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Open research questions in Pediatric Pain Management Techniques

154 unresolved questions extracted from the limitations and future-work sections of 799 Pediatric Pain Management Techniques papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Further research is needed to evaluate the HRS with a larger and more diverse sample, - Research should investigate the long-term effects of the HRS on user engagement

    Impact of coping profiles on social identity in a youth chronic pain recommender system: qualitative descriptive study · 2026 · DOI

  • The study identifies a gap in the existing literature on the application of health recommender systems in pediatric chronic pain management. The study highlights the need for accessible, personalized digital health support for pediatric chronic pain patients.

    Impact of coping profiles on social identity in a youth chronic pain recommender system: qualitative descriptive study · 2026 · DOI

  • The co-occurrence of mental and physical conditions, such as pain, is often overlooked in the treatment of mental ill-health. There is a need for further understanding of the etiology of mental ill-health disorders and barriers and facilitators to recovery. The study aims to address this gap by estimating the longitudinal association between pain characteristics and clinical outcomes in young people with mental ill-health.

    Estimating the longitudinal association between pain characteristics and clinical outcomes in young people with mental ill-health · 2025 · DOI

  • The study had a small sample size. The study was conducted in a single French university hospital ED. The study had a limited time frame of 3 months. The study did not account for other potential factors that may influence IV morphine prescription.

    Severe pain management in the emergency department: patient pathway as a new factor associated with IV morphine prescription · 2024 · DOI

  • Further studies are needed to investigate the impact of organizational factors on IV morphine prescription. Research should be conducted to identify other factors that may influence IV morphine prescription. Studies should be done to develop more effective strategies for managing acute pain in EDs.

    Severe pain management in the emergency department: patient pathway as a new factor associated with IV morphine prescription · 2024 · DOI

  • Their developmental origins, particularly before menarche, remain poorly understood.

    Somatic Symptoms Before Menarche: The Role of Parents and Pain Sensitivity · 2026 · DOI

  • Few studies have focused on the stress experiences of teens with diverse CHCs who are in one developmental stage, including the stressors they experience and their impact on teens' lives more broadly.

    Exploring Shared Stress Experiences Among Teens With Chronic Health Conditions · 2026 · DOI

  • Little is known about their recovery experience, including pain trajectory, pain treatment, and prolonged opioid use.

    Adolescent Surgery Experience (ASE) Prospective Cohort Study: Postoperative Pain Trajectory, Opioid Use, and Satisfaction · 2026 · DOI

  • Overall, neonatal pain management and sedation encounter gaps in evidence and practice, emphasizing the need for standardization, improved personalized approaches based on pharmacokinetic and pharmacodynamic maturation, multimodal strategies to minimize opioid and benzodiazepine exposure, and rigorous studies of new therapies to ensure safe, effective, and equitable care for newborns.

    Pharmacological therapy of neonatal analgosedation: current status, dilemmas, and perspectives · 2026 · DOI

  • Background Preterm infants are frequently exposed to painful procedures during neonatal intensive care, yet their physiological capacity to respond to pain and the reliability of related biomarkers remain incompletely understood.

    Physiological correlates of pain in preterm infants: evidence from a meta-analytic approach · 2026 · DOI

  • Few studies have delivered pain education to schoolchildren, and none have considered their preferences for learning about pain.

    Adolescents’ understanding of pain and their preferences for learning about pain at school: a cross-sectional survey · 2026 · DOI

  • Virtual Reality Exposure-Based Therapy has shown promise as an effective and accessible intervention for anxiety disorders but remains under-explored.

    Virtual reality delivered exposure for fear of needles: a small-scale pilot · 2025 · DOI

  • Future research should investigate long-term impacts, applicability across diverse populations, and comparative efficacy in various clinical settings.

    Play dough or balloon blowing? A clinical trial comparing creative interventions for reducing preoperative anxiety in children aged 4–8 years · 2025 · DOI

  • OBJECTIVES: Pain and anxiety are not limited to a certain age group; however, their thresholds are closely correlated with age, and they can cause irreversible mental disorders in children.

    Comparative efficacy of virtual reality headset and auditory distraction for reducing anxiety and pain during inferior alveolar nerve block in 7–10-year-old children: a clinical trial · 2025 · DOI

  • Little is known concerning how these co-occurring symptoms are associated with adolescent functioning.

    The impact of co-occurring chronic pain and mental health symptoms on adolescent functioning, a cross-sectional survey · 2024 · DOI

  • Future research is needed to develop standardised assessment and treatment plans to facilitate a thorough understanding of symptoms presented by adolescents who experience co-occurring pain and mental health symptoms.

    The impact of co-occurring chronic pain and mental health symptoms on adolescent functioning, a cross-sectional survey · 2024 · DOI

  • Future investigation is warranted to determine if preferential use of non-opioid therapy for pain control can reduce acute healthcare costs in this population.

    Impact of chronic opioid use on acute health care utilization in children with IBD and arthritis: a retrospective cohort study · 2024 · DOI

  • The developmental neural mechanisms of multisite pain are unclear. There is a lack of understanding of the relation between cortical brain structure and multisite pain in adolescents. Sex differences in nociplastic pain conditions emerge during adolescence, but the underlying mechanisms are not well understood.

    Cortical thickness, surface area, and multisite pain: distinct patterns by sex in adolescence · 2026 · DOI

  • The study faced challenges in terms of small sample size and lack of control group. The study also faced challenges in terms of patient recruitment and retention. The use of immersive VR technology also presented technical challenges.

    Combining Virtual Reality and Cognitive Behavioral Principles in Treating Long-term Pain: A Feasibility Study · 2026 · DOI

  • Controlled trials are needed to explore the efficacy of immersive VR in managing long-term pain. Further research is needed to develop and refine immersive VR interventions for managing long-term pain. The study highlights the need for more research on the clinical impact of immersive VR on patient outcomes.

    Combining Virtual Reality and Cognitive Behavioral Principles in Treating Long-term Pain: A Feasibility Study · 2026 · DOI

  • There is a lack of research on the use of virtual reality in pediatric oncology for pain and anxiety relief. The study aims to address this gap by evaluating the effect of virtual reality on preconsultation anxiety and pain in children with cancer.

    Preconsultation Anxiety and Pain during Blood Collection: Impact of Virtual Reality in Children with Cancer – Randomized Clinical Trial · 2026 · DOI

  • To use more rigorous, mechanism-driven designs that combine objective physiological metrics with subjective assessments. To consider a more balanced control group, for example, using standard screens to present the same animated video content as the VR group. To elaborate on the missing data handling strategy in the protocol.

    How Can the Sedative and Analgesic Effects of Virtual Reality Technology Be More Precisely Assessed in Pediatric Dental Care? Methodological Insights from an Ongoing Randomized Controlled Trial [Letter] · 2026 · DOI

  • The lack of rigorous methodological designs in the current trial protocol. The omission of anxiety assessment at certain time points. The imbalance in non-specific psychological effects between the intervention and control groups.

    How Can the Sedative and Analgesic Effects of Virtual Reality Technology Be More Precisely Assessed in Pediatric Dental Care? Methodological Insights from an Ongoing Randomized Controlled Trial [Letter] · 2026 · DOI

  • Acute pain is a significant problem in African hospitals, with limited resources and infrastructure to address this issue. There is a lack of data on the prevalence and severity of acute pain in African hospitals, making it difficult to develop effective pain management strategies.

    One in seven has severe pain: A point-prevalence study of hospitalised patients across Africa · 2026 · DOI

  • There is a lack of data on the prevalence and severity of acute pain in African hospitals. Prior studies on acute pain have been conducted in high-income countries, limiting their applicability to low-resource settings.

    One in seven has severe pain: A point-prevalence study of hospitalised patients across Africa · 2026 · DOI

Most-cited papers in Pediatric Pain Management Techniques

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154 open questions have been extracted from the limitations and future-work passages of 799 Pediatric Pain Management Techniques papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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