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Open research questions in Urinary Tract Infections Management

150 unresolved questions extracted from the limitations and future-work sections of 680 Urinary Tract Infections Management papers in our library. Each links back to the study that raised it.

What the literature leaves open

  • The study faces the challenge of limited and heterogeneous evidence on digital health interventions for UTI prevention and management in people living with dementia. The review has to deal with the diversity in different stages of the dementia population and their caregivers. The study has to address the lack of relevant comprehensive reviews in prior literature.

    Digital health interventions for urinary tract infection prevention and management in people living with dementia and their family caregivers: a scoping review · 2025 · DOI

  • The evidence on digital health interventions for UTI prevention and management in people living with dementia is both limited and heterogeneous, - None of the studies included a control group, - The sample size of the participants varied between 15 and 117

    Digital health interventions for urinary tract infection prevention and management in people living with dementia and their family caregivers: a scoping review · 2025 · DOI

  • Prospective studies linking symptoms, susceptibility profiles and clinical outcomes are warranted.

    Uropathogen Distribution Across Successive Positive Urine Cultures Among Female Patients with Dysglycaemia · 2026 · DOI

  • Because urinary symptoms and isolate-level susceptibility results were unavailable, positive cultures could not be classified as symptomatic infection, asymptomatic bacteriuria or candiduria, and treatment appropriateness could not be assessed.

    Uropathogen Distribution Across Successive Positive Urine Cultures Among Female Patients with Dysglycaemia · 2026 · DOI

  • Routine urine culture, locally generated antibiograms, and structured antimicrobial stewardship are warranted.

    Antimicrobial Susceptibility of Urinary Tract Pathogens in a Resource-Limited Southern Nigerian Setting: Data to Inform Local Stewardship Frameworks · 2026 · DOI

  • Background: Urinary tract infections (UTIs) contribute substantially to infectious disease morbidity, while locally derived antimicrobial resistance data remain limited in many semi-urban Nigerian settings.

    Antimicrobial Susceptibility of Urinary Tract Pathogens in a Resource-Limited Southern Nigerian Setting: Data to Inform Local Stewardship Frameworks · 2026 · DOI

  • coli is found in high abundance in large intestine mucus, little is known about how it is able to maintain residence in this continuously secreted hydrogel.

    Mechanisms of uropathogenic E. coli mucosal association in the gastrointestinal tract · 2025 · DOI

  • Although numerous drugs are associated with UR, comprehensive and reliable studies identifying drugs that induce UR are scarce.

    Drug-induced urinary retention: a real-world pharmacovigilance study using FDA and Canada vigilance databases · 2025 · DOI

  • Background: Comprehensive estimations regarding the worldwide burden of urinary tract infections (UTIs) in older women aged ≥ 65 years are lacking.

    Global burden of urinary tract infections in older women from 1990 to 2021 with projections to 2040: a trend analysis of the Global Burden of Disease Study 2021 · 2025 · DOI

  • Data on the prevalence of urinary tract infections, antimicrobial susceptibility patterns, and the associated factors are scarce in the study area.

    Prevalence, antimicrobial sensitivity patterns and associated factors of urinary tract infection among patients attending Nekemte Comprehensive Specialized Hospital, Western Ethiopia, 2024: a cross-sectional study · 2025 · DOI

  • INTRODUCTION: In Bangladesh, the antibiotic resistance patterns of uropathogens in patients with complicated urinary tract infections (cUTIs) remain poorly understood.

    Bacterial profile and antibiotic resistance pattern of uropathogens isolated from patients with complicated urinary tract infections in a tertiary care hospital in Dhaka, Bangladesh · 2025 · DOI

  • However, the specific virulence factor genes (VFGs) driven by urobiome contributing to infection recurrence remain poorly understood.

    Urogenital microbiota-driven virulence factor genes associated with recurrent urinary tract infection · 2024 · DOI

  • While the composition of the urobiome has been investigated in adults for over a decade now, only a few studies have considered the presence and composition of the urobiome in children.

    Synthesis of current pediatric urinary microbiome research · 2024 · DOI

  • Background Despite a unique microbiome in urine, the relationship between nocturnal enuresis and the urobiome remains unclear.

    Propionimicrobium lymphophilum in urine of children with monosymptomatic nocturnal enuresis · 2024 · DOI

  • Unique bacterial behaviors in refractory disease. Limited understanding of the immune response in chronic LUTS patients. Small sample size and limited to female participants.

    Circulating Neutrophils Exhibit an Altered Immune Response in Chronic LUTS: An Image-Based Deep Learning Analysis · 2026 · DOI

  • Small sample size (7 healthy controls and 4 chronic LUTS patients). Limited to female participants. No known co-morbidities that may influence normal immune functions.

    Circulating Neutrophils Exhibit an Altered Immune Response in Chronic LUTS: An Image-Based Deep Learning Analysis · 2026 · DOI

  • The emergence of multidrug-resistant pathogens. The need for alternative therapies to antibiotic prophylaxis. The variability in the quality of the evidence on non-antibiotic therapies.

    Effectiveness of Non-Antibiotic Therapies in the Management of Recurrent Urinary Tract Infections in Women: A Systematic Review · 2026 · DOI

  • The study has a limited number of studies on some non-antibiotic therapies, such as probiotics and cranberry products. The study notes that the quality of the evidence varies, with some studies having a high risk of bias.

    Effectiveness of Non-Antibiotic Therapies in the Management of Recurrent Urinary Tract Infections in Women: A Systematic Review · 2026 · DOI

  • There is a need to investigate the relationship between dietary habits and rUTI in women. The study aims to address this gap by examining the relationship between dietary habits and rUTI in women.

    IP07-07 DIFFERENCES IN THE PREVALENCE OF RECURRENT URINARY TRACT INFECTIONS IN WOMEN BASED ON DIETARY HABITS · 2026 · DOI

  • The inability of bedridden patients to manage their own elimination needs. The need for nurses to adhere to standard operating procedures to prevent catheter-associated infections.

    Nurses’ Compliance with Elimination Care and Urinary Tract Infection Risk in Bedridden Patients · 2026 · DOI

  • The relationship between nurses' compliance with elimination care SOPs and UTI risk remains limited. There is a need to examine the association between nurse compliance and UTI risk among bedridden patients.

    Nurses’ Compliance with Elimination Care and Urinary Tract Infection Risk in Bedridden Patients · 2026 · DOI

  • The gap in current diagnosis and treatment of urinary tract infections, which can lead to inappropriate antibiotic treatment. The need for rapid antibiotic susceptibility testing to support antimicrobial stewardship. The lack of effective measures to avoid the spread of resistance.

    Impact of PA-100 AST System Rapid Antibiotic Susceptibility Test on Antibiotic Prescription for Community-Acquired Urinary Tract Infections in Spanish Primary Care Settings · 2026 · DOI

  • UTIs are common among women and pose significant public health challenges. There are anatomical and behavioral risk factors that facilitate bacterial entry into the urinary system. There is a need to improve UTI prevention and awareness among female university students.

    Hydration, Hygiene, and Health: Understanding Urinary Tract Infections Awareness in Female University Students · 2026 · DOI

  • Future studies should investigate the effectiveness of targeted educational interventions in improving UTI prevention and awareness. Future studies should explore the impact of health promotion strategies on UTI prevention and awareness. Future studies should examine the knowledge-practice gaps among female university students in different contexts.

    Hydration, Hygiene, and Health: Understanding Urinary Tract Infections Awareness in Female University Students · 2026 · DOI

  • Nursing home residents are vulnerable to infections and avoidable hospital transfers. Strengthened IPC and improved on-site decision-making may reduce preventable admissions.

    A multicomponent control programme in nursing homes in Singapore · 2026 · DOI

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150 open questions have been extracted from the limitations and future-work passages of 680 Urinary Tract Infections Management papers in our library. Each one below links back to the study that raised it, so you can read the original claim in context.

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