There is a need for a comprehensive review of septal anatomy, patient evaluation, and an updated algorithm for management of caudal septal deformities (“Contemporary Management of Caudal Septal Deformities: An Algorithmic Approach”, 2026). 243 gap statements have been mined from Nasal Surgery and Airway Studies papers in our 7.9M-paper local library, which holds 1,572 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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