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Open research questions in Pregnancy and preeclampsia studies

866 gap statements mined from Pregnancy and preeclampsia studies papers in our 7.9M-paper local library, which holds 4,906 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • It highlights the need for accurate blood pressure measurements in antenatal care.

    Terminal Digit Preference and Threshold Avoidance in Digital Blood Pressure Measurements During Pregnancy: Secondary Analysis of Data From the CLIP and PRECISE Cohorts · 2026 · DOI

  • Several limitations inherent to this study should be acknowledged.

    Sexually Dimorphic Regulation of MiR‐29a/c‐3p in Human Endothelial Cells: Cell Functions and Transcriptome · 2026 · DOI

  • Current diagnostic methods for placental abruption have limitations, including low sensitivity for early cases. There is a need for efficient, accurate, and timely diagnostic methods.

    A study on the diagnostic value of ultrasound combined with serum MK and TSP-1 in diagnosing placental abruption · 2026 · DOI

  • Prior work has not investigated the association between placental volume and fetal growth disorders in an unselected cohort of singleton pregnancies.

    Does Looking at the Placenta Improve First-Trimester Screening? Placental Volume, Vascular Indices and Fetal Growth Disorders in an Unselected Cohort · 2026 · DOI

  • The biological mechanisms of preeclampsia have not been fully resolved. Current reviews describe interacting placental, angiogenic, endothelial, oxidative, and inflammatory pathways.

    Maternal Biochemical Profiles in Hypertensive Disorders of Pregnancy: An Observational Study · 2026 · DOI

  • The complex relationship between maternal obesity and the development of hypertensive disorders of pregnancy is not fully understood. There is a need for further research into the pathophysiology of hypertensive disorders of pregnancy and the role of maternal obesity. The review highlights the importance of addressing the research gap to improve pregnancy outcomes for women with maternal obesity.

    Pathophysiology of Maternal Obesity and Hypertension in Pregnancy · 2025 · DOI

  • The paper identifies the challenge of balancing the need to manage dyslipidemia with the need to ensure the health and well-being of both mother and child. The paper highlights the challenge of developing effective individualized guidance and multidisciplinary lifestyle and dietary strategies, along with targeted pharmacological interventions, for the successful management of lipid disorders in pregnancy.

    Lipid Profile and Management of Dyslipidemias in Pregnancy · 2025 · DOI

  • The paper identifies a need for effective individualized guidance and multidisciplinary lifestyle/dietary strategies, along with targeted pharmacological interventions, for the successful management of lipid disorders in pregnancy.

    Lipid Profile and Management of Dyslipidemias in Pregnancy · 2025 · DOI

  • The paper identifies the need to consider pre-eclampsia as a proinflammatory state and the importance of angiogenesis, inflammation, and oxidative stress in its pathogenesis. The review highlights the challenges in diagnosing and treating pre-eclampsia, including the need for early detection and effective management strategies.

    Behind the Curtain of Abnormal Placentation in Pre-Eclampsia: From Molecular Mechanisms to Histological Hallmarks · 2024 · DOI

  • There is a need to investigate the histomorphometric measurements of the wall thickness and internal diameter of the macrovessels of the chorionic villi of placentas from pregnancies complicated by preeclampsia or fetal growth restriction. The study aims to fill this gap by providing a comprehensive analysis of the placental macrovascular pattern in these complications.

    Placental Macrovascular Pattern from Pregnancies with Maternal Hypertensive and Fetal Growth Capacity Complications · 2024 · DOI

  • Further studies are needed to investigate the underlying mechanisms of reduced H2S production in pre-eclamptic pregnancies. Studies should examine the expression of other H2S-converting enzymes in placental trophoblasts. Research should focus on the potential therapeutic applications of H2S in the treatment of pre-eclampsia.

    Altered Production and Cellular Levels of Hydrogen Sulfide (H2S) in Placental Trophoblasts from Pregnancies Affected by Pre-Eclampsia · 2025 · DOI

  • Although significant advances have been made in defining the molecular networks governing placental development, the contribution of cellular prion protein (PRNP) remains poorly characterized, warranting a focused review.

    Beyond neurobiology: cellular prion protein (PRNP) as an emerging regulator of decidual and utero-placental vascular function · 2026 · DOI

  • Chronic hypertension may impair uteroplacental perfusion and promote a pro-inflammatory intrauterine environment, potentially disrupting foetal gut development; however, its independent effect on offspring GI health has not been examined.

    Long‐Term Gastrointestinal Outcomes in Children Exposed in Utero to Maternal Chronic Hypertension · 2026 · DOI

  • These findings underscore the need for tailored clinical protocols for populations living at HA and highlight the relevance of further research into the genetic and physiological adaptive mechanisms involved.

    Outcomes in pregnant women diagnosed with preeclampsia with and without fetal growth restriction at high altitude: A cross-sectional study · 2026 · DOI

  • The lack of standardized recommendations for postpartum (PP) management remains a limiting factor in care.

    Post-partum follow-up after hypertensive disorders during pregnancy: Review of national and international clinical practice guidelines · 2026 · DOI

  • While animal models have demonstrated compromised fetal pulmonary vasculature in preeclampsia, evidence in human fetuses remains lacking.

    Fetal pulmonary vascular volume is impaired in mothers with early onset preeclampsia – a proof of concept study · 2026 · DOI

  • However, a clear signature to identify women at high risk of developing late-onset PE remains to be uncovered.

    Gut microbiota is different before the development of preeclampsia · 2026 · DOI

  • However, whether the onset time of chronic hypertension influences the risk of developing preeclampsia and the severity remains unclear.

    The timing of chronic hypertension onset in pregnancy was not associated with the severity of superimposed preeclampsia · 2026 · DOI

  • Although rare coding variants are known to cause a subset of stillbirths, their contribution to PI is poorly understood.

    Genetic Variants Associated with Placental Abnormalities in Stillbirths · 2026 · DOI

  • Investigate the effects of miR-29a/c-3p knockdown on other cell types, - Examine the effects of miR-29a/c-3p knockdown on HUVECs at different concentrations, - Study the mechanisms underlying the sex-specific effects of miR-29a/c-3p…

    Sexually Dimorphic Regulation of MiR‐29a/c‐3p in Human Endothelial Cells: Cell Functions and Transcriptome · 2026 · DOI

  • Prospective evaluation of the combined strategy to potentially improve diagnostic discrimination in suspected cases - Validation of the results in a larger…

    A study on the diagnostic value of ultrasound combined with serum MK and TSP-1 in diagnosing placental abruption · 2026 · DOI

  • The study was conducted at a single tertiary centre - The study had a limited sample size of 445 pregnancies - The acquisitions were separate and the difference between paired acquisitions combines the effect of PRF with acquisition-to-acquisition variability - The study did not account for other potential confounding…

    Does Looking at the Placenta Improve First-Trimester Screening? Placental Volume, Vascular Indices and Fetal Growth Disorders in an Unselected Cohort · 2026 · DOI

  • Exploration of cuffless monitoring devices, - Development of innovative care pathways, - Investigation of the potential of HBPM to provide an opportunity for earlier detection of BP…

    Blood pressure changes across pregnancy and postpartum: from physiological adaptations to pathological deviations · 2026 · DOI

  • The results of the studies are contrasting, - Few studies evaluated the possible predictive role of some biomarkers in IUGR, - The correlation between some biomarkers and pregnancy complications is not fully…

    First Trimester Placental Biomarkers for Pregnancy Outcomes · 2024 · DOI

  • Further research is needed to investigate the temporal and spatial nature of the action of the pathological factor, - Studies should be conducted to examine the effects of preeclampsia and fetal growth restriction on the placental macrovessels, - Research should be done to develop new methods for the diagnosis and treatment of preeclampsia and fetal growth…

    Placental Macrovascular Pattern from Pregnancies with Maternal Hypertensive and Fetal Growth Capacity Complications · 2024 · DOI

Most-cited papers in Pregnancy and preeclampsia studies

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Open questions raised by papers listed on this page include: (1) There is a need for efficient, accurate, and timely diagnostic methods (“A study on the diagnostic value of ultrasound combined with serum MK and TSP-1…”, 2026); (2) Chronic hypertension may impair uteroplacental perfusion and promote a pro-inflammatory intrauterine environment, potentially disrupting foetal gut development; however, its independent effect on offspring GI health has not been examined (“Long‐Term Gastrointestinal Outcomes in Children Exposed in Utero to Maternal…”, 2026); (3) The lack of standardized recommendations for postpartum (PP) management remains a limiting factor in care (“Post-partum follow-up after hypertensive disorders during pregnancy: Review of…”, 2026); (4) A clear signature to identify women at high risk of developing late-onset PE remains to be uncovered (“Gut microbiota is different before the development of preeclampsia”, 2026); (5) Whether the onset time of chronic hypertension influences the risk of developing preeclampsia and the severity remains unclear (“The timing of chronic hypertension onset in pregnancy was not associated with…”, 2026). 866 gap statements have been mined from Pregnancy and preeclampsia studies papers in our 7.9M-paper local library, which holds 4,906 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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