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Open research questions in Uterine Myomas and Treatments

291 gap statements mined from Uterine Myomas and Treatments papers in our 7.9M-paper local library, which holds 1,353 papers on the topic — drawn mostly from each paper's own stated research gap, future-work, challenge and limitation notes, and its abstract. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one.

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What the literature leaves open

  • Future research should move from feasibility reporting toward clinically meaningful evaluation. Priority outcomes should include registration accuracy, operative time, blood loss, complications, conversion, cavity entry, completeness of lesion removal, surgeon workload, workflow burden, cost, and fertility-related outcomes.

    Augmented Reality, Mixed Reality, Computer Vision, and Three-Dimensional Modeling in Fertility-Preserving Minimally Invasive Gynecologic Surgery: A Scoping Review with Narrative Synthesis · 2026 · DOI

  • For directed biopsy, the difficulty is of a different kind: the published series are small and selected, so the evidence is insufficient to establish diagnostic accuracy and clinical utility in unselected populations, which is not evidence that the technique is ineffective.

    Pretreatment Assessment of Occult Uterine Sarcoma Risk Before Uterus-Preserving Treatment of Presumed Fibroids: A Narrative Review · 2026 · DOI

  • The paper identifies the challenge of limited procedure-specific evidence for minimally invasive gynecological surgery. It notes the challenge of defining and measuring postoperative ileus, which requires a multidimensional assessment. The study faces the challenge of potential overfitting and sparse-data concerns due to the limited number of delayed passage of flatus events.

    Perioperative factors associated with delayed passage of flatus after laparoscopic uterine myomectomy: a single-center retrospective cohort study · 2026 · DOI

  • There is a gap in procedure-specific evidence for minimally invasive gynecological surgery. Prior work has studied postoperative gastrointestinal dysfunction most extensively after colorectal and major abdominal surgery.

    Perioperative factors associated with delayed passage of flatus after laparoscopic uterine myomectomy: a single-center retrospective cohort study · 2026 · DOI

  • Future research should focus on validating predictive biomarkers, elucidating mechanisms of therapeutic resistance, and exploring targeted agents and immunotherapies in well-defined molecular subgroups of ESS.

    Endometrial Stromal Sarcoma: An Update · 2025 · DOI

  • Given the clinical course of this patient, prominent sclerosis may be a histologic feature that warrants further investigation as to the possible impact on prognosis/prediction of malignant potential. Our case report is limited by the fact that our panel did not include evaluation for ESR or GREB1 or NCOA3 rearrangements, but no NCOA1/2 rearrangements were identified.

    Sclerosis in Metastatic Uterine Tumor Resembling Ovarian Sex Cord Tumor: Diagnostic Dilemma Presented by Unusual Morphology · 2025 · DOI

  • Future studies are needed to confirm our findings, and to elucidate the specific mechanisms involved in the shared genetic influences and their potential impact on UL development.

    A comprehensive genome-wide cross-trait analysis of sexual factors and uterine leiomyoma · 2024 · DOI

  • Further studies incorporating genome-wide methylation profiling and functional analyses are warranted to elucidate the specific pathways through which these factors may influence leiomyoma development and progression.

    Genetic–Epigenetic Interactions in Uterine Leiomyomas: MED12 Mutations as Predictors of Aberrant DNA Methylation · 2026 · DOI

  • At present, however, validated real-time AR navigation for endometriosis surgery has not yet been established.

    Augmented Reality, Mixed Reality, Computer Vision, and Three-Dimensional Modeling in Fertility-Preserving Minimally Invasive Gynecologic Surgery: A Scoping Review with Narrative Synthesis · 2026 · DOI

  • Because the formal classification and long-term behavior of this emerging molecular group remain incompletely defined, cautious terminology and continued clinical surveillance are warranted.

    KAT6B::KANSL1 fusion-positive uterine mesenchymal neoplasm with hybrid endometrial stromal and smooth muscle features: a case report · 2026 · DOI

  • For directed biopsy, the evidence is insufficient to establish diagnostic accuracy in unselected populations, which is not the same as evidence of ineffectiveness.

    Pretreatment Assessment of Occult Uterine Sarcoma Risk Before Uterus-Preserving Treatment of Presumed Fibroids: A Narrative Review · 2026 · DOI

  • Previous studies examining the effect of hysterectomy on vaginal length and sexual function have reported inconsistent findings, largely due to differences in patient selection and surgical techniques.

    Postoperative vaginal anatomy and dyspareunia after vNOTES hysterectomy without apical suspension: a comparative study · 2026 · DOI

  • Future work is warranted to fully uncover specific pathways that underlie the UL-AFS/NSP biological associations.

    A comprehensive genome-wide cross-trait analysis of sexual factors and uterine leiomyoma · 2024 · DOI

  • Abnormal lipid metabolism and oxidative stress have both been implicated in uterine fibroids (UFs), but the relationship between these processes in patients with UFs remains unclear.

    Correlation Between Superoxide Dismutase and Very-Low-Density Lipoprotein Cholesterol in the Blood of Patients with Uterine Fibroids · 2026 · DOI

  • Careful surgical handling, incision protection, and long-term follow-up are warranted in patients with recurrent or atypically behaving leiomyomas.

    Pulmonary Benign Metastasizing Leiomyoma with Abdominal Wall and Pelvic Cavity Implantation: A Case Report and Literature Review · 2026 · DOI

  • Given the limitations of the single‑case study and the relatively short follow‑up duration, the long‑term efficacy and fertility preservation outcomes remain to be further verified.

    Uterine Artery Embolization Combined with Hysteroscopic Surgery for the Treatment of Complex Submucosal Leiomyomas with Refractory Bleeding: A Case Report · 2026 · DOI

  • Interestingly, in malignant smooth muscle tumors (SMTs), particularly uterine leiomyosarcoma (LMS), aberrant nuclear localization of smoothelin has been observed, though the underlying mechanism remains unclear.

    Association of Smoothelin, a Cytoskeletal Component of Smooth Muscle Cells, With the Proliferative Features of Uterine Smooth Muscle Tumors · 2026 · DOI

  • It offers a more efficient instrument for assessing symptom severity and quality of life and shows potential for use in clinical and research settings, although further validation in independent populations is warranted.

    Development and Validation the Uterine Fibroid Symptom and Quality of Life Short-Form: Integrating Classical and Modern Test Theory · 2026 · DOI

  • The prognostic factors and impact of pelvic lymphadenectomy in uterine sarcomas remain unclear.

    Prognostic Factors and Role of Pelvic Lymphadenectomy in Patients with Uterine Sarcoma: A Multi-Center Population-Based Cohort Study · 2025 · DOI

  • Limited evidence is available regarding preferences of women with uterine fibroids (UF) and treating healthcare providers (HCPs) regarding treatment attributes; this evidence could contribute to patient-centered shared decision-making.

    Understanding Preferences, Needs, and Expectations for Pharmaceutical Treatment of Symptomatic Uterine Fibroids Based on Surveys of Healthcare Providers and Patients · 2025 · DOI

  • Comparison of laparoscopic and abdominal hysterectomy outcomes still need to be explored in a large-scale randomised controlled trial.

    Feasibility, acceptability and appropriateness of laparoscopic versus abdominal hysterectomy for women and healthcare professionals: the LAVA trial qualitative process evaluation · 2025 · DOI

  • The comparative rates of major complications and recovery times between laparoscopic hysterectomy and abdominal hysterectomy for benign gynaecological conditions remain uncertain.

    Laparoscopic hysterectomy versus open abdominal hysterectomy for women with a benign gynaecological condition: the LAVA RCT · 2025 · DOI

  • There are limited data, however, on same-day discharge outcomes for vaginal hysterectomy and pelvic reconstruction.

    Same-Day Discharge is Safe, Feasible Following Vaginal Hysterectomy with Apical Suspension · 2024 · DOI

  • Furthermore, no studies have reported the presence of multiple subserosal adenomyomas.

    A Rare Case of Multiple Subserous Uterine Adenomyomas Misdiagnosed as an Ovarian Cyst, Diagnosed and Treated by Laparoscopy · 2024 · DOI

  • Fourth, the uterine size or uterine volume was not recorded as a continuous quantitative variable in the retrospective dataset; therefore, the potential relationship between uterine dimensions and hemoglobin levels or anemia could not be evaluated.

    Comparative Effectiveness of Hysteroscopic Endometrial Resection Versus the 52-mg Levonorgestrel-Releasing Intrauterine System for Heavy Menstrual Bleeding: A Retrospective Cohort Study · 2026 · DOI

Most-cited papers in Uterine Myomas and Treatments

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Open questions raised by papers listed on this page include: (1) Future research should move from feasibility reporting toward clinically meaningful evaluation (“Augmented Reality, Mixed Reality, Computer Vision, and Three-Dimensional…”, 2026); (2) Further studies incorporating genome-wide methylation profiling and functional analyses are warranted to elucidate the specific pathways through which these factors may influence leiomyoma development and progression (“Genetic–Epigenetic Interactions in Uterine Leiomyomas: MED12 Mutations as…”, 2026); (3) Because the formal classification and long-term behavior of this emerging molecular group remain incompletely defined, cautious terminology and continued clinical surveillance are warranted (“KAT6B::KANSL1 fusion-positive uterine mesenchymal neoplasm with hybrid…”, 2026); (4) Abnormal lipid metabolism and oxidative stress have both been implicated in uterine fibroids (UFs), but the relationship between these processes in patients with UFs remains unclear (“Correlation Between Superoxide Dismutase and Very-Low-Density Lipoprotein…”, 2026); (5) Careful surgical handling, incision protection, and long-term follow-up are warranted in patients with recurrent or atypically behaving leiomyomas (“Pulmonary Benign Metastasizing Leiomyoma with Abdominal Wall and Pelvic Cavity…”, 2026). 291 gap statements have been mined from Uterine Myomas and Treatments papers in our 7.9M-paper local library, which holds 1,353 papers on the topic; the gaps come from whichever of those papers state one. They are mostly the research gaps the authors state and the papers' abstracts, plus future-work, limitations and challenges passages. The ones listed below are a selection still marked open; each names the study that raised it, with a DOI link where the paper has one, so you can read the original claim in context.

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