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Open research questions in Traditional Chinese Medicine Analysis

273 gap statements mined from Traditional Chinese Medicine Analysis papers in our 7.9M-paper local library, which holds 1,103 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • It has various processed products in clinical prescription; however, the quality distinctions among different processed products of CR remain unexplored.

    E‐Eye, Flash GC E‐Nose, and HS‐GC–MS Combined With Chemometrics to Identify the Different Processed Products of Cyperus rotundus · 2026 · DOI

  • The findings provide an overall view of the in vivo exposure and metabolic characteristics of the extract and offer useful reference information for quality evaluation and further investigation of its material basis.

    Investigation of the Chemical Constituents and Hepatic‐Exposed Components of the Bupleuri Radix–Rhei Radix et Rhizoma Herbal Pair Based on UPLC‐Q‐Orbitrap‐MS Analysis · 2026 · DOI

  • Bupleuri Radix (BR) and Rhei Radix et Rhizoma (RR) are commonly used in combination in traditional Chinese medicine, yet the chemical basis of their compatibility and the liver-exposed constituents after oral administration remain unclear.

    Investigation of the Chemical Constituents and Hepatic‐Exposed Components of the Bupleuri Radix–Rhei Radix et Rhizoma Herbal Pair Based on UPLC‐Q‐Orbitrap‐MS Analysis · 2026 · DOI

  • The role of macromolecular components in traditional Chinese medicines (TCMs) decoction remains poorly understood, primarily because of their structural complexity and limited systemic bioavailability.

    LC–MS‐Based Serum Pharmacochemistry Combined With Network Pharmacology and Pharmacodynamics to Evaluate the Role of Macromolecular Components in TCMs' Decoction: A Case Study on Qi‐Huo‐Yi‐Fei Decoction for COPD Therapy · 2025 · DOI

  • However, the active components and in vivo metabolism of the Coptidis Rhizoma-Aucklandiae Radix herb pair (CR-AR) in the treatment of AAD remain unclear.

    Integrated LC‐MS and Network Pharmacology Reveal Metabolic Profile and Quantitative Analysis of Active Components in Coptidis Rhizoma–Aucklandiae Radix Herb Pair Between Healthy and Diarrheal Mice · 2025 · DOI

  • At present, the quality standards for hemp kernels have not yet established content control for single or whole components.

    Herbal Research, Phytochemistry, Pharmacology, Comprehensive Utilization, and Quality Control of Hemp Seed: A Comprehensive Review · 2025 · DOI

  • However, the current research on the chemical composition and the material basis of the medicinal effect of WDD is not perfect, which limits further research on it.

    A Comprehensive Quality Evaluation Strategy of Wendan Decoction Based on Qualitative, Fingerprint, and Quantitative Analyses · 2025 · DOI

  • Whether this empirical criterion can accurately reflect the quality of the medicinal material has not been systematically studied.

    Chemical Fingerprinting and Multivariate Analysis of Different Grades of Farfarae Flos Using HPLC and UPLC‐ESI‐Q/TOF‐MS/MS · 2025 · DOI

  • This study aimed to identify the differential compounds of licorice between traditional and fresh processing methods and provide a scientific basis for the fresh processing of licorice and for further research on the processing mechanism.

    Effects of different post‐harvest processing methods on changes in the active ingredients of licorice based on LC‐MS and plant metabolomics · 2024 · DOI

  • However, the metabolic choreography of these Asparagus species is not well characterized, and the compounds contributing to their bioactivities remain unknown.

    Comparative metabolites profiling of different solvent extracts of Asparagus species cladodes using liquid chromatography–mass spectrometry‐based metabolomics and molecular networking · 2024 · DOI

  • However, these compounds have not been thoroughly studied as key metabolites in T.

    HPLC/ESI‐QTOF‐MS/MS based untargeted metabolomics authentication of Taxus × media six tissues · 2024 · DOI

  • To date, there is no quality control method to ensure batch-to-batch consistency of Qi-Fu-Yin, and the potential antioxidant compounds in Qi-Fu-Yin remain uncertain.

    Spectrum–effect relationship between HPLC fingerprints and antioxidant activity of Qi‐Fu‐Yin based on multiple statistical correlation analysis · 2024 · DOI

  • Despite its known anti-inflammatory and choleretic effects, its quality has not been extensively evaluated.

    Comprehensive quality evaluation of Lysimachia christinae Hance via fingerprint, spectrum–effect relationship, and quantitative analyses of multiple components by single marker · 2024 · DOI

  • Nevertheless, the specific variations in chemical constituents of ST before and after honey-fried remain unclear.

    Spatial metabolomics method to reveal the differences in chemical composition of raw and honey‐fried Stemona tuberosa Lour. by using UPLC‐Orbitrap Fusion MS and desorption electrospray ionization mass spectrometry imaging · 2024 · DOI

  • Raw PMR was prepared into processed PMR via processing procedure; however, there is a lack of standardized protocols ensuring the completeness of processing.

    A Metabolomics Strategy Combining Countercurrent Separation and qNMR for the Comprehensive Chemical Evaluation of Polygoni Multiflori Radix Processing · 2024 · DOI

  • Few studies on CAP have been reported; therefore, it is necessary to clarify the material basis of CAP to lay the foundation for further elucidating its functional mechanism and support the rational use of drugs.

    A comprehensive strategy for quality evaluation of Changan powder by fingerprinting combined with rapid qualitative and quantitative multi‐ingredients profiling · 2024 · DOI

  • However, quality standards have not yet been established, although some studies have been conducted on their composition.

    Study on the quality evaluation of the leaves of Croton tiglium from different regions based on quality markers · 2024 · DOI

  • The proportions of the constituent herbs in Jakyakgamcho-tang are important but underexplored. The efficacy of herbal medicine may vary with the extraction solvent, mixing ratio, and extraction method.

    Multidimensional transcriptome dataset for systematic evaluation of Jakyakgamcho-tang-induced cell signatures · 2026 · DOI

  • There is a lack of rigorous pharmacological validation of traditional uses of Salvia species. Less than 30% of studies met high-evidence criteria due to inadequate botanical authentication, uncharacterized extracts, and non-physiological dosing.

    The “habitat-phytochemistry-pharmacological effect” nexus: a multidimensional review of ethnomedicinal Salvia in China · 2026 · DOI

  • There is a lack of effective clinical treatments for myocardial ischemia-reperfusion injury. The mechanisms of Astragalus membranaceus-Salvia miltiorrhiza in treating myocardial ischemia-reperfusion injury are not well understood. There is a need for comprehensive studies on the bioactive compounds and targets of herbal compounds in the development of therapeutic strategies.

    Network pharmacology and molecular dynamics study of Astragalus membranaceus-Salvia miltiorrhiza in the treatment of myocardial ischemia-reperfusion injury · 2026 · DOI

  • As a widely used Chinese herbal medicine, Mume Fructus pulp (MFP) has rich nutritional value and biological activity, but its quality control research is relatively scarce.

    Characterization of Quality Marker for Mume Fructus Pulp by Ultra‐Performance Liquid Chromatography‐Quadrupole Time‐of‐Flight Mass Spectrometry‐Based Untargeted Metabolomics Combined With Biological Activities · 2025 · DOI

  • However, the chemical characteristics and its effective constituents are still scarcely studied.

    Characterization of the chemical constituents of Croton crassifolius Geisel extract and plasma pharmacokinetics of 6 terpenoids after oral administration by UPLC‐Q/TOF‐MS · 2024 · DOI

  • There is currently no standardized or widely accepted research strategy for evaluating the quality of kidney tea granules (KTGs) after granulation.

    Quality Evaluation of Kidney Tea Granules From Different Origins Based on TLC, HPLC Fingerprinting, and Quantitative Analysis Combined With Chemical Pattern Recognition · 2024 · DOI

  • Investigate the relationship between altitudinal gradients and chemical diversification.

    The “habitat-phytochemistry-pharmacological effect” nexus: a multidimensional review of ethnomedicinal Salvia in China · 2026 · DOI

  • A major limitation in current Traditional Chinese Medicine (TCM) research lies in its overreliance on single-factor analyses of chemical composition or pharmacodynamics, or simplistic combined models.

    Quality Analysis of Curcumae Radix From Different Sources Based on the Three‐Dimensional Evaluation System of “Morphology–Composition–Efficacy” · 2025 · DOI

Most-cited papers in Traditional Chinese Medicine Analysis

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Open questions raised by papers listed on this page include: (1) It has various processed products in clinical prescription; however, the quality distinctions among different processed products of CR remain unexplored (“E‐Eye, Flash GC E‐Nose, and HS‐GC–MS Combined With Chemometrics to Identify the…”, 2026); (2) Bupleuri Radix (BR) and Rhei Radix et Rhizoma (RR) are commonly used in combination in traditional Chinese medicine, yet the chemical basis of their compatibility and the liver-exposed constituents after oral administration remain unclear (“Investigation of the Chemical Constituents and Hepatic‐Exposed Components of…”, 2026); (3) There is a lack of rigorous pharmacological validation of traditional uses of Salvia species (“The “habitat-phytochemistry-pharmacological effect” nexus: a multidimensional…”, 2026); (4) There is a lack of effective clinical treatments for myocardial ischemia-reperfusion injury (“Network pharmacology and molecular dynamics study of Astragalus…”, 2026); (5) The role of macromolecular components in traditional Chinese medicines (TCMs) decoction remains poorly understood, primarily because of their structural complexity and limited systemic bioavailability (“LC–MS‐Based Serum Pharmacochemistry Combined With Network Pharmacology and…”, 2025). 273 gap statements have been mined from Traditional Chinese Medicine Analysis papers in our 7.9M-paper local library, which holds 1,103 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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