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Open research questions in Traditional Chinese Medicine Analysis

35 unresolved questions extracted from the limitations and future-work sections of 88 Traditional Chinese Medicine Analysis papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The goal is to clarify research advancements, pinpoint key areas of interest, and predict future trends in this field, thereby offering a theoretical foundation and guidance for further studies on managing LUAD with traditional Chinese medicine (TCM).

    The research hotspot and trend for traditional Chinese medicine treatment of lung adenocarcinoma: Based on bibliometric analysis · 2026 · DOI

  • Secondly, although correla- tive changes in intestinal flora were observed following XFZCD treatment, a causal relationship between the altered gut microbiota and the anti-TD effects has not been established.

    Xifeng Zhichou decoction mitigates tic disorder on juvenile rats by regulating neuroinflammation and neurotransmitter homeostasis: dual modulation of Nr4a2 and gut microbiota · 2026 · DOI

  • Xinyang Tablet (XYT), a clinically used traditional Chinese medicine, demonstrates cardioprotective effects, but its mechanisms against cardiac hypertrophy remain unclear.

    Data mining based on multiomic data integration to explore the mechanism by which a proprietary Chinese medicine improves cardiac hypertrophy in heart failure. · 2026 · DOI

  • Acorus tatarinowii Schott (AT) and Panax notoginseng saponins are traditional Chinese medicines with neuroprotective potential, yet the mechanism underlying their combined action remains elusive.

    Combined treatment with Acorus tatarinowii Schott and Panax notoginseng saponins ameliorates brain–gut axis dysfunction in MCAO/R rats with suppression of TLR4/MyD88/NF-κB signaling and associated gut microbiota changes · 2026 · DOI

  • Because the present study did not include dose-response matrices, a formal dose-response interaction profile and a causal microbiota-TLR4 mechanism remain to be established in future studies.

    Combined treatment with Acorus tatarinowii Schott and Panax notoginseng saponins ameliorates brain–gut axis dysfunction in MCAO/R rats with suppression of TLR4/MyD88/NF-κB signaling and associated gut microbiota changes · 2026 · DOI

  • Radix Bupleuri (RB)-induced hepatotoxicity and herb-drug interactions have raised clinical concerns, yet the role of its intestinal metabolites, saikogenins (SGs), in modulating human UDP-glucuronosyltransferase (UGT) activity remains poorly understood.

    Intestinal Deglycosylation Activates Saikosaponins as Potent, Selective UGT2B7/2B15 Inhibitors: Structural Basis and Implications for Herb–Drug Interactions · 2026 · DOI

  • Tanyu Tongzhi Decoction (TYTZD) exerts clear cardioprotective effects on CHD patients with SI-GPBS, while its specific regulatory mechanism remains unclear.

    Tanyu Tongzhi Decoction Improves Cardiac Function by Inhibiting Platelet Activation and Alleviating Coronary Microthrombosis for Coronary Heart Disease Mice · 2026 · DOI

  • regulation, and dose-effect thresholds, to fully elucidate and validate the targets of ATL-III and their interactions, and to draw a more accurate map of the regulatory mechanisms. This will enable the systematic construction of a temporal-spatial regulatory network of “target-pathway-disease” and “target-cell type-organ” for ATL-III, further clarifying its mechanism of action against neurological diseases. Third, the safety profile of ATL-III must be rigorously and comprehensively evaluated. Systematic reports on the toxicity, dosetoxicity relationship, and detailed toxicological mechanisms of pure ATL-III compound require further in-depth investigation. Fourth, studies on the bioavailability and BBB penetration of ATL-III must be strengthened. Integrating modern pharmaceutical technologies, advanced excipients, and biomaterials to enhance the stability of ATL-III, and synergistically optimizing its bioavailability, BBB targeting, and brain retention, is a key and challenging direction for future research. The ultimate goal is to develop a quality-controllable, highly efficient, and stable ATL-III formulation suitable for clinical application. Finally, clinical trials must be conducted to provide direct evidence for the use of ATL-III in treating CNSDs. In the future, conducting large-scale, multicenter randomized controlled trials is essential to validate the efficacy and safety of ATL-III. rigorous, high-quality, 6.4 Limitations of this review It is important to note that this review prioritized studies utilizing CNS-relevant cellular models. Consequently, findings from non-neural in vitro systems were excluded. Although this ensures biological relevance, it introduces a constraint; the excluded data, while valuable for elucidating fundamental systems-level molecular functional recovery. This limitation should be considered when evaluating the comprehensiveness of the mechanistic profile presented for ATL-III.

    Atractylenolide III for central nervous system disorders: a review of multi-target mechanisms and therapeutic potential · 2026 · DOI

  • Integrated eco-genomic approaches combining whole-genome resequencing, common-garden experiments, transcriptomic profiling, and gene-editing validation have not been simultaneously applied to Salvia species. This integrated strategy is necessary to advance from merely describing correlations between habitat altitude and phytochemical composition to revealing the actual causal genetic and molecular mechanisms.

    The “habitat-phytochemistry-pharmacological effect” nexus: a multidimensional review of ethnomedicinal Salvia in China · 2026 · DOI

  • Functional validation of candidate genes identified as potentially controlling Salvia phytochemical biosynthesis is absent. Gene-editing techniques must be applied to experimentally validate the causal roles of specific genes in the production of bioactive compounds like salvianolic acids and diterpenoid quinones in Salvia miltiorrhiza and related species.

    The “habitat-phytochemistry-pharmacological effect” nexus: a multidimensional review of ethnomedicinal Salvia in China · 2026 · DOI

  • The genetic mechanisms underlying observed altitudinal patterns in Salvia phytochemistry remain uncharacterized. Common-garden experiments combined with metabolomic and transcriptomic analyses are needed to dissect environmental effects on gene expression and phytochemical ingredient accumulation under controlled genetic backgrounds across different Salvia species.

    The “habitat-phytochemistry-pharmacological effect” nexus: a multidimensional review of ethnomedicinal Salvia in China · 2026 · DOI

  • Current evidence does not establish direct causal links between altitudinal gradients and adaptive differentiation of specific enzyme genes in Salvia species. Future studies must perform whole-genome resequencing of Salvia populations across altitude gradients to detect altitude-associated selection signals and identify the specific polygenic loci responsible for chemical composition variation.

    The “habitat-phytochemistry-pharmacological effect” nexus: a multidimensional review of ethnomedicinal Salvia in China · 2026 · DOI

  • The study focuses on transcriptome-level analysis and HPLC chemical profiling, but lacks explicit discussion of functional validation of identified pathway perturbations or translation of findings to in vivo systems.

    Multidimensional transcriptome dataset for systematic evaluation of Jakyakgamcho-tang-induced cell signatures · 2026 · DOI

  • The UPLC fingerprinting method combined with chemometrics should be further validated and applied to assess authenticity, quality, and development of herbal medicines and related food and pharmaceutical products.

    Quality Evaluation of the Traditional Chinese Medicine Moutan Cortex Based on UPLC Fingerprinting and Chemometrics Analysis · 2025 · DOI

  • The study examined only 14 batches of Moutan Cortex samples from limited geographical regions within China; expansion to more samples and broader geographic coverage would strengthen the conclusions.

    Quality Evaluation of the Traditional Chinese Medicine Moutan Cortex Based on UPLC Fingerprinting and Chemometrics Analysis · 2025 · DOI

  • The action mechanism of Duzhong (Eucommiae Cortex) on LDH is characterized by multiple paths, multiple targets, and multiple component cross-actions, but the direct effects of specific components of Duzhong (Eucommiae Cortex) on LDH pathological tissues have not been clarified in the existing studies.

    Research Progress on the Mechanism of the Effective Components of Duzhong (Eucommiae Cortex) on Lumbar Disk Herniation · 2023 · DOI

  • These findings demon- strate that structural analogy alone is insufficient for pre- dicting pharmaceutical cocrystal formation and underscore the importance of empirical screening during solid-form de- velopment.

    Pharmaceutical Sciences: International Scientific Conference on Medicine and Health Sciences of the University of Latvia, 2026 · 2026 · DOI

  • In this commentary, we highlight the strengths of the study and discuss several aspects that warrant further investigation to enhance mechanistic depth and translational relevance.

    Letter to the Editor: Hepatic transcriptome and metabolome analysis of Jiangtang Tiaozhi formula · 2026 · DOI

  • Natural Products and Bioprospecting (2026) 16:69 Page 11 of 14 Salvia species remains to be further investigated and exploited.

    Rapid exploration of anti-MRSA components from plants of Salvia · 2026 · DOI

  • While the paper demonstrates transcriptomic reproducibility and external validity, there is no discussion of potential limitations in the generalizability of findings across different cell types or disease contexts beyond those studied.

    Multidimensional transcriptome dataset for systematic evaluation of Jakyakgamcho-tang-induced cell signatures · 2026 · DOI

  • While geographical location was correlated with chemical composition differences, the underlying environmental and cultivation factors causing these variations were not investigated in detail.

    Quality Evaluation of the Traditional Chinese Medicine Moutan Cortex Based on UPLC Fingerprinting and Chemometrics Analysis · 2025 · DOI

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35 open questions have been extracted from the limitations and future-work passages of 88 Traditional Chinese Medicine Analysis papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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