Science AI Journal
Medicine · Research topic

Open research questions in Urinary Bladder and Prostate Research

172 unresolved questions extracted from the limitations and future-work sections of 725 Urinary Bladder and Prostate Research papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • Investigating the effects of exercise on bladder pain sensitivity in other animal models, - Examining the mechanisms by which exercise restores TAC levels and reduces carbonyl content, - Studying the long-term effects of exercise on WAS-induced changes

    Exercise decreases stress induced bladder hyperalgesia, voiding frequency and oxidative load · 2026 · DOI

  • There is a lack of understanding of the effects of exercise on stress-induced bladder hyperalgesia. The therapeutic benefits of exercise for treating bladder hyperalgesia are unknown. The study aims to address this gap by investigating the effects of exercise on stress-induced bladder hyperalgesia and oxidative load.

    Exercise decreases stress induced bladder hyperalgesia, voiding frequency and oxidative load · 2026 · DOI

  • Investigate the mechanisms by which WWI mediates the relationship between LC9 and OAB. Examine the relationship between LC9, WWI, and OAB in different populations. Develop interventions aimed at improving LC9 scores and reducing OAB prevalence.

    Association between Life’s Crucial 9 and overactive bladder: the mediating role of weight-adjusted-waist index · 2025 · DOI

  • The precise etiology of overactive bladder remains incompletely understood. Overactive bladder presents increasing challenges to healthcare systems, particularly with the progressive aging of the global population.

    Combined healthy lifestyles and overactive bladder: a cross-sectional study of NHANES 2007–2020 · 2025 · DOI

  • Direct comparisons between SNM and peripheral nerve electrical stimulation are lacking.

    Efficacy differences between SNM and various peripheral nerve electrical stimulation modalities for NLUTD: a Bayesian network meta-analysis · 2026 · DOI

  • Its treatment responsiveness and long-term effectiveness need to be investigated further.

    Psychometric validation and cross-cultural adaptation of the Persian ICIQ-CLUTS child module for assessing pediatric lower urinary tract symptoms · 2026 · DOI

  • However, the mechanisms by which obesity influences the relationship between cardiovascular health and OAB remain unclear.

    Association between Life’s Crucial 9 and overactive bladder: the mediating role of weight-adjusted-waist index · 2025 · DOI

  • Objectives: The relationship between adherence to a combined healthy lifestyle and the risk of overactive bladder (OAB) remains unclear.

    Combined healthy lifestyles and overactive bladder: a cross-sectional study of NHANES 2007–2020 · 2025 · DOI

  • Recent evidence points toward a possible link between joint hypermobility and NE, but the underlying mechanisms remain unclear, and existing data are limited.

    Association between joint hypermobility and primary nocturnal enuresis: a cross-sectional study in children aged 6–13 years · 2025 · DOI

  • Future research should explore long-term efficacy and innovative approaches to enhance the management of nocturnal enuresis.

    Exploring clinical and urinary factors in treatment-resistant vs. treatment-responsive childhood enuresis: a comparative study · 2025 · DOI

  • BACKGROUND: Urinary frequency and vulvovaginitis are common diseases in girls, but there is insufficient emphasis on the relationship between them.

    The relationship between urinary frequency and vulvovaginitis in girls: a single-center retrospective study · 2025 · DOI

  • Whether the dynamic nature of depression affects the incidence of LUTS/BPH remains unknown.

    Longitudinal association between the dynamic nature of depression with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) · 2024 · DOI

  • For a long time, CP/CPPS has been considered a complex and variable disease, and its pathogenesis remains incompletely understood.

    Research progress on the relationship between chronic prostatitis/chronic pelvic pain syndrome and the microbiota of the reproductive system · 2024 · DOI

  • Although viral infection is a potential etiological cause, few studies have detected the effect of antiviral treatment.

    Intravesical Interferon Therapy vs Hyaluronic Acid for Pain Among Female Individuals With Interstitial Cystitis · 2024 · DOI

  • The study faces challenges in terms of the complexity of the disease mechanisms and the need for frequent injections of anti-VEGF for wet AMD. The study requires the enrollment of a large number of patients with specific inclusion and exclusion criteria.

    Mirabegron in patients with age-related macular degeneration treated for overactive bladder: a study protocol for a prospective observational non-randomized trial · 2026 · DOI

  • There is a need for common therapies for OAB and AMD, as they share common risk factors. The current treatment for wet AMD, intravitreal injection of anti-VEGF, requires frequent injections and may not be decisive in providing a solution.

    Mirabegron in patients with age-related macular degeneration treated for overactive bladder: a study protocol for a prospective observational non-randomized trial · 2026 · DOI

  • The study is limited by its small sample size, which may not be representative of the larger population. The study is limited by its retrospective design, which may introduce biases and limitations. The study notes that the relationship between psychiatric history and urinary symptoms is complex and requires further exploration.

    Lower Urinary Tract Symptom Scores Among Patients Presenting for Gender Affirming Orchiectomy: An Exploratory Analysis · 2026 · DOI

  • Small sample size (n = 26) - Retrospective study design - Lack of systematically collected questionnaire data for earlier patients - No imputation was performed due to the small sample size - The study was not powered to detect modest associations

    Lower Urinary Tract Symptom Scores Among Patients Presenting for Gender Affirming Orchiectomy: An Exploratory Analysis · 2026 · DOI

  • Oxidative stress and redox dysregulation are complex processes, - The development of effective treatment strategies for BPH is challenging, - The identification of patient subgroups with high levels of oxidative stress or certain redox imbalances is needed

    Redox Biology of Prostatic Enlargement: The Role of Antioxidants in BPH Progression and Therapy · 2026 · DOI

  • The current understanding of the role of redox biology in BPH is limited, - There is a need for further research on the potential use of antioxidants in prevention and treatment of BPH

    Redox Biology of Prostatic Enlargement: The Role of Antioxidants in BPH Progression and Therapy · 2026 · DOI

  • There is a need to assess the learning curves of surgeons with different levels of experience when switching from HoLEP to pulsed Thulium YAG lasers for ThuLEP. The study aims to address this gap by evaluating the learning curves of three surgeons with varying levels of experience.

    Switching lasers: assessing the learning curves of surgeons with different levels of surgical experience when switching from HoLEP to pulsed Thulium YAG lasers for ThuLEP · 2026 · DOI

  • Robust predictive tools for bladder stone risk in BPH patients remain underdeveloped. There is a need for a validated visual nomogram to predict bladder stone risk in BPH patients.

    Establishment and validation of a risk scoring model for predicting the risk of bladder stones in patients with benign prostatic hyperplasia · 2026 · DOI

  • High level of heterogeneity in the studies. Limited generalizability to humans. Variability in study designs, plant species, and parts of plants, extraction methods, dosages, and administration routes.

    Herbal Medicine in the Treatment of Benign Prostate Hyperplasia: A Systematic Review and Meta-Analysis of Animal Studies · 2026 · DOI

  • Future studies should investigate the long-term outcomes of RASP and LEP. Future research should aim to identify the optimal strategy (RASP or LEP) for large-volume BPH. Future studies should explore the use of new technologies and techniques for the treatment of large-volume BPH.

    Robot-assisted simple prostatectomy vs. laser enucleation of the prostate for large-volume benign prostatic hyperplasia (BPH, ≥80 mL): a systematic review and meta-analysis · 2026 · DOI

  • The optimal strategy (RASP or LEP) for large-volume BPH remains uncertain due to inconsistent clinical findings. There is a need for a comprehensive comparison of the perioperative efficiency, safety, and functional outcomes of RASP and LEP.

    Robot-assisted simple prostatectomy vs. laser enucleation of the prostate for large-volume benign prostatic hyperplasia (BPH, ≥80 mL): a systematic review and meta-analysis · 2026 · DOI

Most-cited papers in Urinary Bladder and Prostate Research

Most recent work

Find a gap in your own Urinary Bladder and Prostate Research sub-topic

This page shows what the Urinary Bladder and Prostate Research literature already flags as unresolved. To narrow it to your specific question, run the guided finder — it searches the gap library on demand and checks candidates against 250M+ OpenAlex works.

Open the Research Gap Finder →

Related topics in Medicine

Artificial Intelligence in Healthcare and Education
2,044 open questions
Substance Abuse Treatment and Outcomes
1,964 open questions
Smoking Behavior and Cessation
990 open questions
Dementia and Cognitive Impairment Research
974 open questions
Innovations in Medical Education
960 open questions
Physical Activity and Health
923 open questions
Attention Deficit Hyperactivity Disorder
839 open questions
Schizophrenia research and treatment
709 open questions
172 open questions have been extracted from the limitations and future-work passages of 725 Urinary Bladder and Prostate Research papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 120,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? A Tier 1–5 acceptance probability in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck prior-publication & salami-slicing risk across 8 sources.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.