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Open research questions in Salivary Gland Tumors Diagnosis and Treatment

203 gap statements mined from Salivary Gland Tumors Diagnosis and Treatment papers in our 7.9M-paper local library, which holds 1,902 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • A limitation of this report is the relatively short follow-up period of 18 months, which is insufficient to fully assess long-term oncological outcomes. Therefore, continued long-term surveillance for local recurrence and distant metastasis is warranted.

    A Rare Case of Benign-Appearing Myoepithelial Carcinoma of the Hard Palate in an Adolescent · 2026 · DOI

  • The limitations of this study include its retrospective design and the relatively small number of cases.

    Validation of the 9th Edition of the UICC TNM classification and the prognostic impact of nodal spread in salivary gland cancer · 2026 · DOI

  • The expression profile and clinical significance of SLFN11 in salivary gland cancer remain poorly understood. Effective systemic treatment options remain limited for many histological subtypes of SGC. The study aims to address the gap in understanding the role of SLFN11 in SGC.

    Histological heterogeneity of SLFN11 expression and its association with response to carboplatin plus paclitaxel therapy in salivary gland cancer · 2026 · DOI

  • In recent years, it has been shown to offer several advantages in medical oncology, including the capacity to overcome the limitations of traditional tissue biopsy through a minimally invasive and quick approach. Among the various biomarkers, the most studied are represented by circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), extracellular vesicles (EVs), and circulating microRNAs (miRNAs) (Figure 3).

    Salivary Gland Cancers in the Era of Molecular Analysis: The Role of Tissue and Liquid Biomarkers · 2025 · DOI

  • Although sialoblastoma (SBL) is defined as a low-grade malignant salivary gland anlage neoplasm in the 2022 World Health Organization (WHO) Classification of Head and Neck Tumors, its histology, genetics, and behavior remain controversial due to the rarity of the tumor.

    Sialoblastomas With Solid Pattern Have FGFR2 Mutations and an Unfavorable Prognosis · 2025 · DOI

  • Its etiopathogenesis remains poorly understood, but it is believed that the development of this tumor is due to the accumulation of genetic, protein, metabolic, and epigenetic alterations in a PA.

    Expanding the Molecular Spectrum of Carcinoma Ex Pleomorphic Adenoma · 2024 · DOI

  • The major limitation of this study is its retrospective nature, owing to which, we were unable to reliably assess certain areas of contention, like the role of adjuvant radiotherapy.

    Does the site of origin of mucoepidermoid carcinoma impact treatment outcomes? Long-term analysis of 244 patients over a decade · 2026 · DOI

  • Due to the rarity and heterogeneity of radiation-induced sarcomas, clear treatment guidelines are lacking.

    Radiation-induced undifferentiated spindle cell sarcoma following adenoid cystic carcinoma of minor salivary gland · 2026 · DOI

  • Comprehensive studies with larger datasets and external validation are warranted to confirm our findings.

    Investigating the Radiomic Performance Gap Driven by Delineation Strategy: Radiotherapy Gross Tumor Volume vs. Dedicated Lesion Segmentation in Proton-Treated Adenoid Cystic Carcinoma · 2026 · DOI

  • The optimal extent of surgery for parotid pleomorphic adenoma remains debated.

    Extracapsular Dissection Versus Superficial or Partial Superficial Parotidectomy for Pleomorphic Adenoma of the Parotid Gland: A Systematic Review and Meta-Analysis · 2026 · DOI

  • The trend toward worse survival outcomes in high TF-expressing tumors warrants further investigation.

    Tissue factor expression in salivary gland carcinoma: a potential novel therapeutic target for advanced disease · 2025 · DOI

  • Their symptoms are usually not specific, and there are no guidelines for their management, which makes their clinical management a challenge for pediatricians.

    Clinical presentation and treatment of four children with pulmonary mucoepidermoid carcinoma · 2024 · DOI

  • The diagnosis of parotid gland tumors is challenging due to their varied histopathological subtypes. Current imaging techniques have limitations in characterizing parotid gland tumors. The development of new diagnostic protocols is needed.

    Added value of diffusion tensor imaging in characterization of parotid gland tumors: bridging current diagnostic gaps · 2026 · DOI

  • There is a need for improved imaging techniques for parotid gland tumor diagnosis. Current diagnostic methods have limitations in characterizing parotid gland tumors. Diffusion tensor imaging has the potential to address this gap.

    Added value of diffusion tensor imaging in characterization of parotid gland tumors: bridging current diagnostic gaps · 2026 · DOI

  • The feasibility and signal characteristics of viscoelastic imaging in parotid gland tumors need to be evaluated. The diagnostic value of viscoelastic imaging in differentiating benign from malignant lesions needs to be assessed.

    Reply to the letter to the Editor: Advancing parotid tumor diagnosis—insights and limitations of viscoelastic imaging · 2026 · DOI

  • Therapeutic challenges due to the lack of established standard first-line systemic therapy. The need for comprehensive molecular profiling to avoid misclassification.

    Solid-variant primary pulmonary adenoid cystic carcinoma with pleural metastasis and malignant pleural effusion: a rare case report · 2026 · DOI

  • The case report is based on a single patient. The molecular findings were interpreted cautiously. The treatment was followed by a partial response, but the long-term outcome is unknown.

    Solid-variant primary pulmonary adenoid cystic carcinoma with pleural metastasis and malignant pleural effusion: a rare case report · 2026 · DOI

  • Second, detailed information regarding the surgical technique used during the initial operation in 2020, including the status of the tumor capsule, possible intraoperative tumor spillage, and the precise histological margin status, was limited by the information available from the referring institution.

    Recurrent Pleomorphic Adenoma of the Palate: A Case Report · 2026 · DOI

  • Investigate the therapeutic efficacy of CBDCA+PTX therapy in larger cohorts. Establish a standardized cutoff for SLFN11 immunohistochemistry in SGC. Explore the biological mechanisms underlying SLFN11 expression in SGC.

    Histological heterogeneity of SLFN11 expression and its association with response to carboplatin plus paclitaxel therapy in salivary gland cancer · 2026 · DOI

  • Our study documented 3 cases of AdCC of salivary glands harboring novel gene fusions TULP4::MYB, ACTN4::MYB, and ACTB::MYB, in 1 case each, which have not been described before.

    Discovery of Novel TULP4/ACTN4/EWSR1/ACTB::MYB and ESRRG::DNM3 Fusions Expands Molecular Landscape of Adenoid Cystic Carcinoma Beyond Fusions Between MYB/MYBL1 and NFIB Genes · 2024 · DOI

  • Finally, this study did not include direct patient-level cost data, reimbursement information, or formal cost-effectiveness analysis; therefore, the financial value of robot-assisted parotidectomy could not be assessed.

    Robotic-assisted parotidectomy as a remote-access alternative to conventional open surgery: a single-center comparative experience · 2026 · DOI

  • Few data have been published concerning anti-HER2 therapies for SDC, mainly concerning T-Dxd, most of the studies described treatment with docetaxel or trastuzumab alone.

    Trastuzumab-deruxtecan shows interesting disease control in a multitreated patient with ERBB2 amplified parotid carcinoma, a case report · 2025 · DOI

  • To our knowledge, this novel gene fusion has not been described previously in salivary gland tumors.

    Uncovering the WWTR1 :: NCOA2 Gene fusion in low‐grade myoepithelial‐rich neoplasm with HMGA2 expression: A case report · 2024 · DOI

  • Obstructive sialadenitis of the parotid and SMG is an uncommon and underreported complication of FRPs, distinct from sialocele and fistulas, that can significantly impact patient well-being.

    Iatrogenic Obstructive Sialadenitis of the Parotid and Submandibular Glands Following Facial Rejuvenation · 2026 · DOI

  • This study accentuates PON3::LCN1 and HTN3::MSANTD3 fusions as recurrent molecular events in AciCC, offering potential diagnostic and prognostic utility and propelling further research into targeted therapeutic strategies.

    PON3::LCN1 and HTN3::MSANTD3 Gene Fusions With NR4A3/NR4A2 Expression in Salivary Acinic Cell Carcinoma · 2024 · DOI

Most-cited papers in Salivary Gland Tumors Diagnosis and Treatment

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Open questions raised by papers listed on this page include: (1) Continued long-term surveillance for local recurrence and distant metastasis is warranted (“A Rare Case of Benign-Appearing Myoepithelial Carcinoma of the Hard Palate in…”, 2026); (2) The expression profile and clinical significance of SLFN11 in salivary gland cancer remain poorly understood (“Histological heterogeneity of SLFN11 expression and its association with…”, 2026); (3) Due to the rarity and heterogeneity of radiation-induced sarcomas, clear treatment guidelines are lacking (“Radiation-induced undifferentiated spindle cell sarcoma following adenoid…”, 2026); (4) There is a need for improved imaging techniques for parotid gland tumor diagnosis (“Added value of diffusion tensor imaging in characterization of parotid gland…”, 2026); (5) Therapeutic challenges due to the lack of established standard first-line systemic therapy (“Solid-variant primary pulmonary adenoid cystic carcinoma with pleural…”, 2026). 203 gap statements have been mined from Salivary Gland Tumors Diagnosis and Treatment papers in our 7.9M-paper local library, which holds 1,902 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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