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Open research questions in Sexual function and dysfunction studies

568 unresolved questions extracted from the limitations and future-work sections of 3,268 Sexual function and dysfunction studies papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • the study received approval from the University Ethics Committee with an exemption from written informed consent, - participation was voluntary, - students who chose not to complete the questionnaire were excluded, - no universal consensus in the literature on the ideal number of experts needed for content validation

    Developing a Nursing Students’ Sexual Health Intentions Questionnaire using Planned Behavior Theory · 2026 · DOI

  • further research is needed to integrate SHA content into nursing curricula, - studies can apply the SHAIQ to assess nursing students' intentions to perform SHA during clinical rotations, - investigation of the relationship between TPB components and behavioral intentions in different contexts

    Developing a Nursing Students’ Sexual Health Intentions Questionnaire using Planned Behavior Theory · 2026 · DOI

  • There is a lack of knowledge about the health care experiences of sexual minority women. Prior studies have focused on reproductive issues, ignoring other important aspects of women's health. There is a need to understand the relationship between sexual orientation and health care experiences.

    Sexual Orientation as a Health Determinant: Care Access, Pelvic Floor Knowledge, and Sexual Function Among Brazilian Women · 2026 · DOI

  • Limited healthcare access and chronic diseases like diabetes and hypertension contribute to the complexity of ED. The study had to account for the complex survey design of the NHANES database. Missing covariates were imputed using chained equations.

    A comprehensive analysis of erectile dysfunction prevalence and the impact of prostate conditions on ED among US adults: evidence from NHANES 2001-2004 · 2025 · DOI

  • The association between ED and prostate pathologies is not well understood. There is a need for a comprehensive analysis of ED prevalence and its relationship with prostate conditions.

    A comprehensive analysis of erectile dysfunction prevalence and the impact of prostate conditions on ED among US adults: evidence from NHANES 2001-2004 · 2025 · DOI

  • It remains investigational, and prospective randomized controlled trials are warranted to confirm long-term durability and comparative efficacy.

    Clinical outcomes of selective dorsal cryoneurolysis in patients with lifelong premature ejaculation: a retrospective cohort of 108 men · 2026 · DOI

  • The study design appears to be feasible, although the generalizability of the findings is limited.

    Bidirectional associations between daily subjective stress and sexual desire, arousal, and activity in healthy men and women · 2025 · DOI

  • Despite current guidelines recommending multidisciplinary management, there is limited evidence on long-term outcomes, particularly in untreated patients.

    Long-term outcomes of untreated micropenis: growth patterns and predictive factors · 2025 · DOI

  • Introduction: Erectile dysfunction (ED) affects approximately 40% of men; however, the true prevalence remains uncertain owing to various factors.

    Primary Research on Correlation between Erectile Function Assessment through International Index of Erectile Function Score and Nocturnal Penile Tumescence and Rigidity Measurements in Men with Erectile Dysfunction · 2025 · DOI

  • Vasculogenic impairments are suggested to be related to female sexual dysfunction, but previous literature regarding the association is scarce.

    Associations between arterial health and sexual function in women aged 60–64 years · 2024 · DOI

  • INTRODUCTION: Female sexual dysfunction is very common, but its determinants remain under-investigated.

    Associations between arterial health and sexual function in women aged 60–64 years · 2024 · DOI

  • However, their specific influence on the regulation of male ejaculation remains unclear.

    The association between shift work, shift work sleep disorders and premature ejaculation in male workers · 2024 · DOI

  • The complicated pathophysiological changes of DMED, involving vascular, neurological, muscular, and endocrine variables, have not been well addressed by any one treatment technique, and no widely approved treatment strategy has been developed.

    The multifaceted nature of diabetic erectile dysfunction: uncovering the intricate mechanisms and treatment strategies · 2024 · DOI

  • Recently, a novel inflammation-lipid composite marker, CRP/HDL, has been proposed to integrate the impact of both pathways on health, yet its relationship with ED remains unexplored.

    Association between a novel inflammation-lipid composite marker CRP/HDL and erectile dysfunction: evidence from a large national cross-sectional study · 2024 · DOI

  • ED is currently considered to be a predictor of cardiovascular disease (CVD), but few studies have observed the association between ED and clinical features of coronary heart disease (CHD).

    Does erectile dysfunction predict cardiovascular risk? A cross-sectional study of clinical characteristics in patients with erectile dysfunction combined with coronary heart disease · 2024 · DOI

  • Up to 80% of women living with chronic kidney disease (CKD) experience sexual dysfunction, though its link with sexual activity and sexual satisfaction is not well understood.

    Sexual Activity, Function, and Satisfaction in Reproductive-Aged Females Living with Chronic Kidney Disease · 2024 · DOI

  • However, only a few studies have been conducted with representative groups of men that had well-balanced demographic characteristics.

    Lower Urinary Tract Symptoms Correlate with Erectile Dysfunction and Premature Ejaculation but Not with Men’s Sexual Activity: Results from a Large Population-Representative Study · 2024 · DOI

  • Thai Female Sexual Function Index discrimination using the new Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision criteria has not been investigated.

    Female sexual function index for screening of female sexual dysfunction using DSM-5-TR criteria in Thai women: A prospective cross-sectional diagnostic study · 2024 · DOI

  • The complex etiology of ED, resulting from the interplay of bio-psychosocial multidimensional factors. The need for multidisciplinary management, including control of underlying disease, individualized ED treatment, psychological intervention, and lifestyle optimization. The importance of identifying and managing ED in patients with arthritis.

    From arthritis to erectile dysfunction: potential pathophysiological mechanisms and multidisciplinary integrated management · 2026 · DOI

  • The underlying mechanisms of the link between arthritis and ED are not fully understood. There is a need for further research on the management strategies for ED in patients with arthritis.

    From arthritis to erectile dysfunction: potential pathophysiological mechanisms and multidisciplinary integrated management · 2026 · DOI

  • Further studies are needed to validate the findings and explore the mechanisms of ED in more detail. The development of new treatments and preventive strategies for ED is also an area for future research. The study's results can inform public health policies and guide the development of new policies to reduce ED risk.

    Integrating multi-omics, EWAS, and reverse network toxicology to explore environmental pollutant risks in erectile dysfunction · 2026 · DOI

  • The lack of understanding of the interactions between genetic susceptibility and environmental exposures in ED. The need for a comprehensive understanding of the mechanisms of ED. The gap in current research on the identification of causal molecular targets and environmental pollutants underlying ED risk.

    Integrating multi-omics, EWAS, and reverse network toxicology to explore environmental pollutant risks in erectile dysfunction · 2026 · DOI

  • The authors recommend that future studies include a validated outcome measure of distress. The paper highlights the need for further research on the impact of psychological interventions on partners or couples.

    Beyond the medicine cabinet: psychological approaches to midlife sexual concerns · 2026 · DOI

  • The available studies focused only on the individual, without evaluating the impact on partners or couples. No studies assessed the impact of interventions on sexually related personal distress.

    Beyond the medicine cabinet: psychological approaches to midlife sexual concerns · 2026 · DOI

  • The effectiveness of Vybrique has only been shown in a single placebo-controlled trial. The trial had a limited sample size of 475 men. The long-term effects of Vybrique are not known.

    In Brief: Vybrique — Sildenafil Oral Film for Erectile Dysfunction · 2026 · DOI

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568 open questions have been extracted from the limitations and future-work passages of 3,268 Sexual function and dysfunction studies papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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