Science AI Journal
Medicine · Research topic

Open research questions in Peripheral Artery Disease Management

349 gap statements mined from Peripheral Artery Disease Management papers in our 7.9M-paper local library, which holds 2,043 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

Choosing where to publish on Peripheral Artery Disease Management? See the ranked Medicine journals.

What the literature leaves open

  • The current literature lacks comprehensive data on the outcomes of kissing stenting for TASC C/D lesions. There is a need to evaluate the technical success, primary patency, and reintervention rates of this technique.

    Outcomes of Kissing Stent Technique for the Endovascular Treatment of Aorto-Iliac TASC C/D Lesions · 2026 · DOI

  • There is a need to evaluate the long-term outcomes of Jetstream atherectomy combined with DCB angioplasty in a real-world population. Prior studies have consistently reported severe calcification as a major risk factor for restenosis after EVT with DCB.

    Two-year clinical outcomes of jetstream atherectomy followed by drug-coated balloon angioplasty for severely calcified femoropopliteal lesions · 2026 · DOI

  • The need for a classification to define the revascularization strategy. The lack of a standardized approach to anatomical complexity. The need for a reliable tool to predict revascularization success.

    Is Global Limb Anatomic Staging System Classification a Useful Tool in Predicting Lower Limb Revascularization Procedures’ Success? · 2025 · DOI

  • Chronic limb-threatening ischemia (CLTI) represents the most severe form of peripheral artery disease, yet long-term cardiovascular outcomes after endovascular revascularization compared with claudication remain poorly defined.

    Cardiovascular Impact of Endovascular Revascularization in Chronic Limb-Threatening Ischemia Versus Claudication: A Contemporary Real-World Analysis · 2026 · DOI

  • Lack of consensus was observed in small-vessel disease, complex bifurcations, long-segment disease requiring multiple scaffolds, thrombotic lesions, and scenarios involving interruption of antiplatelet therapy.

    Contemporary Indications for Bioresorbable Scaffolds for Infrapopliteal Peripheral Artery Disease: An International Expert Consensus · 2026 · DOI

  • However, the utility of imaging, in particular, intravascular ultrasound (IVUS) and optical coherence tomography (OCT), in endovascular interventions of the lower extremities has been limited by a lack of quantitative data and evidence-based protocols.

    A Prospective Evaluation of Optical Coherence Tomography in Below-the-Knee Endovascular Interventions · 2026 · DOI

  • However, the optimal interval between revascularization and amputation remains unclear.

    Early Versus Delayed Endovascular Revascularization: Implications for Limb Salvage and Survival After Transmetatarsal Amputation · 2026 · DOI

  • However, little is known about its uptake and associated outcomes in real-world practice.

    Temporal Trends, Practice Variation, and Outcomes of Intravascular Lithotripsy Versus Atherectomy Use for Peripheral Arterial Intervention in the United States · 2026 · DOI

  • Technological progress has broadened treatment options, but its independent contribution to long-term outcomes remains uncertain.

    Endovascular recanalization of chronic total occlusion of the subclavian artery: fifteen years of technological evolution · 2026 · DOI

  • However, its prognostic relevance in peripheral artery disease (PAD) remains unclear.

    Circulating Human Epididymis Protein 4 Predicts 10‐Year Mortality and Major Adverse Cardiovascular Events in Patients With Peripheral Artery Disease · 2026 · DOI

  • However, its prognostic performance in diabetic patients after endovascular revascularization remains unclear.

    Prognostic performance of the WIfI classification in diabetic patients with infrapopliteal CLTI after endovascular revascularization: a subgroup analysis of the PRIME-WIFI registry · 2026 · DOI

  • Head-to-head research comparing invasive revascularization strategies for chronic limb-threatening ischemia (CLTI) is sparse, partly due to challenges in conducting randomized controlled trials in the CLTI space.

    Contemporary Chronic Limb-Threatening Ischemia Care in the United States—Part 2: Designing Clinical Device Trials · 2025 · DOI

  • Peripheral artery disease (PAD) and its most severe manifestation, chronic limb-threatening ischaemia (CLTI), are serious yet under-recognized conditions associated with functional limitation and increased risks of major adverse limb events (MALE), major adverse cardiovascular events, and mortality1.

    International BEST-CLI Collaborative: next steps to create a coordinated global initiative to improve awareness and access while reducing mortality and amputation for patients with chronic limb-threatening ischaemia · 2025 · DOI

  • Further study of microvascular dysfunction as a mechanistic driver of ambulatory function is warranted.

    Microvascular Function and Ambulatory Capacity in Peripheral Artery Disease · 2025 · DOI

  • The impact of age on outcomes after revascularization for chronic limb-threatening ischemia has not been studied in a prospective trial.

    Age-Related Outcomes After Revascularization for Chronic Limb-Threatening Ischemia: An Analysis of BEST-CLI · 2025 · DOI

  • There are limited data on the mechanism of the Rotarex Rotational Excisional Atherectomy System in treating femoropopliteal arterial disease.

    Intravascular Ultrasound Assessment of Arterial Dissections Following Rotarex Atherectomy: Results of the iDissection Rotarex Study · 2024 · DOI

  • There is limited data available on the impact of anemia on the peripheral artery disease (PAD) outcomes.

    F-9 | Clinical Outcomes for Patients with anemia and Peripheral Artery Disease(PAD): An Analysis of the National Inpatient Sample · 2024 · DOI

  • Recent trial data support both surgical-first and endovascular-first revascularization approaches for chronic limb-threatening ischemia (CLTI), but variations and outcomes associated with each strategy among capable hospitals are lacking.

    OR9-1 | Variations in Revascularization Strategies for Chronic Limb-Threatening Ischemia: A Nationwide Analysis of Medicare Beneficiaries · 2024 · DOI

  • There are limited data comparing endovascular intervention outcomes in heart failure (HF) patients presenting with symptomatic peripheral artery disease (PAD).

    OR9-3 | Endovascular Outcomes of Patients with Heart Failure Undergoing Non-Stent Infrainguinal Interventions from the XLPAD Registry · 2024 · DOI

  • However, it remains unclear whether these walking tests effectively manifest clinical impairment in individuals with asymptomatic peripheral artery disease (PAD).

    A comparison of walking performance between individuals with and without asymptomatic peripheral artery disease using the six-minute walk test and the incremental shuttle walk test · 2024 · DOI

  • In complex patients, current calcium modification technologies can be limited by an inability to deliver across severely stenosed lesions and associated risks of vessel damage and distal embolization.

    Treatment of Calcified Peripheral Artery Disease With the Shockwave Forward Peripheral Intravascular Lithotripsy System: One-Year Outcomes From the FORWARD PAD IDE and Mini S Feasibility Studies · 2026 · DOI

  • Whether the risk of major adverse cardiovascular events and MALE and the effect of rivaroxaban are consistent in patients with a history of prior LER versus those without has not been described.

    Low-Dose Rivaroxaban Plus Aspirin in Patients With PAD Undergoing Lower Extremity Revascularization With and Without History of Prior Limb Revascularization: Insight From the VOYAGER-PAD Trial · 2026 · DOI

  • Limited long-term follow-up data on vascular patency and functional recovery, - Small sample size (single case report), - Lack of control group…

    Acute popliteal artery thrombosis after simultaneous bilateral total knee arthroplasty: a case report with long-term follow-up · 2026 · DOI

  • Investigation of risk factors for popliteal artery thrombosis after total knee arthroplasty, - Development of strategies for early detection and prevention, - Study of long-term outcomes and vascular patency in larger…

    Acute popliteal artery thrombosis after simultaneous bilateral total knee arthroplasty: a case report with long-term follow-up · 2026 · DOI

  • However, there is a lack of data regarding the rates of amputation and outcomes following…

    OR9-2 | Impact of Endovascular Revascularization on Amputation Rates in Chronic Total Occlusion-Peripheral Artery Disease: Insights from a National Registry · 2024 · DOI

Most-cited papers in Peripheral Artery Disease Management

Most recent work

Find a gap in your own Peripheral Artery Disease Management sub-topic

This page shows what the Peripheral Artery Disease Management literature already flags as unresolved. To narrow it to your specific question, search the Research Gap Finder: the search is free with a free account and lists the papers closest to your topic first. Unlocking that topic (50 credits, charged once) fills the comparison table from our 7.9M-paper local library and writes the gaps from its rows.

Open the Research Gap Finder →

Related topics in Medicine

Artificial Intelligence in Healthcare and Education
4,200 open questions
Dementia and Cognitive Impairment Research
2,789 open questions
Substance Abuse Treatment and Outcomes
2,285 open questions
Cancer Immunotherapy and Biomarkers
2,273 open questions
Liver Disease Diagnosis and Treatment
2,102 open questions
Sports Performance and Training
1,952 open questions
Parkinson's Disease Mechanisms and Treatments
1,915 open questions
Mosquito-borne diseases and control
1,849 open questions
Open questions raised by papers listed on this page include: (1) There is a need to evaluate the technical success, primary patency, and reintervention rates of this technique (“Outcomes of Kissing Stent Technique for the Endovascular Treatment of…”, 2026); (2) There is a need to evaluate the long-term outcomes of Jetstream atherectomy combined with DCB angioplasty in a real-world population (“Two-year clinical outcomes of jetstream atherectomy followed by drug-coated…”, 2026); (3) Lack of consensus was observed in small-vessel disease, complex bifurcations, long-segment disease requiring multiple scaffolds, thrombotic lesions, and scenarios involving interruption of antiplatelet therapy (“Contemporary Indications for Bioresorbable Scaffolds for Infrapopliteal…”, 2026); (4) The optimal interval between revascularization and amputation remains unclear (“Early Versus Delayed Endovascular Revascularization: Implications for Limb…”, 2026); (5) Little is known about its uptake and associated outcomes in real-world practice (“Temporal Trends, Practice Variation, and Outcomes of Intravascular Lithotripsy…”, 2026). 349 gap statements have been mined from Peripheral Artery Disease Management papers in our 7.9M-paper local library, which holds 2,043 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 1,100,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? Acceptance odds for top, mid and open/emerging journals, in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck for prior publication across 7 sources and our local library.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

How Pre-Check worksHow AI Review works

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.