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Open research questions in Traumatic Brain Injury Research

310 unresolved questions extracted from the limitations and future-work sections of 1,717 Traumatic Brain Injury Research papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Investigating the use of symmetry as a marker of incomplete recovery, - Examining the effectiveness of biofeedback-guided movement retraining in addressing subtle sensorimotor asymmetries, - Establishing clinically meaningful thresholds for symmetry-related measures in post-concussion populations

    Restoring Symmetry After Sport-Related Concussion: A Viewpoint on Biofeedback-Guided Rehabilitation · 2026 · DOI

  • The current management approach may not fully capture persistent functional deficits relevant to recovery. There is a lack of emphasis on symmetry restoration as an explicit rehabilitative construct in SRC management. The paper identifies a need for a more comprehensive approach to concussion rehabilitation that addresses unresolved asymmetries.

    Restoring Symmetry After Sport-Related Concussion: A Viewpoint on Biofeedback-Guided Rehabilitation · 2026 · DOI

  • The study aimed to minimize emotional activation while still enabling clinicians to establish whether events with a known association to traumatic or hypoxic brain injury have occurred. The study had to balance the need for a comprehensive screening tool with the need to minimize demand on participants. The study had to ensure that the tool was appropriate for use in an Australian context and included the voices of Aboriginal and Torres Strait Islander people.

    Brain Injury and Family Violence: Establishing a Tool to Support Clinical Practice · 2026 · DOI

  • Pilot studies to investigate the psychometric properties of the BIC-FV screening tool - Investigation of the tool's effectiveness in identifying cognitive dysfunction and brain injury in victim-survivors of family violence

    Brain Injury and Family Violence: Establishing a Tool to Support Clinical Practice · 2026 · DOI

  • Hypermetabolism and hypercatabolism in patients with severe traumatic brain injury. Feeding intolerance in patients with severe traumatic brain injury. Lack of standardized and integrated protocols for nutritional management.

    Development of a nutritional management protocol for patients with severe traumatic brain injury: a Delphi study · 2026 · DOI

  • Small sample size, - Limited to adolescents aged 12-17.99 years, - No long-term follow-up

    The impact of an app-delivered mindfulness-based intervention on resting-state functional connectivity in pediatric concussion: a pilot study · 2026 · DOI

  • Investigate the long-term effects of MBI on FC in pediatric concussion, - Examine the effects of MBI on other neural networks, - Compare the efficacy of MBI to other interventions for pediatric concussion

    The impact of an app-delivered mindfulness-based intervention on resting-state functional connectivity in pediatric concussion: a pilot study · 2026 · DOI

  • Further research is needed to develop more complete models of language processing that incorporate discourse-level organization, - Investigating why communication abilities are vulnerable to disruption from cognitive deficits, such as those seen in individuals with TBI

    Topic shifts elicit costs in naturalistic discourse: evidence from healthy adults and individuals with traumatic brain injury · 2026 · DOI

  • There is a lack of understanding about how individuals respond to changes in topic structures and the cognitive-linguistic consequences for discourse understanding and production. The cognitive demands of tracking topic changes and their effects on language production are not well understood.

    Topic shifts elicit costs in naturalistic discourse: evidence from healthy adults and individuals with traumatic brain injury · 2026 · DOI

  • Utilize PVTs when assessing the relationship between SCCs and objective neuropsychological performance, - Investigate the relationship between SCCs and objective neurocognitive performance in larger samples, - Examine the impact of psychiatric factors on SCCs in different clinical populations

    Relationship between subjective cognitive concerns and objective neurocognitive performance in primary medical versus primary psychiatric populations · 2025 · DOI

  • The extant literature has under-utilized performance validity tests when analyzing objective neuropsychological outcomes. The relationship between subjective cognitive concerns and objective neurocognitive performance is complex and may be influenced by underlying mechanisms of various impairments or etiologies. The study aims to address the gap in the literature by examining the associations between subjective cognitive concerns, performance validity, neurocognitive performance, and psychiatric distress.

    Relationship between subjective cognitive concerns and objective neurocognitive performance in primary medical versus primary psychiatric populations · 2025 · DOI

  • The long-term cognitive and behavioral outcomes following pediatric mTBI are not well understood. The effect of age-at-injury on long-term outcomes is largely unknown. There is a need for more research on the underlying pathophysiology of mTBI.

    Executive functioning, behavior, and white matter microstructure in the chronic phase after pediatric mild traumatic brain injury: results from the adolescent brain cognitive development study · 2024 · DOI

  • Footballers are routinely exposed to repeated non-concussive head impacts with (soccer) heading, the acute neurobiological consequences of which remain poorly characterised.

    Acute Temporal Dynamics of Brain Injury Plasma Biomarkers following Controlled Football Heading · 2026 · DOI

  • The paper also highlights the incremental value of neuropsychological assessment in complex cases, including differential diagnosis, identification of co-occurring neurodevelopmental, psychiatric, and medical conditions, clarification of mechanisms underlying poor academic performance, and development of individualized intervention recommendations when school-based evaluation or response to intervention is insufficient.

    The critical role for neuropsychologists in the assessment and diagnosis of learning disorders: a position paper from the National Academy of Neuropsychology position, education, and response committee · 2026 · DOI

  • Abstract Objective Neuropsychological assessment feedback has the potential to promote cognitive/brain health, yet few studies have tested how feedback can be modified to improve its uptake.

    Spaced retrieval practice improves the uptake of and intention to use personal neuropsychological assessment feedback: a randomized cognitive experiment in a sample of older black and white veterans · 2026 · DOI

  • Future studies are needed to determine the mechanisms of SRP’s benefits on memory for feedback, and to develop methods for improving adherence to feedback in neuropsychological populations.

    Spaced retrieval practice improves the uptake of and intention to use personal neuropsychological assessment feedback: a randomized cognitive experiment in a sample of older black and white veterans · 2026 · DOI

  • Further research into energy needs after concussion may inform therapeutic targets to facilitate recovery.

    Physical activity and caloric expenditure after adolescent concussion: a comparison with uninjured controls · 2026 · DOI

  • However, the lack of standardized severity grading limits comparison with other studies.

    Five-Year Follow-Up of Work Disability After Traumatic Brain Injury · 2026 · DOI

  • BACKGROUND AND OBJECTIVES: The link between repetitive head impact (RHI) exposure, later-life cognitive decline, and neurobehavioral dysregulation (NBD) is not well understood.

    Inflammation, Limbic White Matter Microstructure, and Clinical Symptoms in Retired American Football Players With Repetitive Head Impacts · 2026 · DOI

  • However, their relationship with intermediate health outcomes (specifically within 5 years of collegiate sport retirement) remains unknown.

    Sport-Related Head Exposure Characteristics and Health Outcomes in Former Collegiate Athletes · 2026 · DOI

  • However, little is known about how student-athletes themselves interpret and make meaning of these repeated injury experiences.

    The Lived Experiences of Student-Athletes with a History of Multiple Concussions · 2026 · DOI

  • CTE cases show cognitive deficits resembling Alzheimer dementia, but a direct clinicopathologic link is inconclusive.

    Cognitive Impairment and Dementia-Related Diagnoses in Chronic Traumatic Encephalopathy · 2025 · DOI

  • Clinical criteria have been proposed, although cognitive correlates of CTE remain unknown.

    Cognitive Impairment and Dementia-Related Diagnoses in Chronic Traumatic Encephalopathy · 2025 · DOI

  • BACKGROUND AND OBJECTIVES: Repetitive head impacts (RHIs) in sports are associated with adverse clinical and neuropathologic outcomes, but there is limited evidence from in vivo human imaging studies to inform risk assessment, exposure standards, and interventions.

    Soccer Heading Exposure–Dependent Microstructural Injury at Depths of Sulci in Adult Amateur Players · 2025 · DOI

  • These results suggest that universal screening for and prompt treatment of depressive symptoms in among older adults with a history of TBI is warranted.

    Traumatic Brain Injury and Depressive Symptoms in Community-Dwelling Older Adults · 2025 · DOI

Most-cited papers in Traumatic Brain Injury Research

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310 open questions have been extracted from the limitations and future-work passages of 1,717 Traumatic Brain Injury Research papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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