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Open research questions in Peripheral Artery Disease Management

89 unresolved questions extracted from the limitations and future-work sections of 331 Peripheral Artery Disease Management papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Limited pharmacological treatment options for symptomatic PAD. The need for a more effective treatment strategy to improve health-related quality of life and walking performance in patients with PAD. The gap in current international guidelines for treating symptomatic PAD.

    Efficacy and Safety of Fixed-Dose Combination Therapy with Cilostazol and Rosuvastatin in Patients with Symptomatic Lower Extremity Peripheral Artery Disease: A Multicenter Randomized Controlled Trial · 2026 · DOI

  • Significant urban-rural variation in strong opioid prescribing. Limited utilisation of strong opioids among patients with severe pain. Need for improved pain management strategies in CLTI, particularly in county hospitals.

    Pain management in chronic limb-threatening ischaemia: a multi-centre cross-sectional study · 2026 · DOI

  • reviewing how narcotic regulations affect legitimate clinical use, - expanding nurse training and electronic integration of BPI, - targeted support for county hospitals

    Pain management in chronic limb-threatening ischaemia: a multi-centre cross-sectional study · 2026 · DOI

  • Further studies with larger sample sizes and randomized treatment allocation are needed, - Comparison of endovascular stenting and bypass surgery in different patient populations, - Investigation of the long-term outcomes of endovascular stenting and bypass surgery

    Clinical outcomes of endovascular stenting versus bypass surgery for aortoiliac occlusive disease: a single-center retrospective cohort study · 2026 · DOI

  • There is a need to compare the outcomes of endovascular stenting and bypass surgery for AIOD. The study aims to fill this gap by providing a comparison of the two treatments.

    Clinical outcomes of endovascular stenting versus bypass surgery for aortoiliac occlusive disease: a single-center retrospective cohort study · 2026 · DOI

  • However, the association between admission BP and outcomes after EVT remains poorly understood.

    Admission Systolic Blood Pressure and Outcomes After Endovascular Thrombectomy · 2026 · DOI

  • The Healthy Ageing Index (HAI) is a comprehensive measure of health, but there is limited research on its association with other age-related outcomes.

    Association of a healthy ageing index with health-related outcomes in a multi-ethnic cohort from Singapore · 2024 · DOI

  • There is a need for long-term outcomes data for the Kanshas DCB. Prior studies have reported limited follow-up periods.

    Three-year outcomes of the TCD-17187 (Kanshas) drug-coated balloon for the treatment of atherosclerotic lesions in the superficial femoral and proximal popliteal artery · 2026 · DOI

  • Limited access to vascular surgeons. Potential travel burden of transitioning care. Balancing the benefits of surgical bypass with the risks and challenges of implementation.

    9. Local Referral Of Peripheral Arterial Disease Patients To Improve Surgical Outcomes · 2026 · DOI

  • Limited access to vascular surgeons may hinder implementation of bypass-first strategies. There is a need to evaluate the geographic availability of vascular surgeons relative to other specialties performing lower extremity endovascular procedures.

    9. Local Referral Of Peripheral Arterial Disease Patients To Improve Surgical Outcomes · 2026 · DOI

  • There is a lack of understanding of the impact of anxiety on patients with PAD. The mechanisms by which anxiety increases the risk of complications in patients with PAD are not well understood.

    Anxiety and peripheral artery disease · 2026 · DOI

  • The study had to account for the complexity of chronic kidney disease and its impact on patient outcomes. The study had to balance the need for effective treatment with the risk of major adverse limb events. The study had to consider the patient-centered outcomes and the traditional outcomes.

    Balancing Days at Home and Major Adverse Limb Events After Surgical Versus Endovascular Lower‐Extremity Revascularization in Chronic Kidney Disease · 2026 · DOI

  • The study excluded patients with end-stage kidney disease before revascularization. The study excluded patients with both surgical and endovascular revascularization on the same day. The study excluded beneficiaries residing outside the 50 United States or with unknown race.

    Balancing Days at Home and Major Adverse Limb Events After Surgical Versus Endovascular Lower‐Extremity Revascularization in Chronic Kidney Disease · 2026 · DOI

  • The study is limited by its small sample size and low number of outcome events. The woundosome concept was not operationalized as a measurable patient-level variable within the present dataset. Direct physiological assessment of tissue perfusion was not available.

    A Conceptual Wound-Oriented Reinterpretation of Perfusion Heterogeneity in Chronic Limb-Threatening Ischemia · 2026 · DOI

  • Small sample size, - Limited number of outcome events, - No new data were collected, - The original dataset was reanalyzed without modification, - No standardized wound perfusion scoring system, microcirculatory assessment, or functional perfusion measurements were available

    A Conceptual Wound-Oriented Reinterpretation of Perfusion Heterogeneity in Chronic Limb-Threatening Ischemia · 2026 · DOI

  • The study is limited by its retrospective design. The sample size is relatively small, with 241 CLTI limbs included.

    Factors Associated With Below-the-Ankle Lesions and Their Impact on Clinical Outcomes Following Revascularization in Chronic Limb-Threatening Ischemia · 2026 · DOI

  • The natural history and long-term impact of BTA lesions remain incompletely understood. There is a need for longitudinal data to better understand the clinical implications of BTA lesions.

    Factors Associated With Below-the-Ankle Lesions and Their Impact on Clinical Outcomes Following Revascularization in Chronic Limb-Threatening Ischemia · 2026 · DOI

  • One limitation of the study is that we used only a brief (10 minute) paper and pencil test of IQ. A frequent criticism of written IQ tests, as used here, is their potential cultural bias. Whether an estimate of general mental ability obtained from a longer, more varied, test battery would result in greater attenuation of the social gradients in health remains to be seen.

    Avoiding central line complications . . . and other research · 2026 · DOI

  • Further research is needed to investigate the role of IQ in explaining the socioeconomic gradients in health. Future studies could use longer, more varied, test batteries to estimate general mental ability. The study's findings suggest that interventions aimed at reducing socioeconomic inequalities in health should consider IQ as a potential explanatory factor.

    Avoiding central line complications . . . and other research · 2026 · DOI

  • The artery's rare presence in literature despite its importance. The need for bibliometric analysis to assess the artery's position in existing literature.

    Mapping the publications on the thyroidea ima artery with Vosviewer · 2026 · DOI

  • Future research may investigate regional prevalence and variations in branching patterns. Studies may explore surgical implications and the application of radiological evaluation methods.

    Mapping the publications on the thyroidea ima artery with Vosviewer · 2026 · DOI

  • Pedal acceleration time (PAT) has recently attracted clinical interest for assessing peripheral arterial disease (PAD), particularly in patients in whom ankle–brachial index (ABI) or toe pressure measurements are unreliable or not feasible, yet its diagnostic worth has not been systematically evaluated.

    Pedal Acceleration Time as a Marker of Limb Perfusion: A Systematic Review and Correlation Meta-Analysis · 2026 · DOI

  • There is a need for awareness of the uncommon but devastating complication of vasopressor-induced acral ischaemia and necrosis. There is a need for early recognition and a clear understanding of the multifactorial pathogenesis of vasopressor-induced acral necrosis.

    Life-saving but limb-threatening: vasopressor-induced acral ischaemia and necrosis – two cases and review of the literature · 2026 · DOI

  • Multilevel disease is associated with an increased risk of major amputation. Post-amputation prognosis remains poor. Current treatments may be associated with high morbidity and mortality.

    Feasibility and early outcomes of single-stage hybrid revascularization for femoroiliac occlusive disease in patients with advanced peripheral arterial disease · 2026 · DOI

  • There is a need for effective treatment of multilevel peripheral artery disease. Current treatments may be associated with high morbidity and mortality.

    Feasibility and early outcomes of single-stage hybrid revascularization for femoroiliac occlusive disease in patients with advanced peripheral arterial disease · 2026 · DOI

Most-cited papers in Peripheral Artery Disease Management

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89 open questions have been extracted from the limitations and future-work passages of 331 Peripheral Artery Disease Management papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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