Science AI Journal
Medicine · Research topic

Open research questions in Skin Protection and Aging

624 gap statements mined from Skin Protection and Aging papers in our 7.9M-paper local library, which holds 1,938 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

Choosing where to publish on Skin Protection and Aging? See the ranked Medicine journals.

What the literature leaves open

  • The need for careful consideration of matrix complexity, preservation of functional constituents, and compatibility with downstream analytical and application contexts in extraction and processing strategies. The lack of standardized methods for evaluating enzyme inhibition in complex matrices.

    Agro-Industrial Residues as Sources of Dermo-Cosmetic Enzyme Inhibitors: Extraction Strategies, Matrix Effects, and Cosmetic Potential · 2026 · DOI

  • The current research on the association between sunlight exposure and the risk of developing various diseases has two main deficiencies: focusing on specific organs and neglecting the impacts of sunlight exposure on other systems. There is a need for a comprehensive examination of the associations between outdoor sunlight exposure duration and a broad spectrum of diseases.

    Associations between the duration of outdoor sunlight exposure and the risk of developing 134 different diseases · 2026 · DOI

  • The lack of effective treatments for skin photoaging. The need to understand the mechanisms of UV-induced skin photoaging and the effects of Handelin on these mechanisms.

    Handelin Attenuates Ultraviolet-Induced Skin Photoaging and Associated Oxidative Stress and Extracellular Matrix Damage in Mice · 2026 · DOI

  • One challenge is the limited number of donors, which restricts the statistical analysis. Another challenge is the detection of residual bacterial DNA in uninoculated controls, which limits the interpretation of UV effects on microbial composition. The study also faces the challenge of ensuring that explant colonization reflects the composition of the inoculated microbiome.

    Assessment of microbiome-UV interactions in a physiological ex vivo human skin model · 2026 · DOI

  • There is a need for a practical in vitro model for evaluating bladder toxicants and carcinogens. The current models do not closely resemble the human bladder epithelium.

    Construction of a Novel 3D Urinary Bladder Mucosa Model and Its Application in Toxicity Assessment of Arsenicals · 2025 · DOI

  • Limited understanding of human exposure to thioxanthones. Lack of comprehensive analysis of thioxanthones and their metabolites in human urine. Need for estimation of daily exposure value of thioxanthones for the general population.

    Presence of Thioxanthones and Their Metabolites in Human Urine and Human Exposure Assessment · 2025 · DOI

  • Further verification by means of larger numbers of cases or, preferably, by evaluating areawide data is needed. Continuous measurements over decades and with a very large number of participants are required to determine individual UVR exposure.

    Impact of Long-Term Changes in Ambient Erythema-Effective UV Radiation on the Personal Exposure of Indoor and Outdoor Workers—Case Study at Selected Sites in Europe · 2025 · DOI

  • There is a lack of understanding of the impact of long-term changes in ambient UVR on human personal radiation exposure. Prior studies have not evaluated the change in the number of days with different UVI exposure categories. The study aims to address this gap by analyzing the effects of ambient UVR on indoor and outdoor workers.

    Impact of Long-Term Changes in Ambient Erythema-Effective UV Radiation on the Personal Exposure of Indoor and Outdoor Workers—Case Study at Selected Sites in Europe · 2025 · DOI

  • The need for a sunscreen that provides broad-spectrum coverage and minimizes dermal penetration. The challenge of formulating an effective sunscreen that meets consumer expectations and regulatory safety standards. The lack of a suitable carrier for encapsulating UV absorbers.

    Mesoporous Silica Encapsulation of Octyl Methoxycinnamate and Benzophenone-3: Structural Characterization, Enhanced UV Protection, and Reduced In Vitro Skin Penetration · 2025 · DOI

  • The complexity of skin aging, which is regulated at both the epidermal and dermal levels. The difficulty of maintaining mitochondrial quality and cellular homeostasis during senescence. The need to develop novel therapeutic strategies to mitigate senescence-associated phenotypes.

    Starfish-Derived Extracts Enhance Mitophagy and Suppress Senescence-Associated Markers in Human Dermal Fibroblasts · 2025 · DOI

  • The effect of ZnO nanoparticle size on sunscreen performance and skin interactions is not well understood. There is a lack of comprehensive studies on the physical stability and cosmetic acceptability of ZnO nanoparticle-based sunscreens.

    Experimental and molecular dynamics investigation of ZnO nanoparticle size effects on sunscreen performance and skin-lipid interactions · 2026 · DOI

  • However, little is known about awareness and use of the Ultraviolet Index among U.

    Awareness and Use of the Ultraviolet Index Among U.S. Adults · 2026 · DOI

  • The four components combination has not been directly tested in the literature reviewed.

    A Narrative Review on a Photoprotective Cream Enriched with Zinc Oxide and Herbal Ingredients · 2026 · DOI

  • However, its compositional variations across flowering stages and their functional relevance remain unclear.

    Kanzan cherry blossom and its active compounds attenuate methylglyoxal-induced skin fibroblast senescence through RAGE/NF-κB suppression and ECM restoration · 2026 · DOI

  • These effects may be mediated by microbial metabolites (MM), yet the impact of UVR on microbial metabolism and its subsequent effects on skin health remains poorly understood.

    The Skin Microbiome, Microbial Metabolites and the Epidermal Response to Ultraviolet Radiation—Towards Next Generation Suncare · 2025 · DOI

  • While its pathophysiology remains incompletely understood, environmental factors and impaired barrier function are key contributors.

    The Relationship Between Sensitive Skin and Skin Aging in Han Chinese · 2025 · DOI

  • Pinus morrisonicola (Taiwan white pine), known for its anti-cancer, anti-inflammatory, and antioxidant properties, is used in health-promoting beverages, but its skin-protective effects remain underexplored.

    Ultraviolet B-induced oxidative damage in human skin keratinocytes is alleviated by Pinus morrisonicola leaf essential oil through activation of the Nrf2-dependent antioxidant defense system · 2025 · DOI

  • Further studies in diverse populations are warranted to confirm these benefits and explore underlying mechanisms.

    Porcine placenta peptides as a complementary functional food for skin rejuvenation: A 12-week randomized, double-blind, placebo-controlled trial · 2025 · DOI

  • However, its potential benefits for the skin and the underlying molecular mechanisms remain unclear.

    Echinacoside promotes collagen synthesis and survival via activation of IGF ‐1 signaling to alleviate UVB ‐induced dermal fibroblast photoaging · 2025 · DOI

  • Despite high UV levels in Saudi Arabia, public awareness and adherence to melanoma preventive behaviours remain underexplored.

    Sun‐Safety Knowledge, Attitudes and Behaviour in Western Saudi Arabia: Implications for Psycho‐Oncology Prevention Services · 2025 · DOI

  • Only a few reports have studied the multipollutant interaction and its effect on skin damage.

    Vitamin C compounds mixture prevents skin barrier alterations and inflammatory responses upon real life multi pollutant exposure · 2024 · DOI

  • Limited number of donors (three), - Small sample size, - Presence of residual bacterial DNA in uninoculated controls, - Study duration limited to 48 h, - Lack of long-term…

    Assessment of microbiome-UV interactions in a physiological ex vivo human skin model · 2026 · DOI

  • Investigating the long-term effects of the composite, - Exploring the potential applications of the composite in advanced skincare and cosmeceutical formulations, - Studying the effects of different mass ratios of OMC to BP-3 on the encapsulation…

    Mesoporous Silica Encapsulation of Octyl Methoxycinnamate and Benzophenone-3: Structural Characterization, Enhanced UV Protection, and Reduced In Vitro Skin Penetration · 2025 · DOI

  • The efficacy and safety of some artificial UV filters are hampered by their photoinstability, toxicity, and damage to marine ecosystems, - Natural UV filters with UV-absorptive capacities are limited by low specific extinction values, - The inability to incorporate natural UV filters into large-scale sunscreen cosmetic…

    Characterizing the Ultraviolet (UV) Screening Ability of L-5-Sulfanylhistidine Derivatives on Human Dermal Fibroblasts · 2025 · DOI

  • Investigating the potential of marine-inspired sulfur-containing amino acids in developing alternative eco-safe sunscreens, - Studying the effects of L-5-sulfanyl histidine derivatives on human skin, - Examining the photoinstability and toxicity of artificial UV…

    Characterizing the Ultraviolet (UV) Screening Ability of L-5-Sulfanylhistidine Derivatives on Human Dermal Fibroblasts · 2025 · DOI

Most-cited papers in Skin Protection and Aging

Most recent work

Find a gap in your own Skin Protection and Aging sub-topic

This page shows what the Skin Protection and Aging literature already flags as unresolved. To narrow it to your specific question, search the Research Gap Finder: the search is free with a free account and lists the papers closest to your topic first. Unlocking that topic (50 credits, charged once) fills the comparison table from our 7.9M-paper local library and writes the gaps from its rows.

Open the Research Gap Finder →

Related topics in Medicine

Artificial Intelligence in Healthcare and Education
4,200 open questions
Dementia and Cognitive Impairment Research
2,789 open questions
Substance Abuse Treatment and Outcomes
2,285 open questions
Cancer Immunotherapy and Biomarkers
2,273 open questions
Liver Disease Diagnosis and Treatment
2,102 open questions
Sports Performance and Training
1,952 open questions
Parkinson's Disease Mechanisms and Treatments
1,915 open questions
Mosquito-borne diseases and control
1,849 open questions
Open questions raised by papers listed on this page include: (1) The lack of standardized methods for evaluating enzyme inhibition in complex matrices (“Agro-Industrial Residues as Sources of Dermo-Cosmetic Enzyme Inhibitors:…”, 2026); (2) There is a need for a comprehensive examination of the associations between outdoor sunlight exposure duration and a broad spectrum of diseases (“Associations between the duration of outdoor sunlight exposure and the risk of…”, 2026); (3) The effect of ZnO nanoparticle size on sunscreen performance and skin interactions is not well understood (“Experimental and molecular dynamics investigation of ZnO nanoparticle size…”, 2026); (4) Little is known about awareness and use of the Ultraviolet Index among U (“Awareness and Use of the Ultraviolet Index Among U.S. Adults”, 2026); (5) Its compositional variations across flowering stages and their functional relevance remain unclear (“Kanzan cherry blossom and its active compounds attenuate methylglyoxal-induced…”, 2026). 624 gap statements have been mined from Skin Protection and Aging papers in our 7.9M-paper local library, which holds 1,938 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 1,100,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? Acceptance odds for top, mid and open/emerging journals, in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck for prior publication across 7 sources and our local library.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

How Pre-Check worksHow AI Review works

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.