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Open research questions in Sexual function and dysfunction studies

988 gap statements mined from Sexual function and dysfunction studies papers in our 7.9M-paper local library, which holds 5,197 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

Choosing where to publish on Sexual function and dysfunction studies? See the ranked Medicine journals.

What the literature leaves open

  • There are no studies investigating the effect of CTM on erectile functions. The current study aims to fill this gap by investigating the effect of CTM on ED symptoms, autonomic dysfunction, and wellbeing.

    Connective tissue massage improves symptoms, autonomic dysfunctions and wellbeing in erectile dysfunction: a randomized controlled trial · 2026 · DOI

  • Longitudinal changes in sexual activity and their impact on quality of life in older adults have not been thoroughly examined.

    Change of sexual activity and its relation to the quality of life in older people: Cognition of Older People, Education, Recreational Activities, NutritIon, Comorbidities, fUnctional Capacity Studies (COPERNICUS) · 2026 · DOI

  • Erectile dysfunction (ED) is increasingly recognized as an early clinical marker of cardiovascular disease (CVD); however, the causal role of familial predisposition to CVD in ED development remains insufficiently defined.

    The causal effect of family history of cardiovascular disease on erectile dysfunction: a randomized clinical study and Mendelian randomization study · 2026 · DOI

  • Erectile dysfunction (ED) is a prevalent complication of both type 1 and type 2 diabetes mellitus (DM), but the shared molecular mechanisms underlying this complication remain unclear.

    Molecular mechanisms of erectile dysfunction in type 1 and type 2 diabetic rats: a multiomics approach · 2026 · DOI

  • There is limited literature on the role of VED use following PPI surgery, which may cause inadvertent damage to the penile tissue with compression of the constriction ring, resulting in distal ischemia of the penis.

    Tips and tricks on penile prosthesis implantation in the fibrosed penis · 2026 · DOI

  • Future research should focus on elucidating shear stress-mediating regulatory mechanisms, and developing diagnostic and therapeutic strategies to improve clinical outcomes in patients with ED.

    Exploring the application of shear stress in erectile dysfunction · 2026 · DOI

  • Simenafil, a newly developed oral phosphodiesterase type 5 (PDE5) inhibitor, substantially improves erectile function; however, its efficacy has not been evaluated via RigiScan monitoring.

    Efficacy and safety of simenafil in erectile dysfunction: a phase II, randomized, double-blind, placebo-controlled, crossover study · 2026 · DOI

  • While magnetic stimulation has shown neuroregenerative potential in other contexts, its therapeutic efficacy and molecular mechanisms in post-prostatectomy ED remain poorly defined.

    Repetitive pulsed magnetic stimulation attenuates neurogenic erectile dysfunction associated with the upregulation of the BDNF/NGF axis in a rat model of cavernous nerve injury · 2026 · DOI

  • While the impact on physical functioning is well-established, the influence of iSGS on sexual health, a key component of quality of life, remains unexplored.

    Symptom Burden and Sexual Quality of Life in Women With Idiopathic Subglottic Stenosis · 2026 · DOI

  • The study is limited by the retrospective design and the identification of failure only when patients requested surgery.

    Long‐term outcomes for mechanical failure and revision following primary gender‐affirming penile prosthesis insertion · 2026 · DOI

  • Although the association between thyroid dysfunction and female sexual dysfunction (FSD) is well-established, limited data exist regarding FSD in premenopausal women with DTC.

    Sexual Function and Depressive Symptoms in Premenopausal Women with Differentiated Thyroid Cancer: A Cross-Sectional Study · 2026 · DOI

  • Despite its impact on quality of life, sexual health in women with PD remains poorly understood.

    The impact of motor, non-motor, and social aspects on the sexual health of women living with Parkinson's disease · 2025 · DOI

  • Although it is deeply ingrained in our beliefs that stress affects sexual experience and behavior, factual knowledge about this interplay is scarce despite significant impacts on health.

    Too stressed for sex? Associations between stress and sex in daily life · 2025 · DOI

  • These conflicting results prompt an important question: what could explain these differing outcomes? One possible reason for the differing outcomes stems from the variation in patient populations between the studies.

    Two studies, two outcomes: botulinum toxin in lifelong premature ejaculation treatment · 2025 · DOI

  • Looking ahead, future research should focus on standardizing the injection methods, being clear about which patients are most likely to benefit and exploring the idea of repeated treatments to keep the benefits going.

    Two studies, two outcomes: botulinum toxin in lifelong premature ejaculation treatment · 2025 · DOI

  • Many patients experience sexual dysfunction but the underlying cause has not been clarified.

    Sexual Dysfunction and Its Relationship With Hypogonadism and Myelopathy in Male Patients With X‐Linked Adrenoleukodystrophy · 2025 · DOI

  • However, the clinical significance of these findings remains unclear, and definitive selection criteria for Li-ESWT based on preexisting comorbidities have yet to be established.

    Impact of low-intensity extracorporeal shockwave therapy on vascular parameters and sexual function in patients with arteriogenic erectile dysfunction · 2024 · DOI

  • Existing research on the precise link between dietary niacin intake and erectile dysfunction (ED) is scarce.

    Relationship between dietary niacin intake and erectile dysfunction: a population-based study · 2024 · DOI

  • The long-term safety and effectiveness of once-daily tadalafil is crucial, but limited data are available in Chinese patients with erectile dysfunction (ED).

    Long-term tadalafil once daily in Chinese men with erectile dysfunction: a 2-year final analysis of a post-marketing, multicenter, randomized, open-label trial · 2024 · DOI

  • However, specific mechanisms underlying its involvement in various physiological and pathological conditions, especially in erectile dysfunction (ED), remain poorly understood.

    Role of pericytes in regulating penile angiogenesis and nerve regeneration · 2024 · DOI

  • To evaluate the pre- and intraoperative variables that impact the integrity of the corporal bodies over time after inflatable penile prosthesis (IPP) placement, as predictors of intraoperative corporal perforation and delayed cylinder complications have not been well characterized.

    New findings regarding predictors of Poor Corporal Integrity in Penile Implant Recipients: A Multicenter International Invesigation · 2024 · DOI

  • Clinically, proactive ED screening with tools such as the IIEF-5, along with integrated multidisciplinary management (combining arthritis control, individualized ED therapy, lifestyle optimization, and psychological support), is warranted.

    From arthritis to erectile dysfunction: potential pathophysiological mechanisms and multidisciplinary integrated management · 2026 · DOI

  • The authors recommend that future studies include a validated outcome measure of distress. The paper highlights the need for further research on the impact of psychological interventions on partners or couples.

    Beyond the medicine cabinet: psychological approaches to midlife sexual concerns · 2026 · DOI

  • The relationship between hyperuricemia (HUA) and erectile dysfunction (ED) remains inadequately understood.

    Association between metabolic parameters and erection in erectile dysfunction patients with hyperuricemia · 2025 · DOI

  • Despite its prevalence and relevance for quality of life, the factors that affect SH in men with PD (MwPD) are still poorly understood.

    The Impact of Motor, Non-Motor, and Social Aspects on the Sexual Health of Men Living with Parkinson’s Disease · 2024 · DOI

Most-cited papers in Sexual function and dysfunction studies

Most recent work

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Open questions raised by papers listed on this page include: (1) There are no studies investigating the effect of CTM on erectile functions (“Connective tissue massage improves symptoms, autonomic dysfunctions and…”, 2026); (2) Longitudinal changes in sexual activity and their impact on quality of life in older adults have not been thoroughly examined (“Change of sexual activity and its relation to the quality of life in older…”, 2026); (3) Erectile dysfunction (ED) is a prevalent complication of both type 1 and type 2 diabetes mellitus (DM), but the shared molecular mechanisms underlying this complication remain unclear (“Molecular mechanisms of erectile dysfunction in type 1 and type 2 diabetic…”, 2026); (4) There is limited literature on the role of VED use following PPI surgery, which may cause inadvertent damage to the penile tissue with compression of the constriction ring, resulting in distal ischemia of the penis (“Tips and tricks on penile prosthesis implantation in the fibrosed penis”, 2026); (5) Future research should focus on elucidating shear stress-mediating regulatory mechanisms, and developing diagnostic and therapeutic strategies to improve clinical outcomes in patients with ED (“Exploring the application of shear stress in erectile dysfunction”, 2026). 988 gap statements have been mined from Sexual function and dysfunction studies papers in our 7.9M-paper local library, which holds 5,197 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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