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Open research questions in Oral health in cancer treatment

258 gap statements mined from Oral health in cancer treatment papers in our 7.9M-paper local library, which holds 1,651 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • Lack of a standardized framework for reporting radiation dose metrics. Limited understanding of the relationship between radiation dose and implant outcomes.

    Beyond Prescription Dose: Implant-Site Radiation Dosimetry and Clinical Outcomes of Dental Implants Placed After Head and Neck Radiotherapy—A Systematic Review and Proposed Dosimetric Framework · 2026 · DOI

  • The use of real-world data may be subject to biases and limitations. The study had to balance the need for a large sample size with the potential for confounding variables and selection bias.

    Semaglutide Exposure and Risk of Oral Mucositis, Systemic Complications, and Mortality Among Patients with a History of Hematopoietic Stem-Cell Transplantation: A Propensity-Matched Real-World Cohort Study · 2026 · DOI

  • Effective pharmacologic strategies to reduce the incidence or severity of oral mucositis remain limited. The relationship between semaglutide and oral mucositis after transplantation is undefined.

    Semaglutide Exposure and Risk of Oral Mucositis, Systemic Complications, and Mortality Among Patients with a History of Hematopoietic Stem-Cell Transplantation: A Propensity-Matched Real-World Cohort Study · 2026 · DOI

  • The lack of understanding of the correlation between pediatric leukemia and gingivo-periodontal alterations. The need to evaluate the oral health status of children and adolescents with leukemia. The importance of analyzing inflammatory biomarkers in gingival crevicular fluid and plasma.

    Gingivo-Periodontal Alterations in Pediatric Leukemia: A Comparative Analysis of IL-1β, IL-6, IL-17α and TGF-β1 Levels in Gingival Crevicular Fluid and Plasma · 2025 · DOI

  • Future studies and longer follow-up are warranted to define dose-response relationships in dysgeusia.

    Time Course and Determinants of Acute Dysgeusia in Patients Receiving Head and Neck Radiation Therapy · 2026 · DOI

  • There is some inconsistent evidence for mucosal-protective and tissue-repair agents, and it is important to differentiate between symptom relief and improvement of mucosal function.

    Management of Oral Mucositis Induced by Cancer Therapy: A Review of Pharmacological Prevention and Treatment · 2026 · DOI

  • There is a lack of confidence and knowledge among parents regarding oral health care for children with cancer. Oral health is frequently overlooked during cancer treatment.

    The parents voice on oral health care from two paediatric oncology units · 2026 · DOI

  • The questionnaire did not collect respondent profile or family sociodemographic data related to gender, age, parental education, and income. Future research in paediatric oncology oral health should systematically assess how sociodemographic variables and access to dental services in predominantly private healthcare systems influence parental oral health practices and oral complication outcomes.

    The parents voice on oral health care from two paediatric oncology units · 2026 · DOI

  • This proposed protocol is repeatable and testable and provides opportunities for future research concerning clinical effectiveness and feasibility. Protocol for Integrating MOG and Jaw Exercises Rest position of the tongue (6x6 #1): Repeated upward tongue positioning on the anterior one-third roof of the mouth area while performing slow diaphragmatic breathing.

    A Standardized Protocol for Enhancing Oral Appliance Therapy: Integrating Morning Occlusal Guide and Jaw Exercises · 2026 · DOI

  • There is a need for effective treatments for radiation-induced bone damage. The radioprotective effects of ascorbic acid and telmisartan on gamma-irradiated mandibular bone in rats are not well understood.

    Comparative radioprotective effects of ascorbic acid and telmisartan, alone and in combination, on gamma-irradiated mandibular bone: an experimental rat study · 2026 · DOI

  • Further studies with PCM-based approaches are warranted. Studies to evaluate the long-term efficacy and safety of the intraoral device are needed.

    Safety and Efficacy of an Led-Based Intraoral Device for Daily Photobiomodulation Therapy Prior to Radiation Treatment in Reducing Severity of Oral Mucositis in Head and Neck Cancer Patients · 2026 · DOI

  • The number and complexity of inclusion criteria limited the number of potentially eligible patients. Logistical challenges, such as avoiding public transport during the COVID-19 pandemic, were significant barriers.

    Acupuncture for chemotherapy-induced dysgeusia (AcuDysg): a randomized controlled trial · 2026 · DOI

  • There is a lack of effective treatments for chemotherapy-induced dysgeusia. The underlying mechanisms of chemotherapy-induced dysgeusia are not fully understood.

    Acupuncture for chemotherapy-induced dysgeusia (AcuDysg): a randomized controlled trial · 2026 · DOI

  • The study faced challenges due to the limited sample size. The research had to account for the complex interactions between different cells in the mucosa.

    Mucositis bucal en leucemia aguda: Efecto aditivo de la neutropenia y el tratamiento cistostático · 2026 · DOI

  • The study has a limited sample size of 46 patients. The research only includes patients with specific types of acute leukemia.

    Mucositis bucal en leucemia aguda: Efecto aditivo de la neutropenia y el tratamiento cistostático · 2026 · DOI

  • There is a need for effective treatments to prevent mucositis in chemotherapy patients. The therapeutic potential of probiotics in preventing mucositis is not fully understood.

    Comparative preventive effects of probiotic and postbiotic preparations of Lacticaseibacillus rhamnosus L156.4 and GG in a 5-FU-induced mucositis model · 2026 · DOI

  • There is a need for further research on the application of low-level laser therapy for oral mucositis. The current literature lacks a comprehensive review of the topic.

    OS BENEFÍCIOS DA LASERTERAPIA DE BAIXA POTÊNCIA NO TRATAMENTO DE PACIENTES ONCOLÓGICOS PORTADORES DE MUCOSITE ORAL: UMA REVISÃO DE LITERATURA · 2026 · DOI

  • There is little data on the efficacy of Rocabado procedures in patients with post-operative buccal mucosa cancer. The study aims to fill this gap by assessing the efficacy of Rocabado procedures in conjunction with traditional physiotherapy.

    Effectiveness of Rocabado Techniques and Conservative Treatment in Post?Operative Buccal Mucosa Carcinoma Patients: A Randomized Controlled Trial · 2026 · DOI

  • Given that this study is among the first to specifically address the oral implications of this emerging therapeutic modality, further research is warranted to strengthen and expand the current evidence base and to support the development of standardized oral care protocols for patients undergoing CAR-T therapy.

    Oral manifestations and dental management in patients undergoing CAR-T cell therapy: a retrospective observational study · 2026 · DOI

  • Effective supportive management of oral mucositis remains an unresolved clinical priority. Single-ingredient treatments often fall short due to the multiple biological processes driving the condition.

    Formulation and In Vitro Evaluation of a Novel Synergistic Propolis– Curcumin Mouthwash for Oral Mucositis: Anti-Inflammatory, Antimicrobial, Antioxidant, and Cytotoxicity Assessment · 2026 · DOI

  • The study has a small sample size. Further studies with larger sample sizes are needed to better understand the oral health of Hepatit C virus infection patients.

    Evaluating the Effects of Cigarette Smoking and Heated Tobacco Products on the Oral Mucosa and Periodontium in Patients with Hepatit C virus in Armenia: A Pilot Study · 2026 · DOI

  • There is a lack of studies examining the effects of heated tobacco products on oral health. There is a need for further research on the oral health of patients with hepatit C virus infection.

    Evaluating the Effects of Cigarette Smoking and Heated Tobacco Products on the Oral Mucosa and Periodontium in Patients with Hepatit C virus in Armenia: A Pilot Study · 2026 · DOI

  • The study used a rat model, which may not directly translate to human periodontitis. The sample size was limited to 72 rats. The study only examined the effects of radiotherapy on periodontal tissues at specific time points.

    Histological Evaluation of Radiotherapy-Induced Changes in Periodontal Tissues in a Rat Model of Experimental Periodontitis · 2026 · DOI

  • Further analysis of the differences between the groups using the Tamhane T2 post hoc test, - Application of ANOVA method to determine causal…

    Gingivo-Periodontal Alterations in Pediatric Leukemia: A Comparative Analysis of IL-1β, IL-6, IL-17α and TGF-β1 Levels in Gingival Crevicular Fluid and Plasma · 2025 · DOI

  • The study identifies a gap in understanding the effects of radiotherapy on periodontal tissues in the presence of pre-existing inflammation. The study aims to fill this gap by evaluating radiotherapy-induced changes in periodontal tissues in a rat model of experimental periodontitis.

    Histological Evaluation of Radiotherapy-Induced Changes in Periodontal Tissues in a Rat Model of Experimental Periodontitis · 2026 · DOI

Most-cited papers in Oral health in cancer treatment

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Open questions raised by papers listed on this page include: (1) Lack of a standardized framework for reporting radiation dose metrics (“Beyond Prescription Dose: Implant-Site Radiation Dosimetry and Clinical…”, 2026); (2) Effective pharmacologic strategies to reduce the incidence or severity of oral mucositis remain limited (“Semaglutide Exposure and Risk of Oral Mucositis, Systemic Complications, and…”, 2026); (3) Future studies and longer follow-up are warranted to define dose-response relationships in dysgeusia (“Time Course and Determinants of Acute Dysgeusia in Patients Receiving Head and…”, 2026); (4) There is a lack of confidence and knowledge among parents regarding oral health care for children with cancer (“The parents voice on oral health care from two paediatric oncology units”, 2026); (5) There is a need for effective treatments for radiation-induced bone damage (“Comparative radioprotective effects of ascorbic acid and telmisartan, alone and…”, 2026). 258 gap statements have been mined from Oral health in cancer treatment papers in our 7.9M-paper local library, which holds 1,651 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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