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Open research questions in Preterm Birth and Chorioamnionitis

127 unresolved questions extracted from the limitations and future-work sections of 594 Preterm Birth and Chorioamnionitis papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • lack of pregnancy-specific delivery systems, - safety concerns arising from the multi-target nature of miRNAs, - challenge of targeting multi-tissue synergistic pathological changes with single-agent interventions

    Multi-tissue miRNA networks in preterm birth: from molecular mechanisms to precision medicine · 2026 · DOI

  • exploration of exosome-based delivery and combination therapies, - investigation of miRNA-based therapeutic strategies targeting uterine smooth muscle, - study of the role of exosomes in pregnancy-associated diseases

    Multi-tissue miRNA networks in preterm birth: from molecular mechanisms to precision medicine · 2026 · DOI

  • Observational evidence concerning the association between depression and PTB remains inconclusive. The effect of depression on PTB attenuated to null when restricted to women without antidepressant use. The study used summary statistics from genome-wide association studies, which may have limitations.

    Genetic overlap and causality between depression and preterm birth: a large-scale genome-wide cross-trait analysis · 2025 · DOI

  • Investigating the biological mechanisms underlying the genetic overlap between depression and preterm birth. Examining the potential causal relationships between depression and preterm birth using different methodologies. Studying the effects of antidepressant use on the association between depression and preterm birth.

    Genetic overlap and causality between depression and preterm birth: a large-scale genome-wide cross-trait analysis · 2025 · DOI

  • pregnant women are widely excluded from clinical trials due to the high risks posed to unborn children, - stringent regulatory guidelines, ethical principles protecting vulnerable populations, and liability concerns further limit their participation, - the study uses a simulated system

    Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women · 2025 · DOI

  • Limited knowledge about drug metabolism and safety in pregnant women. Current preclinical models fail to accurately replicate human pregnancy conditions. Lack of data regarding the safety and efficacy of medications in pregnant women.

    Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women · 2025 · DOI

  • INTRODUCTION: Labor epidural analgesia (LEA) is widely used for intrapartum pain management, but its effects on uterine activity (UA) remain unclear.

    The effect of labor epidural analgesia on uterine activity using electrohysterography monitoring: A follow‐up study · 2026 · DOI

  • Little is known about pregnancy outcomes when a cerclage is left in situ across consecutive pregnancies; this study aims to investigate neonatal outcomes following laparoscopic cervical cerclage placement in first and subsequent pregnancies and to compare pre- and postconception placement of the laparoscopic cervical cerclage on neonatal survival.

    Laparoscopic cervical cerclage and pregnancy outcomes in consecutive pregnancies: An observational study · 2026 · DOI

  • Outpatient management (OM) has emerged as a potential alternative to prolonged hospitalization, but selection criteria remain ill-defined.

    Management of preterm pre‐labor rupture of membranes between 24 and 34 weeks: A before‐and‐after study of the implementation and modifications of an outpatient management protocol · 2026 · DOI

  • While the procedural aspects, indications, and pregnancy outcomes associated with TAC are subject to ongoing research, little is known about how women experience the decision to undergo a TAC and the pregnancy that follows.

    Women's motivations for and experiences with transabdominal cerclage: A qualitative study · 2026 · DOI

  • Future research should explore long-term physical and psychological outcomes and develop supportive interventions to improve care for this high-risk population.

    Women's motivations for and experiences with transabdominal cerclage: A qualitative study · 2026 · DOI

  • However, the long-term effects of a permanent transabdominal cerclage have not been investigated.

    Quality‐of‐life and late effects after transabdominal cerclage: A nationwide matched cohort study · 2026 · DOI

  • The most frequent reasons for non‐administration were lack of guideline awareness/oversight at later gestational ages and rapid delivery or maternal/fetal instability at earlier gestations.

    Magnesium sulfate for neuroprotection before preterm birth: Uptake and adherence in clinical practice after National Guideline Implementation · 2026 · DOI

  • 9% of pregnancies worldwide and is driven in part by placental dysfunction, yet the signalling events linking placental dysregulation to spontaneous prematurity remain incompletely defined.

    Placental LBX1 dysregulation drives ribosomal dysfunction and unfolded protein response in spontaneous preterm birth · 2026 · DOI

  • Intrauterine inflammation is major trigger of adverse outcomes such as preterm birth, yet the cell-specific inflammatory responses at the FMi -; poorly defined.

    Heterogeneity in inflammatory responses to endotoxin at the fetomaternal interface · 2026 · DOI

  • INTRODUCTION: Randomized trials have shown that progesterone treatment in mothers with a short cervix may reduce the risk of preterm birth, but the optimal time window for treatment remains unknown.

    Timing of progesterone treatment to prevent preterm birth in pregnancies with a short cervix: A population‐based historical cohort study · 2025 · DOI

  • Despite significant advances in prenatal care, proper management, particularly in early gestational age, remains unclear.

    Perinatal outcomes and predictors of neonatal mortality in preterm premature rupture of membranes: a tertiary center experience · 2025 · DOI

  • However, the molecular mechanisms underlying PTB remain incompletely understood, and the etiology of many PTB cases is still largely unexplained.

    Transcriptomics reveals preterm birth risk: identification and validation of key genes in monocytes · 2025 · DOI

  • There is an increased concern for various risk factors for PROM and PPROM, in the context of inconsistent findings.

    Determinants for premature rupture of membranes: a prospective cohort study · 2025 · DOI

  • Risk for PTB is influenced by multiple biological pathways, many of which are poorly understood.

    Pre-conception clinical risk factors differ between spontaneous and indicated preterm birth in a densely phenotyped EHR cohort · 2025 · DOI

  • Previously, investigation of potential risk factors has been limited by a lack of data on maternal medical history and the difficulty of classifying PTBs as indicated or spontaneous.

    Pre-conception clinical risk factors differ between spontaneous and indicated preterm birth in a densely phenotyped EHR cohort · 2025 · DOI

  • Prevalence varies widely, ranging from 5% in high-income countries to 18% in LMICs.

    Preterm birth and its associated factors among women of reproductive age in Zambia: a survey analysis · 2025 · DOI

  • However, the relationship between body composition, a detailed reflection of maternal nutrition, and PROM remains under-explored.

    Associations between maternal body composition in the second trimester and premature rupture of membranes: a retrospective study using hospital information system data · 2025 · DOI

  • Emerging research indicates that tRNA-derived small RNAs (tsRNAs) are involved in various diseases; however, their potential association with PTL remains underexplored.

    Maternal plasma extracellular vesicles tsRNA as potential biomarkers for assessing preterm labor risk · 2025 · DOI

  • However, data on its burden and predictors remain scarce in Africa, including Uganda.

    Histological chorioamnionitis and its predictors among mothers with premature rupture of membranes delivering at tertiary hospitals in Uganda: a multicenter cross-sectional study · 2025 · DOI

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127 open questions have been extracted from the limitations and future-work passages of 594 Preterm Birth and Chorioamnionitis papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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