Science AI Journal
Medicine · Research topic

Open research questions in Parathyroid Disorders and Treatments

26 unresolved questions extracted from the limitations and future-work sections of 384 Parathyroid Disorders and Treatments papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Abstract Background Existing studies have focused on secondary hyperparathyroidism with elevated PTH in CKD, but survival outcomes of CKD patients with low PTH remain underexplored.

    Prognosis comparison in chronic kidney disease stages 4–5 patients with low parathyroid hormone level due to different causes · 2026 · DOI

  • Third, the absence of high-sensitivity imaging such as ¹⁸F-fluorocholine PET/CT repre- sents a major limitation. Consequently, the reported 0% RLN injury rate should be interpreted with caution because routine postoperative laryngoscopy was not performed; transient or subclin- ical nerve dysfunction may have been underreported.

    A novel optimized surgical strategy for secondary hyperparathyroidism: clean parathyroidectomy combined with autotransplantation and its clinical analysis · 2026 · DOI

  • Conclusion In addition to the comparable control of serum calcium and serum phosphorus levels to conventional therapy, limited data indicate that PTH analogs treatment may be better in regulating the serum vitamin D and maintaining the eGFR for patients with HypoPTH.

    Efficacy and safety of parathyroid hormone analogs therapy on hypoparathyroidism: a meta-analysis · 2026 · DOI

  • Although routine IOPTH use in concordantly localized single-gland disease remains debated, evidence suggests it reduces persistent disease and reoperation rates, particularly when imaging is inconclusive.

    Primary hyperparathyroidism: targeted, focused exploration with “selective” parathyroidectomy · 2026 · DOI

  • Hypophosphatemia may serve as an early predictor of ICANS, warranting further study of phosphate correction as a preventive strategy and potentially a predictor marker.

    Hypophosphatemia as a Marker for Immune Effector Cell-Associated Neurotoxicity Syndrome in Chimeric Antigen Receptor T Cell Recipients · 2026 · DOI

  • We showed that BMS-204352’s anti-metastatic effect requires T-lymphocytes, but our data does not rule out contributions from other cells of the tumor microenvironment, such as macrophages and fibroblasts or from activation of the inflammasome complex by enhanced K+ efflux.81 Furthermore, BMS-204352 can have off-target effects on KCNQ2 channels, which are expressed by the peripheral blood mononuclear cells in certain pathological conditions and changing K+ efflux in these cells can also alter metastatic colonization.82,83 Finally, ion flux independent functions of the KCNMB1E65K gain-of-function mutant may also contribute to regulation of cancer cell stiffness, for example, through changing protein-protein interactions of BK channels, since iberiotoxin treatment did not fully reduce Dev Cell. Author manuscript; available in PMC 2026 June 05. A u t h o r M a n u s c r i p t A u t h o r M a n u s c r i p t A u t h o r M a n u s c r i p t A u t h o r M a n u s c r i p t Gajda et al.

    Ionic regulation of cancer cell stiffness and metastatic colonization via the MRTFA-KCNMB1 axis · 2026 · DOI

  • A limitation of this study is the absence of a stan- dardized imaging protocol, particularly for MRI, CT, SPECT-CT, and scintigraphic examinations.

    Preoperative imaging strategies to optimize surgical treatment in primary hyperparathyroidism (pHPT) · 2026 · DOI

  • Despite the promising results, our study has several limitations. Given the retrospective study design, CT acquisition protocols were not uniform, leading to minor heterogeneity in imaging analysis. Tumor volume was delineated using a 40% isocontour threshold.

    Diagnostic Performance of Somatostatin Receptor-directed PET/CT for Tumor-induced Osteomalacia · 2026 · DOI

  • The first preoperative localization studies, surgical notes, operation drawings, if any, intraoperative PTH results, pathological results, and post-operative biochemical results of these patients should be examined.

    Persistent and Recurrent Primary Hyperparathyroidism: Etiological Factors and Preoperative Evaluation · 2023 · DOI

  • While hypercalcemia is one of the complications of various types of cancerous diseases, it has not been reported still as the first presentation of the coexistence of RCC and DLBCL.

    The coexistence of renal cell carcinoma and diffuse large B-cell lymphoma with hypercalcemic crisis as the initial presentation · 2014 · DOI

  • However, it is clear that the PTH/Vitamin D axis does not account for the entire picture, and a new bone-renal metabolic milieu has emerged, implicating a novel set of matrix proteins, hormones, and Zn-metallopeptidases.

    T<scp>he</scp> W<scp>rickkened</scp> P<scp>athways of</scp> FGF23, MEPE <scp>and</scp> PHEX · 2004 · DOI

  • overcome that remodelling and systemic outputs. in order to bridge We only considered osteoclastic resorption and osteoblastic turnover the only bone formation.

    The interrelationship between calcium-phosphorus homeostasis and bone remodelling. Impact of dietary changes on bone in patients with primary hyperparathyroidism and chronic kidney disease · 2026 · DOI

  • 1,3) Secondary tumoral calcinosis has rarely been reported in patients with chronic renal failure before the initiation of di- alysis, and most cases occur in patients already undergoing dialysis.

    A Case of Tumoral Calcinosis at Cervical Muscles · 2026 · DOI

  • In XLH, both OLF and OPLL are likely manifestations of heterotopic ossification, although the underlying mechanisms remain unclear.

    X-linked hypophosphatemia and spinal cord compression: a systematic review and illustrative case · 2026 · DOI

  • These disorders, known as renal osteodystrophy, vary widely and are classified into secondary hyperparathyroidism, adynamic bone, and osteomalacia based on bone turnover.

    Bilateral Olecranon and Left Lesser Trochanter Avulsion Fractures in Renal Osteodystrophy: A Rare Case Report and Comprehensive Review · 2025 · DOI

  • We present a case of simultaneous avulsion fractures in the left lesser trochanter and bilateral olecranon processes secondary to minor trauma in a young patient with End Stage Renal Disease, which has not been previously reported, and review the literature.

    Bilateral Olecranon and Left Lesser Trochanter Avulsion Fractures in Renal Osteodystrophy: A Rare Case Report and Comprehensive Review · 2025 · DOI

  • Whether it is necessary to continue with other imaging techniques as typically seen in primary hyperparathyroidism is still an open issue, and so is the panel of indications to perform its surgical removal instead of serial follow-up.

    Parathyroid adenoma versus primary hyperparathyroidism · 2021 · DOI

Most-cited papers in Parathyroid Disorders and Treatments

Most recent work

Find a gap in your own Parathyroid Disorders and Treatments sub-topic

This page shows what the Parathyroid Disorders and Treatments literature already flags as unresolved. To narrow it to your specific question, run the guided finder — it searches the gap library on demand and checks candidates against 250M+ OpenAlex works.

Open the Research Gap Finder →

Related topics in Medicine

Substance Abuse Treatment and Outcomes
989 open questions
Artificial Intelligence in Healthcare and Education
607 open questions
Attention Deficit Hyperactivity Disorder
448 open questions
Physical Activity and Health
436 open questions
Smoking Behavior and Cessation
402 open questions
Innovations in Medical Education
364 open questions
Dementia and Cognitive Impairment Research
363 open questions
HIV/AIDS Research and Interventions
342 open questions
26 open questions have been extracted from the limitations and future-work passages of 384 Parathyroid Disorders and Treatments papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 120,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? A Tier 1–5 acceptance probability in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck prior-publication & salami-slicing risk across 8 sources.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.