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Open research questions in Parathyroid Disorders and Treatments

144 unresolved questions extracted from the limitations and future-work sections of 504 Parathyroid Disorders and Treatments papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • further studies are needed to confirm the findings, - research on the long-term outcomes of MIP

    Pitfalls of minimally invasive parathyroidectomy for the treatment of primary hyperparathyroidism · 2026 · DOI

  • Prior work has not fully identified risk factors associated with failure of minimally invasive parathyroidectomy. The current study aims to fill this gap by analyzing demographic, intraoperative, and postoperative variables.

    Pitfalls of minimally invasive parathyroidectomy for the treatment of primary hyperparathyroidism · 2026 · DOI

  • Further studies are needed to confirm the findings, - Research on the cost-effectiveness of FCH-PET/CT is required, - Investigation of FCH-PET/CT in patients with secondary hyperparathyroidism

    Conventional imaging techniques plus 18F-Fluorocholine PET/CT: a comparative study of diagnostic accuracy in localizing parathyroid adenomas in primary hyperparathyroidism · 2025 · DOI

  • The localization accuracy of US and MIBI can be as low as <50% in the presence of multiglandular parathyroid disease, small glands or multinodular goiter. There is a need for a more effective technique for preoperative localization of parathyroid adenomas. FCH-PET/CT is a promising technique, but its effectiveness needs to be evaluated.

    Conventional imaging techniques plus 18F-Fluorocholine PET/CT: a comparative study of diagnostic accuracy in localizing parathyroid adenomas in primary hyperparathyroidism · 2025 · DOI

  • Traditional BTM do not reflect osteocyte function - The lack of a standardized method and test units for RANKL and OPG measurements - Discrepancies between findings have revealed the unsatisfactory reproducibility of RANKL and OPG measurements - Further standardization of the RANKL/OPG ratio is needed

    Novel aspects of biochemical assessment of bone remodeling and mineralization · 2025 · DOI

  • New methods are being explored, including Multiplex electrochemical detection techniques - The application of omics techniques in bone remodeling assessment - Standardization of the RANKL/OPG ratio

    Novel aspects of biochemical assessment of bone remodeling and mineralization · 2025 · DOI

  • Routine biochemical and BMD surveillance, with a particular focus on phosphate control, is warranted in this high-risk population.

    Prevalence of Bone Mineral Disorders in Hemodialysis Patients: A Prospective Observational Study from a Tertiary Care Hospital in South India · 2026 · DOI

  • However, its relationship with severe abdominal aortic calcification (SAAC) remains poorly understood.

    Association between life’s crucial 9 and severe abdominal aortic calcification in U.S. Adults: the mediating role of the systemic inflammatory response index · 2025 · DOI

  • However, the precise relationship between the NLR and vascular calcification remains unclear.

    Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States · 2025 · DOI

  • Objectives Intrauterine growth restriction (IUGR) significantly affects neonatal development, but its pathogenesis is not fully understood.

    Expression and clinical significance of Klotho protein in serum, umbilical cord blood, and placenta of pregnant women with intrauterine growth restriction · 2025 · DOI

  • Objectives: Chronic kidney disease (CKD) and osteoporosis (OP) frequently coexist, yet their shared molecular pathogenesis remains incompletely characterized.

    Identification of shared lactylation-related gene signatures between osteoporosis and chronic kidney disease · 2025 · DOI

  • BACKGROUND: Although evidence for exercise-induced changes in neurocognitive biomarkers is emerging, research examining acute responses to different exercise regimes across sex and age is lacking.

    Acute effects of a single bout of high-intensity strength and endurance exercise on cognitive biomarkers in young adults and elderly men: a within-subjects crossover study · 2025 · DOI

  • Although old age and preexisting medical conditions have been identified as principal risk factors for COVID-19-associated AKI, the molecular basis behind such a connection remains unknown.

    Klotho-derived peptide KP1 ameliorates SARS-CoV-2-associated acute kidney injury · 2024 · DOI

  • Currently, data on the relationship of BUN levels with the risk of diabetes mellitus (DM) in Chinese adults are sparse.

    Association between blood urea nitrogen levels and the risk of diabetes mellitus in Chinese adults: secondary analysis based on a multicenter, retrospective cohort study · 2024 · DOI

  • However, in critically ill patients with coronary heart disease (CHD) accompanied by chronic kidney disease (CKD), the prognostic value of serum phosphate remains unclear.

    Correlation between serum phosphate and all-cause mortality in critically ill patients with coronary heart disease accompanied by chronic kidney disease: a retrospective study using the MIMIC-IV database · 2024 · DOI

  • Background Despite the essential role of ectopic osteogenic calcium-phosphate metabolism in the development of calcific aortic valve disease (CAVD), the implications of high serum phosphate levels in CAVD development are not fully understood.

    Higher serum phosphate within the normal range is associated with the development of calcified aortic valve disease · 2024 · DOI

  • It remains unclear whether nephrocalcinosis occurs in patients now treated with burosumab.

    X-linked hypophosphatemic rickets and nephrocalcinosis: clinical characteristics of a single-center pediatric cohort in North America before and after burosumab · 2024 · DOI

  • This combination of gene variants has not been previously reported in the literature.

    Family analysis and literature study of hereditary hypophosphatemic rickets with hypercalciuria · 2024 · DOI

  • Although protein-restricted diets, especially when supplemented with keto-analogues and highly personalized and monitored, do not appear to be associated with malnutrition, research on their effects on bone and mineral disorders is scarce, deserving further investigation.

    Low-Protein Diets, Malnutrition, and Bone Metabolism in Chronic Kidney Disease · 2024 · DOI

  • BRCA1/BRCA2-containing complex subunit 36 (BRCC36) has been implicated in osteoblast osteogenic conversion; however, its specific role in VC remains to be fully elucidated.

    BRCC36 regulates β-catenin ubiquitination to alleviate vascular calcification in chronic kidney disease · 2024 · DOI

  • The pathophysiological mechanisms linking chronic kidney disease to parathyroid carcinoma remain an area of ongoing research. The diagnosis of parathyroid carcinoma remains clinically challenging due to its rarity and overlap with benign parathyroid lesions.

    A patient with CKD complicated by secondary hyperparathyroidism and parathyroid carcinoma: a case report · 2026 · DOI

  • Hyperphosphatemia is a persistent challenge in chronic kidney disease management. Phosphorus control remains suboptimal despite clinical attention. Elderly patients face unique barriers to effective phosphorus management.

    Phosphorus management behaviors in elderly patients with chronic kidney disease: a comparison between pre-dialysis and hemodialysis stages · 2026 · DOI

  • The behavioral determinants of phosphorus control have received limited attention. There is a lack of understanding of the factors associated with adequate phosphorus management in elderly patients with chronic kidney disease.

    Phosphorus management behaviors in elderly patients with chronic kidney disease: a comparison between pre-dialysis and hemodialysis stages · 2026 · DOI

  • The efficacy of SSTR-directed PET/CT in localizing PMT in patients with suspected TIO is not well established. There is a need for a diagnostic tool that can accurately distinguish between PMT and fractures.

    Diagnostic Performance of Somatostatin Receptor-directed PET/CT for Tumor-induced Osteomalacia · 2026 · DOI

  • Despite the promising results, our study has several limitations. Given the retrospective study design, CT acquisition protocols were not uniform, leading to minor heterogeneity in imaging analysis. Tumor volume was delineated using a 40% isocontour threshold.

    Diagnostic Performance of Somatostatin Receptor-directed PET/CT for Tumor-induced Osteomalacia · 2026 · DOI

Most-cited papers in Parathyroid Disorders and Treatments

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144 open questions have been extracted from the limitations and future-work passages of 504 Parathyroid Disorders and Treatments papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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