How were these Tuberculosis Research and Epidemiology research gaps identified?

They are mined from the papers themselves, not generated. A gap is a sentence in which the authors state something that remains unresolved; each is quality-filtered, de-duplicated, and checked to be still open before it appears here.

How do I find a research gap in Tuberculosis Research and Epidemiology for my own work?

Browse the questions on this page for a sense of what the Tuberculosis Research and Epidemiology literature leaves open, then narrow it to your own sub-topic with the Research Gap Finder. The search is free and needs only a free account: it returns a live OpenAlex field overview, a comparison table that lists the papers closest to your sub-topic first, and every paper the search found in one list you can filter, sort and export as RIS or BibTeX. Unlocking that topic costs 50 credits, charged once — it fills the table from our 7.9M-paper local library and writes the research gaps from its rows, and the research proposal and one Pro Report run on the same topic are included, with nothing inside it sold separately. A free account starts with 25 welcome credits.

Medicine · Research topic

Open research questions in Tuberculosis Research and Epidemiology

1,542 gap statements mined from Tuberculosis Research and Epidemiology papers in our 7.9M-paper local library, which holds 5,162 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

The study highlights the need for improved global tuberculosis control strategies. The study identifies the challenge of understanding the attributable risk factors for these diseases.
The burden of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis and its attributable risk factors in 204 countries and territories, 1990–2021 · 2026 · DOI
The study aims to address the gap in understanding the genetic diversity and genotypic resistance profiles of Mycobacterium tuberculosis isolates in Indonesia. The study aims to identify drug resistance-associated mutations and determine strain lineage/sub-lineages.
Genomic profiling and drug resistance patterns of Mycobacterium tuberculosis in Indonesia: whole-genome sequencing of isolates from the 2017–2018 national Tuberculosis Drug Resistance Survey · 2026 · DOI
The previous baseline study in Ecuador reported a low prevalence of 2.09% for 2012-2016, but there is a need to update the molecular epidemiology of the RDRio genotype. The large influx of migrants from Venezuela, where RDRio is highly endemic, has occurred since 2015, which may have affected the prevalence of the RDRio genotype.
Molecular epidemiology of the RDRio genotype of Mycobacterium tuberculosis in Ecuador: a tracking update for the years 2018 and 2023 · 2026 · DOI
The prevalence of the Beijing sublineage in Ecuador is not well understood. There is a need to update the molecular epidemiology of the Beijing sublineage in Ecuador. The study aims to fill this gap by analyzing recent isolates from 2018 and 2023.
Monitoring changes in the prevalence of the Beijing lineage of Mycobacterium tuberculosis in Ecuador: 2018 and 2023 · 2026 · DOI
Current diagnostic methods for extrapulmonary tuberculosis have limitations such as low sensitivity and long turnaround times. There is a need for more sensitive and rapid diagnostic tools for extrapulmonary tuberculosis. The performance of the MPT64 antigen detection test in a high-TB, low-HIV setting is not well established.
Advancing Extrapulmonary Tuberculosis Diagnosis: Potential of MPT64 Immunochemistry-Based Antigen Detection Test in a High-TB, Low-HIV Endemic Setting · 2025 · DOI
The effect of TB preventive therapy in adolescents is unstudied in China. There is a lack of research on the protective effect of isoniazid-rifampicin preventive therapy in Chinese adolescents. The study aims to fill this gap by evaluating the protective effect of TPT in this group.
Efficacy of Isoniazid–Rifampicin Preventive Therapy in Adolescent Contacts in School Outbreaks: A Retrospective Cohort Study in Eastern China · 2025 · DOI
It also highlights the need for more accurate and efficient diagnostic tools. The gap in TB drug discovery is also identified, including the need for new anti-TB medications to treat drug-resistant TB.
Integration of AI and ML in Tuberculosis (TB) Management: From Diagnosis to Drug Discovery · 2025 · DOI
There is a lack of adherence to national guidelines in EPTB diagnosis and treatment. The study identifies gaps in the diagnosis and treatment of EPTB, including limited access to microbiological testing.
Evaluating the Gaps in the Diagnosis and Treatment in Extra-Pulmonary Tuberculosis Patients Under National Tuberculosis Elimination Programme (NTEP) Guidelines: A Multicentric Cohort Study · 2025 · DOI
Limited understanding of the facilitators and barriers to tuberculosis preventive treatment initiation and completion among people living with HIV in Uganda. Limited evaluation of the tuberculosis preventive treatment cascade among people living with HIV in Uganda.
Tuberculosis Preventive Treatment in People Living with HIV in Uganda: Facilitators and Barriers for Initiation and Completion · 2025 · DOI
Issues of tastelessness and food insecurity were also reported. Access-related gaps in Direct Benefit Transfer (DBT) were identified as a challenge.
Qualitative Study of Nutritional Support-Related Perceptions and Preferences Among Persons Affected by TB, Family Caregivers, and Healthcare Providers in India · 2025 · DOI
Limited evidence on the implementation aspects of nutritional support interventions for persons with TB in India. Lack of understanding of the knowledge, perceptions, and practices of persons with TB, family caregivers, and healthcare providers regarding nutritional support. Need for more research on the delivery of nutritional support to persons with TB in India.
Qualitative Study of Nutritional Support-Related Perceptions and Preferences Among Persons Affected by TB, Family Caregivers, and Healthcare Providers in India · 2025 · DOI
Healthcare providers noted the need for more training sessions. The study faced challenges in ensuring facility readiness to implement the intervention.
Process Evaluation of Pragmatic Cluster-Randomized Trials of Digital Adherence Technologies for Tuberculosis Treatment Support: A Mixed-Method Study in Five Countries · 2025 · DOI
The need for more evidence on the effectiveness of digital adherence technologies for tuberculosis treatment support. The mixed results from recent studies suggest a gap in understanding the fidelity of digital adherence technologies.
Process Evaluation of Pragmatic Cluster-Randomized Trials of Digital Adherence Technologies for Tuberculosis Treatment Support: A Mixed-Method Study in Five Countries · 2025 · DOI
Limited access to shorter regimens and adherence counseling.
Tuberculosis Preventive Treatment in People Living with HIV in Uganda: Facilitators and Barriers for Initiation and Completion · 2025 · DOI
Infrastructure constraints, including limited access to molecular diagnostics and capacity-building for health workers. Limited community involvement, with weak engagement of civil society organizations and community health workers in TB prevention and care activities.
Ending the TB Crisis in Low- and Middle-Income Countries of the Eastern Mediterranean Region—Overcoming Inaction Through Strategical Leaps · 2025 · DOI
Developing safe and effective strategies for Mtb elimination without drug resistance, - Investigating the multifaceted implications of Z-DNA in biofilm integrity and immune…
Nano-NucleOTAC-mediated Z-DNA transformation disrupts mycobacterium tuberculosis biofilms and activates antibacterial immunity · 2026 · DOI
Low quality of evidence due to non-uniform definition of cure, - Lack of bacteriological confirmation of cure, - Non-representative study population, - Use of a single method with low discriminatory power for distinguishing between relapse and reinfection, - Geographical imbalance in the application…
Impact of Follow-Up Duration and Geographical Distribution of Whole-Genome Sequencing Studies on Estimates of Exogenous Reinfection in Recurrent Tuberculosis: A Systematic Review and Meta-Analysis · 2026 · DOI
Inherent limitations of short-read sequencing technologies, - Limited to 12 clinical MTB isolates, - No mention of limitations on generalizability to other…
Long-read sequencing of clinical multidrug-resistant Mycobacterium tuberculosis reveals a novel ethA structural variant conferring ethionamide resistance · 2026 · DOI
Further study of the novel ethA structural variant, - Investigation of other potential SVs conferring drug resistance, - Expansion to larger and more diverse…
Long-read sequencing of clinical multidrug-resistant Mycobacterium tuberculosis reveals a novel ethA structural variant conferring ethionamide resistance · 2026 · DOI
Small sample size of 14 participants, - Limited to urban Blantyre, Malawi, - No repeat interviews were conducted, - Study only explored pre-diagnostic experiences of TB…
Navigating uncertainty: pre-diagnostic tuberculosis experiences and care-seeking in Blantyre, Malawi · 2026 · DOI
Further research on diagnostic delays and treatment outcomes, - Investigation of health system factors contributing to diagnostic and treatment delay, - Exploration of patient-centered approaches to improve TB diagnosis…
Navigating uncertainty: pre-diagnostic tuberculosis experiences and care-seeking in Blantyre, Malawi · 2026 · DOI
Small sample size of 56 participants, - Limited to adult Peruvian patients, - No comparison with other diagnostic…
IL-5 and IP-10 Detected in Quantiferon Supernatants Distinguish Latent Tuberculosis from Healthy Individuals in Areas with High Burden in Lima, Peru · 2025 · DOI
Research into biomarkers for TB is crucial to achieving global goals for eliminating the disease, - Efforts to understand immunological changes such as cytokines and their differential expression during the different stages…
IL-5 and IP-10 Detected in Quantiferon Supernatants Distinguish Latent Tuberculosis from Healthy Individuals in Areas with High Burden in Lima, Peru · 2025 · DOI
Developing new anti-TB medications, - Identifying pharmacological action targets, - Exploring the use of sophisticated AI models in global TB…
Integration of AI and ML in Tuberculosis (TB) Management: From Diagnosis to Drug Discovery · 2025 · DOI
Investment in local research ecosystems - Addressing the gap between evidence and policy in TB prevention and control - Embedding evidence generation into national TB…
Ending the TB Crisis in Low- and Middle-Income Countries of the Eastern Mediterranean Region—Overcoming Inaction Through Strategical Leaps · 2025 · DOI

Most-cited papers in Tuberculosis Research and Epidemiology

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence · Nature · 1998 · 6,528 citations
Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent · New England Journal of Medicine · 2001 · 2,938 citations
Global Burden of Tuberculosis · JAMA · 1999 · 2,064 citations
Efficacy of BCG Vaccine in the Prevention of Tuberculosis · JAMA · 1994 · 2,059 citations
The Growing Burden of Tuberculosis · Archives of Internal Medicine · 2003 · 1,788 citations
Rapid Molecular Detection of Tuberculosis and Rifampin Resistance · New England Journal of Medicine · 2010 · 1,775 citations
Global epidemiology of tuberculosis. Morbidity and mortality of a worldwide epidemic · JAMA · 1995 · 1,655 citations
Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa · The Lancet · 2006 · 1,170 citations
Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis · The Lancet · 1993 · 1,027 citations
Treatment of Highly Drug-Resistant Pulmonary Tuberculosis · New England Journal of Medicine · 2020 · 1,004 citations

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What the literature leaves open

Most-cited papers in Tuberculosis Research and Epidemiology

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