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Open research questions in Ophthalmology and Visual Impairment Studies

347 unresolved questions extracted from the limitations and future-work sections of 1,225 Ophthalmology and Visual Impairment Studies papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The paper identifies a gap in the performance of SRK/T formula at low powers, particularly in plano and negative power IOLs. The study highlights the need for optimizing A-constants for SRK-T formula at low powers.

    Prediction error in low power intraocular lens in highly myopic eyes · 2026 · DOI

  • The study only included healthy volunteers with stable fixation. The study used a specific microperimetry device (MAIA). The study had a limited number of participants (25).

    How “Micro” Is Microperimetry? Characterizing the Effect of Fundus Tracking on the Psychometric Function · 2026 · DOI

  • Investigating the effect of fundus tracking on microperimetry in patients with fixation instability. Comparing the performance of different microperimetry devices. Examining the relationship between fundus tracking and other factors that affect microperimetry outcomes.

    How “Micro” Is Microperimetry? Characterizing the Effect of Fundus Tracking on the Psychometric Function · 2026 · DOI

  • Investigate the repeatability of slope parameters, - Explore relationships between the various tests, - Examine the effectiveness of the AIM and FInD paradigms in clinical settings

    Repeatability and behavioral relationships of acuity, contrast sensitivity, form, and motion perception measurements using a novel tablet-based vision test tool · 2026 · DOI

  • Current visual function tests have limitations, including restricted range and coarse diagnostic resolution. There is a need for more comprehensive and precise visual function tests.

    Repeatability and behavioral relationships of acuity, contrast sensitivity, form, and motion perception measurements using a novel tablet-based vision test tool · 2026 · DOI

  • The data will not represent the full burden of visual impairment due to several likely confounders. The study identifies a gap in understanding the trends in visual impairment certifications.

    Visual impairment certifications in England over 16 years: annual numbers attributable to age-related macular degeneration, glaucoma, diabetes and hereditary eye disease · 2026 · DOI

  • Further studies are needed to confirm the findings in other populations. Long-term follow-up studies are needed to evaluate the stability of ICL sizing using CBID.

    Investigation of ciliary body inner diameter in Chinese myopic adults using ArcScan Insight® 100 · 2026 · DOI

  • The gap is the lack of accurate characterization of ciliary body inner diameter in Chinese myopic adults. The gap is the need to assess the influence of ciliary body inner diameter on Implantable Collamer Lens size recommendations.

    Investigation of ciliary body inner diameter in Chinese myopic adults using ArcScan Insight® 100 · 2026 · DOI

  • The paper identifies technical challenges, such as the risk of uncontrolled polymerisation and optical distortion, associated with the use of the light-adjustable lens. The authors also note the importance of patient compliance with postoperative UV protection and the need for careful management of patients choosing this technology.

    The adjustability-related adverse events of the light-adjustable lens · 2026 · DOI

  • Further case reports of similar lens material-related adverse events are warranted - Research on optical materials is essential to provide better refractive results and management of patients

    The adjustability-related adverse events of the light-adjustable lens · 2026 · DOI

  • Limited evidence on the effectiveness of interventions to reduce access inequities to eye health screening and treatment for vulnerable groups. Health inequities result in a greater disease burden on certain populations. The need for effective interventions to reduce access inequities and improve eye health outcomes.

    Eye care interventions that reduce access inequities for women, rural residents and older people in low-middle-income countries: a scoping review · 2025 · DOI

  • Future research should focus on hybrid models combining multiple techniques and developing standardized protocols for better clinical outcomes.

    Methods of Determining the Amount of Prism Prescription in Heterophoria · 2026 · DOI

  • Quantitative parameters derived from color fundus photography (CFP) may capture subtle structural and microvascular features relevant to axial length (AL) progression, yet their predictive value remains insufficiently characterized.

    Quantitative color fundus photography parameters as potential biomarkers of axial length progression: evidence from a machine learning cohort study · 2026 · DOI

  • White Without Pressure (WWOP) is a common but under-recognized peripheral retinal finding associated with myopia-related complications, yet its objective assessment remains challenging.

    Development and application of an artificial intelligence-based quantitative system for white without pressure in myopic retinopathy · 2026 · DOI

  • While clinical outcomes have been well-documented, little is known about the lived experiences of families navigating this condition, particularly in middle-income countries.

    In their eyes: parental experiences navigating pediatric glaucoma diagnosis, treatment, and care in Turkey — a qualitative study · 2025 · DOI

  • However, school-level AI models for predicting myopia onset in non-myopic children are lacking.

    School-level prediction and management of myopia in children and adolescents · 2025 · DOI

  • Conclusion This study reveals critical gaps in knowledge and diverse attitudes toward myopia management among participants, highlighting the need for targeted educational interventions.

    Assessment of the level of knowledge, attitude, and preference for myopia management among patients and university students in Trinidad · 2025 · DOI

  • BACKGROUND: Visual impairment is associated with cognitive dysfunction in older adults; however, a relationship between stereopsis and cognitive function remains unclear.

    The association between stereoscopic vision and cognitive function on community-dwelling older adults: a cross-sectional study · 2025 · DOI

  • BACKGROUND: Few studies have examined the association between visual and hearing impairments with all-cause mortality, with inconsistent findings.

    Association of visual and hearing impairments with all-cause mortality in older adults in China · 2025 · DOI

  • The specific backgrounds and characteristics of target participants and the combination of AR with other pedagogical approaches warrant further investigation to maximize the impact of AR-based workshops in health education in broader healthcare contexts.

    The interactive use of augmented reality for educating the elderly on common age-related eye disease · 2025 · DOI

  • CONCLUSIONS: The literature on vision screening in this population was sparse and there was heterogeneity in current practices, highlighting the need for standardised screening protocols.

    Vision screening in older adults who attend hospital following a fall: a scoping review · 2025 · DOI

  • Importance: The association of digital screen time with myopia has been documented, but the dose-response association and safe exposure threshold remain unclear.

    Digital Screen Time and Myopia · 2025 · DOI

  • Further research on adjusting intervention strategies is therefore needed to eliminate preventable visual impairments.

    Prevalence and association of uncorrected refractive error among Chinese adolescents: a cross-sectional study · 2024 · DOI

  • Results: Despite far-reaching examination, the relationship between these factors and myopia control remains inconclusive with varying degrees of evidence supporting their roles.

    Interdependence of Nutrition, Physical Activity, and Myopia · 2024 · DOI

  • The impact of diet and lifestyle on the progression of myopia is still not fully understood.

    Interdependence of Nutrition, Physical Activity, and Myopia · 2024 · DOI

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347 open questions have been extracted from the limitations and future-work passages of 1,225 Ophthalmology and Visual Impairment Studies papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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