Science AI Journal
Medicine · Research topic

Open research questions in Urinary Tract Infections Management

388 gap statements mined from Urinary Tract Infections Management papers in our 7.9M-paper local library, which holds 1,819 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

Choosing where to publish on Urinary Tract Infections Management? See the ranked Medicine journals.

What the literature leaves open

  • The need to evaluate the antimicrobial activity of older drugs. The challenge of determining the bactericidal activity of furazidin against Enterobacterales.

    In vitro activity of furazidin and comparator agents against bacterial isolates from urinary tract infections · 2026 · DOI

  • The need to re-evaluate the antimicrobial activity of older drugs. The lack of understanding of the in vitro activity of furazidin against bacterial isolates from urinary tract infections.

    In vitro activity of furazidin and comparator agents against bacterial isolates from urinary tract infections · 2026 · DOI

  • It highlights the need for more transparent and comprehensive reporting of clinical studies. It notes the limitations of current treatment options, such as antibiotic resistance.

    Clinical research landscape and evidence gaps in Traditional Chinese Medicine for recurrent urinary tract infections: a scoping review · 2026 · DOI

  • There is a need to understand how urinary bacterial ecology and antimicrobial resistance change over time and vary across clinical settings.

    Urinary Bacterial Isolate Distribution and Laboratory-Reported Antimicrobial Resistance in a Romanian Tertiary Urology Department: A Retrospective Comparison of 2013 and 2023 · 2026 · DOI

  • The current treatment strategies for CAUTIs are often ineffective due to the formation of bacterial biofilms on catheter surfaces. There is a need for innovative treatment strategies that can combat these biofilm-associated infections. The development of dedicated and innovative methods is required based on our understanding of the intricate nature of biofilms.

    Catheter-Associated Urinary Tract Infections: Understanding the Interplay Between Bacterial Biofilm and Antimicrobial Resistance · 2025 · DOI

  • The lack of robust evidence for non-antibiotic alternatives. The need for controlled and comparative trials to confirm the effectiveness and clinical applicability of Uromune.

    Current Evidence on Safety, Efficacy and Efficiency of Sublingual Vaccine Uromune® in Prevention of Recurrent Urinary Tract Infections: A Literature Review · 2025 · DOI

  • The lack of standardized treatment approaches for UTIs despite the existence of diverse guidelines from various medical specialties. The increasing incidence of multidrug resistance, which complicates UTI management. The need for effective strategies to balance antimicrobial stewardship with infection control.

    Understanding the Burden and Management of Urinary Tract Infections in Women · 2025 · DOI

  • Real data regarding antimicrobial resistance rates of positive urine cultures from Romania are scarce. The focus was mainly on female patients, with limited data on mixed adult populations.

    In and Outpatients Bacteria Antibiotic Resistances in Positive Urine Cultures from a Tertiary Care Hospital in the Western Part of Romania—A Cross-Sectional Study · 2025 · DOI

  • The risk of underdiagnosis or underestimation of resistance in settings with limited microbiological capacity - The need for vigilant antimicrobial stewardship and further research to develop standardized treatment protocols for managing infections caused by K.

    First Report from Colombia of a Urinary Tract Infection Caused by Kluyvera ascorbata Exhibiting an AmpC Resistance Pattern: A Case Report · 2025 · DOI

  • The study had to overcome the limitation of scarce antimicrobial resistance data in low- and middle-income countries.

    The Etiology and Antimicrobial Susceptibility of Community-Onset Urinary Tract Infections in a Low-Resource/High-Resistance Area of Latin America · 2025 · DOI

  • The lack of knowledge of the local epidemiology of antimicrobial susceptibility among the most common pathogens.

    The Etiology and Antimicrobial Susceptibility of Community-Onset Urinary Tract Infections in a Low-Resource/High-Resistance Area of Latin America · 2025 · DOI

  • Accordingly, international guidance is sparse and inconsistent, and preoperative pathways for urine culture and its treatment differ between institutions.

    Are we far from getting it right? Contemporary practices in culturing urine pre‐ureteroscopy · 2026 · DOI

  • There is conflicting evidence regarding the association of preoperative asymptomatic bacteriuria (ASB) with postoperative urinary tract infection (UTI).

    Are we far from getting it right? Contemporary practices in culturing urine pre‐ureteroscopy · 2026 · DOI

  • Despite this, there are limited data on the impact of oral antibiotic treatment failure (TF) on health care resource utilization (HCRU) and costs for patients with empirically treated uUTIs.

    Impact of empirical treatment failure on health care resource utilization and costs among female patients with uncomplicated urinary tract infections in a US-based Integrated Health Delivery Network · 2025 · DOI

  • Urinalyses (UAs) have been increasingly incorporated into diagnostic stewardship interventions, but the impact of these interventions nationally has not been assessed.

    Urine culture and urinalysis utilization practices in United States acute care hospitals between 2017 and 2020 · 2025 · DOI

  • Based on findings regarding risk factors for CAUTI, focus on reducing LOS and UC utilization is warranted, as well as implementing evidence-based CAUTI-prevention recommendations.

    Incidence and risk factors for catheter-associated urinary tract infection in 623 intensive care units throughout 37 Asian, African, Eastern European, Latin American, and Middle Eastern nations: A multinational prospective research of INICC · 2024 · DOI

  • Management of asymptomatic bacteriuria in kidney transplant recipients remains uncertain.

    Clinical Urinary Tract Infections in Kidney Transplant Recipients With Initially Asymptomatic Bacteriuria: A Single-Center Retrospective Cohort Study · 2024 · DOI

  • Examining the benefit of screening and treatment of asymptomatic bacteriuria in patients with these high-risk features warrants further investigation.

    Clinical Urinary Tract Infections in Kidney Transplant Recipients With Initially Asymptomatic Bacteriuria: A Single-Center Retrospective Cohort Study · 2024 · DOI

  • Limited understanding of the immune response in chronic LUTS patients. Small sample size and limited to female participants.

    Circulating Neutrophils Exhibit an Altered Immune Response in Chronic LUTS: An Image-Based Deep Learning Analysis · 2026 · DOI

  • The study has a limited number of studies on some non-antibiotic therapies, such as probiotics and cranberry products. The study notes that the quality of the evidence varies, with some studies having a high risk of bias.

    Effectiveness of Non-Antibiotic Therapies in the Management of Recurrent Urinary Tract Infections in Women: A Systematic Review · 2026 · DOI

  • Limited to female participants. No known co-morbidities that may influence normal immune functions.

    Circulating Neutrophils Exhibit an Altered Immune Response in Chronic LUTS: An Image-Based Deep Learning Analysis · 2026 · DOI

  • Future trials should consider feasible bias-control strategies, - Future research should prioritize transparent reporting of ethics approval, informed consent, randomization, allocation concealment, blinding, and protocol…

    Clinical research landscape and evidence gaps in Traditional Chinese Medicine for recurrent urinary tract infections: a scoping review · 2026 · DOI

  • Methodological limitations of the narrative review, - Lack of systematic criteria for study selection and analysis, - Potential bias, - Limited external validity, - Need for controlled and comparative…

    Current Evidence on Safety, Efficacy and Efficiency of Sublingual Vaccine Uromune® in Prevention of Recurrent Urinary Tract Infections: A Literature Review · 2025 · DOI

  • Further studies are needed to establish the trajectory of change during the intervening decade, - Research on the factors contributing to the changes in bacterial composition and antimicrobial resistance patterns is necessary, - Studies on the clinical implications of the observed changes…

    Urinary Bacterial Isolate Distribution and Laboratory-Reported Antimicrobial Resistance in a Romanian Tertiary Urology Department: A Retrospective Comparison of 2013 and 2023 · 2026 · DOI

  • A survey of advanced practice clinicians (APCs), physicians, residents, and medical students at an academic medical center and community practices in southeastern Texas revealed a gap in knowledge and practice related to testing and treatment for asymptomatic bacteriuria (ASB) in older adults.

    Assessing clinicians’ and trainees’ knowledge and practice of the IDSA guidelines for asymptomatic bacteriuria in older adults · 2024 · DOI

Most-cited papers in Urinary Tract Infections Management

Most recent work

Find a gap in your own Urinary Tract Infections Management sub-topic

This page shows what the Urinary Tract Infections Management literature already flags as unresolved. To narrow it to your specific question, search the Research Gap Finder: the search is free with a free account and lists the papers closest to your topic first. Unlocking that topic (50 credits, charged once) fills the comparison table from our 7.9M-paper local library and writes the gaps from its rows.

Open the Research Gap Finder →

Related topics in Medicine

Artificial Intelligence in Healthcare and Education
4,200 open questions
Dementia and Cognitive Impairment Research
2,789 open questions
Substance Abuse Treatment and Outcomes
2,285 open questions
Cancer Immunotherapy and Biomarkers
2,273 open questions
Liver Disease Diagnosis and Treatment
2,102 open questions
Sports Performance and Training
1,952 open questions
Parkinson's Disease Mechanisms and Treatments
1,915 open questions
Mosquito-borne diseases and control
1,849 open questions
Open questions raised by papers listed on this page include: (1) The lack of understanding of the in vitro activity of furazidin against bacterial isolates from urinary tract infections (“In vitro activity of furazidin and comparator agents against bacterial isolates…”, 2026); (2) There is a need to understand how urinary bacterial ecology and antimicrobial resistance change over time and vary across clinical settings (“Urinary Bacterial Isolate Distribution and Laboratory-Reported Antimicrobial…”, 2026); (3) There is a need for innovative treatment strategies that can combat these biofilm-associated infections (“Catheter-Associated Urinary Tract Infections: Understanding the Interplay…”, 2025); (4) The lack of robust evidence for non-antibiotic alternatives (“Current Evidence on Safety, Efficacy and Efficiency of Sublingual Vaccine…”, 2025); (5) The lack of standardized treatment approaches for UTIs despite the existence of diverse guidelines from various medical specialties (“Understanding the Burden and Management of Urinary Tract Infections in Women”, 2025). 388 gap statements have been mined from Urinary Tract Infections Management papers in our 7.9M-paper local library, which holds 1,819 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

Tools for your next paper

Gaps & Literature SearchFind open questions in any field — 1,100,000+ open gaps mined from our own library.Pre-CheckIs your paper ready? Acceptance odds for top, mid and open/emerging journals, in seconds.Journal FinderA ranked shortlist of target journals from a 17,500-venue index.Duplicate Publication CheckerCheck for prior publication across 7 sources and our local library.Citation GeneratorFreeA DOI or title → APA, MLA, Vancouver, Chicago, BibTeX, RIS. No signup.Graphical Abstract MakerFreeTurn your findings into a colorblind-safe graphical abstract.

How Pre-Check worksHow AI Review works

Compare the category — Honest roundups of the AI research tools, ours listed alongside the alternatives.

Command palette

Jump anywhere, run any action.