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Open research questions in Prostate Cancer Diagnosis and Treatment

254 unresolved questions extracted from the limitations and future-work sections of 824 Prostate Cancer Diagnosis and Treatment papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Integration of molecular and genomic information to develop multimodal predictive models - Further evaluation of micro-US as an alternative image-guidance strategy for prostate biopsy - Investigation of the role of AI in dedicated radiomics and AI-based analysis

    The Role of Artificial Intelligence in Optimizing Diagnosis in Prostate Cancer—A Narrative Review · 2026 · DOI

  • The current diagnostic methods for prostate cancer are invasive and have potential complications. There is a need for non-invasive and accurate diagnostic methods for clinically significant prostate cancer.

    MRI-based habitat radiomics analysis for predicting clinically significant prostate cancer: a retrospective dual-center study · 2026 · DOI

  • The study faced challenges in terms of heterogeneity between studies. The study also faced challenges in terms of the limited number of studies available for analysis. The study had to deal with the issue of extreme heterogeneity in some outcomes.

    Aquablation versus laser enucleation of the prostate for benign prostatic hyperplasia: a systematic review and pairwise meta-analysis of head-to-head studies including the first randomized trial · 2026 · DOI

  • Limited partially randomized base, - Short follow-up, - Studies had varying levels of risk of bias, - Analysis was not powered or designed as a non-inferiority study

    Aquablation versus laser enucleation of the prostate for benign prostatic hyperplasia: a systematic review and pairwise meta-analysis of head-to-head studies including the first randomized trial · 2026 · DOI

  • The individual biopsy strategy was not recorded at the patient level, - The study was a single-center retrospective study, - The study had a limited sample size of 192 patients

    Minimum ADC outperforms PSA and PSA density for predicting ISUP grade group in prostate cancer: a retrospective study of 192 patients undergoing radical prostatectomy · 2026 · DOI

  • Further studies are needed to validate the findings, - Studies should investigate the combination of ADC with other biomarkers, - Research should focus on improving the accuracy of biopsy grading

    Minimum ADC outperforms PSA and PSA density for predicting ISUP grade group in prostate cancer: a retrospective study of 192 patients undergoing radical prostatectomy · 2026 · DOI

  • There is a lack of comprehensive analysis of multiple genitourinary cancer types. Prior studies have focused on individual cancer types, but there is a need for a study that investigates disparities across multiple cancer types.

    Trends in genitourinary cancer mortality in the United States: analysis of the CDC-WONDER database 1999–2020 · 2024 · DOI

  • Further research is needed to address the disparities in genitourinary cancer mortality, - Studies should investigate the factors underpinning the disproportionate representation of Blacks/African Americans in prostate cancer incidence and mortality, - Research should focus on developing targeted interventions to improve outcomes for all populations affected by genitourinary cancers

    Trends in genitourinary cancer mortality in the United States: analysis of the CDC-WONDER database 1999–2020 · 2024 · DOI

  • Persistent racial and socioeconomic differences in discharge patterns warrant further research into whether early discharge is equally safe and beneficial across patient populations.

    Geographic and clinical predictors of one-day discharge after radical prostatectomy: a SEER-Medicare cohort study · 2026 · DOI

  • Direct evidence that AI improves nerve preservation, continence, erectile function, or margin control remains insufficient for routine adoption.

    Function-preserving strategies for localized prostate cancer: minimally invasive radical surgery, focal therapy and AI-assisted surgery · 2026 · DOI

  • Conclusion RARP combined with ADT was significantly associated with improved oncological outcomes in patients with OmPCa, and this association was independent of baseline characteristics; however, this finding is limited by the relatively small sample size and requires validation in prospective studies.

    Association of robot-assisted radical prostatectomy with improved oncological outcomes in patients with oligometastatic prostate cancer: A multicenter exploratory study in China · 2026 · DOI

  • We also explore emerging strategies such as penumbra-targeted sampling, discuss ongoing clinical challenges, and examine the impact of biopsy underestimation and lack of standardization.

    Advances and Challenges in Prostate Cancer Diagnosis: A Comprehensive Review · 2025 · DOI

  • Asia comprises 60% of the global male population, yet Asian men's health issues, such as prostate cancer, remain sparse in the literature.

    Rising Trends in Prostate Cancer Among Asian Men: Global Concerns and Diagnostic Solutions · 2025 · DOI

  • Further prospective evaluation is warranted to confirm long-term oncologic efficacy.

    Early Continence and Erectile Function Recovery Following Transvesical Single-Port Robot-Assisted Radical Prostatectomy: Initial Single Institution Experience · 2025 · DOI

  • The transvesical single-port robot-assisted radical prostatectomy (SP-TV-RARP) approach is a novel technique with very limited evidence that has been suggested to preserve the Retzius space and allow extraperitoneal access through the bladder.

    Early Continence and Erectile Function Recovery Following Transvesical Single-Port Robot-Assisted Radical Prostatectomy: Initial Single Institution Experience · 2025 · DOI

  • CONCLUSIONS: The cancer-related identity in long-term PCa survivors of advanced old age varies widely.

    Cancer-related identity and advanced old age – analysis of prostate cancer survivors after radical prostatectomy over the age of 75 · 2025 · DOI

  • CONCLUSIONS: Definitive treatment is warranted in appropriately selected elderly men with clinically localized prostate cancer.

    Long-term prostate cancer survival outcomes including patterns of death in men >=75 years of age treated with low dose rate brachytherapy · 2025 · DOI

  • BACKGROUND: Potentially curative therapeutic interventions in elderly men with prostate cancer remain controversial due to the presence of concomitant medical comorbidities and concerns of over-treatment and poor tolerance.

    Long-term prostate cancer survival outcomes including patterns of death in men >=75 years of age treated with low dose rate brachytherapy · 2025 · DOI

  • However, few studies have directly compared institutional outcomes before and after the adoption of robotic platforms.

    Transition to robotic surgery in urologic oncology: a comparative analysis between pre-robotic and robotic eras in a high-volume tertiary center · 2025 · DOI

  • Importance: Magnetic resonance imaging (MRI) has been proposed to enhance the benefit-to-harm ratio of prostate cancer screening, but data on repeated screening outcomes are lacking.

    Repeated Prostate Cancer Screening Using Prostate-Specific Antigen Testing and Magnetic Resonance Imaging · 2024 · DOI

  • In regions where access to MRI is lacking, the Stockholm3 test can aid in selecting patients for systematic prostate biopsy.

    Biomarker vs MRI-Enhanced Strategies for Prostate Cancer Screening · 2024 · DOI

  • The impact of these changes on PC epidemiology and racial disparities across disease states remains underexplored.

    Racial and Ethnic Differences in Prostate Cancer Epidemiology Across Disease States in the VA · 2024 · DOI

  • However, few data are available comparing performance of different MRI-based risk calculators in external cohorts across different countries or screening paradigms.

    Comparison of Magnetic Resonance Imaging–Based Risk Calculators to Predict Prostate Cancer Risk · 2024 · DOI

  • Few studies have empirically evaluated these disparities across different health care systems.

    Neighborhood Deprivation, Race and Ethnicity, and Prostate Cancer Outcomes Across California Health Care Systems · 2024 · DOI

  • Importance: There is no consensus in prostate-specific antigen (PSA) screening guidelines regarding transgender women despite their known prostate cancer risk.

    Prostate Cancer Screening Uptake in Transgender Women · 2024 · DOI

Most-cited papers in Prostate Cancer Diagnosis and Treatment

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254 open questions have been extracted from the limitations and future-work passages of 824 Prostate Cancer Diagnosis and Treatment papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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